Chapter 127 That’s right, you will be caught (please subscribe)
Many people know that India is the world’s largest generic drug factory, and its sales of generic drugs account for 25% of the global total.
But what many people don’t know is that India is also the world’s largest clinical trial base for innovative drugs.
Almost all well-known pharmaceutical companies in the United States and Europe have their own clinical trial bases in India.
Why do Western pharmaceutical companies want to establish clinical trial bases in India?
This needs to start with generic drugs in India.
Why can India unscrupulously imitate new drugs developed by major Western pharmaceutical companies at a cost of billions or tens of billions of dollars?
Do you really think that because the Indian official does not recognize that "drugs have patents", Indian pharmaceutical companies can copy this statement at will?
Are you kidding me? When did Western capitalists become so kind? The medicine he developed with real money was given to India for free, and then all sentient beings were saved?
The West really wants to take advantage of India with just a raise of its hands. The real reason that makes the West acquiesce that India can ignore patents and imitate is——
In exchange for human life.
To be precise, it was exchanged for the lives of Indians.
As we all know,
the development of any new drug not only takes a long time to develop and costs a lot of money, but also there are not many patients willing to undergo clinical trials.
Especially in developed countries such as Europe and the United States, the cost of recruiting a patient for a complete cycle of trials is about US$15,000. But what about India?
Three hundred dollars.
A gap of 50 times.
A clinical trial of an innovative drug requires at least several hundred people. If the drug ingredients are repeatedly modified and clinical trials are repeated, the number of subjects can even reach one or two thousand.
How can the cost gap not make capitalists excited?
In addition, compared with the European Union and the United States, which have complete and strict approval processes, Indian clinical trial approval is extremely relaxed!
Did the test drug die?
Just lose some money!
This kind of environment is simply a paradise for pharmaceutical companies!
This is not alarmist. A few years ago, it was revealed that a well-known American pharmaceutical company had not conducted animal experiments on innovative drugs, but directly tested them on Indians.
The reason is that experimental monkeys are more expensive than Indians...
Therefore,
Under such an environment, Western and Indian officials have reached a delicate balance. I don’t care if you copy our innovative drugs, but you also allow us to conduct various clinical trials in India to the maximum extent.
Of course, Zhang Yang also knows something about the situation in India. If the "Kidney Toxin Clearing Dialysis Injection" is launched in clinical trials in India, there will definitely be no problem with safety approval or subject recruitment.
In addition, GlaxoSmithKline itself is the largest pharmaceutical company in the UK. As the sovereign state, GlaxoSmithKline has unique advantages.
Thinking of this, Zhang Yang nodded slightly. Lucas on the side saw this and spoke quickly, taking advantage of others to strike:
"Zhang, if you are willing to hand over the European agency rights of 'Kidney Clear Dialysis Needle' to us, we can also bear 80% like Novartis..."
"Oh no, we are willing to 100% The cost of clinical trials, in short!”
“You don’t have to worry about anything, we will be responsible for all the clinical trials and marketing approvals!”
Zhang Yang is definitely satisfied with this answer. Are the lives of Indians participating in clinical trials safe?
Just kidding, he doesn’t care about Americans, but he still cares about dead Indians?
"Lucas, your proposal is very constructive, and I look forward to working with you in depth again."
"Okay, I agree to be the exclusive agent in Europe for this 'Kidney Clearance Replacement Injection' The power is given to you, but the premise is that you must launch and pass clinical trials as soon as possible!”
“Of course, our R&D team will also join in this process. Continuously improve drug ingredients.”
“As I said at the summit this afternoon, our current effective toxin removal rate is only 60%, but we are already a little bit ahead of improving the effect by 80%. We should have a breakthrough in one year, or as little as half a year, don’t worry!”
Zhang Yang’s last words completely reassured the two of them.
If this dialysis needle can really achieve 80% effectiveness, let alone pass clinical trials, future market sales will definitely be even more promising!
"Haha, Zhang, you are really my best friend and our best partner at Novartis!!"
"Zhang, thank you for your trust. I can come to the UK next time when you are free. Just for fun, I will definitely accompany you."
Zhang Yang smiled, and the three of them held their hands tightly.
“A pleasure to work with.”
...
Zhang Yang and the other three decided on the main market agency rights for the "Kidney Toxin Clearing Dialysis Injection" while walking along the Huangpu River. Early the next morning,
Friedman and Lu Cass also changed his itinerary and urgently booked the same flight as Zhang Yang to Qingshan Pharmaceutical.
When the three of them came to Qingshan Pharmaceutical, Ren Xiaomin, who stayed at home, was stunned.
He didn’t expect that Zhang Yang would be able to secure the agency rights for “Kidney Toxic Clearing Replacement Injection” just after attending a kidney disease summit, and...
It also seems to have solved the problem that has been plaguing Tsingshan Pharmaceutical about "how to conduct and whether to conduct clinical trials of dialysis needles."
Taking advantage of the gap, he hurriedly pulled Zhang Yang aside and lowered his voice:
"Zhang Yang, you are saying that our 'kidney dialysis replacement needle' will not be tested in China first. Let’s talk about the completion of clinical trials in the United States and India?”
Zhang Yang nodded.
When Ren Xiaomin got the accurate answer, a smile suddenly appeared on his face and his voice became lower.
"Zhang Yang, how did you convince them? I can still understand India. The FDA is the United States. Novartis are really willing?"
"This might kill people."
Zhang Yang shrugged, and his eyes fell on Friedman, who was smiling.
He patted Ren Xiaomin on the shoulder and lowered his voice:
"Brother Ren, this world may not be as beautiful as we imagined."
"This society is cannibalistic!"
"Huh?"
...
Zhang Yang then left Ren Xiaomin to take charge of the details of the agency contract.
With previous experience in agency cooperation, Tsingshan Pharmaceutical quickly signed intention contracts with Novo and GlaxoSmithKline for priority agency rights in the US market and EU market respectively.
As long as Novartis and GlaxoSmithKline pass the drug marketing approval certification in their respective markets, they will automatically obtain the local agency rights for the "Kidney Clear Dialysis Injection".
At noon the next day, Friedman returned to the United States with a large amount of clinical data and patent power of attorney provided by Qingshan Pharmaceutical;
Lucas also left with a large amount of clinical data. , but instead of returning to the UK, he flew directly to GlaxoSmithKline’s clinical trial center in India.
After the two left, Ren Xiaomin approached Zhang Yang again. This time he asked about the "Kidney Toxin Clearing Dialysis Needle."
"Zhang Yang, currently our 'Kidney Toxin Clearing Dialysis Needle' has officially entered the clinical trial stage. Do you think we should announce the latest progress on the official website? Or promote it?"
Zhang Yang thought for a moment and shook his head:
"Forget it about publicity, but we can disclose the news about the 'Kidney Toxin Clearing Dialysis Needle' on the official website."
"Let me show it to everyone. Our latest R&D results, plus This should also bring some hope to countless dialysis patients."
"Okay."
With Zhang Yang's permission, Ren Xiaomin immediately performed some simple functions of the "Kidney Toxin Clearing Dialysis Needle." The introduction and effects are posted on the official website.
Tsingshan Pharmaceutical is now considered a leading pharmaceutical company in China. Within two days of the news being released, some medical self-media and public account UP owners noticed Tsingshan Pharmaceutical’s latest research results.
Soon, articles on public accounts introducing Qingshan Pharmaceutical's "Kidney Toxin Clearing Dialysis Injection" appeared. With rapid forwarding, they appeared in various groups of kidney disease patients, attracting the attention of many kidney disease patients. .
“Look, look, look, Qingshan Pharmaceutical has released new research and development results. This time it is finally our kidney patients’ turn!”
“Really? Let me see, it is It’s not that Qingshan Pharmaceutical has developed a drug that can reverse chronic nephritis. Medicine? That would be great! ""That's not the case. It is a 'dialysis replacement injection' mainly for dialysis patients. It seems that it can be given twice in a row and can replace the function of the dialysis machine in a short time!" >
"Replacement of dialysis machine? Let's see...hiss! My God, reactivating the kidneys can also restore the kidneys' urinary function?! Do you know how long it has been since I urinated? I haven't urinated for 5 years!"
“Fuck, I have to try. I am a dialysis patient. I have to try even if it is just to experience the feeling of urination again. , when will this drug be launched?
“It’s still early to launch. This is the announcement of the latest research and development results, and we don’t know when clinical trials will be carried out...”
“Qingshan The pharmaceutical industry is very efficient. Once they release research results, they almost always start clinical trials quickly, and so on. "
"Okay! Then I'll wait! ”
Just as Zhang Yang thought, many dialysis patients began to look forward to it after noticing the "Kidney Toxin Clearing Dialysis Needle", and they all looked forward to getting news about clinical trials as soon as possible.
Of course Zhang Yang could not see the discussion among the patients. At this moment, he had already started the next phase of the "Kidney Toxin Clearing Dialysis Replacement Injection" work.
In the next time, he will lead the entire R&D team to increase the toxin removal effect from 60% to 80% step by step, and finally achieve a complete product.
However, in addition to this, he has not forgotten another unexpected gain at this "Kidney Disease Summit", which is BI Company's "catalyst needle" that improves the toxin removal effect of dialysis machines by 7%.
Zhang Yang’s idea is very simple. BI’s “catalyst needle” can crush macromolecular toxins in the human body, thereby improving the toxin removal rate of the dialysis machine. So, can the “catalyst needle” be combined with his own “kidney” "Duqing replacement injection" combined use?
Or even say, can some of these "catalytic molecules" be added to the "kidney-toxin-clearing drugs"?
With this idea, Zhang Yang began to collect and learn more about this "catalyst needle".
Of course, the current "catalyst needle" of BI Company is also It’s just that the laboratory stage has not even been tested in clinical trials yet...
Zhang Yang is not in a hurry.
Time passed very quickly. About three weeks later, news from Novartis came from the United States.
"Shenduqing Dialysis Needle" has passed the clinical trial application and is about to start a phase I clinical toxicity test.
Almost at the same time,
GlaxoSmithKline also received news from Lucas in India.
Compared to the FDA, which is still taking one step at a time, GlaxoSmithKline’s progress in India is a big step forward!
Because the "Shenduqing Dialysis Needle" is only targeted at specific dialysis patients, the first and second phase clinical trials are combined and conducted simultaneously.
Of course, Zhang Yang was happy to see this situation. After calling the two of them to congratulate him, the clinical trial of the "Kidney Toxic Clear Dialysis Replacement Injection" has officially begun!
While Lucas was launching clinical trials in full swing in India, the wholesale market for generic drugs a few kilometers away was bustling with activity, and small parcels were packed into express vehicles. in the car.
Almost all of these packages containing medicines come from overseas purchasing agents. They will travel through the sky and oceans with planes and cargo ships to the hands of patients...
One week later,
One of the packages crossed the Indian Ocean via a cargo ship and arrived at Shenzhen City, a coastal city in China.
Hu Adi was sitting in the living room, looking at his five-year-old daughter with doting eyes.
Suddenly, the cell phone in the bag rang.
He quickly covered his phone, fearing that the sudden ringing would scare his daughter.
After a moment, he quickly picked up the phone and whispered:
"Hello, who is this?"
"I'm a courier. Your courier has arrived. Please come down and get it."
"Oh."
Hu Adi said oh, counting the time quickly in his mind.
Express delivery from India to China takes about 3-10 days, air transportation takes about 3 days, and if you are lucky, it takes about 7 days by sea.
It has been exactly a week since I last contacted the Indian seller to deliver the goods... If the time is right, it should be the batch of medicine I bought.
However, he soon felt something was wrong again.
Usually the courier guy sends a text message and leaves it at the courier station. Why did he make a phone call in person today?
Fortunately, this thought only passed by for a moment, and he immediately said:
"Thank you, please leave it at the express station. I will go down and pick it up when it is empty."
There was silence on the other end of the phone for two seconds.
"Well... no; it's like this, your express package is a little damaged, you have to come and see it in person."
"If there is any problem, refuse it on the spot, and I'll just return it. .”
Damaged?
Hu Adi's heart suddenly thumped. He knew very well that the package was filled with generic drugs that he purchased from India.
If something goes wrong, money is a trivial matter. The key is that many patients are still waiting to take medicine!
Those are life-saving medicines!
"Okay, wait for me for two minutes, I'll be down right away!"
Hu Adi felt a flash of uneasiness in his heart, and then put the phone back into his pants pocket.
He looked at his five-year-old daughter, thought for a moment, and finally went to the bedroom to wake up his wife who was catching up on her sleep.
My daughter was very noisy all night last night, and his wife Wang Mei was also in trouble all night long. Now she is finally catching up on sleep.
"Mei, wake up."
"Brother, what's wrong?"
"There is something wrong with the express package purchased from India. The courier boy said that the package seems to be damaged. I'll go down and take a look. You can take care of your daughter."
Wang Mei raised her sleepy eyes and looked at her daughter, then nodded:
"Okay, you go ahead. Brother.”
Hu Adi finally felt relieved. Her daughter is a patient with a rare disease called epilepsy. She is prone to seizures when she gets emotional or is stimulated. This requires the couple to pay attention to their daughter almost anytime and anywhere.
He quickly went downstairs to the express station and saw the courier boy next to the express truck at a glance.
Hurry over and walk over:
"Hello courier guy, I'm the one you called just now and said the express package was damaged. Let me take a look at the courier..."
The courier boy glanced at Hu Adi with evasive eyes, and then looked at the two people around him.
Hu Adi felt a little strange. At this moment, the two people next to the express suddenly jumped out. They grabbed his hands from the left and the right, and then pressed his head down hard.
The sudden movement startled the people who were picking up express delivery. Before everyone could recover, another plainclothesman took out his police officer ID card from his bag and explained to everyone:
"The police are handling the case, the police are handling the case, don't be afraid."
Police?
Hu Adi suddenly panicked and hurriedly shouted:
"Comrade police, you have arrested the wrong person! You have arrested the wrong person! I am a good person!"
The policeman who just took out his police officer ID card put away his ID card, then walked up to Hu Adi and looked straight at it Looking at him:
"Is your name Hu Adi?"
"Yes."
"What did you buy in the express delivery?"
"What I bought... I bought some generic drugs, generic drugs for rare diseases!"
"Drug?"
"That's right, you are the one being arrested!"
(End of this chapter)