Chapter 128 Rules (Medium Cup)
December arrives quietly.
The company's various projects are in full swing.
Jiang Miao is still doing various research.
Originally, there were no arrangements for the past few days, so we were just waiting for Yang Hejun from the Chengyi Group to visit on the 6th.
However, at noon on the 3rd, as soon as he came out of the laboratory, he saw a familiar figure chatting and laughing with a girl wearing glasses not far away.
"Brother Jianming, what kind of wind brings you here?"
As soon as he heard Jiang Miao's voice, Li Jianming also reacted and said with a smile: "Ah Miao, long time no see."
After five months of treatment, Li Jianming's complexion improved a lot. Last month, his wife became pregnant and even called Jiang Miao to thank her.
"Who is this?" Jiang Miao was a little surprised. After all, the other party's wife had just become pregnant, and the girl in front of her showed no signs of pregnancy, and she still had major physical problems.
"Let me introduce you. This is He Youwei, the daughter of my father's old comrade. She is a native of Beijing. She is twenty-six this year. She just returned from the exchange program at the University of Melbourne last year. She is a doctoral student in the medical experimental class of PBC University. She is currently studying at Union Medical College Hospital internship." Li Jianming turned to look at the girl:
"Youwei, this is the founder of Hailufeng Company and the inventor of eel artificial breeding technology. His wife Lin Shuya is the inventor of white truffle artificial cultivation technology."
"Hello! Mr. Jiang!" He Youwei smiled and stretched out her hand.
Jiang Miao shook hands with the other party: "Hello, Ms. He. Brother Jianming, let's go to the restaurant on the second floor to eat and chat!"
"Okay."
The three of them went to the small private room of the restaurant on the second floor.
After taking a seat, Jiang Miao said: "What do you want to eat?"
"You're welcome, just boxed lunches are fine." Li Jianming said with a smile. He had eaten boxed lunches at Hailufeng Company several times and found that the taste was good. The key was cleanliness and hygiene.
"Me too." He Youwei nodded.
Jiang Miao turned her head: "Zixuan, help me get a lunch box, a clerk's meal for Brother Jianming, and prepare a special meal for Ms. He."
As soon as he heard about the special meal, Li Zixuan became cautious. He took out a small notebook and ballpoint pen: "Boss, what should I pay attention to during the special meal?"
"Mr. Jiang, don't go to too much trouble." He Youwei was a little at a loss.
"It doesn't matter." Jiang Miao smiled and said richly: "No need for celery, coriander, mushrooms, peppers, Sichuan peppercorns, raw garlic, fried foods, animal offal, and cream products. Others will be arranged according to the situation."
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Li Zixuan quickly took notes and then repeated it again. After confirming that it was correct, he quickly went down to arrange the food.
After Li Zixuan left, Li Jianming said, "It seems that you have already figured it out, Amiao."
He Youwei on the side was also a little shocked. If she hadn't told Li Jianming not to tell the other party about her situation in advance, she would have doubted whether Li Jianming had notified the other party in advance.
"You still need to pay attention to your diet for systemic lupus erythematosus." Jiang Miao knew He Youwei had systemic lupus erythematosus as soon as he saw her.
This disease is an autoimmune disease.
In terms of pathogenesis, the patient's own immune system mistakenly attacks its own tissues and organs.
Under normal circumstances, the immune system can recognize foreign pathogens and defend them, but in SLE patients, the antibodies and immune complexes produced by the immune system attack their own cells and tissues.
In short, the body is in a state of self-mutilation all the time.
"Amiao, I brought Youwei here this time because I want you to help see if it can be treated with traditional Chinese medicine."
Jiang Miao glanced at He Youwei and then said: "Judging from Ms. He's condition, she should be taking medicine regularly now!"
He Youwei raised her glasses and nodded: "Yes, I currently take hydroxychloroquine and mycophenolate mofetil regularly. If the situation is serious, I will add methylprednisolone."
"Do you feel that the effect of glucocorticoids has weakened and the side effects are obvious, such as frequent proteinuria?"
In an instant, He Youwei's eyes widened. She remembered very clearly that she only told Li Jianming that he had systemic lupus erythematosus and did not tell the details. She was calmed down and nodded immediately: "Yes, I was taking it before. Prednisone, now switch to methylprednisolone.”
"Let me tell you the truth! A simple treatment plan of traditional Chinese medicine and Western medicine for your disease will not have very good results. You should know this very well as you are an intern at Union Hospital."
"I understand." He Youwei's face darkened.
"Amiao, is there really nothing you can do?" Li Jianming still cares about He Youwei. After all, He Youwei always followed his brother before his brother when he was a child, and the relationship between the two families is also very good.
Jiang Miao waved his hand: "Simple diet therapy will not have much effect, gene target therapy must be carried out."
"Gene target therapy? Is this technology not very mature now?" He Youwei naturally knows this technology.
To be precise, she previously studied in the medical experimental class of PBC University because this medical experimental class has an exchange mechanism for international exchange students, and they can go to the University of Pittsburgh or the University of Melbourne for exchanges.
The exchange university that He Youwei chose is the University of Melbourne, where she conducts exchanges and internships with the team at the Peter Doherty Institute of Infection and Immunity.
Over the past 23 years, a team from this institute has discovered a unique mechanism that controls different types of immune cells in the skin. It is able to distinguish cells that cause autoimmune diseases from "good" cells that maintain protective immunity, and provides a way to cure skin diseases such as psoriasis, vitiligo, and alopecia areata. Provides precise targets.
However, He Youwei did not find a way to treat her systemic lupus erythematosus, so she had no choice but to return to China to continue her PhD studies and then interned at Union Hospital.
"I know this technology, and its therapeutic principle is mainly to intervene in specific gene targets related to the disease. For example, targeted regulation of immune system-related genes, regulating immune responses by interfering with abnormal gene expression or protein function."
"Currently, targeted therapy targeting B cell activating factor (BAFF) is one of the hot spots of research. The one I know better is belimumab, which is now approved for the treatment of systemic lupus erythematosus. It can specifically Combined with BAFF, it reduces the survival and differentiation of B cells, thereby reducing the production of autoantibodies and reducing disease activity. ”
"That's right." Jiang Miao nodded.
He Youwei frowned: "However, gene target therapy still faces some challenges. I can afford the high cost of treatment, but there may be off-target effects, long-term efficacy and safety, which are the key."
"I can carry out treatment in this area, but there is a problem here, that is, I am not qualified to practice medicine, so I need to avoid unnecessary risks." Jiang Miao had a different look in his eyes.
After all, Li Jianming had been treated with a dietary regimen, which was equivalent to the advice of a nutritionist and did not require a medical qualification certificate.
But He Youwei's situation involving gene target therapy cannot be fooled by a diet regimen.
If someone catches this, it can easily be taken advantage of to cause trouble.
Jiang Miao didn't want to leave a hidden danger for herself.
Li Jianming and He Youwei immediately realized that after all, they both knew a lot of things. Once they did something, as long as someone really wanted to cause trouble, they could take the opportunity to amplify it.
"Amiao, what do you think?" Li Jianming asked directly.
Jiang Miao said his solution: "I will acquire a medical device and pharmaceutical R&D company in a private capacity, then hire Ms. He as the chief technology executive, and then recruit some people with medical qualification certificates to join, in the name of experiments. , just carry out treatment.”
"How can you let Mr. Jiang spend so much money? Or forget it." He Youwei was a little embarrassed.
"It doesn't matter. Anyway, I do have the idea of entering the medical industry, but I don't have the energy to manage it." Jiang Miao explained with a smile.
In essence, Jiang Miao's purpose is not just that.
After all, the domestic medical industry is too deep for Hailufeng Company to enter, so he must recruit a qualified person to stand up.
Originally, he planned to wait a few more years.
Now He Youwei's situation made Jiang Miao change his mind. Judging from his observation, the other party's mind is still relatively simple. Perhaps this is the reason why she graduated from the science and engineering major. In addition, she has been frail and sick since she was a child, so she has not developed any bad habits. Jiang Miao knew Li Jianming's family situation. After all, he could collect a lot of information using the Internet.
As far as he knew, Li Jianming's father had two comrades named He. When they introduced him just now, they said that He Youwei was from the capital, so the identity of his father was very clear.
If He Youwei is willing to join this pharmaceutical company, her domestic troubles will be reduced by 99% instantly, and the remaining 1% can only be caused by force majeure.
Rather than being passive when the time comes, it is better to take the initiative now and find a more suitable partner.
Even though He Youwei was relatively simple, she still heard the implication of Jiang Miao's words.
"Youwei, you can rest assured about Amiao's medical skills. Don't hesitate. What's more, Amiao is also a rule-abiding person and will not use your name to do anything illegal." Li Jianming quickly persuaded.
After all, Li Jianming, who has been with Jiang Miao for a while, knows Jiang Miao's character. In the development process of Hailufeng Company, shortcuts can often be taken. Whenever Jiang Miao is willing to speak, it only takes one sentence, but he does not do this. I have done it before, but I would rather spend a little more money and make all the procedures and procedures legal and compliant.
Of course, Li Jianming also had selfish motives for doing this. If He Youwei could be cured, the relationship between the two families could go further.
That's why he persuaded He Youwei to join.
He Youwei thought for a while and quickly figured it out.
'The other party's condition is not a big problem. Anyway, if my body continues like this, there is no solution. What's more, my brother's body also needs treatment. ’
Her parents did not have systemic lupus erythematosus, but her grandmother did, and she obviously inherited it from her grandmother.
After opening up for their second child, her parents originally planned to practice another trumpet. They did an in vitro fertilization in 2016, but they were still disappointed.
After her brother was born, he did not show symptoms of systemic lupus erythematosus, which made the family very happy. However, the good times did not last long. In 22 years, due to infection with the influenza virus, her brother's immune cells were stimulated and he developed systemic lupus erythematosus. broke out.
At this time, her parents were in their forties, and the risk of having a third child was too great. Coupled with the conditions of their previous two children, they did not dare to have another child for fear of having another child with a genetic disease. .
"I can agree to join Mr. Jiang's pharmaceutical company."
"In that case, it will be a pleasure to cooperate." Jiang Miao smiled and extended his hand.
The two shook hands again.
At this moment, Li Zixuan also brought up three lunch boxes with a basket. After putting them down, he left consciously and closed the private room door.
Jiang Miao took his own portion and handed He Youwei's portion of the special meal to her. The remaining portion belonged to Li Jianming.
After taking a bite of rice, He Youwei asked: "Mr. Jiang, I wonder how your treatment plan will be carried out?"
"First, we need to conduct a comprehensive test on your genes, and then determine the gene fragments in your genes that are related to systemic lupus erythematosus, and then conduct in vitro cell culture."
"Is it similar to last year's breakthrough of stem cells being directed into islet cells and then transplanted in vivo?" He Youwei guessed.
Jiang Miao shook his head: "No, systemic lupus erythematosus is a problem with the immune system. Even if stem cells are used to cultivate immune cells, there is no way to transplant them. If the transplant is forced, it may trigger a violent reaction of the immune system in the body. At that time, it will aggravate the condition.”
He Youwei nodded, this possibility is indeed very big.
"My plan is to shut down part of your immunity. Systemic lupus erythematosus is when immune cells attack other cells in the body indiscriminately. In essence, the immune system is overactive and part of the immunity needs to be shut down."
"Can this really be done?" He Youwei was very shocked.
"You should browse my related papers." Jiang Miao reminded with a smile.
"Your paper?" He Youwei has been paying attention to relevant medical journals over the years. In the impression, Jiang Miao has not published relevant papers in medical journals.
"The underlying biological logic of humans and fish is the same. In the process of researching eel artificial breeding technology, I discovered many systematic correlation combinations of genes, some of which can be applied to humans. After all, the genetic sequences of humans and eels are not the same. Da, I have conducted research on my own genes and found that through specific diet and drug intake, people’s immunity, vitality, and physical fitness can be enhanced to varying degrees.”
"..." He Youwei was dumbfounded.
Li Jianming, who was immersed in his work, couldn't understand what the two were talking about. After all, he majored in law and only had a little knowledge of this kind of biomedical knowledge.
"I named this mechanism the systemic nature of genes. A part of the gene sequence constitutes a genome, a gene group, or a gene family. It will produce specific functions. Intervening these genes in a specific way is somewhat similar to the systemic treatment of traditional Chinese medicine. Of course, because Considering confidentiality, I only wrote part of the thesis.”
At this time, He Youwei had already understood: "Mr. Jiang has discovered a specific gene combination pattern, or a research method."
"That's right." Jiang Miao indeed discovered the pattern.
After browsing the genes of hundreds of employees and thousands of their relatives, as well as the genes of various animals and plants, Jiang Miao knew the corresponding functions of these gene fragments, genomes, gene groups, and gene families. 37 specific rules were summarized.
Through these rules, even if he loses the identification panel at this time, he can still detect the genetic sequence of an earth creature and analyze 99.9% of the corresponding functions of the biological genes based on these genetic rules.
He has tried before, without using an identification panel, directly using instruments to detect the genes of pigs, cows, sheep, mantises, cicadas, cobras, shrimps, barnacles, dandelions, and banyan trees, and then analyzed these genes by himself based on genetic rules. The gene function of the organism is then compared with the identification status of the identification panel.
The accuracy of the comparison results was between 97% and 99%. Some of the errors were caused by his unfamiliarity at the beginning. After mastering these genetic rules, the accuracy has been maintained at above 99%.
In fact, this is very normal.
After all, he already knows the answer, and there is no shortage of reference samples. It is naturally very easy to use these answers to reverse the rules and formulas.
Give me a chestnut.
This is like having successfully detonated a large number of atomic bombs and hydrogen bombs, and knowing the structures of these atomic bombs and hydrogen bombs very well. Now it is not too simple for you to summarize how to design atomic bombs and hydrogen bombs.
You know, America spent astronomical amounts of manpower and material resources to develop the first atomic bomb, but the difficulty of developing and manufacturing atomic bombs for subsequent imitators plummeted.
The most typical example is that America successfully detonated the world's first hydrogen bomb in 1952, followed by Lucia in 1953, detonating a mille-feuille-shaped hydrogen bomb, and completed the real hydrogen bomb in 1955. The hydrogen bomb detonated, and it only took 3 years to catch up.
Sometimes, technology is like a layer of paper. As long as there are successful examples, it will be relatively simple for other forces to catch up if they try their best.
For example, many people feel that domestic lithography machine technology will never surpass ASML.
In fact, this is a wrong perception.
If the domestic market fails and completely ignores international patent laws, it will soon catch up. Don’t underestimate the only country in the world with a full industrial system.
The problem is that international patent laws now need to be complied with, and the patent moat built by ASML has blocked many technical routes, making domestic lithography machines difficult to develop.
Even so, in September this year, relevant domestic companies also completed the first deep ultraviolet lithography machine platform that can process 10-nanometer chips.
Jiang Miao saw the complete answer first, and then deduced the rules and formulas, so it was naturally not difficult.
But He Youwei didn't know that there was only one thought in her mind at this moment. If what Jiang Miao said was true, then there would be a lot of Nobel Prize-level achievements in front of her.
He Youwei asked: "Mr. Jiang, I heard that you are applying for an honorary doctorate. Are you interested in becoming a distinguished professor and doctoral supervisor at PBC University? If your genetic rules can be verified, I can use my connections to pass it quickly."
"I have agreed to become a distinguished professor and doctoral supervisor at Shizishan Agricultural University."
"Oh?" He Youwei has already made up her mind. If Jiang Miao's genetic pattern really exists, then she will no longer be an intern at Union Hospital, but will apply to be Jiang Miao's doctoral student.
After all, if Jiang Miao's genetic pattern is true, then he is a golden thigh in academia.
If you don’t hold your thighs now, when will you wait?
(End of chapter)