Chapter 124: The whole audience was surprised by the kidney toxin replacement injection (please subscribe!)
BI Company’s influence in the field of kidney disease drugs is still recognized by everyone.
When Hans said this, everyone stopped discussing and looked at the center of the booth.
Hans did not leave the circle behind, and projected the prepared information on the screen through his mobile phone, and then said:
"As we all know, there are more than 5 million dialysis patients in the world, and most of them Most are using the most common form of hemodialysis ”
"But hemodialysis also has big disadvantages. Currently, no matter what brand of dialysis machine or dialysate, it can only remove about 85% of the toxins in human blood."
"Some macromolecular toxins and some metabolites produce The toxic elements cannot be completely removed through hemodialysis."
"This also makes Analysis of patients has some toxins remaining in the body at all times, and eventually these toxins will invade the body for a long time, eventually causing heart failure, organ failure and other problems.”
“It can be said that this drawback has already occurred. It has become the biggest factor affecting the lives of dialysis patients!”
After the words fell, everyone in the room nodded.
The principle of the dialysis machine is actually the same as that of the water purifier, mainly through the principles of adsorption and dispersion.
Adsorption is to use the adsorbent in the dialyzer to absorb metabolites and some toxins in the blood. However, adsorption is a physical method and it is difficult to achieve 100% adsorption.
The principle of dispersion can be understood as the principle of concentration.
The concentration of metabolic wastes such as urea, creatinine, uric acid, and excess electrolytes and other solutes in the blood of patients with uremia is relatively high. When the blood passes through the dialysis machine, these toxic substances with higher concentrations will be separated and diffused into the blood. in the dialysate to achieve purification of blood and harmful substances.
The principle of diffusion is also the most important principle of the dialysis machine.
However, these two methods are actually high-probability methods. Whether it is adsorption or dispersion, it is impossible to achieve 100% complete filtration of toxins.
At this moment, Hans continued:
“So, given that hemodialysis cannot achieve a higher toxin filtration rate at present, we developed such an injection;
It can be injected into the patient's body through the blood catheter when the patient is undergoing hemodialysis, allowing the drug ingredients to directly act on the blood, thereby increasing the filtration of dialysis toxins. The purpose of efficiency. ”
“You can think of it as a catalyst, just like the ‘fuel treasure’ in a fuel vehicle. Its pharmaceutical ingredients can quickly metabolize macromolecular toxins and residues in the blood. It decomposes and crushes harmful substances such as chemicals, allowing the dialysis machine to better absorb and disperse blood, thereby achieving a higher toxin filtration rate of the dialysis machine. ”
"The data currently obtained from our laboratory shows that the dialysis effect can be increased to 92% after adding this agent, and the effective improvement rate has increased by 7% compared to the current level!"
"And normal people can effectively filter The rate is about 98%, which means...if this drug is successfully launched, we are very likely to be able to reduce the number of current dialysis patients to 13.7%. The median survival time of 8 years has been increased by 3-5 years. ”
“Even in the future, we may achieve the same 98% filtration rate as normal people through continuous improvement!”
< br>"This is a historic moment!"
After the words fell, everyone present couldn't help but take a deep breath.
Zhang Yang noticed that even Friedman and Lucas beside him were slightly startled, and their eyes became serious and serious.
It must be admitted that once such a drug is developed, it will definitely be a major monument in the history of kidney dialysis!
And...
Both of them realized how much commercial profits this drug would bring once it is launched!
Although there are only 5 million dialysis patients in the world, the frequency of these dialysis patients is three times a week, or twelve times a month!
If this agent is added to every dialysis, the benefits will be unimaginable!
Friedman and Lucas were frantically calculating the market prospects of this drug, and the doctors on the left, Dr. Xili, were also completely interested.
Dialysis has been popular for so many years, and its toxin filtration rate has been improving.
However, after the filtration rate reached 85% in the past 20 years, it has been difficult to improve it. After all, there is still a big difference between machines and human kidneys. Even if modern technology is so advanced, it still cannot achieve the precise operation of human kidneys.
Now BI Company is taking a different approach, and this approach does sound like it has a good chance of success.
For a while, the doctors raised their hands to ask, and the scene was lively.
Zhang Yang couldn't help but be surprised by this medicine from BI Company. Recently, due to the "Kidney Clear Dialysis Replacement Injection", he has been paying attention to various matters related to dialysis patients.
The biggest trouble in the lives of dialysis patients is that they have to undergo dialysis three times a week and are almost tied to the dialysis machine.
The biggest trouble in survival is that toxins accumulate in the body for a long time and are not completely removed.
If this drug can really be put on the market, it will definitely significantly improve the survival time of dialysis patients!
"BI company still has something to offer..."
Zhang Yang couldn't help but sigh, but suddenly, he had a flash of inspiration, and a wild idea suddenly appeared in his mind.
What if
the complete "Kidney Toxic Clear Dialysis Needle" in my hand, which has only 80% filtration effect, can be combined with the ingredients of this drug from BI...
Hiss!
You should know that "Kenduqing Dialysis Replacement Injection" is a drug that can activate the kidneys after injection and allow patients to resume urination.
However, because it only has an 80% removal effect of drug toxins, it can only last for two injections at most, and then a full dialysis with a dialysis machine is required to avoid accumulation in the body.
And if the catalyst from BI Company is added, will it improve the toxin filtration effect of the "Kidney Toxin Clear Dialysis Needle"? !
If so!
Wouldn’t the “Kenduqing Dialysis Replacement Needle” completely replace the dialysis machine?
The more Zhang Yang thought about it, the more excited he felt, but he soon calmed down. BI Company's drug has not even started its first clinical phase, and it is not certain whether it will actually have any effect on the human body.
While thinking, the exchange between Hans from BI Company and the doctors was finally coming to an end.
Everyone can see that many doctors are very interested in the drug BI, and they even took the initiative to leave Hans’s contact information, hoping to get more relevant information.
Hans is also quite satisfied with this publicity. Although it is still in the laboratory stage, after such publicity, once the drug enters the first clinical phase, it will inevitably attract the attention of many kidney hospitals around the world, and if If it can be put on the market, it will undoubtedly be quickly introduced to the global market.
This is what the Kidney Summit is about.
"Okay, that's all I have to share about medicine today, thank you all."
Hans smiled and waved as he walked down the booth, and the conference hall suddenly burst into warm applause. This was everyone's contribution to BI Company. Applause from the heart!
This is cutting-edge technology!
Friedman and Lucas also clapped their hands. Apart from the business perspective, they were equally happy about the possible medical advancements.
Hans returned to his seat, and the time quietly came to 4:30 pm, and there was only the last half hour left before the end of the summit.
The host seemed to realize that BI Company should be the last one to speak, so this "new drug sharing" session was over.
According to the meeting procedure, the last half hour is a period for major pharmaceutical companies and doctors to speak freely and communicate.
However.
Adhering to professionalism, she still glanced at the pharmaceutical company's representatives, and then asked politely:
"Is there any other company that needs to go on stage to share new drugs? If not, we Let’s enter the last step.”
After saying that, she was about to start the next opening remarks, but at this moment, Zhang Yang stood up.
“Yes, I also want to share a medicine.”
Zhang Yang’s words were very soft, but the moment he stood up, everyone present was stunned.
Friedman and Lucas on the side even widened their eyes and looked at Zhang Yang in surprise.
Good guy!
Just now you said you had the idea to join the research and development of kidney disease drugs, and now you are about to take the stage? !
Is this going to be shown?
Is this going to be shared?
The host couldn't help but be stunned for a moment, then looked at the seat ticket in front of Zhang Yang, and hurriedly said: "Okay, then we welcome Mr. Zhang Yang from Qingshan Pharmaceutical to share his medicine with us."
"Everyone welcomes them with applause."
The surprised Lucas and Friedman finally reacted and took the lead in applauding, and then the conference room began to burst into warm applause.
Dean Gan Weiguo, who was sitting at the doctor's seat, watched Zhang Yang calmly walk onto the stage, and a trace of cold sweat broke out on his forehead.
He also knows that Qingshan Pharmaceutical intends to develop kidney drugs, but this time the original intention was for Zhang Yang to show his face and feel the atmosphere,
But you actually went on stage? !
Of course, Zhang Yang didn't know what Dean Gan Weiguo was thinking at this moment. He walked up to the booth, took a deep breath, and skillfully shared the prepared information on the screen through his mobile phone.
Then, he stood in the center of the booth, coughed lightly into the microphone, and said in a low voice:
"Hello everyone, I am Zhang Yang from Qingshan Pharmaceutical."
“What I brought today is also a product about The drug for dialysis patients is, to be precise, an injection. "
" Its chemical name is 'polyethylene glycol-nephrotoxic targeted scavenger injection', and the Chinese name of the drug is 'nephrotoxic.' Clear Dialysis Replacement Needle'
"Its function, just like the name of the drug, allows patients to get rid of the dialysis machine in a short time. Only injections are needed to achieve the same effect as dialysis!"
Get rid of the dialysis machine!
Injection can achieve the same effect as dialysis!
After the words fell, everyone present was stunned and surprised!
Can one injection replace dialysis? !
Impossible?
You need to know what is the most difficult thing about letting injections replace dialysis!
Not how to remove toxins, but how to remove toxins from the body!
Under great confusion, a doctor immediately stood up and spoke:
"Mr. Zhang Yang, I would like to interrupt you. You should know that almost all dialysis patients will lose their ability to urinate after long-term dialysis. Function, I would like to ask you, these dialysis patients have no urinary function, how do they discharge toxins?”
Zhang Yang smiled slightly and said:
"Yes, the vast majority of dialysis patients have lost their urinary function, but our 'Kidney Toxic Clear Dialysis Replacement Needle' will be able to regain its function within an hour after being injected intravenously." Urinating! ”
Urinating again!
After the words fell, this time, not to mention the doctor who just asked the question, even all the doctors present who were invited could not sit still!
They are the top nephrologists in the world, and they have never heard of any drug that can reactivate the kidneys and start urination!
What a joke!
The root cause of uremia is that kidney damage results in the inability to filter toxins, resulting in the inability to urinate!
For example, in the field of nephrology, there is a very common classification of nephrotic syndrome called "nephrotic syndrome". Once patients reach renal failure and uremia, they will develop edema all over the body. The reason is that the kidneys stop working due to severe damage, resulting in a large number of Toxins and water cannot be eliminated from the body!
At this time, doctors will use a large amount of diuretics, but diuretics are also resistant. They are very effective the first time, but after several times, the kidneys will become resistant and the effect is not good!
The final solution is dialysis.
And now!
Zhang Yang, the president of Qingshan Pharmaceutical, actually said that he can reactivate the shut down kidneys? !
Zhang Yang smiled slightly, understood everyone's doubts, and continued:
"I know everyone has doubts. Let me first briefly introduce the principle of our 'Kidney Toxin Clear Dialysis Replacement Needle'. ”
“First of all, after the drug is injected intravenously, its drug molecules will quickly reach the renal tubular epithelial cell pathway as soon as possible,
The renal tubular epithelial pathway is the key point to stimulate the kidneys to start.
After the connection is established, the 'pathway mitogen-activated protein kinase (MAPK)' is reactivated, thereby stimulating the kidneys to open the channel and ultimately achieve urination. "
As he spoke, he paused and continued:
"It is undeniable that patients who meet the dialysis standards have serious kidney damage, but I think you can't deny that even uremia Patients in the advanced stage still retain 20-30% of their kidney function. "
As soon as these words came out, many shocked doctors nodded.
really.
Uraemia is not a complete necrosis of the kidneys, but when the number of glomeruli is reduced to only 500,000, the human body has difficulty completing its work, and symptoms such as edema and vomiting will gradually appear.
99% of people will be sent to the hospital at this time. Once sent to the hospital for dialysis, the remaining glomeruli will almost retain their function.
“That’s right!”
Seeing everyone nodding, Zhang Yang continued:
"So, we only need the kidneys to open the urinary pathway, and the remaining 20% of kidney function is enough to form urine, and then the urine formed by the drug is excreted through the urinary system."
"And those who were originally undergoing dialysis It is even simpler for patients who still have urine. Although the kidneys are shut down at the request of the body's immune system, their urinary function is actually normal."
"We only need to reactivate their kidneys to achieve urination..."
Voice. After falling, the doctors present took a deep breath and looked at each other.
I have to say that the principle explained by Zhang Yang is indeed correct, but!
Is Qingshan Pharmaceutical, which had no achievements in the field of kidneys before, so powerful in its research on kidneys?
The doctors present may just be surprised, but the eyes of the pharmaceutical company representatives on the side are full of shock for the first time!
You know, whether it is Roche's "Empagliflozin" or the drugs promoted by the other two companies, they are nothing more than eye-catching.
Even BI's catalyst to improve dialysis is just amazing!
What about the "Kidney Toxin Clear Dialysis Replacement Injection" from Qingshan Pharmaceutical?
Its drug mechanism is shocking and incredible!
Others don’t know, but they know very well that despite Zhang Yang’s easy words, it is not easy to find the pathway that activates the kidneys and the target that activates the kidneys!
I admit that Qingshan Pharmaceutical is very strong in the fields of blood diseases and liver diseases!
But is Qingshan Pharmaceutical so strong in the kidney field? !
At this moment, Zhang Yang’s voice came again.
"Okay, since everyone has no doubts, let me briefly introduce the toxin removal effect of our 'Kidney Clearing Dialysis Replacement Needle'!"
"Currently our 'Dialysis Replacement Needle' has achieved The toxin filtration rate of 60% is still far behind the 85% effective filtration rate of the dialysis machine, but we are confident that the toxin filtration rate can be increased to 80% in the future.”
Everyone breathed a sigh of relief.
“However, although our current effective filtration rate cannot reach the effect of a dialysis machine, compared with traditional dialysis, which requires two days of accumulation of toxins before dialysis, we have a huge advantage!”
"The human body will resume urination function one hour after we inject the drug."
"In other words, the 'Kidney Clear Dialysis Replacement Needle' will completely simulate the human kidney and can pass drug molecules immediately after ingesting food. The effect is to expel toxins from the body, and there is no need to wait for toxins to accumulate!”
“This is our biggest advantage!”
The scene fell silent.
Everyone suddenly realized this very critical issue with their eyes widened!
Clear it promptly!
……
PS: Thank you Francisco for the big 500 coin reward!
The previous chapter is 4.8K, this chapter is 4.7K, and the total is 9.5K. Although it is not a million, it is only 500 words short!
This is a great update for Majia Box!
Asking for a monthly ticket.
Tomorrow we will continue to add more updates for the boss!
(End of this chapter)