Chapter 116 A historic moment that shocked the world! (Big update for Majia Box!)
“@马小红, don’t pretend to be dead, come out and say it quickly, didn’t you say that ‘LivClearX’ is a miracle drug? It turns out that the drug patent belongs to Qingshan Pharmaceutical! Surprise! Aren’t you surprised? ”
“Haha, there are those idiots who say Novartis is a beacon for mankind and that Novartis benefits all mankind. Come out, I want to see what you do. Let’s blow Qingshan Pharmaceutical!”
“Hahahaha, cool! I read the comments on the Internet, many Americans have broken the defense, won’t you also break the defense?”
"Hahaha, they must have broken the defense. Anyway, as long as there is something wrong in the country, they will talk about the free market and the system. Now I want to see what other reasons they have?!"
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"Hahaha, @马小红大公 know why you haven't spoken? Is there no internet?"
"I still like your unruly look."
The news spread back to China , those netizens who supported Qingshan Pharmaceutical did not expect that revenge would come so quickly and be so satisfying!
It was so cool that Tsingshan Pharmaceuticals didn’t even need to reply. Novartis’ clarification immediately smashed the faces of all public celebrities.
Kill them all.
However, after the carnival and pride, through Novartis’ clarification, netizens began to really care about Qingshan Pharmaceutical’s “hepatocyte activator” for the first time!
“Brothers, let’s talk about it, let’s talk about it. What’s going on with Qingshan Pharmaceutical’s ‘hepatocellular activator’? Is it going to be launched?”
“I don’t know. It is said that the third clinical phase is in progress, but I don’t know when it will end..."
< br>"Did you say that Qingshan Pharmaceutical has noticed recent events?"
Of course Zhang Yang has noticed recent events, but he just glanced at Novartis's clarification statement before getting involved again." "Hepatocyte Activator" is in the final sprint of the third phase of clinical trials!
At this moment, the "hepatocyte activator" has entered the third month of clinical phase III, which is the critical period of the last month!
Because the condition of patients with "decompensated" liver cirrhosis is indeed somewhat serious, he adjusted the activator component from 75% to 90% just after the beginning of the third clinical phase.
In the second month, he immediately revised 90% of the ingredients to 100%, truly becoming a complete body.
After taking the complete product "Liver Cell Activator" for two months, the clinical effect of "Liver Cell Activator" finally achieved a breakthrough!
The breakthrough development is——
The compensatory phase, that is, early cirrhosis, begins to show signs of reversal after two months of taking it!
Reversal!
As we all know, liver cirrhosis is a disease that is difficult to be quantified by a single indicator.
At present, the conventional methods to judge liver cirrhosis are mainly through imaging, that is, B-ultrasound and CT.
To put it simply, B-ultrasound is used to observe whether there are obvious changes in the shape of the liver and whether there are obvious sclerotic nodules. CT is used to observe whether the density becomes smaller.
But in clinical practice, the most accurate and only gold standard is:
Liver puncture - liver puncture!
Liver puncture is to use a puncture needle to penetrate the skin to remove a little liver tissue from the liver, and then conduct a liver cell biopsy on the removed liver tissue to determine the true condition of the liver.
Puncture can determine the degree of inflammation and fibrosis of the liver. The degree of inflammation represents the ongoing damage to the liver;
Fibrosis can determine the degree of damage to the liver!
Judging from the two-month medication period, the first inflammation level in patients with early cirrhosis dropped from A3 (severe inflammation) to A1 (mild inflammation) during the compensatory period!
The focus is fiber change!
Downgraded from grade F4 (cirrhosis) to F3 (fibrosis)!
You must know that fibrosis and cirrhosis are two completely different states!
Liver cirrhosis is a hard nodule, like a scar on a human wound!
Although fibrosis is still a large amount of unhealthy liver tissue, it is not completely necrotic. Strictly speaking, fibrosis is 'living' and can continue to be reversed!
Can be reversed!
This clinical result has completely inspired the entire Qingshan Pharmaceutical R&D team. Everyone has determined that if these patients with early cirrhosis continue to take "hepatocellular activators" for a long time,
It is entirely possible to transform from a liver cirrhosis patient to a "liver fibrosis patient" or even an ordinary, common "liver function impairment" patient!
Qingshan Pharmaceutical!
Hepatocellular activator has truly achieved the reversal of "cirrhosis" patients for the first time in human history!
In the conference room of Qingshan Pharmaceutical Drug Research and Development Center, Zhang Yang was a little excited after listening to Wei Tian's complete report and looking at the 40 centimeters thick clinical data in front of him!
In the previous clinical phase I and clinical phase II, 50%, 60% or even 75% of the effects could only be maintained, and the blood indicators of patients with cirrhosis were slightly improved, but the transformation from cirrhosis to fibrosis had not been truly achieved. A reversal of change!
Now!
Did it!
Of course,
Although the reversal status of late-stage liver cirrhosis has not yet been seen, he believes that it is not impossible for late-stage liver cirrhosis to reverse to the mid-term or even early stage after long-term medication!
As long as it is reversed to the middle or early stage, the patient's life will be greatly improved!
Thinking of this, he took a deep breath and no longer hesitated!
“Although our clinical phase III is not over yet, let’s announce this historic moment to the public!”
"We have finally developed the first drug in human history that can reverse liver cirrhosis!"
The thirty or so researchers present clenched their fists and were excited;
Although the entire drug They are all led by Mr. Zhang Yang, but everyone has dedicated their own efforts in it!
From animal experiments to clinical trials, drugs are improved again and again, and experiments are repeated again and again!
They are also worthy of respect!
......
Just when Zhang Yang was excited and decided to announce the major news that the "hepatocyte activator" could reverse liver cirrhosis,
about Novartis's "LivClearX" and "LivClearX" on the domestic Internet Discussions at Tsingshan Pharmaceutical are still hotly debated.
Of course, the news about Novartis’ “LivClearX” on the external North American network has calmed down.
After being angry for a few days when they first learned the truth, faced with the real effects of "LivClearX", countless middle-class Americans finally chose to shake their heads and shrug their shoulders helplessly. After all, their health is more important.
Besides,
Didn’t Novartis say that “LivClearX” is localized production, localized sales, and localized improvement?
Then it can be considered a joint venture drug.
A joint venture does not count as an enemy.
However, just when everyone in the United States wanted to turn over the past and comfort themselves, the news of Qingshan Pharmaceutical came suddenly like thunder!
Reuters:
【Breaking News! 】
【Huaxia Qingshan Pharmaceutical officially announced! ]
[After one and a half years, Tsingshan Pharmaceutical's latest liver cirrhosis treatment drug - 'Hepatocyte Regeneration Activator' has achieved a historic breakthrough, achieving the first clinical reversal of liver cirrhosis in human history! 】
The first clinical reversal of liver cirrhosis in human history!
Liver cirrhosis reversed!
As soon as the news was sent out, it immediately made the headlines on Twitter!
Countless American netizens were instantly shocked!
“???F…uck!!”
“Cirrhosis! Reversal?!”
The shocking news reminded all American netizens of the wildly touted “LivClearX” before. If Novartis’ “LivClearX” for treating fatty liver was touted as a miracle drug, it was touted as the greatest contribution to modern medicine in the 21st century!
So!
So what if liver cirrhosis was reversed for the first time in human history!
A miracle medicine? !
The huge gap has almost completely silenced the American Internet and American netizens. Finally, two hours after the news appeared, the top medical journal in the United States, the New England Journal of Medicine, took the lead in publicly inviting Tsingshan Pharmaceuticals to its website. Publish any information and clinical data on "hepatocellular activator" in the latest journals!
Take the initiative to invite manuscripts!
The New England Journal of Medicine, the top journal in the United States, took the initiative to invite!
Are American medical academics impressed by the achievements of Tsingshan Pharmaceuticals? !
Gradually, countless netizens on Twitter finally recovered, and there were more and more comments about Qingshan Pharmaceuticals and liver cell activators.
“Really, really, really can reverse liver cirrhosis?”
"Huaxia, Qingshan Pharmaceutical...Okay! I think I have to take off my colored glasses. This Huaxia Pharmaceutical Company is so powerful, much stronger than I imagined, and I admire it for being so powerful!"
"Medicine should not have national boundaries. I admit that I had strong discrimination against Qingshan Pharmaceutical before, but he conquered me, to be fair! He is the real light of medicine, the light of medicine for all mankind!"
“I think we must reflect. From now on, we must reflect on what went wrong with us?”
“Yes, Qingshan Pharmaceutical deserves our admiration, but we Are pharmaceutical companies investing less and less? Is there something wrong with our market environment and system? ”
“…”
There was a heated discussion on the Internet. In the risk control office on the 17th floor of the HSBC headquarters, Winston Davis stared at the news in front of him, shocked and speechless.
He is not cold towards China, and is even a little disgusted with it.
But the Qingshan Pharmaceutical in front of him simply overturned his understanding of Chinese pharmaceutical companies!
Novartis' "LivClearX" drug patent originated from them. Unexpectedly, they actually developed a drug that is several times stronger than "LivClearX" and can reverse liver cirrhosis!
After a while, he opened the drawer, and in the drawer was Novartis' local "LivClearX".
To be honest, he had good results after taking it for two months. Although the fatty liver still exists, liver inflammation, blood indicators and even his mental state have indeed improved significantly!
This is the credit of this drug!
Thinking of this, he couldn't help but touch the right side of his abdomen, where the liver was.
A full minute later, his eyes suddenly flashed with light!
“No, I have to take the original medicine, this imported medicine from China!”
...
The news spread back to China!
To be precise, the domestic network was the first to receive the historic news of Qingshan Pharmaceutical’s official announcement of an “activating agent that promotes liver cell regeneration”!
The news was released from the official website of Qingshan Pharmaceutical. It was not even confirmed. The official media People's Daily immediately reprinted the news.
As soon as the news came out, it immediately caused forwarding on the entire Internet. In just ten minutes, it was ranked among the top ten hot searches on Weibo, and then it quickly swept all news and topped the list!
Not only on Weibo, the news about Tsingshan Pharmaceutical quickly swept across the Baidu Hot List and Douyin Popularity List. The first topics on all major APPs were:
[First time for mankind! Tsingshan Pharmaceutical achieved the first reversal of liver cirrhosis in human history! 】
The exciting news quickly spread throughout the Chinese Internet, and almost every netizen clicked to take a look!
You must know that there are many hepatitis B patients in China, and there are tens of millions of patients with cirrhosis caused by hepatitis B patients!
More importantly, how many years!
Chinese pharmaceutical companies finally have someone who can fight and conquer the world!
“What is the light of mankind, what is the beacon of mankind! This is it! Qingshan Pharmaceutical is it!”
“It’s so fucking exciting, so exciting, @青山药业, when Novartis' new drug 'LivClearX' came out, how many people in China were jealous of you, and how many people are laughing at you now! !
No one thinks highly of you, but you are the most promising!”
“Yes, why do I feel that my eyes are sore? After so many years, we finally have our own pharmaceutical company. , someone finally got a chance to live up to his expectations! Really, you are so proud, you really made us proud!”
"Before, those Americans were still bragging that their 'LivClearX' could treat fatty liver. Look at us, look at us! We can now reverse cirrhosis! It's awesome!"
"Awesome Damn! Qingshan Pharmaceutical is awesome! We used to envy them for having so many good pharmaceutical companies, but now it’s their turn to envy me. Don’t ask who we have, we have Qingshan Pharmaceutical!”
“Fuck, cool!”
……
Hot on the Internet! It's hot and spicy. Various media outlets are frantically reporting on this historic achievement of Qingshan Pharmaceutical. It's almost impossible for anyone who browses the Chinese Internet not to know this news.
No,
To be precise, there is a high probability of seeing this news even when browsing the Internet.
Modu, HSBC Headquarters Building, George Lin looked at the news in front of him with some bitterness. Novartis' previous clarification announcement gave him a blow, but he didn't expect that just one month later, Tsingshan Pharmaceutical gave him another heavy blow.
This is not the most important thing.
The last time he went on a business trip to the United States, although his aunt Wang Guilan did not let him help purchase "LivClearX" in the end,
but breathing the fresh air of the United States and watching a lot of publicity in the media, he thought of his immediate superior, the audit Department Manager - David.
During the last physical examination, he noticed that David's B-ultrasound result was fatty liver, so after thinking about it, he took the initiative to buy six bottles of "LivClearX" for David.
When I first gave it to David, he was very happy. After all, David also knew about this fatty liver treatment drug that has recently become very popular among the middle class from abroad.
However.
When Novartis clarified that "LivClearX" was derived from Tsingshan Pharmaceutical's patented technology, he vaguely felt that David seemed a little dissatisfied with him.
After all, he secretly looked at Twitter, and many people said that "LivClearX" is a castrated version of Qingshan Pharmaceutical and a semi-finished product.
But now,
LivClearX is no longer just a question of the castrated version. With the launch of Tsingshan Pharmaceutical’s top “hepatocyte activator”,
“ "LivClearX" will undoubtedly become a second-tier product, and its positioning will be too embarrassing.
"Hey!"
George Lin sighed slightly, and at this moment, the phone on the desk suddenly rang.
He was startled, and when he picked up the call, it turned out to be the boss David.
"George, come to my office right now."
"Okay, BOSS!"
After hanging up the phone, George Lin felt very uneasy. After quickly arriving at David's office, he quickly adjusted his breathing and whispered:
"Boss, I'm here. Please tell me if I have anything."
David glanced at George Lin and said:
" Nothing happened. Winston, the manager of the risk control department at the HSBC headquarters in the United States, personally called me."
"He wanted to buy some Qingshan Pharmaceutical's 'hepatocyte activator', Qingshan. Are you familiar with medicine? I’ll leave this matter to you.”
George Lin was suddenly stunned.
Manager Winston is looking for him to purchase for himself? !
No,
Winston wants to purchase the liver cell activator from Qingshan Pharmaceutical?
After a moment, he reacted:
"BOSS, the drug from Qingshan Pharmaceutical has not yet been launched. It is still in clinical trials... I don't know when it will be launched."
David shook his head:
" Manager Winston just told me that he has After learning about this drug in detail, the third clinical phase is about to be completed and it will be on the market in about two months.” Report! ”
Follow Qingshan Pharmaceutical every day?
George Lin felt like the sky was falling.
"Is there a problem?"
"No...no."
David finally showed a smile on his face.
Just when George Lin thought it was over, his immediate boss David suddenly spoke again:
"By the way, George, I only opened one bottle of Novartis' LivClearX' you gave me last time. You can take back the remaining five bottles."
"I'm a little bit used to things made in the United States. . ”
“I heard about this product from Qingshan Pharmaceutical” The hepatoprotective effect of the liver cell activator will be several times that of 'LivClearX'. When Tsingshan Pharmaceutical's medicine comes out, I want to try Tsingshan Pharmaceutical's "
George Lin's eyes suddenly became dull. ……
……
The news that Tsingshan Pharmaceutical's "hepatocyte activator" has made a historic breakthrough shocked the world.
Zhang Yang, who was in the midst of the storm, immediately received interview requests from many media, including CCTV, but Zhang Yang declined them all.
At present, the "hepatocyte activator" has not officially completed the third phase of clinical trials, but its clinical data is sufficient to support its successful passage of the third phase of clinical trials.
What he has to do now is:
First, take the green approval channel of the "National Key Disease Catalog" and start the pre-approval application for production approval.
Second, it is very important to determine the final retail price of the "hepatocyte activator".
The first thing he handed over to Liu Fei, who is in charge of the production project, is that with the cooperation of Hehua Pharmaceutical, once the third phase of clinical trials is approved, the production approval will be quickly obtained and put into sale.
The second thing is pricing.
This time he did not act arbitrarily, but convened Ren Xiaomin, Wei Tian, and several colleagues from the marketing department to discuss the final pricing of the "hepatocyte activator".
Zhang Yang and the entire Qingshan Pharmaceutical Industry position this drug for patients in the "compensation phase" and "decompensation phase" of liver cirrhosis.
Although the clinical data is not very sufficient, it has been determined that the "compensation period", that is, early-stage liver cirrhosis can begin to reverse after taking the drug for two months.
According to calculations and preliminary estimates, patients with early-stage liver cirrhosis should be able to completely reverse the disease and transform from cirrhosis to liver fibrosis after taking it for about one year;
After one year, Gradually reduce the dosage from 4 pills of 200mg per day to 2 pills of 100mg per day.
Although patients with advanced liver cirrhosis have not yet shown significant reversal, the R&D team has also calculated that they should be able to reverse to the "compensation phase" level after one year of taking it.
That is, mid-stage cirrhosis and early-stage cirrhosis.
Of course, as late-stage liver cirrhosis has caused extensive cirrhosis of the liver, it is no longer possible to fully recover. It would be very good to restore a certain degree of liver function.
Advanced liver cirrhosis requires continuous medication after one year of medication, and there is currently no complete data on the specific subsequent medication cycles.
Of course, because the drug itself contains a large amount of liver cell regeneration activation substances, it naturally has a liver-protective and hepatoprotective effect.
Furthermore, it can also be seen from the fact that Novartis’ “LivClearX” with only 50% ingredients has a good therapeutic effect on severe fatty liver disease. The complete “hepatocyte activator” will only have stronger , the effect is more obvious.
After comprehensive consideration, the final price was set at 6,500 yuan per bottle.
After confirming his retail price, almost at the same time, Liu Weiguo, deputy director of the Procurement Department of the Medical Insurance Bureau, who received the news, came to Qingshan Pharmaceutical in person
Liu Weiguo and Zhang Yang are also old friends.
The last time Zhang Yang took the initiative to reduce the price of the hepatitis B drug "Ecofovir" to 500 yuan per box, he was deeply moved.
It would be a lie to say that I don’t admire you.
"Mr. Zhang, we meet again. I am really happy to see you in good health."
Zhang Yang smiled slightly, a little surprised by Liu Weiguo's active visit, but it was also reasonable.
"Director Liu, you are so proactive. You came here before we even finished the third phase of clinical trials. You are not so impatient."
"Haha."
Liu Weiguo shook his head with a smile and said with emotion:
"Mr. Zhang, you may not know that many patients with liver cirrhosis across the country are looking forward to your drug being launched soon."
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"We have a burden on our shoulders, so we have to do something practical for the people, right?
Your drug is as scarce as the previous 'Ecofovir', and it is urgently needed by the people. Naturally, we should also Let's deal with these things before it goes on the market."
"At least the people will be able to repay part of the medicine."
Zhang Yang nodded.
Although there are many bad things about this country, even in the darkest times, there are still many pure people.
Liu Weiguo should be counted as one.
"Okay, let's talk about the price."
"But...to tell you the truth, our internal retail price has been set."
"Yeah , please tell me first..."
This time Liu Weiguo also knew the gold content of "Hepatocyte Activator" and also knew that it was an innovative drug. After a simple bargaining, the final price included in the medical insurance was 500 cheaper. Yuan.
The price of entering the medical insurance is 6,000 yuan, which is a Class B reimbursable drug.
Because the unit price is relatively expensive, the state reimburses 35%, totaling 2,100 yuan, and individuals bear 65%, totaling 3,900 yuan.
After all matters were determined, and with the end of the third clinical phase of the "hepatocyte activator", Zhang Yang immediately revealed the price in advance on the official website.
Retail price: 6,500 yuan.
Medical insurance price: 6,000 yuan.
The individual bears 65% of the cost, and the self-expense is 3,900 yuan.
Medical insurance will bear 35% and reimburse 2,100 yuan.
News of the pricing appeared on the Internet and quickly sparked a lot of heated discussions!
(End of this chapter)