Chapter 131: Imitation clobazam? No, I want the original drug (please subscribe)
About 20 minutes later, Zhang Yang was invited into the director's office.
After receiving the call, Bureau Song quickly returned to the bureau from outside. This was also the first time he saw Zhang Yang in person.
It’s not that he is not worthy enough to know Zhang Yang, but it’s because Qingshan Pharmaceutical has been dealing with another person in these years: Ren Xiaomin.
He is very familiar with Ren Xiaomin.
30 minutes later, Ren Xiaomin also hurried to the director's office.
Soon, after a brief chat, everyone understood all the causes and consequences.
Zhang Yang did not expect that things would develop like this. His original idea was to accompany He Ping to submit the information in person and then get it approved as soon as possible.
Unexpectedly,
after a few words, Director Kong directly slapped the table and threatened himself, and simply revealed his identity directly.
But this little conflict was okay.
Director Song looked at Zhang Yang apologetically:
"Mr. Zhang and Mr. Ren, I'm very sorry about this matter. Don't worry, the next step will be the approval of your company's 'Clobazhan' I will be responsible for it myself."
"I will start the approval process soon, and I will work overtime this weekend to speed up the approval process."
As he said that, he looked at Kong Xiang aside.
"Director Kong, please express your opinion to Mr. Zhang."
Director Kong is no longer as arrogant and condescending as before, lowering his head:
"Mr. Zhang, I'm sorry, I just said It’s just a bad attitude, I hope you can forgive me.”
“Don’t worry, just like Director Song said, I will stay up late and work overtime this weekend to get all the approval materials for your company.”
Zhang Yang slowly exhaled.
After a moment, he stood up and looked at Song Bureau.
"Song Bureau, I'm sorry to trouble you. If you need me to supplement any information, just contact us. I'll leave first."
As he said that, he took the initiative to stretch out his right hand and Bureau Song shook his hand, and then led He Ping and Ren Xiaomin out of the office.
......
Zhang Yang breathed a sigh of relief after the matter of approval of production qualifications for "Clobazam" was resolved.
The next step is to find a way to imitate "Clobazam".
Clobazam was developed and synthesized by a Danish company, H. Lundbeck, in 1966. After more than 60 years, its patent has long expired.
Zhang Yang soon found the patent drawings of "Clobazam" in the database of the New Drug Research and Development Center.
In the pharmaceutical field, drug patents generally refer to drug compound patents.
What is a compound patent?
To put it simply, Western medicine is actually a variety of artificially synthesized compounds. For example, "clobazam" is an organic compound with the chemical formula C16H13ClN2O2.
With chemical formulas, even slightly more professional drug researchers can synthesize compounds through their chemical formulas.
However, this does not mean that the compound with the chemical formula "C16H13ClN2O2" is equivalent to "clobazam".
In nature, the chemical formula of carbon is C, and the chemical formula of diamond is also C. We cannot say that carbon is diamond, right?
So,
In addition to compounds, there is another very important patent that distinguishes medicines: crystal form patents.
Crystal form patent, to put it bluntly, is the internal molecular structure of the drug in the solid state, and it is the internal molecular structure that truly determines whether the compound has a therapeutic effect.
So.
A drug can be understood as: chemical formula + internal molecular crystal structure = a certain designated drug.
Of course,
The crystal form patent of "Clobazam", like the compound patent, has expired over sixty years ago.
But unlike what many people think, the expiration of a patent does not mean that you can produce exactly the same medicine.
Patent expiration only means that you can use the same crystal form and the same compound for free. However, how the patented crystal form was synthesized and what route it was used for, the original drug manufacturer will not announce.
Do you want to imitate?
Then try it yourself step by step.
90% of pharmaceutical companies can slowly test it out over one, two, or even several years, but even so, subtle differences in crystalline forms will lead to certain differences in the therapeutic effects of original drugs and generic drugs.
The difference is about 10%-20%.
And this is also the reason why original drugs must be more effective than generic drugs.
While thinking, Zhang Yang carefully looked at the crystal form patent and various information of "Clobazam".
About two hours later, he had a preliminary idea on how to imitate "clobazam", and the next step was to verify his synthesis route in the laboratory.
It has to be said that after extracting drug patents from simulators so many times, Zhang Yang’s level in the field of biopharmaceuticals has been greatly improved.
In addition, "Clobazam" has been around for decades. It is indeed not difficult for him to use old drugs and there are a lot of imitation materials.
Zhang Yang soon arrived at the drug research and development center. In order not to disrupt the progress of other drug research and development teams, especially the improvement progress of the "Kidney Toxic Clear Dialysis Injection", Zhang Yang decided to synthesize clobazam himself.
He immediately found Wei Tian and asked Wei Tian to arrange two less important researchers to help him. But when he told Wei Tian that the drug he was going to try to imitate was "Clobazam", Wei Tian suddenly pushed Push up the glasses frame.
“Mr. Zhang, when I was in college a few years ago, I accidentally saw a piece of news about ‘Clobazam’.”
"It seems that the Danish company that developed 'clobazam' was acquired by Novartis..."
"Why don't you ask Novartis whether it inherited the technical documents of its production process and synthesis path? The current market economic value of this drug is also It’s not high. Based on your relationship with Novartis, you should be able to buy it for not much money. Isn’t it much faster than if you try to imitate it?”
Zhang Yang was slightly stunned. He really didn’t know that Novartis could master it. The production technology of "Clobazam".
But Wei Tian is right. If you have the production materials of the original drug, you can just buy it and produce it. It’s useless to imitate it.
After a moment, he dialed Friedman's phone.
Friedman was a little surprised when he suddenly received a call from Zhang Yang.
"Zhang, luckily I didn't sleep. Do you want to know the progress of the 'Kidney Toxin Clearing Dialysis Injection' when I called you in the middle of the night? Don't worry, everything is progressing smoothly, and the response in our country is still good. Very good!”
Zhang Yang smiled politely and then said his purpose.
Friedman was obviously a little surprised when he heard Zhang Yang’s inquiry about Clobazam:
“Zhang, we did acquire all the shares of the Danish company ‘H.Lundbeck’ a few years ago. shares, they are now our wholly-owned subsidiaries.”
"But I don't know much about the drug 'Clobazam'. Can I get back to you during the day tomorrow?"
"Of course."
Friedman is very efficient. , at nine o'clock in the evening, Zhang Yang received an overseas call from Friedman.
"Zhang, I have confirmed for you that we do have all the production materials and technical documents of 'Clobazam', and after so many years of improvement, our original research on 'Clobazam' now has the calming effect It’s better, with less side effects and addiction.”
Zhang Yang was immediately relieved.
"That's just right." "Friedman, I told you on the last phone call that I want to buy the production technical data of this drug. Of course... I am only producing this drug in China and will not export it." Affect the normal sales of your subsidiary abroad."
"If you want, you can set a price."
"Set a price?"
Friedman’s voice on the other end of the phone raised slightly by two degrees:
"Oh, Zhang, you look down on my friend so much!"
"Since you have already spoken, how can I ask for your money? I will provide you with the production technical data of this 'Clobazam' tomorrow. Arrange for technicians to deliver it to you personally.”
Zhang Yangwei. He was stunned for a moment and said hurriedly:
“No, Friedman, there’s no need for this, this is your core information.”
“You just need to authorize me to use it, and I’ll pay for it. Just pay the fee, you can pay it in one lump sum or per box.”
"OH, Zhang, if you continue like this, you won't treat me as a friend..."
Friedman has obviously made up his mind. No matter how Zhang Yang refuses, he will give away the core of "Clobazam" for free. The production materials are licensed to Qingshan Pharmaceutical for free use.
In desperation, Zhang Yang had no choice but to accept Friedman's "kindness".
The next day, two staff members from Novartis China came to Qingshan Pharmaceutical, bringing with them a thick stack of production materials.
It is the synthetic route and technical information of the original version of "Clobazam" from H. Lundbeck of Denmark.
Now Zhang Yang finally felt relieved. The two conditions for producing "Clobazam": "production qualification" and "pharmaceutical technology" have been implemented. Next, all he has to do is wait for the approval!
Just when Zhang Yang finally took a breath, on the other side, the home of "Dad Songsong" far away in Zhejiang Province was extremely messy.
"Is your son sleeping?"
"Sleeping."
Dad Songsong glanced at his son who was sleeping soundly on the bed, and then carefully closed the door to the room. .
Next to him is his wife, Songsong’s mother.
“Fortunately, we didn’t break too many things during this attack, just two cups. By the way, did you break your mobile phone?”
Songsong’s dad said this He just took out his cell phone from his pants pocket. He accidentally dropped it when he was controlling his son.
He checked the phone screen carefully and breathed softly:
“It’s okay.”
"That's good."
Songsong's mother sighed helplessly, her face full of exhaustion.
Thirty minutes ago, their son suddenly had an epileptic seizure, and then broke two water glasses during the convulsions. Fortunately, Songsong's father was at home, and the epilepsy was finally controlled after giving him medicine.
“This disease is really torture. We are already taking the best medicine, but we still have sudden seizures after a year and a half. It’s so uncomfortable to live like this... We did this in our previous life What a sin, letting the child encounter such a disease!"
Songsong's father also sighed heavily.
For refractory epilepsy, ordinary epilepsy drugs have no effect at all. Only continuous use of clobazam can control the condition.
However... even if he takes clobazam for a long time, the child will occasionally have sudden attacks in a year and a half. At first, he thought it was his son's cause. Later, he asked several parents of patients and found out that this was the cause. common phenomenon.
I found out later that this was the reason for taking generic drugs. This would not happen if I took original drugs.
However, it would be nice to have generic drugs, but now even generic drugs are out of stock.
Thinking of this, his heart tightened and he looked at Songsong’s mother sadly:
"Honey, how much clobazam is left at home?"
"There are only two boxes left...Songsong Dad, we really need to think of a solution. What should we do if our child gets sick if we can't buy medicine again?" "
"Hey... I'll ask in the group again to see if anyone can help spread the two boxes. "
Songsong's dad quickly took out his mobile phone and opened it. WeChat group.
Since the video of the "joint petition" was posted online, it has indeed caused quite a stir, and countless netizens have spoken out for them.
The latest news is that even the court has considered that "Iron Horse" purchased drugs for medical treatment and subjectively had no intention of drug trafficking, so it is already discussing a decision not to prosecute "Iron Horse".
"Iron Horse" should not be sentenced.
But the problem is,
After this incident, "Clobazam" is completely out of stock. Even those patients who did not buy from "Iron Horse" before Feedback is that all purchasing channels have been cut off, and no one is willing to help purchase Clobazam.
Think about it. Before this incident, everyone thought that just purchasing drugs on behalf of others was considered a good deed.
But I didn't expect that this matter involved drug trafficking. Even if Tiema was finally acquitted, who would be willing to take such a big risk for a purchasing fee of several hundred yuan?
Songsong’s father shook his head helplessly and started sending messages to the patient group, asking if any patients still had sufficient medicine reserves and could help spread a few boxes for emergency use.
Soon, replies from patients came to the group.
"Dad Songsong, we only have a few boxes of medicine at home. I'm sorry, but I can't give them to you."
"I still have about ten boxes, so I can give them two. You, but there is nothing we can do if this continues; I have distributed almost ten boxes in the past two days and I will run out of them soon."
"Hey, yes, I originally thought that if I wrote a 'joint petition', everyone would pay attention to us, a vulnerable group, but I didn't expect that it would be even harder to buy medicine!"
"Yes, Dad Songsong, We have to think of a way, it won’t work if we continue like this! It’s better to take advantage of the situation! While it’s still a bit hot, let’s contact several media for help and ask the relevant departments to help solve the problem of buying medicines.”
Songsong’s father looked at the news that was quickly flooding the screen, and then thought about his own family! There are only two boxes of medicine left, and I have already made a decision in my heart!
“Okay, I was interviewed by a media before, I will contact them right away!”
The next day Songsong’s dad contacted a media who had interviewed him before, and it was indeed As the patient said, the "Glacier" issue is still a bit hot right now. After the request for help was sent out, it quickly attracted the attention of netizens who have been paying attention to this matter.
Everyone also began to realize that the arrest of "Iron Horse Glacier" was easy to solve, and the court agreed not to prosecute.
How to solve the problem of "Clobazam"?
"How to solve it? If you want to solve it, you need to understand why no one sells it in the country. Is it because the country does not allow it?"
"Didn't the relevant departments refute the rumors before? Although it is a controlled drug, The state allows and supports major pharmaceutical companies to carry out the work of copying 'clobazam', but no pharmaceutical company is willing to do it."
"Why?"
"Still asking why, less money, more trouble, and drug control. One of the raw materials in it is heroin. Do you find it troublesome when you think about it?"
"Hey, having said that, there is really no one. Are pharmaceutical companies willing to take some social responsibility? This is still more than 10,000 families!”
"Yes! By the way, isn't there Qingshan Pharmaceutical? Wasn't the boss of Qingshan Pharmaceutical previously rated as a model of the times? A model of the times should at least set an example!"
No Young netizens quickly thought of Tsingshan Pharmaceutical, especially the anti-fans of Tsingshan Pharmaceutical who finally found an opportunity to express their sorrow.
It’s not that they can’t stand Tsingshan Pharmaceuticals, it’s just that many fans can’t stand how much they praise Tsingshan Pharmaceuticals.
"That's right! I almost forgot about Tsingshan Pharmaceutical! Didn't many people boast about Tsingshan Pharmaceutical's righteousness before and that Tsingshan Pharmaceutical serves the country and the people? Now that something is not making money, why doesn't Tsingshan Pharmaceutical come out? Why doesn't it speak out?"
“Haha, it makes me laugh so hard. Why is no one claiming that Qingshan Pharmaceutical is the national brand now? The light of the nation? If you stand up and produce clobazam, you can really solve the problems of these patients!"
"Yes, if you are really awesome, just stand up and slap me in the face! My face was swollen!”
(End of this chapter)