Chapter 179 What is the reason for the sudden increase in pulmonary nodules?
"Lao Zhang, Lao Zhang, good news, good news!"
"? What good news?"
"Didn't your company's physical examination in the past two years say that you have lung disease? Are there several ground glass nodules? We have seen several doctors but none are accurate. "You are asked to follow up every year."
"Aren't you worried about lung cancer? I just saw the news that Qingshan Pharmaceutical has developed a drug that can identify whether lung nodules are benign or malignant. , just take a CT scan after the injection!”
"Clinical trials are currently underway and clinical patients are being recruited. Do you think we should also participate?"
"Ah?! Qingshan Pharmaceutical!"
"Being able to identify pulmonary nodules is Conscience or viciousness?”
Lao Zhang was obviously stunned for a moment, and his expression became excited after a moment!
“Hey, what are you waiting for? Wife, where are they conducting clinical trials?!”
"Oh, forget it, I'll go to the official website of Qingshan Pharmaceutical to see the official news!"
...
On the other side, in a university female dormitory.
"Xiao Min, Director Dai's outpatient clinic has released numbers today. Have you grabbed Director Dai's number?"
"Hey! No! Dai Shen's number is too difficult to grab. It was gone in less than five seconds after it came out. I’ve been trying to grab it for three weeks and I haven’t gotten it once. It’s so difficult.”
"It's really difficult, but I want to tell you, Xiao Min, don't be too anxious. Just forget it if you can't get it. Didn't the doctor tell you to follow up first and then take a CT scan in half a year?"
< br>"No, no! I have to let Dai Shen personally check the results for me before I can rest assured! Oh, I just don't know why so many people have pulmonary nodules and it's so difficult to register!"
"By the way, Xiaolin, why are you suddenly concerned about this matter? ?”
“Oh, that’s right. I just saw on the news that a pharmaceutical company named Qingshan Pharmaceutical seems to have developed a drug that can identify the nature of pulmonary nodules. The main principle is through injection. Contrast agent identifies lung cancer markers..."
"We are now recruiting subjects with multiple lung nodules, and there is a subsidy of 500 yuan for each one...Everyone is talking about it on the Internet now!"
"I think you are so anxious and can't get registered, so you might as well give it a try!"
The girl named Xiao Min was suddenly stunned for a moment, and then reacted quickly the next second:
< br>“Qingshan Pharmaceutical has developed a contrast agent that can identify pulmonary nodules?!”
“Quick, show me the news, where is it?!”
……
Beijing Union Medical College Hospital.
As one of the top general hospitals in China, Xiehe Hospital only treats patients with difficult and complicated diseases.
Director Qiao’s one-day outpatient clinic number every week was sold out instantly as soon as it was released. All patients are looking forward to receiving personal diagnosis and treatment from the top thoracic surgery director in the country.
In the clinic, Director Qiao frowned slightly. The patient in front of him was in a difficult situation.
"Mr. Cao, right? You came to Xiehe in a roundabout way, so I will tell you directly!"
"You have already had a pulmonary nodule removal operation, and now less than two-thirds of your lung tissue is left;
If another part of the lung tissue is removed, your lung function will not be good in the future. It will definitely be seriously affected, and may even cause complications such as emphysema and pleural effusion.”
“You! You have to think about it carefully.”
Patient Cao nodded and sighed:
“Director Qiao, there’s nothing we can do about it. Look, I just had pulmonary nodule surgery two years ago. There were several lung nodules on my lungs, and several doctors said they might be malignant, and they all advised me to have them removed immediately.”
"It doesn't matter whether I cut it or not!"
Director Qiao pushed up the frame of his glasses.
Indeed, it is very troublesome for patients who have already had a lung operation and have damaged lung function.
If it is cut,
the lung function will be damaged again. If the cut is benign, it will be even more painful!
Don’t cut it!
If it is really lung cancer, then there will be no chance of regret!
So.
For patients who have already had one lung operation, it is very difficult to decide whether to perform pulmonary nodule surgery.
"Mr. Cao, if I could before, I would also advise you to be on the safe side."
"But..."
As he said that, Director Qiao took out a piece of promotional material from the drawer and handed it to Lao Cao.
“But now a new technology has emerged. Our domestic company Qingshan Pharmaceutical has developed a drug that can identify the nature of pulmonary nodules. You only need a CT scan to know which nodules you have. Which ones are malignant and which ones are benign?”
“This is very important to you, your lungs can’t tolerate any mistakes!”
Lao Cao was also confused and looked at it. I glanced at the information in my hand and didn't react for a moment.
"Director Qiao... you are saying that there is now a drug that can identify whether my lung nodules are lung cancer?"
"Yes."
Director Qiao continued:
< br>"Now they are conducting clinical trials and recruiting patients. If you take this promotional material and go to Chengdu Third People’s Hospital, they will arrange for you to be enrolled in the trial as soon as possible!”
“If it is malignant after the CT scan, you can come back again! Come to me and I will help you with the surgery!”
Lao Cao finally reacted and nodded repeatedly.
But when he stood up, he suddenly realized a problem:
"Director Qiao, I would like to ask, why can't our Xiehe take this CT?"
Director Qiao He was stunned for a moment, then smiled and said:
“Because this identification technology requires a specially matched CT machine. Now there is only one in the whole country, the Chengdu Third People’s Hospital. Anyone who wants to take a CT identification has to go there. Chengdu Third People’s Hospital!”
"But don't worry, we, Xiehe, are already preparing to cooperate with Qingshan Pharmaceutical, and we will introduce this CT machine soon!"
"Oh, okay, thank you, Director Qiao!"
On the second day after Zhang Lao completed the operation, Qingshan Pharmaceutical's "Nano Nodule Developer" also received approval for clinical trials.
Zhang Yang did not hesitate, and immediately announced the news that Qingshan Pharmaceutical had developed a "nano-nodule imaging agent", and began recruiting Phase II clinical subjects.
For a time, countless patients suffering from pulmonary nodules were surprised and happy, cheering;
Even doctors from major hospitals noticed it immediately and began to seriously understand this "nano nodule developer".
You must know that the judgment of the nature of pulmonary nodules has always troubled the entire thoracic surgery academic community. No medical method can be 100% sure of the nature of a certain nodule.
In addition, top doctors like Director Hao, Director Qiao, and Director Dai are only a handful nationwide. With more patients, ordinary people still encounter ordinary thoracic surgery departments in major hospitals. Doctors.
Subject to their own professional abilities, doctor-patient relationship, fear of responsibility and other factors, most doctors often give ambiguous answers, which makes patients even more worried and anxious.
Every year, there are not a few people who end up misdiagnosing and removing lung nodules because they are afraid that they are lung cancer!
And now!
This "nano-nodule developer" from Tsingshan Pharmaceutical not only greatly reduces the pressure on doctors to make judgments, but is also a huge boon to patients.
So after the news was announced, countless patients enthusiastically signed up that day, and even some patients from far away coastal cities came all the way just to participate in the clinical trial of the "nodule developer"!
Fortunately, there are enough people recruited for the second clinical phase of the "Nano Nodule Developer" this time! Compared with conventional clinical trials of new drugs, which often require long-term medication trials ranging from three months to half a year, "nano-nodule imaging agent" is a one-time drug and only needs to be tested once.
Therefore, the Chinese Food and Drug Administration has significantly increased the number of participants required for the second phase of the clinical trial of the "nodule imaging agent". The number of subjects that need to be recruited for the second phase of the clinical trial alone has reached 300!
Zhang Yang also agrees with this clinical trial plan.
However, on the day when the clinical trial started, he noticed that there was another rigid requirement in the Phase II clinical trial plan, which was the need to verify the accuracy of the "nano-nodule developer".
In other words, after the "nano nodule developer" determines that the patient has a malignant nodule, it must also provide the patient's post-operative data, that is, the large pathology that was cut out, so that the subject's All data form a complete closed loop.
It is obviously impossible for patients with benign pulmonary nodules to undergo surgery. As a last resort, Zhang Yang can only ask the subjects participating in the clinical trial to select patients with "high-risk pulmonary nodules" as much as possible.
However, this requires the screening of CT images of applicants, which requires specialized doctors to screen with clinical experience.
Obviously, Qingshan Pharmaceutical did not have qualified thoracic surgeons to complete this task, so it had to turn to Dean Zhou for help.
In the office of the president of the Third People’s Hospital of Chengdu.
Director Hao and Director Qi flew back to the capital after completing Mr. Zhang’s surgery. Only Director Dai planned to return to the mountain city tomorrow because the mountain city was close.
The three of them were sitting in the office. Zhang Yang looked at Dean Zhou beside him and said, "You are not polite:
"Yuan Zhou, you also know the situation. If we want to quickly complete the clinical trial of 'nodule imaging agent', we must try our best to select patients with malignant nodules to participate in the clinical trial first!"
"We Qingshan The pharmaceutical industry definitely doesn’t have such experienced doctors, so we need you to ask the thoracic surgery doctors to help us select suitable subjects!”
Dean Zhou agreed immediately.
“No problem!”
But as soon as he finished speaking, Dean Zhou said again:
"But Zhang Yang, there's no problem in helping. But to be honest, thoracic surgery is not the dominant department of our hospital. The level of Director Liu in our department..."
As he spoke, Dean Zhou couldn't help but lower his voice. Showing a wry smile:
“Director Liu of our department’s judgment on pulmonary nodules is only at a medium level. Do you remember Feng Gang’s example?”< br>
“Feng Gang was misdiagnosed by Director Liu and received a knife in vain, so I can’t guarantee you how many real malignant nodules can be screened out. You have to be mentally prepared, otherwise don’t say that I cheated you. You."
Zhang Yang was stunned for a moment, and suddenly remembered Feng Gang, who had been misdiagnosed as carcinoma in situ. In this way, Director Liu was indeed a bit unreliable.
However, the current clinical trial of the "nodule imaging agent" is being carried out at the Third People's Hospital of Chengdu, and can only rely on the efforts of Director Liu and others in the department.
Thinking of this, Zhang Yang couldn't help but smile bitterly:
"Zhou Yuan, I understand, but there is nothing we can do about it. Besides, no matter how unreliable Director Liu is, he is more reliable than us. Right!"
"That's right! Then I will arrange for Director Liu to cooperate with you."
Zhang Yang and Dean Zhou were talking quickly.
Dean Zhou is also an impatient person, and he was about to call Director Liu to arrange work, but when he just took out his mobile phone, Director Dai, who had been silent for a long time, suddenly said:
" Zhou Yuan, Mr. Zhang, if you don’t mind , I can help screen the subjects' CT images. I think I am still certain about malignant nodules!"
"You?"
Dean Zhou stopped. He looked at Director Dai in surprise.
Zhang Yang on the side also looked a little surprised.
Of course he hopes Director Dai can help. If a top doctor like Director Dai can sit in and conduct the preliminary screening, there is no doubt that at least 290 of the 300 subjects will have malignant nodules. , which means it can provide at least 290 points of complete closed-loop data!
This will undoubtedly greatly speed up the clinical approval of "nano-nodule imaging agent"!
Just!
He said in surprise:
"Director Dai, aren't you going back tomorrow?"
"Besides, you are the head of the department at Xinqiao Hospital. If you will be away for a long time..."
Dai The director waved his hand and said with a smile:
“It’s okay, I can temporarily hire the hospital for a few days. Fake, two to three days should be enough to screen out 300 patients with malignant nodules for you!"
"To be honest, I am also very interested in your accuracy, and I also want to know what I have been doing for so many years! How different is the accumulated experience and judgment from your developer?”
"Besides, it's quite exciting for me to think about being able to screen 300 CT images of malignant nodules at one time!"
Excited?
Zhang Yang was stunned for a moment. In just a few words, he truly felt Director Dai’s love for pulmonary nodule research.
“He is indeed a man called ‘Dai Shen’ by netizens!”
“In addition to professionalism, there is more of a true love!”
Thinking of this, Zhang Yang sighed:
"Okay, I'll trouble you, Director Dai!"
"No trouble!"
......
< br>The unexpected addition of Director Dai undoubtedly accelerated the recruitment progress of "nodule developer"!
In just five days, Director Dai selected 300 patients with suspected "high-risk pulmonary nodules" from more than 800 patients with pulmonary nodules.
After confirming the enrollees, the next step is to conduct a CT scan. If it is confirmed to be a malignant nodule, a doctor will recommend surgery as soon as possible. At the same time, the postoperative pathology will also be used for the clinical diagnosis of "contrast agent" data.
Of course Director Dai is no longer needed for the surgery and follow-up work. After five days of helping with the screening at the Third People's Hospital of Chengdu, Director Dai is ready to return to the mountain city and start working.
The day before leaving, Zhang Yang specially invited Dai Shen to have dinner with him. After they had had enough wine and food, unknowingly, the conversation between the two of them returned to lung nodules.
"Mr. Zhang, to be honest, judging from the CT test data and surgical data in the past five days, the accuracy of your company's 'Nano Nodule Developer' is beyond my imagination, far beyond my imagination. Beyond our subjective judgment!”
"This is the power of technology! I estimate that once this drug is launched, the number of patients who come to me to diagnose pulmonary nodules in my outpatient clinic will be reduced by at least two-thirds!"
Zhang Yang couldn't help but smile bitterly. :
"Director Dai, don't you blame us? Because our Is it possible to say that it has influenced your...sign?"
"After all, your nickname on the Internet is 'Dai Shen'! Everyone recognizes your ability to diagnose pulmonary nodules!"
“Whatever you wear, it’s just the patient’s favor!”
As he spoke, Director Dai suddenly shook his head and sighed:
“I don’t know what’s going on. In the past two years, especially after the pneumonia outbreak, more and more people have suffered from pulmonary nodules. I really don’t want to see this!”
“And, according to this year’s statistics, the incidence of lung cancer is The incidence rate has increased by 5% again, especially lung adenocarcinoma, which has increased from 40% in 2018 to 50%! "
"In just a few years, the overall incidence of lung cancer has increased, and lung adenocarcinoma has increased even more. 10%, this is so strange!”
(End of this chapter)