Chapter 1225: From a country based on trade to a country based on technology (Third update, please subscribe)
“Havana compromised! They have agreed to allow the expatriates to leave with their personal belongings.”
After receiving this report Finally, there was no smile on Li Yian's face, he just nodded slightly, and then said:
"What a pity..."
Why Li Yian said this is a pity, because in Cuba" On the matter of "nationalization", Nanyang can't do much.
According to the normal routine, Nanyang should directly "strike hard" and smash Havana to pieces, or even directly bring the bearded man to Nanyang and take him to court, just like what the Americans did in Panama.
Then let the whole world understand the truth - Nanyang's steamed buns are not delicious.
But the problem is - you can't do this now, because Cuba has not yet become a high pill for the United States, and Cuba has not yet completely become a pawn of the Soviet Union.
Only after the Soviet Union deploys nuclear missiles in Cuba will Americans realize how terrible it is for their country to have a Russian ally around them.
“It’s a pity. I could have killed the chicken and showed it to the monkey, but I never thought that the chicken would kneel down first.”
Li Guoren smiled.
“I thought they would fight to the end, but I never expected that they would kneel down so quickly.”
When he said these words, his tone was proud. Only as a diplomat Only then did he realize what was behind this compromise - it was a reflection of national strength, and more importantly - they had never compromised in the face of pressure from the United States.
But here in Nanyang, they have become very "sane".
“This is because we can really punch! So, they understand what the price of not compromising will be.”
Li Yian said casually:
"If we hit Cuba hard now, the Americans will not feel the pain, and they will inevitably stop our actions in other areas, such as Jakarta..."
After a slight pause, Li Yian continued.
“For Nanyang, Cuba is just a problem, but Jakarta is a real threat. In the past few years, with the help of the Soviets, Jakarta not only established a modern The army, and they are also suppressing local rebels little by little.
It can be said that Jakarta's military power is far more powerful than in history, and the threat to Nanyang is also increasing day by day.
Because of this, resolving the Jakarta threat has always been Nanyang's top priority. However, the United States had previously stepped in to stop Nanyang.
At that time, they did not feel the pain of seppuku. Now - those Americans feel it in Cuba, let them understand that some things must be struck hard, and there is no room for slacking off. ”
This is the United States - the current United States is actually not much different from that of later generations. They are the kind of people who want to be bitches and also want to build memorials.
They don’t do that at all. We know that compromise will never be tolerated on some issues. It was not until after the Cuban Missile Crisis that the United States finally understood one thing - core security must not be compromised.
Later, the United States invaded Grenada and Panama. Basically for this reason.
"Your Excellency, now..."
"Continue to negotiate with the Cubans. We must ensure the interests of the expatriates as much as possible. At the same time, we must also send a signal to the world - things from Southeast Asia will not be tolerated. Anyone can touch it."
Li Yian thought for a while and said:
"Let Americans first feel the pain of skin-cutting."
… …
"...After long-term negotiations, regarding the evacuation of Cuban nationals, the Ministry of Foreign Affairs has reached an agreement with the Cuban authorities yesterday. According to the agreement, the Cuban authorities allow Nanyang to send aircraft and ships to evacuate the nationals, and allow each national to carry weight Personal belongings not exceeding 100 kilograms..."
Listening to the news on the radio, the corners of Zhang Zhiquan's lips raised, although the news only mentioned the mediation of diplomatic officials.
But as a doctor of organic chemistry, but in connection with the failure of the US operation in Cuba last month, and in connection with the news of the naval fleet's "visit" to North America, the answer is obvious.
"It should be said that the naval exercises scared them. Sure enough, the world is still afraid of power."
Although power is not good, at this time, Zhang Zhiquan came to a conclusion in his heart At the same time, it is more of a sense of national pride.
This pride comes from the heart!
Like young scholars in Nanyang, Zhang Zhiquan also attended high school in Tangshan, and then was admitted to Nanyang University. At Nanyang University, he studied organic chemistry from undergraduate to master's degree, and then went to the United States to study for a doctoral degree.
It was this experience that made him full of gratitude for Nanyang. After all, if it were not for Nanyang, he would not even have the chance to study in college.
So, he has a very strong sense of belonging to Nanyang, and it is this sense of belonging that makes him feel such pride.
The United States is not Nanyang, and Nanyang is not the United States!
What the United States cannot do does not mean that Nanyang cannot do it - Nanyang has successfully protected the property of its own citizens, at least to a certain extent.
In this way, while listening to the news on the radio, Zhang Zhiquan drove his car into the company. As a researcher at the Saaz Laboratory, he has been conducting some research in the past two years. .
As early as when I was a graduate student, I became interested in the biosynthesis of cholesterol. For this reason, he also wrote a letter to Konrad Bloch, expressing his hope to study under his leadership. Bloch was an authority on the biosynthesis of cholesterol and fatty acids.
In the United States, Zhang Zhiquan noticed that there are many elderly and overweight people in the United States. In the community where he lives, there are many elderly couples living alone. He often sees ambulances arriving to take elderly people having heart attacks to the hospital. Coronary heart disease was the leading cause of death in the United States. At that time, the number of Americans suffering from hypercholesterolemia, a precursor to coronary heart disease, exceeded 10 million.
The experience of studying with Bloch made him understand that there are two main sources of cholesterol in the human body, which can be synthesized by the body or absorbed from food. Studies have shown that in humans, the cholesterol produced in the liver far exceeds the cholesterol absorbed from the diet, and HMG-CoA reductase is a key enzyme in the cholesterol synthesis process and has been shown to be the enzyme that controls the rate of cholesterol synthesis. Based on these facts, Zhang Zhiquan speculated that cholesterol synthesis inhibitors, especially HMG-CoA reductase inhibitors, would be effective agents for lowering cholesterol. The situation at that time was that there were many types of lipid-lowering drugs on the market, but none of them were considered safe and effective. Moreover, HMG-CoA reductase inhibitors have not yet been developed in various countries.
Zhang Zhiquan, who has ultra-high scientific acumen, realized the importance of developing cholesterol-lowering drugs. After successfully completing his studies in the United States, he returned to Chang'an to continue overcoming this problem.
After returning to China, the Satz Laboratory gave Zhang Zhiquan a great deal of freedom, giving him the opportunity to work on projects of his own choice.
It was here that I boldly proposed an idea: looking for substances in fungi that can block HMG-CoA reductase.
When Zhang Zhiquan got out of the car and walked to the elevator, in the laboratory, Lin Yongsheng, who had just come from the assignment, asked curiously while sorting out the fungal samples to be used today:
< br>
"Why are we studying fungi? Can we find substances in fungi that can prevent HMG-CoA reductase?"
Bai Longkang asked:
"How did our laboratory come about? "
Lin Yongsheng replied: "Streptomycin invented by Mr. Satz."
"In fact, Dr. Zhang chose this direction because he believed that bacteria. Like humans, cholesterol is needed to keep cell walls together, so some fungi may have evolved something as a defense mechanism against microorganisms that require sterols to grow.
Now, we just need to find the right fungi. ”
So with the support of the laboratory, they started working. Inspired by Fleming’s success in mold, Zhang Zhiquan’s team began to use a large number of fungal culture fluids to screen for suitable compounds, which also involved Complex detection technology.
Everyone knows that this is just like buying a lottery ticket, it is just a gamble.
In the past two years, Zhang Zhiquan and his team have demonstrated. Amazing perseverance. They worked day and night in the laboratory.
After screening thousands of fungi, they still did not give up, but they still did not give up. One year later. , after screening the 3800th strain of fungus, they found that the culture fluid of the mold showed strong inhibitory activity
The active ingredient was shown to be a known substance, citrinin, which strongly inhibited HMG-CoA reductase and reduced serum cholesterol levels in rats. However, the study was suspended due to its toxicity to the kidneys. Nonetheless, the experience of this preliminary screening gave them great hope and courage, strengthening their confidence that they can discover better active substances in the future.
Recalling some of the results achieved in the past two years, Zhang Zhiquan said to himself:
“It’s just 99% of the sweat. Maybe only 50% of the sweat has been shed now...”< br>
It may be 98%, just the last step. Now they are doing hard work every day until they are exhausted.
Over the past two years, they have tested up to 6,000 fungal cultures.
"Doctor,"
As soon as Zhang Zhiquan walked into the laboratory, Long Baikang introduced:
"This is Lin Yongsheng, who graduated from Yongping University and just joined the laboratory."
"Hello, Doctor."
"Welcome to join you."
After welcoming him, Zhang Zhiquan asked:
"How is it? Are today's samples ready?"
"Everything is ready,"
Lin Yongsheng While answering, they introduced the origin of the samples, and soon they started working.
As usual, after briefly understanding the origin of these samples, Zhang Zhiquan inspected the petri dish. Suddenly, he said in surprise.
"Pen-3751 is ready for separation."
Listening to the doctor's surprise, Lin Yongsheng asked:
"What is Pen-3751?"
"Pen- 3751 was collected from a large grain store in Chang’an. A fungus was isolated from the rice sample, which is a blue-green mold that can contaminate oranges, melons and other fruits. However, due to the very low production rate of active compounds, the petri dish has been used for almost a year."
< br>On the same day, the active ingredients were isolated from the culture solution. They finally found a second active fungal culture.
Finally, in July of this year, Zhang Zhiquan isolated the inhibitory compound-ML-236B, also called mevastatin. So the first statin was born in Nanyang.
At this time, Jianmin Pharmaceutical, as the sponsor of the laboratory, did not know at this time that on this day, they would get the medicine they had been waiting for for a long time - in the future, statins will not only save lives Tens of millions of patients, and it will also bring tens of billions of dollars in revenue to the company.
Many times, countless inventions and innovations are discovered by chance and accident. In the development process of Nanyang, there are always too many scientific researchers like Zhang Zhiquan, whose wisdom and sweat are as much as theirs. It is changing this country bit by bit, turning this country from a "nation based on trade" to a "nation based on technology."
Fifteen years of continuous emphasis on education has enabled a new generation of scholars to finally develop their talents in various aspects. The vast majority of these people would have lost their jobs due to war or education and other factors. Buried, or obscured by chance.
But now that they have received modern higher education in Nanyang, along with the rise of Nanyang, especially Nanyang's investment in science and technology, they have been able to achieve surprising achievements in many fields.
Sometimes, their achievements change not just the fate of individuals, but even the fate of mankind.
(End of this chapter)