Chapter 61 The strongest in the world in thirty minutes! (Third update!!!)
After sorting out his thoughts, Xu Yun returned to the bookshelf again and found the books he needed again.
But what was different from before was that the two girls who were suspected of being physics majors and had talked about Professor Lu had disappeared. It was not known whether they had found the Newton information they wanted.
At this moment, Xu Yun somewhat realized that his previous behavior was indeed a bit strange. Fortunately, the school spirit of the University of Science and Technology was clear. In some schools, he would have been wiped out before he could finish his words.
Then Xu Yun shook his head, put these things aside, and spent half an hour finding three books and several journals.
After completing the borrowing and follow-up procedures, I returned to my home.
As mentioned before, there are 9 subtypes of mammalian sodium channels, namely NaV1.1-NaV1.9.
Currently, there are six subtypes that are under relatively in-depth biological research, and the typical representatives of technological applications are some Class I antiarrhythmic drugs.
For example, quinidine, lidocaine, and propafenone all work by blocking sodium channels.
Another example is if you are accidentally bitten by spiders, poisonous snakes, scorpions, succubi, etc., the toxins also act on the sodium ion channel and produce adverse consequences.
As for the sodium channel in insects.
The situation is more complicated.
In fact, insects only have one or two voltage-gated sodium channel alpha subunit genes, but two post-transcriptional modifications, namely alternative splicing and RNA editing, lead to the functional diversity of insect sodium channels.
In addition, the insect β-auxiliary subunits TipE and TEH1-4 also play an important role in the expression and regulation of sodium ion channels.
Therefore, the binding formula that Xu Yun needs to derive is not just a matter of piecing together the protein, but the binding speed of the specific receptor is the big factor.
This is just like the little blue pill. It takes two hundred minutes to take effect and two minutes to take effect are completely different concepts.
In more detail, the crystal structure and modeling issues of NDT-A need to be taken into consideration.
At present, many teams in the biological world are studying sodium channels in insects, but the results are generally not obvious. They are scattered here and there, and it is difficult to form a complete module chain.
However, this just gives Xu Yun an opportunity to use reference materials from multiple angles. The more important point is
He still has one trump card that he doesn't use yet.
At this moment, Xu Yun was sitting at the desk, holding a small black card and turning it gently.
The card is about the same size as a bank card and has an alloy texture. It has a calf's head painted on it, with sharp eyes and a confident expression.
That's right.
This is one of the rewards for the novice mission. Thirty minutes of Mavericks asking God is wrong, experience card!
According to Xu Yun's induction, as long as he activates this card secretly, he can have the thinking ability of Mavericks when he was 22 years old, and it will last for thirty minutes.
How powerful the 22-year-old Mavericks is has been briefly mentioned before, so I won’t go into details here.
"Tsk, it's a pity that it's only half an hour, it's still a bit short."
Xu Yun rubbed his temples with a headache, picked up a pen and paper, and started making arrangements:
"The expression of TipE definitely cannot consume experience cards. It is best to use or not use the action potential conduction of neurons in the peripheral nervous system. After all, there are many related papers."
"You must use the combination points. There are more than two thousand combination points."
Xu Yun just wrote and drew like this, thinking carefully about it. It took him a full hour to finalize several nodes:
First, the expression of TipE, the open conformational structure, and the derivation of the adjacent subunits of the β1-β2 chain were completed independently.
Secondly, the structure of the binding site and cytoplasmic region of the sodium ion channel and imidacloprid was handed over to Mavericks.
The final combined review is summarized and completed by myself.
After determining these steps, Xu Yun immediately started calculating.
At present, most papers on insect sodium ion channels have been submitted to "Annual Review of Entomology", so four of the materials Xu Yun brought back were serialized in previous issues of "Annual Review of Entomology".
And coincidentally, TIPE2 is a new immune checkpoint molecule for NK cells, and Tian Liangwei happens to be an expert on NK cells, so the first problem is not particularly difficult to solve, but no one has diverted the attractant protein there. .
Just like online novels, the styles of Chendong and Fenghuo are unique and difficult to imitate. However, for Sign-in and Siheyuan, it’s not that no one wrote them at the beginning, but that no one thought of these directions.
Once someone discovers this kind of subject matter, there will be a bunch of followers in the recommendation position every minute. The reason is the same.
Soon, Xu Yun locked onto one of the more authoritative papers:
"DOI:10.33086/jhs.v10i2.136 Well, the author is a senior who has graduated a long time ago? Associate professor at Stanford
The potential difference between the receptor subtypes of Lygus bug and Periplaneta americana is 2.344, which is obviously a type of expression. Very good, that’s it! ”
At present, Xu Yun's comprehensive ability is roughly equivalent to that of an associate professor at HKUST, that is, above the associate-level level, barely equivalent to the full-level level of a minor discipline, but still some distance away from the full-level level of a mainstream discipline.
There are many 30-year-old seniors in China, so Xu Yun’s original goal was to obtain the professional title of HKUST at the age of 28, which is almost the same path as Academician Cao Xuetao of Nankai University.
Of course.
Now as the halo effect gradually manifests, Xu Yun's subsequent trajectory will definitely change, but for now, his ability is still at a quasi-high level. With the reference of papers, it is not difficult to independently derive chemical formulas. of.
Xu Yun then used the data in this paper to derive three pieces of data for the first node.
"Huh."
Then Xu Yun took a deep breath, solemnly picked up Mavericks' thinking experience card, and thought to himself.
"Activate!"
Phew——
As the command was given, the experience card instantly turned into a stream of light and escaped into his mind.
Xu Yun's temples felt cold at first, and within a moment, a rather mysterious feeling immediately filled his mind.
How to say it
It feels like everything suddenly becomes clear.
For example, Xu Yun's eyes inadvertently caught a glimpse of a penguin group called the "Qidian Seven Fine Groups". At this time, an author named "The Tenth Little Horn" was sending a series of mysterious codes.
Xu Yun just scanned it in a hurry and wrote down all the numbers in this string of codes:
“magnet:?xt=urn:btih:”
But he soon came back to his senses and focused on the problem in front of him.
At this moment, Xu Yun came up with many feasible deduction directions after just thinking about the many problems that originally made him unable to solve them.
Although these deduction directions are not as exaggerated as the results can be seen at a glance, some key links already have solutions to the problem.
This is the 22-year-old Mavericks, a genius who laid the foundation of modern mathematics and physics in 18 months!
It can even be said that in the next thirty minutes, Xu Yun's thinking ability briefly became the first echelon in the world, and can even be said to be the best today.
The strongest!
After the first half minute of adaptation, Xu Yun immediately picked up a pen and paper and quickly calculated the combined problem.
"The action potential threshold is 130mV and should be able to reach 133mV"
"There should be five types of binding protein axon depolarization process. I don't know which one Lao Qiu and his lures are connected to. Forget it, let's calculate it together"
"For the point stimulation of IL-12, IL-15 and IL-18, let's use the paper from the University of Pennsylvania as the base for deduction. One of the universities in Pennsylvania is Professor James Alwine."
that's all.
Xu Yun flipped through the calculation information at a speed similar to quantum wave speed reading, and time slowly passed by minute by second.
Three minutes.
Five minutes.
Ten minutes.
Twenty minutes
At the twenty-sixth minute, Xu Yun's deduction reached the most critical moment.
The veins on his forehead bulged, and he was breathing rapidly. He adjusted his posture and launched the final sprint like the gap that was not locked.
Three minutes later, the final seconds of the time limit were approaching.
I saw Xu Yunchang exhaling a turbid breath and writing down a cell section on the paper:
MC38.
Then I threw away the pen and felt a sense of fatigue that I had never experienced before:
"Good Guy"
"Finally."
"It's done!" (End of this chapter)