Chapter 139 Goodbye Jiang Yong. (Please subscribe)
Fang Hanliang decided to return to China to join Tsingshan Pharmaceutical more than half a year ago, and he began to deal with resignation matters at BI Company in the past six months.
BI company did not make things difficult for him. After half a year of work handover, he successfully resigned.
Back in China, he originally wanted to join the job quickly, but Zhang Yang suggested that he spend a few days with his family and give the company some time to help him find a suitable place to live.
Fang Hanliang is also a good-natured person. When he heard that Zhang Yang was so considerate, he simply took his parents to Rongcheng and took advantage of the few days he spent with his parents to check out the house and prepare to settle down in Rongcheng.
Therefore,
Zhang Yang did not rush to contact Fang Hanliang to ruin his rare vacation. Instead, it was not until three days later that Fang Hanliang came to Zhang Yang's office after he had finished his vacation.
"Fang Bo (Doctor), how have you looked at the house in the past ten days? Have you chosen it?"
"Yes, you have chosen it."
Fang Hanliang He nodded with a smile on his face, looking quite satisfied.
"In Jinlin Peninsula in the south of the city, the balcony and living room are quite large, and the apartment layout is also very suitable. My parents liked it very much after seeing it, and I was quite satisfied myself, so I bought it without much hesitation!"
"As long as you are satisfied."
Zhang Yang also laughed.
Of course he does not doubt Fang Hanliang's financial resources. After working in a top foreign pharmaceutical company for so many years, and his father is a university professor, it is more than enough to buy a house.
The two chatted for a few more words, and then Zhang Yang gradually entered the topic.
"By the way, Fang Bo, I have something I want to ask you about. Do you know about BI Company, the drug called 'BI-Toxin Filtration Catalyst' from your previous company?"
"' BI-Toxin Filtration Catalyst'? "What's wrong?"
Fang Hanliang was a little surprised and didn't quite understand what Zhang Yang meant by suddenly asking this.
“It’s nothing.”
Zhang Yang didn’t go around in circles anymore and explained:
"A few days ago, the clinical phase 1 data of this drug came out. The clinical data are not very good, with only a 2-3% improvement effect."
"I heard this before at the 'Global Kidney Disease Summit' President Hans’ promotional introduction, their laboratory’s expected data is 7 %, right? The current clinical data is only 2-3%. Do you think there is a chance that they will continue to improve to 7%?”
Fang Hanliang understood instantly, but he did not answer immediately, but frowned. Zhumei took out his phone from his bag and flicked it quickly.
“Are you looking for their phase 1 clinical data?”
“Hmm.”
"Here it is."
Zhang Yang then handed the Pad on his desk to Fang Hanliang and said slowly:
"I have downloaded all the data, and it is all on the tablet. Wait, wait." Just wait and see, don't be in a hurry."
Fang Hanliang was really surprised at this moment. He didn't expect Zhang Yang to attach so much importance to this drug.
However, he didn’t say much. His years of working in Germany allowed him to develop the rigorous habit of “reading the data before speaking”.
About fifteen minutes later, he slowly raised his head and handed the tablet back to Zhang Yang.
“Mr. Zhang, although I did not participate in the research and development of this drug at BI Company, this clinical data is indeed somewhat lower than expected; I have talked with many core developers of this drug, and their psychology It is expected to be at least 5%.”
“Back to your question, will they have a chance to pass in the future? By adjusting the drug ingredients to 7%? To be honest, I don’t know. It requires a bit of luck.”
“But what is certain is that I have learned about this drug and I think it is designed. There’s no problem with the idea!”
Zhang Yang nodded slightly and did not answer, signaling Fang Hanliang to continue talking.
Seeing this, Fang Hanliang continued:
"There are mainly two molecular substances in the blood of uremic patients, one is macromolecule substances and the other is small molecule substances."
"Currently the blood The working principle of dialysis can only remove harmful small molecule substances Excretion, such as metabolites urea, creatinine and uric acid"
"Another example is excess water in the body, potassium ions, sodium ions and other trace elements eaten into the body."
"Another example. A macromolecular substance..."
"Hemodialysis cannot remove macromolecular substances, the most common of which is low-density lipoprotein (LDL), but the most important and most toxic are 'protein-bound toxins'."
"These toxins are They are tightly bound to proteins in the blood to form macromolecular complexes, making it difficult for the dialysis membrane to effectively remove them. Over time, they will accumulate in large amounts in the body and continue to cause harm to dialysis patients.”
< br>"The core pharmaceutical ingredient of 'BI-Toxin Filtration Catalyst' is to quickly decompose and break macromolecular complexes into small molecules, thereby improving filtration efficiency."
"The idea is That’s right, and the laboratory data is also okay. According to common sense, there won’t be such a big error in clinical data. It’s really strange...”
As he spoke, he shook his head:
"To be honest, Mr. Zhang, I don't know the specific reasons that caused such a big difference in data. It's even possible that their R&D team doesn't necessarily know where the problem lies."
"So, luck is needed. ”
Zhang Yang sighed slightly, this is the real drug research and development process.
The laboratory data are good, but when you go to the clinic, you will encounter some strange problems, but what is even more desperate is that you don’t even know where the problem is.
If you are lucky, you can find it quickly. If you are not lucky, it is normal for it to be stuck for three to five years.
"Okay..."
Zhang Yang did not continue to discuss this topic and pondered for a moment:
"To tell you the truth, I am indeed very interested in this drug."< br>
“Given that you have worked at BI for so many years, do you think it is possible for us to buy out the patent for this drug from them?”
“Buy out the patent?”
< br>
This time Fang Hanliang hardly hesitated and kept shaking his head.
"Mr. Zhang, as far as I know, 'BI-Toxin Filtration Catalyst' is one of the three key R&D projects within BI Company. They have invested a lot of manpower and R&D funds."
"Even if the current phase 1 clinical data is not ideal, I want them to It is absolutely impossible to sell the patent of this drug."
"Unless they still can't solve this problem after continued testing, but if that is the case, what is the use of buying it?"
Zhang Yang exhaled gently, this is indeed the truth.
However, he was indeed very interested in this drug, and he was still unwilling to buy it and study it, so he had to say:
"Okay, then let's wait and wait for more clinical data. Let’s talk about it later.”
“Yeah.”
The discussion between the two about BI Company’s “toxin filtration catalyst” quickly ended, and Fang Hanliang officially joined the company to build his own R&D team.
This is the task assigned to him by Zhang Yang. There is no need to rush to establish a project to develop drugs first. He should first get familiar with the personnel and build a team first.
As for Zhang Yang, he is temporarily hiding his interest in "BI-Toxin Filtration Catalyst" and waiting to see what happens next. Zhang Yang's work focus began to shift to the domestic clinical trial of "Kidney Toxin Clearing Dialysis Replacement Injection", but soon his work plan was interrupted by another incident.
The liver-protecting regeneration capsule, a 50% effective "hepatocyte activator" previously applied for health care products, is ready to be put on the market.
The ingredients of this drug are exactly the same as "LivClearX" sold in the United States, but compared with the US market price of up to 1,500 US dollars, the domestic price is finally set at 350 yuan per bottle.
On the one hand, fatty liver is indeed not a serious disease in China, and fatty liver can also be eliminated by losing weight, controlling diet, etc. If the price is too expensive, it is estimated that few people will buy it.
On the other hand, in Zhang Yang's words, this can be regarded as a benefit that Qingshan Pharmaceutical has given to the Chinese people, so that everyone can afford truly effective liver-protecting drugs.
Of course,
In order to take care of the sales of LivClearX in the US market, Zhang Yang did not advertise that the ingredients of the drug were exactly the same as "LivClearX", and did not even advertise to the outside world. He simply introduced its effects on fatty liver, Alcoholic liver disease has certain hepatoprotective effects.
But this is the case,
Because "LivClearX" was very popular in China before, "Liver Protection Regeneration Capsules" still attracted everyone's attention when they were first launched, especially the price of 350 yuan a bottle. The price makes many ordinary people willing to buy it and give it a try.
Tsingshan Pharmaceutical also opened its official store in JD Pharmacy this time. In just two days, it received nearly 5,000 orders without any publicity.
Zhang Yang is quite satisfied with this data.
After paying attention to this episode, Zhang Yang focused his attention again on the most important project at present - the third phase of the domestic clinical trial of "Kidney Toxic Clear Dialysis Replacement Injection", but when he was looking at the latest week's clinical results While collecting data, a familiar yet unfamiliar phone call came.
Lin Xiang.
If it weren’t for the note on the phone, he could hardly remember who this familiar name was.
He is the director of the Department of Nephrology of the Third People's Hospital of Chengdu, and is also the main source of subjects for the current phase III clinical trial of "Kidney Toxin Clearing Dialysis Injection".
Seeing Lin Xiang’s call, Zhang Yang felt inexplicably nervous. Could it be that something happened in the clinical trial?
"Director Lin, hello."
"Mr. Zhang, hello. I am not disturbing you, right?"
The relaxed tone made Zhang Yang relax a lot. , but Lin Xiang's sudden call made him a little curious.
For what purpose?
"No need to bother me, Director Lin, do you have something to do?"
"It's nothing particularly important. I suddenly met an acquaintance at the clinical trial center today. The two of us were together before. I’ve seen it before, so I called you specifically to ask.”
Acquaintance?
Have we met before?
Zhang Yang was a little surprised. At this moment, Lin Xiang continued:
"It's the uremic man we met in the dialysis room last time, named Jiang Yong."
" Didn't you later write a note asking him to come to work in your company? Today I am in a clinical trial? I met him in my heart, and he also signed up to participate in the Phase III clinical trial of 'Shenduqing'."
"So I'm a little surprised. Logically speaking, he already works in your company, so he shouldn't come to participate. Clinical trials..."
"Jiang Yong?"
Zhang Yang was startled, Lin Xiang only knew that he gave Jiang Yong a note to come to work, but what Lin Xiang didn't know was:
Jiang Yong later wanted to divorce because his wife cheated, so he quit his job and ran to Shenzhen City. I want an explanation. I didn’t expect it to come back after a few months?
Is it finished?
Thinking of this, Zhang Yang was even more surprised. He remembered telling Jiang Yong that if he didn't find a job when he came back, he could come back to work again.
But in the past half month, I haven’t seen Jiang Yong on my way to and from get off work, and no one has reported Jiang Yong’s situation to me. There is a high probability that he has not come back to work.
After a while, thinking that we were still on the phone at this time, I had to say:
"Director Lin, Jiang Yong is not working in our company now, but..."
"I have something to do. I want to find him. When will he come to the hospital for medication next time? "
"Don't you work in your company? Oh, he will come to the hospital next time at 9 o'clock tomorrow morning."
"Okay."
Zhang Yang exchanged a few words with Director Lin and hung up the phone.
The next day, he arrived at the clinical trial center of the Third People's Hospital of Chengdu early.
As soon as he arrived, his old acquaintance Deputy Director Feng Gang welcomed him into the office.
Waiting for a cup of fragrant Biluochun to be placed in front of Zhang Yang's table, Director Feng Gang looked at Zhang Yang with a smile on his face:
"Mr. Zhang, please come as soon as you come." I haven’t seen you for more than half a year. I’m afraid you have almost forgotten us old friends.”
"Director Feng, how could I forget you? We are still bothering you all the time with all our clinical projects!"
As he said that, Zhang Yang gently placed the ten boxes of "Liver Protection Regeneration Capsules" that he had prepared in advance. Put it on Feng Gang’s desk,
“You know, this thing It does have a very good protective effect on the liver. Director Feng often socializes. Eating this is good for the liver.” Bring it here."
Feng Gang looked shocked and hurriedly resisted.
"Mr. Zhang, how is this possible! You take it, you take it, you know mine, I never accept gifts."
Zhang Yang was amused and smiled:
"Director Feng, I I know you don’t accept gifts, but do you think I’m bribing you?”
“Furthermore, have you seen anyone giving medicine as a bribe?”
Feng Gang was startled. Reacted immediately.
Yes, if other pharmaceutical companies bring something, it can be said to have other motives, but the publicity in front of me...
Qingshan Pharmaceutical never thought of giving gifts when it first started. Now Qingshan The reputation of the pharmaceutical industry in the country no longer requires gifts, or in other words, there is no need to bribe directors at his level.
Suddenly, his heart felt warm and he completely understood what Zhang Yang meant.
This is a small gift he gave to himself as a friend.
But...
After hesitating for a moment, he still pushed away and refused:
"Mr. Zhang, thank you for treating me as a friend, but I really can't have these things; if I need them, I will just buy them, and you will give them to me when the time comes. I can give you a discount.”
“By the way, you’re not just here to give me a gift, are you?”
Zhang Yang was a little surprised by Feng Gang’s rejection, but Soon he became even more awe-struck.
He no longer dwelled on the matter, and immediately explained his purpose:
"Today I mainly came to see an employee of the previous company, who is participating in the clinical trial of 'Shenduqing'."
As he said that, Zhang Yang looked at his phone. The time happened to be 9 a.m. This time All the subjects for the batch should have arrived.
He was led by Feng Gang to the lobby of the clinical trial center and saw Jiang Yong who was about to draw blood at a glance.
Jiang Yong also noticed Zhang Yang, and his eyes quickly flashed to the other side.
After a while, looking at Zhang Yang walking in front of him, Jiang Yong whispered:
"Mr. Zhang..."
(End of this chapter)