Chapter 95 Can ekofovir be used in patients with liver cirrhosis? (Ask for monthly ticket)
I don’t know how long I watched in the group, but Liang Guangming finally put down his phone and lay on the hospital bed again.
Gradually, he thought of his daughter and his wife...
Maybe it was because he couldn't sleep at all these nights. Unknowingly, Liang, who was lying on the bed at this time, The light gradually falls asleep.
I don’t know how long it took, but he was woken up by the rustling sound coming from the bed next door.
Liang Guangming was in bed No. 14, and bed No. 15 next door was previously empty...
He looked curiously and saw that the patient who had just been admitted had a skinny face and looked about 50 years old. At this time He lay quietly on the bed, and it was obvious at a glance that his condition was serious.
The accompanying family member is about thirty years old and should be the patient’s son.
Waiting for the patient's son to pack up his belongings, he couldn't help but curiously asked during a break:
"Little brother, what is your father's disease?"
"Cirrhosis, decompensation."
Decompensation...
Liang Guangming's heart trembled for no reason.
In fact, after being diagnosed with early-stage liver cirrhosis these days, he has a deeper understanding of liver cirrhosis.
To put it simply, people with liver cirrhosis often distinguish between early cirrhosis and late stage cirrhosis, while from a professional perspective: compensation period and decompensation period.
Early cirrhosis is equivalent to the compensatory stage of cirrhosis.
Advanced cirrhosis is equal to the decompensated stage of cirrhosis.
The symptoms of the compensatory stage of liver cirrhosis are not too obvious. Just like him, transaminases are slightly elevated, and there are occasional symptoms of fatigue, loss of appetite, and upper abdominal pain.
At this time, the compensatory function of the liver is basically normal, but once it reaches the decompensation stage, the liver function is seriously damaged, not only the complete loss of appetite for meals, fatigue, and vomiting.
The most serious case is that patients with decompensated cirrhosis are often prone to serious complications such as hepatic ascites and esophageal and gastric varices.
These complications can be extremely life-threatening.
Once this time comes, life has almost entered a countdown.
Thinking of this, Liang Guangming suddenly glanced at the patient lying on the hospital bed with some fear, as if he had seen his own future.
After a while, he didn’t want to continue the topic:
“From your accent, aren’t you from Chengdu?”
"Well, my name is Liu Haoran, you can call me Xiao Liu. We came from Jieshi, Guangdong Province."
"We went to Guangzhou for treatment, and the doctors there told us to let nature take its course. , but my father is only 52 years old, and we don’t want to give up just like that.”
“It’s just right for me. A doctor relative of ours suggested that we try this hospital.”
“Huh? Try it here?”
Liang Guangming felt a little strange. The Third People’s Hospital of Rongcheng is actually here. The Department of Hepatology is not very famous. After coming all the way from Guangdong Province, we should at least go to West China, right?
Liu Haoran seemed to see the doubts in Liang Guangming's heart and explained:
"My doctor relative told us that we can come here to try 'Acofenprovir'..."
"'Acofenprofovir'? This is not a cure for hepatitis B Medicine?"
"Yes."
Liu Haoran nodded and continued: "In 1984, when he was 12 years old, the school conducted a comprehensive hepatitis B test and found that he was infected with hepatitis B. It has been more than 40 years.”
“His liver cirrhosis is due to the fact that the hepatitis B virus has not been controlled for a long time, and it has developed until now it has become a decompensated stage.”
“My relative’s doctor told us that this hospital is an ‘AIDS hospital’. The clinical trial hospital of fenprofovir' has a large Amount of experience on the clinical use of 'Acofovir'...
He wanted us to see if my father's hepatitis B could be cured by using 'Acofovir', thereby delaying the progression of the disease."
"Of course,"
He paused, glanced at the patient sleeping on the hospital bed, and whispered:
"We don't want to cure him, we just hope he can live a little longer."
< br>Liang Guangming's eyes were startled, and strong hope suddenly burst out in his eyes.
Indeed.
The same goes for him. Hepatitis B is the cause of his cirrhosis.
If I take "Acofenprofovir" to completely eliminate the hepatitis B virus, does that mean that liver cirrhosis will not develop again? !
Suddenly, Liang Guangming became very excited, but the next second,
he thought of the extremely strong side effects and cytotoxicity of "Acofenprofovir"!
"Icofenprofovir" is aimed at ordinary hepatitis B patients. Even if these hepatitis B patients have some liver damage after taking it, they can still recover due to the strong regenerative function of the liver.
And these hepatitis B patients What about patients who already have cirrhosis?
It might directly lead to more serious consequences!
And.
Now that I have developed cirrhosis of the liver, is it useful to take "Acofenprofovir" again?
He was beating a drum in his heart.
But fortunately, Liu Haoran's words gave him a new plan. He decided to ask his bedside doctor for advice when he had time!
Liang Guangming's bedside doctor was Director Chen Wen. After questioning him the next morning, Director Chen Wen did not give a clear answer.
"At present, 'Acofenprofovir' has just been launched, and no clinical trials have been done on patients with liver cirrhosis;
Can it be used in patients with liver cirrhosis? What exactly should it be used for? Whether there will be an obvious prognostic effect in the future, there is currently no clinical precedent, and it is blank. We still need to consider it carefully.”
He also understands Director Chen Wen’s concerns.
However,
As he was hospitalized for several days, he clearly felt that there were more and more inpatients in the liver disease department of Chengdu Third People's Hospital, and the vast majority were patients with cirrhosis.
The purpose of most people is to try to use "icofenprofovir" to treat liver cirrhosis.
More and more patients came forward with requests, and Director Chen Wen held a department meeting in conjunction with the Department of Gastroenterology and the Department of Hepatobiliary Surgery.
"Let me briefly talk about the current situation first. Currently, 95% of the patients with liver cirrhosis treated in our department are caused by the hepatitis B virus."
"Although these patients have now been Antiviral treatment was started, but as everyone knows, even second-generation antiviral drugs can only inhibit the replication of hepatitis B virus and cannot completely kill it. This results in a small amount of hepatitis B virus still attacking the liver in these patients with cirrhosis. "< br>
"Ordinary hepatitis B patients can barely achieve a delicate balance through liver regeneration, but patients with cirrhosis have extremely weak liver cell regeneration. Even a small amount of hepatitis B virus will inevitably cause further damage to the liver in the long run!"
"'Acofenprofovir' can indeed kill all hepatitis B viruses, but the side effect is to cause more Much liver damage."
"The question now is: should we take the risk of using 'icofenprofovir' in patients with cirrhosis?"
"Yes. Will prolonging life be beneficial in the future? Or will it cause further damage and accelerate the progression of the disease?”
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(End of this chapter)