Chapter 148 Buying out the BI-toxin catalyst patent! (Please subscribe)
On the other side, Qingshan Pharmaceutical Drug Research and Development Center.
Since Zhang Yang’s “two tasks” were determined, Fang Hanliang and the newly established R&D project team have devoted themselves wholeheartedly to the imitation work of “BI-Toxin Filtration Catalyst”.
Fang Hanliang knows very well that Zhang Yang attaches great importance to BI Company's "Toxin Catalyst", and also understands that his first priority is to quickly find out whether the combination of "Catalyst" and "Shenduqing" has any effect!
If so, how much toxin filtering effect can be improved? !
The data results he provided will also determine what method and price Tsingshan Pharmaceutical, or Zhang Yang, will take to obtain the patent authorization for the "BI-Toxin Filtration Catalyst".
However, it is not easy to imitate "BI-Toxin Filtration Catalyst",
But fortunately, Fang Hanliang has nearly 15 years of working experience in BI Company, and he knows some BI companies to a certain extent. The research and development ideas, coupled with the fact that the imitation "catalyst" is not intended for commercial use, is only used for scientific research, and some details will be similar.
But even so, it still took more than 4 months to barely get a similar "catalyst", and after more than 3 months of extensive experiments and data analysis, it was finally completed today. The data was summarized and a confirmable data was obtained.
"Mr. Zhang, after more than three months of experimental data, we have been able to confirm that BI's 'Catalyst' is fully compatible with our 'Shenduqing' and can achieve combined treatment!"
"Our data on mice and experimental monkeys both show that the toxin filtration rate of the combined drug is 4.3% higher than that of the injectable 'Kidney Clear Dialysis Needle' alone, and this is still the level of our generic drugs."
"If it was their original After researching the drug and carrying out the next step of purification and improvement, I believe it is possible to approach or achieve the 7% originally announced by BI Company."
After receiving the positive data, Zhang Yang breathed a sigh of relief for half a year. The wait has finally come to an end.
Then next,
he will try his best to obtain the patent authorization of BI Company's "Toxin Filtration Catalyst" at all costs!
Only by obtaining the patent authorization for the "catalyst" can he develop an injection catalyst for use with Shenduqing!
Once the combination of drugs can really increase the toxin clearance rate to 85% or even 87%, it is entirely possible that the current need for dialysis after two injections will be changed to once every two weeks!
It is even possible to get off dialysis completely!
To be able to achieve this step would undoubtedly be a huge benefit to all dialysis patients!
And,
Thanks to the efforts of clinicians, "Shenduqing" has now begun to be used on patients with "stage four kidney disease".
If the toxin clearance rate can be improved, it is possible to develop a "long-acting kidney toxin-clearing dialysis injection" in the future, which will turn the current injection of one injection in two days into one injection for a week and one injection for half a month!
However,
After a brief thought, Zhang Yang came back to his senses and suddenly remembered the first problem he encountered during the initial clinical phase of "BI-Catalyst".
"Fang Bo, during their first phase clinical trial, the clinical effect was only about 2.5%. Do you know the reason now?"
"Yes, I already know."
"To put it simply, the time for the blood to pass through the dialysis machine is too short, and the time for fusion with the catalyst is not enough. The macromolecular toxins cannot be completely decomposed, so the effect is poor."< br>
“But this is for us There is nothing wrong with it. The action time of our 'Shenduqing' drug is to remove toxins one hour after injection."
Zhang Yang understood immediately when he heard it, he smiled and said:
"It's a perfect match."
While the two were talking, Zhou Xiaomei in the laboratory also brought a glass of water and handed it to Zhang Yang.
"Mr. Zhang, please drink water."
"Oh, okay."
In the past six months, Zhang Yang has often paid attention to the progress of "Catalyst", and the two have not been in contact with each other for a long time. More and more.
Seeing Zhang Yang take the paper cup, Zhou Xiaomei smiled and went back to her own business.
A smile appeared on Fang Hanliang's lips, his eyes fell on Zhang Yang again, and he returned to the topic.
"Mr. Zhang, now that we have obtained certain data, what are your plans next?"
"I still have some personal connections in the BI company. Do you want my help?" Do you want to know what they say?"
Zhang Yang frowned slightly.
Now the role of "catalyst" has been confirmed, but judging from the last contact with BI Company, BI Company has little interest in selling patents.
I'm afraid this will cost a lot!
As for his claim that he is conducting research on "macromolecular toxin catalysts", that is an empty trap. BI Company may not believe it or not!
"Fang Bo..."
Zhang Yang was about to speak, but at this moment, the mobile phone in his pocket suddenly sounded two message alerts in a row.
He was slightly stunned. This message notification sound was neither WeChat nor a text message. Two seconds later, he realized that it was WhatsApp, a very popular social networking software on the Internet.
It was a message from Hans, Vice President of BI Company.
"Zhang, are you there?"
Looking at the content of the message, Zhang Yang's originally frowning brows suddenly widened.
Fang Hanliang on the side also noticed the change in Zhang Yang's expression. When he saw the content on the phone screen clearly, his face was full of surprise at first, and then he couldn't help but smile.
“Mr. Zhang, it seems that Hans and the others have encountered some problem!”
Zhang Yang exhaled slightly, there is an old saying in China that no matter what happens, go to the Three Treasures Palace!
After waiting for a minute, he replied:
"Hans, what's wrong?"
"Oh, I can receive your reply so quickly. I’m very happy.”
“I saw your company announced that it is developing a ‘macromolecule toxin catalyst’. I haven’t seen you update the research and development content for a long time. How is the progress recently?”
Seeing this sentence, Zhang Yang already knew in his heart that there was definitely something wrong with Hans contacting him!
There is a high probability that it is the "toxin filtering catalyst" of BI Company!
He replied calmly:
"We are making good progress and will start the first clinical phase soon. President Hans, I have often paid attention to your 'BI-Catalyst' ', your progress is much faster than ours!"
"Is the first clinical phase going to start soon?"
Hans did not answer Zhang Yang's last question, and his attention was obviously on the first clinical phase.
Zhang Yang couldn't help but smile and said quickly:
"Okay, by the way Hans, is there anything important?"
This time It took a full two minutes before Hans replied again:
"Okay, Zhang, it suddenly occurred to me that you were interested in our 'BI-Catalyst' more than half a year ago?"< br>
"I contacted you today to ask if you are still interested?"
Are you still interested?
Seeing this sentence, Zhang Yang's heart couldn't help but beat twice rapidly, and a hint of surprise flashed in the eyes of Fang Hanliang on the side!
After a moment, Zhang Yang took a deep breath and slowly replied:
"Hans, to be honest, I am not very interested anymore. As you know, we are already developing our own Macromolecular toxin catalyst', we have invested a lot of money."
At the end of the sentence, he suddenly added:
"What's wrong? Do you want to sell the patent?"
Seeing the news coming out, even Zhang Yang couldn't help but feel a little agitated. Very excited.
He stared straight at the screen of his mobile phone. As long as Hans revealed the slightest intention to sell, he would be able to take full initiative and know BI's trump card. And just when Zhang Yang was looking forward to it, on the other side of the mobile phone screen, Hans was sitting in the conference room and handed the mobile phone in his hand to President Dusman who was directly in front of him.
It turned out that after BI Company decided to contact Tsingshan Pharmaceutical, Hans volunteered to explore Tsingshan Pharmaceutical's reputation through personal relationships.
Looking at the publicity in front of him, he said:
"Mr. President, how do we reply? Should we reply directly now?"
Dusman frowned. Shake his head slowly.
“Wait for a few minutes and then talk!”
"Although they say they are not interested, no one can be sure whether they are interested!"
"We must find a way to find out their real trump cards. This is very important to us. Only by finding out what they really are." Only with this idea can we take the initiative in the subsequent negotiations!"
Hans nodded and did not reply directly.
Everyone knows that if Zhang Yang is interested, he will inevitably ask questions.
Those who are really not interested may be busy with other things.
One minute, two minutes, five minutes.
Zhang Yang was also a little anxious.
We were having a good conversation, but why did we suddenly get disconnected on the most critical issue?
Didn’t you see it? !
After a while,
He started typing a text in the chat box:
"Hans, are you still there?"
But after typing the last letter, he suddenly realized whether this could be the other person. The temptation? !
Thinking of this, he suddenly woke up. After so many years of growth, he was no longer as flamboyant as before.
He was waiting for news from Hans, why wasn’t Hans waiting for news from him!
Hans doesn't know his trump card, and he doesn't know whether he is interested or not. Whoever can't help but send a message first will be passive!
The testing between both parties actually started from the first message!
After calming down, Zhang Yang simply put the phone back into his bag, then said goodbye to Fang Hanliang and returned to the office.
Just as he entered the office, Hans’ news appeared again.
"Zhang, I just processed a file and was delayed for a while. I'm sorry."
"We do have the idea of conducting BD transactions now, and we are also willing to license the patent as you mentioned before."
"Do you want to know more about it?"
Zhang Yang raised a smile at the corner of his mouth. , then he no longer needs to pretend to wait, follow the normal Sending messages at a normal speed:
"If you really have plans to trade BD, I can learn about it."
"Do you have a plan? Well, you put your plan Send it to me and I’ll take a look.”
But before Zhang Yang could be happy for a second, new news came from the other side of the screen:
"We have not yet formulated a complete BD plan, but we already have a simple framework idea."
“We can license the patent of ‘BI-Catalyst’ to you for US$300 million, but we need to receive 30% of the profits of all new drugs developed based on this patent.”
30% profit dividend?
Zhang Yang frowned, this dividend is a bit high.
...
According to his idea, the "Kidney Toxic Clear Dialysis Replacement Injection" costs 1,000 yuan per injection.
The "macromolecular toxin catalyst" for injection is used as a combination drug and is an accessory. The price is about 300-400 yuan, and the profit should be 200-300 yuan.
Based on the calculation of a profit of 300 yuan per injection and a domestic sales volume of 5 million injections per year, the domestic profit is 1.5 billion per year, and the distribution to BI company is as high as 450 million.
This is still domestic profit.
Foreign profits are higher and sales are larger. According to the share of the global hemodialysis market, foreign profits can reach at least 3.5 billion. Calculating, BI will have to pay 1.5 billion in profits a year!
15 billion in ten years,
30 billion in twenty years!
He didn't like this approach.
Soon, he dialed the number of Finance Lao Qian.
"Lao Qian, come to my office."
Five minutes later, the financial director Lao Qian rushed to Zhang Yang's office.
Zhang Yang didn't talk nonsense. The first sentence was:
"Old Qian, how much cash do we have on our account now?"
"Cash?"
Lao Qian's eyes were startled, and gradually his eyes became excited.
Since the last time the Medical Insurance Bureau purchased 20 million bottles of "Acofenprovir", the company's cash flow suddenly soared to 12.25 billion and has never come down again!
He has reminded Mr. Zhang more than once that he can buy some financial management products, or buy some treasury bonds, but Mr. Zhang doesn’t seem to be interested at all!
You know, as a professional financial person, he wants to cry every day when he sees the company's tens of billions of cash lying in the bank account earning meager current interest!
Could it be!
Is Mr. Zhang finally enlightened?
Finally want to buy financial management?
"Mr. Zhang, during this period we have invested billions in the research and development of new drugs, and currently we only have 23.16 billion in cash!"
"If you want to buy financial management, you can buy 20 billion Yes! The remaining 3.1 billion is enough for working capital!”
“Buy financial management?”
Zhang Yang shook his head, calculating silently in his mind.
“23.16 billion is only 3.3 billion US dollars.”
“To be honest, 3.3 billion does not count in BD transactions that easily cost more than one billion US dollars or more than 20 billion US dollars. Too much!”
“But it should be enough to buy out the ‘BI-Toxin Catalyst’!”
Zhang Yang clenched his fists.
"That's enough!"
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(End of this chapter)