Chapter 189 Shocking discovery!
Zhang Yang is already familiar with simulators.
Locked the office door and immediately entered the simulator.
Opening his eyes and looking around, a familiar feeling suddenly hit his face.
A bright laboratory with various high-end and sophisticated biological instruments. It only took Zhang Yang two seconds to realize that this was the Norwegian "Adlev" where the "Biological Laboratory" of the first stage of the simulation plot was located. Biological Laboratory".
"I didn't expect that the plot scene of the second stage would still be here."
"That's good, no need to be familiar with the scene."
He couldn't help but sigh in his heart, and then turned his head slightly, A familiar yet unfamiliar figure appeared in view at the workstation next door.
It's Evans.
During the last plot "Biological Laboratory", Evans had a very good relationship with him.
He compiles lung adenocarcinoma data for Western Europeans, while Evans compiles data for East Asians.
While Zhang Yang was thinking about how to talk to Evans, Evans suddenly turned his head, looked at Zhang Yang in surprise, and said:
"Zhang, what's wrong with you? Why do I feel so weird about you?”
The words echoed in the laboratory, and the familiar feeling suddenly returned.
Zhang Yang completely remembered every bit of contact with Evans in the last plot, and couldn't help but grin:
"Hello, Evans, long time no see!"
"Long time no see? Zhang, are you not suffering from amnesia again?"
"Last time you grabbed my collar I was really shocked when I asked where this was. Don’t try to prank me again. I don’t want to do it again.”
“Huh?”
Open your mouth slightly. Zhang Da reacted instantly.
Evans actually remembered that at the beginning of the last plot, she grabbed him by the collar and asked him what happened.
In other words, the second stage of the plot not only continued the scenes of the previous plot, but also Have you even retained the memories of the plot characters?
It seems like this is really a continuous plot!
"Haha, Evans, I won't hurt you anymore."
"But, believe me, we haven't seen each other for a long time."
"Hell!"
Evans shook his head helplessly. He seemed to have become accustomed to Zhang Yang's tone:
"Zhang, stop talking nonsense and start working quickly. This This task is much more complicated than the previous one."
Work?
Zhang Yang suddenly perked up. In the previous plot, he completed the task after collecting data on 16,000 Nordic patients with "lung adenocarcinoma" and received the reward.
Is it the same this time to complete the task through work?
He almost blurted out:
"Evans, what is my job this time?!"
"Oh, My God."
Evans Vince thought Zhang Yang was joking with him, so he spread his hands with a wry smile:
"Zhang, please stop playing pranks like this, okay?"
"Well, I really lost to you..."
"Dr. Eric just assigned a new task yesterday , we received an invitation for help from the British company 'AstraZeneca'. Their new drug, 'Osimertinib', which is undergoing phase III clinical trials, has experienced some problems..."
"To be precise, It's not like something happened , but during the Phase III clinical trial, they discovered that the latest 'lung adenocarcinoma cells' contained a specific protein fragment that had not been discovered before!"
"So, they discovered Phase III clinical trials have been postponed, hoping that we can help them figure out the role between the protein structure of this specific protein and cancer cell receptors as soon as possible, as well as the pathway between the specific protein and cells.”
Osimertinib? !
Clinical Phase III Trial? !
Zhang Yang was slightly startled,
Osimertinib is a lung cancer targeted drug launched by "AstraZeneca" at the end of 2019. Once launched, it was hailed as the most powerful "miracle drug for lung cancer" ".
The current simulation plot is in 2018, and the time is really right!
Could it be that this mission is actually related to "AstraZeneca"'s top third-generation targeted drug "Osimertinib"?
Are you asking yourself to participate in the research and development of "Osimertinib"?
Zhang Yang was a little distracted, but soon his attention shifted from "Osimertinib" to the last words Evans said.
Because a new specific protease was discovered on the latest ‘lung adenocarcinoma cells’, the clinical phase III trial of “Osimertinib” was suspended?
This sentence may seem normal to laypeople. After all, with new discoveries, clinical trials should naturally be suspended.
But Zhang Yang is the boss of Qingshan Pharmaceutical, he knows it all too well!
When an innovative drug reaches the third phase of clinical trials, it means that it has entered the final sprint stage of marketing. The main ingredients and target mechanism of the drug have also been basically determined!
Even if there are new discoveries at this time, just focus on the research and development of the next generation of drugs. It will never stop!
This is completely unreasonable!
Unless!
Zhang Yang looked stunned, unless the benefits brought by this discovery are unimaginable!
Hiss!
The huge doubt shocked Zhang Yang, and countless information came to his mind.
"Osimertinib" is known as the "miracle drug for lung cancer", but once it was launched, it became the most profitable targeted drug for lung cancer in the world, with annual sales of up to 5 billion US dollars!
Is it possible that the effectiveness of "Osimertinib" in reality is so good because of this discovery?
Zhang Yang's expression became completely serious, and he suddenly became very interested in the new specific protein mentioned by Evans!
At this moment, Evans saw that Zhang Yang was getting serious, so he simply stood up and walked to the computer where Zhang Yang was sitting, and skillfully helped him click on a work document.
"Zhang! This is the specific work content, it is all in your work document."
"'AstraZeneca' company has temporarily named this newly discovered specific protein For 'T14 protein', all you have to do is seize the time to analyze 'T1 How are the pathways connected between 4 proteins and normal cells and cancer cells? Now AstraZeneca is eager to know their internal connections."
"As for protein structure analysis and other analyses, you don't have to worry about it. There are other colleagues doing it.”
Zhang Yang nodded, this should be the task to be completed in this simulation plot.
After a moment, he glanced at Evans gratefully.
I have to say that Evans has a really good temper and has a very good relationship with himself. Even if he thinks he is playing a prank, he always explains it patiently.
"Thank you Evans, I understand."
"But what about you? What is your mission this time? Is it also studying the T14 protein?"
"Uh..."
After finishing his words, Zhang Yang didn't expect Evans to suddenly appear without warning, and was stunned for a moment unnaturally.
"Me? I don't study T14 protein. Dr. Eric arranged other work for me last night."
Zhang Yang clearly noticed Evans' abnormality, and after thinking for a while, He opened his mouth and said:
“Other work?”
"Evans, can you tell me what the mission is? I'm very curious."
After a brief pause, Evans returned to normal. He shook his head with a wry smile and suddenly lowered his voice:
"Zhang, I'm sorry, I can't tell you, Eric Bo Shi Shi specifically reminded me that it must be kept secret."
"Besides, I don't want you to know about it. Believe me, knowing it will not do you any good!"
After finishing speaking, Zhang Yang said He took a deep look at Evans, his expression a little uncertain.
Fortunately, after a moment, he suddenly exhaled heavily:
"Okay, then I won't ask." "Yeah!"
Evans He was obviously relieved, and a smile appeared on his face again:
"Zhang, you should start working quickly, I am also getting ready to work!"
"By the way, I will be in another laboratory during this time, but I will come here to check in every morning."
"Yes."
Say that, Evans He returned to his seat, then picked up the 14-inch notebook on the table and said goodbye to Zhang Yang and left.
After Evans left, although Zhang Yang was strongly curious about the "secret" work that Evans suddenly mentioned, the most important task at the moment was to quickly complete the plot tasks and get the plot rewards. real!
Thinking of this,
Zhang Yang looked at the computer screen and began to read the work documents carefully.
About ten minutes later, he had read the entire work document completely, and his work ideas became clear.
At this moment, he suddenly discovered that a light blue light screen had appeared in the upper right corner of himself, which actually showed the progress of the task.
Task content:
Analyzing the T14 protein cellular pathway, current progress: 0%.
"Quite smart."
After sighing, Zhang Yang stood up from the chair and began to walk towards the experimental area.
He needs to first take out a piece of "lung adenocarcinoma" tissue, and then use sophisticated biological instruments to find and analyze the "T14 protein" of lung adenocarcinoma mentioned in the work document, and finally figure out its internal pathways.
Zhang Yang soon became immersed in the research of "T14 protein".
It must be said that although his major is drug research and development, he has a good professional foundation and has done some research on cellular proteins. This job is difficult for him, but he can still accept it.
Therefore, in the next few days, Zhang Yang not only did not feel any difficulty, but instead made faster and faster progress while supplementing the knowledge related to specific proteins.
At the same time,
He also determined that the plot of the second phase is the same as the first phase. You clock in to work every day and only need to complete the daily workload, and you can even work overtime to complete it.
About 20 days later, Zhang Yang’s understanding of specific proteins has reached a new level. In addition, the laboratory has sent three more assistants to assist in the analysis. The analysis progress of "T14 protein" on the taskbar has reached 30%.
However.
Just as Zhang Yang was immersed in the analysis of the "T14 protein pathway", he also noticed that Evans was just as he said, he could see him checking in almost every morning, and then disappear throughout the day.
Zhang Yang thought of what Evans said before - work tasks need to be kept confidential.
For a biological laboratory, there are indeed some experimental tasks that require strict confidentiality.
For example, if you cooperate with some pharmaceutical companies to develop a drug, if it involves commercial secrets, you naturally need to keep them confidential.
For another example, when developing an important patent result, it is also necessary to keep it strictly confidential. At least until the patent result is not completely determined, the fewer people who know about it, the better.
I just don’t know what the reason is for Evans and what work tasks need to be kept secret.
So curious!
After thinking to no avail, Zhang Yang simply stopped worrying and continued to focus on the analysis of "T14 protein".
One month later, the analysis progress of "T14 protein" on the taskbar reached 60%.
Evans was also invisible all day long. He came every morning with a laptop and left with the laptop after clocking in. This was repeated every day for a month.
Zhang Yang is also completely used to this kind of simulation work. Although occasionally he still wonders what task Evans is doing, the most important thing at the moment is to complete the "T14 protein" task progress on the task bar as soon as possible.
And just in this month.
While Zhang Yang was completing the analysis of "T14 protein" in the simulator, he was also dealing with various things in reality.
Due to the unique functions of the "nodule imaging CT machine", after the news spread overseas, Samsung Biologics took the lead in reaching a purchase agreement with Elephant Medical.
Samsung Biologics has a number of Samsung hospitals, the most famous of which is Samsung Seoul Hospital. Samsung Biologics purchased a total of 10 "nodule imaging CT" units at one time in the name of "Samsung Hospital". At the same time, A matching "nano-nodule developer" has also been introduced.
Just like Zhang Yang said, you can buy it, but you have to pay more.
Mao Zhiqiang is also merciless. The "nodule imaging CT machine" introduced by Samsung Biologics costs up to 2.3 million US dollars each, equivalent to 16 million yuan!
This is equivalent to twice the price in China!
While the "Nano Nodule Developer" costs 200 yuan/tube in China, the price introduced in South Korea is also 350 yuan/tube, which is nearly twice as expensive.
In addition, Zhang Yang also received a surprising news.
Siemens in Germany seems to have contacted Adelev Biological Laboratory, and the two parties have reached a cooperation agreement and are preparing to develop a developer of the same type as the "nano-nodule developer".
Seeing the news, Zhang Yang was in a daze and didn't know whether to laugh or cry.
At this moment, he was in the simulator, conducting analysis of T14 protein in Adelev Biological Laboratory. Unexpectedly, in reality, "Adelev Biological Laboratory" would actually start to cooperate with Siemens. Development of developer.
It’s just that I don’t know if a similar developer can be developed.
Zhang Yang did not worry for too long. As he continued to analyze the "T14-specific protein" pathway in the simulator, his attention was once again drawn back to the T14 protein.
60%,
70%,
80%...
Zhang Yang’s research and development is getting faster and faster, from the study of T14 protein on cancer cell pathway signaling to Research on the association of T14 protein with normal cells...
Gradually, more and more pathway analysis data of "T14-specific proteins" have been completely recorded!
Gradually, the pathway mechanism of “T14-specific protein” has also been studied and understood!
Analytical data shows that the most important role of "T14-specific protein" in cells is to fuse with key signaling molecules in cells and activate the PI3K-Akt pathway, thereby interfering with normal cells and inducing cancer cells. !
Ke Zhangyang was surprised!
Logically speaking, since the mechanism of T14 protein is to interfere with normal cell proliferation and induce normal cells to become cancer cells, then T14 protein should be effective on all cells.
But there is also a set of data showing that the T14 protein seems to be only effective on certain host cells, and is not sensitive to other experimental host cells!
Zhang Yang was puzzled.
At this moment, he suddenly thought of the shocking conjecture he had made when he learned about "lung adenocarcinoma".
If the pneumonia virus has increased the incidence of "lung adenocarcinoma", then why has there been no significant increase in European and American populations, while it has increased by 10% in Asians!
Is it a racial issue? !
Zhang Yang’s eyes were stunned.
Could it be that the T14 protein is only sensitive to cells from East Asians? Insensitive to Europeans and Americans? !
Before Zhang Yang could verify it, an even more shocking idea suddenly came to his mind.
Where does this T14 protein come from?
(End of this chapter)