Among the "quadruple therapy" medications, isoniazid, rifampicin, and pyrazinamide are all bactericidal drugs.
Ethambutol has a bacteriostatic effect on tuberculosis bacteria. When used in combination with other anti-tuberculosis drugs, it can delay the development of bacterial resistance to other drugs.
However, three of the drug ingredients, isoniazid, rifampicin and pyrazinamide, may damage liver function.
There are also gastrointestinal reactions, such as nausea, vomiting, abdominal discomfort, and may also lead to joint pain, blurred vision, allergic reactions, etc.
Therefore, young people like Zhao Yanxia can receive outpatient treatment and regular reexamination, while old men like Ma Lianliang can only be hospitalized for observation, and the dosage and quantity of drugs can be adjusted at any time according to the examination indicators.
When Dean Shen heard that he was going to be hospitalized, he suddenly became worried and reminded in a low voice:
"Xiao Qi, our traditional Chinese medicine hospital, whether it is the headquarters or the branch, does not have an inpatient department. Look..."
Traditional Chinese medicine hospitals adopt an outpatient model, so neither Kuanjie nor Changping has designed an inpatient department or allocated relevant staff.
If Ma Lianliang needs to be hospitalized, there is really no place to place him.
When Director Su of the Peking Opera Theater heard this, his mind began to work quickly. As long as Grandmaster Ma can recover and return to the stage, he doesn't care how you treat him.
"Old Shen, I see that many of your dormitories are empty? Why don't you make one room available for us as a ward?"
When the Changping branch was built, we were afraid of the policy of downsizing the second and third batches of employees, so we built more dormitories from the beginning to avoid insufficient housing in the future. (The third-tier construction back then was based on this idea)
This time the National Peking Opera Company came to Changping to perform for three days, and these empty dormitories became temporary accommodation for the actors.
After hearing this, Dean Shen thought for a moment and shook his head:
"No, five dormitory buildings are connected together. There are 600 employees and family members in our hospital, many of whom are elderly and children. It is inappropriate to put tuberculosis patients in the dormitory area as a ward."
After all, tuberculosis is an infectious disease, and Dean Shen is still wary of it. He doesn't want to infect people in his unit, and the employees will not agree.
When Ma Lianliang heard this, he felt a little anxious. Zhang Xuejin, the eldest disciple next to him, was very discerning. Seeing that his master was anxious, he immediately suggested:
"Director Shen, Doctor Lin, can you go to Union Medical College Hospital for treatment? The inpatient department there is relatively well-equipped. I heard that a lot of instruments have just been imported from abroad to facilitate monitoring the conditions of my master and Teacher Chen, right?"< br>
The speaker has no intention, the listener has intention.
Dean Shen immediately became unhappy: "What if the patients from our Traditional Chinese Medicine Hospital still need to be admitted to Union Medical College Hospital? Don't our Traditional Chinese Medicine Hospital be shameless?"
Zhang Xuejin is also a human being. Knowing that he might have accidentally violated other people's taboos, he quickly shrank his neck and stepped aside.
Lin Sanqi looked at the 19-year-old handsome boy Zhang Xuejin and thought that the Peking Opera circle is also a circle where people compete for their fathers.
Ma Lianliang is Zhang Junqiu's adoptive father, and Zhang Xuejin is Zhang Junqiu's biological son. However, Zhang Xuejin worshiped Ma Lianliang as his master. Look how messed up this generation is.
However, Zhang Xuejin was a conscientious man. Ma Lianliang was persecuted to death. So many disciples, relatives and friends did not dare to say goodbye for fear of avoiding him. Only Zhang Xuejin went to say goodbye.
Seeing true love in times of crisis shows that Ma Lianliang's apprenticeship was not in vain, and it also shows that Zhang Junqiu's tutoring is really good.
Oh, by the way, Zhang Xuejin later married the movie star Song Jia, which was considered a blessing.
Lin Sanqi thought about it again and thought that Zhang Xuejin's health didn't seem to be very good. He had hepatitis B, which was also an infectious disease. He later died of this disease at an early age.
Although hepatitis B cannot be completely cured like tuberculosis, it is not difficult to control.
Lin Sanqi thought that when she was free, she would have to deal with hepatitis B. After all, China is a big country with hepatitis B, and one in ten people is a hepatitis B patient. This statistic is more exaggerated than tuberculosis, and the consequences are more serious.
Everyone in the small conference room didn't know that Lin Sanqi had so much inner drama. Everyone was still racking their brains to find a way to get out of the inpatient unit.
Dean Su looked out the window at this time, then pointed to a pile of rocks at the foot of the mountain in the distance and said:
"Old Shen, look over there. The ground is full of rocks. You can't grow crops. Anyway, it's empty. You can build wards. This can not only meet the needs of inpatients, but also be far away from your dormitory area. Kill two birds with one stone. ?”
There are 1,000 acres of mountainous land in the area surrounding the Traditional Chinese Medicine Hospital. There are some fruit trees planted on the mountains. They are abandoned because they cannot produce food.
When Dean Shen thought about it, the light on his head suddenly turned on, thinking that this seemed to be a good idea.
Tuberculosis is currently an incurable disease in China. If Lin Sanqi has a secret recipe that can cure tuberculosis, it will greatly improve the reputation of traditional Chinese medicine hospitals.
If a traditional Chinese medicine hospital sets up a special "tuberculosis ward" to fully treat tuberculosis patients, this will not only create great economic benefits, but also have huge social benefits.
Even if traditional Chinese medicine hospitals can cure the vast majority of tuberculosis, not only can they suppress the old enemy of Union Medical College Hospital in China, but they can also make a big splash in the world and become a great satellite of our country's medical and health care industry, which is a great thing that brings glory to the country.
Thinking of this, Dean Shen quietly pulled Lin Sanqi aside and asked seriously:
"Xiaoqi, how confident are you about tuberculosis treatment?"
Lin Sanqi thought that Shen Yuan was talking about the two patients in front of her, so she replied without thinking:
"Zhao Yanxia, I am 100% sure. Ma Lianliang is in more trouble. He is too weak. While undergoing anti-tuberculosis treatment, he needs traditional Chinese medicine to regulate his liver and protect his liver. The cure rate should be... over 99%."
Dean Shen thought Ma Lianliang's treatment rate was 50%, half to half, but unexpectedly it was 99%. What's the difference between that and being cured?
The old man glared at Lin Sanqi openly and continued to ask:
"Xiao Qi, you see there are a lot of tuberculosis patients now. If nothing else, there are 8 employees in our hospital of traditional Chinese medicine suffering from tuberculosis. If our hospital of traditional Chinese medicine sets up a tuberculosis department to specially treat tuberculosis patients, prepare 50 beds. Are you sure about the treatment? Or is there any problem with the drug supply? ”
Lin Sanqi instantly became vigilant.
When he traveled to this era, he planned to make a fortune by monetizing traffic, not to be a doctor.
If he stays in the hospital every day to treat people, even if he becomes the most powerful doctor in the country, what's the use? What can you do with a salary of one or two hundred yuan a month?
Even if he works 12 hours a day, he can only see more than 100 numbers every day. How many patients can he see in a year?
Therefore, he is absolutely unwilling to tie himself to a clinical position. He wants to travel all over the country for procurement.
"Uncle Shen, please don't harm me. You also know that my role is to get supplies that others can't get. I can exchange Chinese medicinal materials for food and so on. I don't want to sit in the clinic every day. You asked me to be the department director. Isn’t this harmful to me?”
Dean Shen became furious when he heard this and slapped Lin Sanqi on the head:
"Go away, how could I harm you? There are so many tuberculosis patients across the country now experiencing the pain of the disease. You, a kid from a well-known family of traditional Chinese medicine, obviously have a prescription, but you don't think about curing diseases and saving lives? Are you all focused on money?"
Lin Sanqi cried out: "Uncle Shen, I don't love money, I only love Chinese medicinal materials. Please don't accuse me, a child of a noble family, okay?"
Dean Shen was furious after hearing this, and reached out and slapped Lin Sanqi on the head:
"Let you treat people, and it won't stop you from making money from traditional Chinese medicine. Think about it, when our tuberculosis ward opens, you will have to provide all the secret recipes by yourself. What kind of traditional Chinese medicine you want, our hospital will give it to you." Shopping all over the world
At that time, the hospital will be responsible for providing you with the quantity and types of medicinal materials you need. You can take them quietly. Our hospital's accounts won't show it anyway. What do you think of my suggestion? ”
Lin Sanqi was a little surprised, thinking that you, Shen Guoming, an old revolutionary with thick eyebrows and big eyes, actually taught him how to steal the Chinese medicinal materials from his work unit? The sun rises from the west?
Dean Shen asked impatiently: "Boy, do you think it's feasible?"
Lin Sanqi thought it was possible, and there would be no problem in actual operation.
Anyway, if he wants wild ginseng, musk, or iron bark maple, the hospital will purchase it and he will take it away secretly. All he needs to do is give the secret recipe and declare to the public that all the medicinal materials have been used.
But in theory, this is a socialist harvest. If someone discovers this and reports it, both Shen Guoming and Lin Sanqi will be unable to eat and walk around with a knife in the market entrance.
"Uncle Shen, is this possible?"
"Why is it not possible? If you can break through the treatment of tuberculosis, it will definitely be a world-wide medical miracle and a great thing that will bring glory to the country. Who dares to question you? As long as you can cure tuberculosis, everyone will only support you.< br>
Besides, you are the only one who knows the secret recipe you want to prepare, and you are the only one who knows how many medicinal materials you need. Anyway, you are not a cow. As long as you transport the medicinal materials without anyone noticing, no one will be able to catch you. If you can't catch it, what are you afraid of? ”
Dean Shen and the Purchasing Section Chief Kong Shuihu, the Pharmacy Section Chief Zhou Mingzhe, and the Finance Section Chief Zheng Meimei got along well. It was very easy for him to "corrupt" these medicinal materials. Anyway, he would never be able to find out just by checking the accounts.
As long as he didn't seek death by sneaking bags of medicinal materials out of the hospital and being caught on the spot, then those medicinal materials would only be considered to have been consumed while making the secret medicine, rather than being greedy.
Lin Sanqi plans to open a pharmaceutical factory in 2023. In addition to valuable natural musk, natural bezoar, and rhinoceros horn, he also needs a large amount of pearls, cinnabar, realgar, coptis, skullcap, gardenia, turmeric, borneol, snake gall, Panax notoginseng, etc. wait.
If all these medicinal materials were obtained from 1960, it would be far more advantageous and more reliable in efficacy than purchasing them in 2023.
Thinking of this, Lin Sanqi nodded firmly:
"Okay, Uncle Shen, I'll do as you say. You'll be responsible for getting the medicinal materials, and I'll be responsible for making the secret medicine. We'll try to build the most advanced tuberculosis treatment center in the world to open the eyes of those people in Xiehe."
"Hey, you finally figured it out, haha."
Dean Shen did what he said and immediately took the people from the General Affairs Department of the Hospital of Traditional Chinese Medicine to the foot of the farm to survey the terrain, contact the construction team, and prepare to build the "Tuberculosis Department" ward.
Many rules and regulations are not perfect these days. There is no need for approval from one department, and approval from another department, so there are fewer mothers-in-law, which can greatly improve work efficiency.
Finally, a relatively flat open space was selected at the foot of "Baihu Mountain" to start building a ward immediately.
It is said to be a ward, but in fact it is just a row of bungalows.
Unlike later generations, it is necessary to distinguish between clean areas, isolation areas, contaminated areas, buffer areas, etc., and to set up independent medical vacuum systems, isolation operating rooms, intensive care units, etc. Keep everything simple and fast.
Wards are being built with great fanfare over there, and Lin Sanqi is also starting to prepare anti-tuberculosis drugs and related examination equipment.
His personality is that he either doesn't do it, or he has to do it perfectly.
In fact, the main reason why Lin Sanqi was unwilling to become a clinician in 1960 was that being a doctor would affect his ability to make money. This cannot be denied.
But another thing is how many patients can a doctor see in a day? It is a drop in the bucket. To be honest, one doctor with more Lin Sanqi is not much, and one doctor with less Lin Sanqi is not much.
But in the end he agreed to be the "Director of the Tuberculosis Department", and the main reason was this.
As long as his appearance can cure tuberculosis, and then he formulates tuberculosis diagnosis and treatment standards, a system can be formed and promoted nationwide, and the people who will benefit from this will be millions of tuberculosis patients.
As for tuberculosis drugs, Lin Sanqi also has plans.
If it really doesn't work, wouldn't it be enough to buy equipment in 2023, then build a pharmaceutical factory in 1960 to mass-produce tuberculosis drugs?
Anti-tuberculosis drugs are generally divided into first-line drugs: isoniazid, rifampicin, pyrazinamide, ethambutol and streptomycin.
Second-line drugs: sodium para-aminosalicylate, prothionamide, amikacin, kanamycin, capreomycin, levofloxacin, moxifloxacin, etc.
Second-line drugs are basically not used because they have mediocre efficacy and severe side effects. They are usually only used if there is an allergy to the first-line drugs.
Among the five first-line drugs, streptomycin was once used as a miracle drug. Selman Abraham, who invented streptomycin, also won the 1952 Nobel Prize in Physiology or Medicine.
However, this drug was later proven to be highly ototoxic and nephrotoxic, and could easily cause damage to vestibular function and cause deafness in patients.
Decades ago, a generation of children became deaf after getting sick and receiving injections. The drug they used was streptomycin, so it later became a backup drug and was easily no longer used.
Lin Sanqi is not going to take out streptomycin this time. If he still uses this medicine even though he knows it is poisonous, wouldn't he be irresponsible to his compatriots?
The remaining four drugs are isoniazid, rifampicin, pyrazinamide, and ethambutol.
Lin Sanqi checked the information and found that in the 1950s and 1960s, the most advanced treatment plan for tuberculosis abroad was: streptomycin + para-aminosalicylic acid + isoniazid.
This treatment plan can indeed treat tuberculosis, but the side effects of these three drugs are very serious, such as damage to the liver and peripheral nerves, strong gastrointestinal reactions, and inevitable allergic reactions, etc.
The key is that the combined treatment course of these three drugs lasts for 12-24 months, which means long-term medication is required for 1 to 2 years, which creates a problem of medical expenses.
Streptomycin, para-aminosalicylic acid, and isoniazid are all drugs that have just been invented. The output is very low and the price is extremely expensive. Even in European and American countries, only a few wealthy people can afford the drugs.
This is why tuberculosis is still an incurable disease in China because anti-tuberculosis drugs have not yet been introduced to the country.
Lin Sanqi is either incurable or not. To treat tuberculosis, the most advanced quadruple therapy must be used:
Isoniazid + rifampicin + ethambutol + pyrazinamide mode.
Isoniazid and pyrazinamide have been invented here, and this piece of fat is no longer available to Talin Panax notoginseng.
So how to patent the two drugs rifampin and ethambutol has become a top priority.
European and American countries are very rogue, and grabbing patents is their favorite thing to do.
If Lin Sanqi used the most advanced drugs of later generations to treat domestic tuberculosis, these advanced drugs would be smuggled out of the country by "spies" and obtained by foreign pharmaceutical companies.
Then it is entirely possible that foreign pharmaceutical companies will be the first to decipher the drug ingredients and then apply for patents.
When anti-tuberculosis treatment is used in China, patent fees will have to be paid to European and American pharmaceutical companies. So isn’t Talin Panax notoginseng’s work in vain?
There are many lessons from this painful drug patent experience.
Taking ginkgo as an example, there are currently 68 patents applied for ginkgo in China. Although only 4 patents have been applied for by foreigners, they cover almost the entire extraction process of ginkgo.
Although the number of applications filed by my country is superior, most of them are only in details such as dosage changes and quality differences, and lack key innovative technologies. This is equivalent to the fact that the lifeblood of Ginkgo biloba leaves has been seized by foreign pharmaceutical companies, and foreign patents have to be paid. fee.
Take artemisinin as an example. It is a specific malaria drug that has been successfully researched by generations of Chinese doctors, such as Tu Youyou, but was finally registered as a patent by a German company.
Our country does not hold the patent equivalent to artemisinin. We have to pay German pharmaceutical companies to use this drug. This alone costs China at least US$200 million to US$300 million every year.
In addition, the Jiuxin Pill produced in Japan was developed on the basis of my country's famous drug Liushen Pill. Because Chinese companies have not registered patents and trademarks, more than 100 million US dollars flow into the pockets of Japanese companies every year.
According to data from the "World Patent Database", more than 70% of traditional Chinese medicine patents are applied for by Japan, followed by North Korea, and my country only has a pitiful 0.3%.
China, the birthplace of Chinese herbal medicine, accounts for only 3% of the global annual trade volume of Chinese herbal medicine of approximately US$30 billion.
A lot of money has been made by foreign companies, which is a very annoying thing.
Some idiots even shout that "the laws of our ancestors cannot be changed." Traditional Chinese medicine must adhere to tradition and cannot follow the rules of modern medicine.
These people are either stupid or bad. They are so stupid and so bad!
If we wait for foreign countries to register all our traditional Chinese medicine patents, it will be difficult to regret it in the future.
As a time traveler, Lin Sanqi attaches great importance to patents. This is a hen that can lay eggs. With the patent in hand, even if he does not produce it, the licensing fee will be a lot of money.
Even if you don’t need any money, it would be a good idea to hand over the patent to the state in exchange for lots of Chinese medicinal materials.
Wait, while Lin Sanqi was scolding others for registering my country's patents, it seems that the two drugs rifampicin and ethambutol were not invented in China, right? Those are drugs invented by foreign pharmaceutical companies.
Lin Sanqi, a time traveler, has registered their patent. Isn't that just as robber and despicable as a foreign pharmaceutical company?
Don't do to others what you don't want others to do to you.
snort! People who say this are pedantic. Others can rob us, so why can’t we rob them?
Lu Shuren once said: We are nobler than the noble and more despicable than the despicable.
On May nights, the temperature in the capital has begun to warm up.
After watching the Peking Opera, Jin Caifeng and her grandchildren had fallen asleep in the room, and Pan Ye also returned to his dormitory.
The bright moonlight shone on the earth, illuminating the surrounding area. Beside the cornfield, a pot of boiling water was boiling on a small table, which was really churning.
Lin Sanqi performed a whole series of tricks to make tea, and finally poured out three glasses of water and gave them to his father with both hands.
Lin Sophora flavescens took the tea cup and smelled it, then chuckled:
“Good tea, I haven’t had this Phoenix Dancong tea in years.”
Lin Sanqi picked up the cup and replied with a smile:
"Dad, I have prepared five pounds of Phoenix Danconong tea and five pounds of Huazhou orange red for you. I will send it to you when you finish drinking it."
Lin Sophora flavescens finished drinking the tea in three gulps and then leaned on the back of the bamboo chair:
"Xiao Qi, I feel that our Lingnan sect is getting better and better. It can reduce fevers, but it can also cure plague? Now you have made another one that can cure tuberculosis. Is this passed down from the ancestors of our Lin family?" br>
Lin Sanqi was a little embarrassed: "It must be passed down from ancestors."
Lin Sophora flavescens nodded slightly, obviously having her own thoughts:
"You can say it's inherited from your ancestors, but I have to know how you plan to treat tuberculosis, right? This time is different from before. In the past, getting rid of a fever was nothing, but this time it is tuberculosis, a big problem that even foreign countries have not overcome. .
If you can really cure tuberculosis, let alone 100%, even if you have an 80% or 90% cure rate, you will have created a medical miracle. At that time, the higher-level department will definitely come to investigate, and maybe we will be asked to hand over the secret recipe. ”
Lin Sanqi thought to herself that this is a high probability thing.
The secret recipe for treating influenza was previously requested by individuals to donate for free, but was finally given back by Dean Shen and Dean Tu of Union Hospital.
This secret recipe for tuberculosis is related to the safety of more than 10 million tuberculosis patients across the country, and the country cannot take it too seriously.
Moreover, Lin Sanqi’s secret recipe can be used domestically, but can it also be used abroad? So can it be made into tablets and exported to earn foreign exchange?
In 1960, the mainstream view was that everything in this land belonged to the country, individuals had no rights and interests, and everything had to be subordinated to the overall situation. As long as a private secret recipe was exposed, it could only belong to the country.
Of course, is there anything wrong with that? In fact, that’s right.
The country is still so poor and the people can't afford it. Does Lin Sanqi still want to make a lot of money from this secret recipe?
If you want to eliminate tuberculosis, one or two doctors will definitely not be able to do it. This must rely on the power of the country.
Then the country needs to get the secret recipe, mass-produce it, and then promote it free of charge to eliminate tuberculosis nationwide. There is no problem with this principle.
"Dad, I will definitely not admit it to others, but you are my father, and I will tell you the truth. I do have a secret recipe for treating tuberculosis. You see, it is this medicine."
Lin Sanqi took out a board of tablets from his pocket, with the name of the medicine written on it: "Ethylamine Pyrazine Rifusin Tablets."
This is a commonly used drug for the treatment of tuberculosis in 2023. In order to make it easier for patients to take it, the four drugs, isoniazid, rifampin, ethambutol, and pyrazinamide, are directly combined into one tablet.
The advantage is that patients only need to take one pill a day.
In the original treatment plan, the patient had to take 4 kinds of pills orally, some once a day, some three times a day, and the quantity was more or less, which was very troublesome, and it was also easy to cause accidental and missed doses, which affected the curative effect. (End of chapter)