Chapter 76: The 25% healing rate is really awesome!
Chen Wen thought for a while and then replied:
“Xu Bo’s patient stated that he was diagnosed with hepatitis B during a physical examination when he was in elementary school.”
“Two years ago, He felt a little uncomfortable and came for examination. At that time, the transaminase reached 14 More than 0, nearly three times higher than the normal value, and then I gave him antiviral treatment.”
“After taking tenofovir for a year, that is, last year, he decided to take interferon while he was still young. I want to give it a try and see if hepatitis B can be completely cured.”
"Until last month, it was exactly one year since he had been receiving interferon treatment. Although the hepatitis B virus DNA was below the detection line and the surface antigen was also very low, it still did not turn negative in the end, so I recommended this product to him." QS-001', let him participate in clinical trials."
Hearing this, Dean Zhou frowned slightly.
"Director Chen, according to what you said, could it be the cause of interferon?"
Chen Wen fell into a brief thought, and after a moment he slowly replied:
"There is such a probability."
"One year after interferon injection, its effect can continue to last three months to half a year in the human body."
"But..."
He paused.
“However, it does not turn negative when interferon is used, but turns negative after stopping the drug. This chance is too small.”
Both Dean Zhou and Feng Gang were silent, Chen What Wen said seemed to answer the question. In fact, there is no accurate conclusion at all.
But no wonder Chen Wen.
When recruiting patients for Tsingshan Pharmaceutical's "QS-001" new drug this time, there are no restrictions on a series of issues such as whether the patients have used interferon, whether they are anti-viral, etc. As long as they are hepatitis B patients, they can participate .
This makes it extremely difficult to confirm whether the negative turn is entirely due to "QS-001".
About ten seconds later, Feng Gang coughed lightly:
"Yuan Zhou, Director Chen, I don’t think we need to worry about this issue now."
"First of all, the second phase of the clinical trial is a double-blind test. We currently don't know whether Xu Bo is the experimental group or the control group;
If it is the control group, it means it has nothing to do with Qingshan Pharmaceutical's 'QS-001' , if it is the experimental group... we still have to observe."
"After all, only one person in the group was cured, could it be accidental?"
Feng Gang's reminder made the two of them. He suddenly became more awake and couldn't help but nod.
Indeed,
Xu Bo's cure brought a big surprise, but just one person's cure cannot prove that Qingshan Pharmaceutical's "QS-001" is really effective.
"Director Feng is right, then we will wait a little longer. When Xu Bo's clinical phase II ends next month, we will first see if he is in the experimental group."
"By the way, I'll send a copy of the clinical results to Qingshan Pharmaceutical as soon as possible. Zhang Yang and the others have probably been waiting."
"Okay."
Zhang Yang also got the clinical second grade soon. The test results of the first batch of the first month of the period.
Compared with the uncertainty of Dean Zhou and Chen Wen, he immediately determined that this was the effect of "Akofuvir"!
Although the effectiveness of "Ekofovir" at this time is only about 25%, he has seen the test data of the patient Xu Bo. The low viral load and low hepatitis B antigen all indicate that the patient has hepatitis B. There are not many viruses and not many infected liver cells.
In addition, I have just received interferon treatment, and with the help of "Ecofovir", it is entirely possible to complete the elimination of hepatitis B virus in one month!
The news also reached Qingshan Pharmaceutical’s “QS-001” project team, and the R&D team headed by Wei Tian was also quite excited.
Although it is not yet completely certain whether "Ecofovir" cured the patient, this is the first good news in the one year since the project was established.
Everyone is more motivated.
In the following time, not only Zhang Yang’s energy was completely focused on the clinical trial of "Ecofuvir", but even Dean Zhou, Feng Gang and Chen Wen were always paying attention to the results of the first batch of clinical phase II patients. Final result.
One month passed in the blink of an eye,
By the time the comprehensive examination was completed on the last day, Dean Zhou and Chen Wen had been waiting in the clinical center office for a long time. After a while, Feng Gang hurried in with the latest clinical data.
"Dean Zhou, Director Chen, good news!"
"Xu Bo has been confirmed and is in the experimental group!"
"And there is even better good news! "
"The final comprehensive examination results show that not only Xu Bo has been completely cured of hepatitis B, but also Zhang Meng, another female patient in the same group, has been cured!"
This is the first sentence! When they came out, Dean Zhou and Chen Wen looked at each other with strong surprise in their eyes!
If one person is cured, it is a coincidence. Now two of the eight subjects in the same group are cured, which means it is not a coincidence!
On the contrary, this innovative drug "QS-100" from Tsingshan Pharmaceutical is really effective!
Chen Wen seemed even more anxious and took the latest clinical data from Feng Gang. He was now eager to know the condition of another patient, Zhang Meng.
I quickly scanned Zhang Meng's information sheet. Compared to Xu Bo, Zhang Meng did not receive interferon treatment, but was taking antiviral drugs normally.
In other words, now even the cause of interferon can almost be ruled out!
He took a deep breath, returned the clinical data sheet to Feng Gang, and said slowly:
"Zhou Hospital, Director Feng, two of the eight experimenters turned negative, and 25% turned negative. The probability is not low!”
“I didn’t expect that Qingshan Pharmaceutical has actually developed a drug that is effective in curing hepatitis B!”
Feng Gang was also very happy. He still has great feelings for Qingshan Pharmaceutical.
But after a moment, he frowned slightly:
"But in addition to the good news, there is also bad news in this clinical data."
"It can't be said to be bad news. Their drug is the same as in the first clinical phase, and the side effects are still obvious!"
As he spoke, he placed the data in his hand in front of Dean Zhou and Director Chen, and explained:
“Clinical data showed that all eight members of the trial group had elevated transaminase levels during the medication, and the highest transaminase level for one person even reached more than 300.”
“Furthermore, all eight trial members had elevated transaminase levels. Obvious side effects include nausea, vomiting, and fatigue. ”
"I guess it is an unavoidable side effect caused by the treatment mechanism of this drug, and it will be difficult to avoid in the future."
As the chief doctor, Chen Wen has the most say in the research and development of hepatitis B virus .
He looked at it carefully and finally said slowly:
"Yes, this drug itself is cytotoxic. It will kill liver cells while killing the hepatitis B virus. , a large number of liver cells will die and transaminases will inevitably increase, which is unsolvable.”
“As long as it does not cause much damage to the liver, I think it is acceptable.”
"By the way, Director Feng, judging from the clinical results in the past two months, have these patients suffered any obvious liver damage?"
"That's not the case!"
Feng Gang shook his head:
“Although transaminases were elevated, there were no obvious abnormalities in the B-ultrasound and liver puncture results, which proves that this drug is good at controlling toxicity. Short-term medication should not cause irreversible effects on the liver.”
Dean Zhou and Chen Wen breathed a sigh of relief.
After a while, Chen Wen's expression relaxed:
"Zhou Yuan, this drug seems to be quite successful so far."
"The cure rate of 25% is almost comparable to interferon. , and the side effects and treatment period are greatly shortened.”
“If the cure rate can be maintained at 25%, it is very likely to be successfully launched.”
Dean Zhou also said on his face. With a smile on his face, he couldn't wait to tell Zhang Yang the good news!
"I'm going to call Zhang Yang right now and let them know the good news and be happy!"
"The cure rate of 25% is really awesome!"
(End of this chapter)