Chapter 87 The surprised reviewer
Morten L. Grobe, translated into Chinese can be called Morten L. Grobe.
He is a Swedish man, 59 years old, who works at the famous Cold Spring Harbor.
Although the name Cold Spring Harbor may sound like a port at first glance, in fact, it is one of the meccas of life sciences in the world.
If there are readers who have not sold their biology textbooks as scrap, they can open the chapter on DNA and find the discoverers of the double helix structure of DNA. You will see one of them, a handsome guy named Watson.
Yes, he worked here before, and he still hasn't hiccupped yet.
Of course.
In 2019, Watson was deprived of his honorary title due to some reasons. I will not comment on the specific right or wrong. In short, he is similar in nature to Rowling, the author of Harry Potter, and his comments are in the opposite direction.
His gaze returned to its original position.
It goes without saying that Cold Spring Harbor's scientific research capabilities can allow a big boss of Watson's level to join.
Putting aside military-affiliated research institutes in various countries, Cold Spring Harbor can firmly rank among the top five among all current life science research institutes.
And Morton can own a laboratory with the same name in such an institute, so his resume is naturally extraordinary.
Morton L. Grobi graduated from the University of Pennsylvania, is a lifelong honorary academician of the Swedish Academy of Sciences, and a foreign academician of the Eagle Academy of Sciences.
In 2017, he won the Lasker Award for his research on histological cells. He is currently one of the top experts who has the best chance of winning the next Nobel Prize.
A few months ago, due to some physical reasons, Morton temporarily returned to his hometown in Sweden, a small town in Westeros, Sweden.
Although with the development of science and technology, many small towns in Europe have gradually acquired a modern atmosphere, it is difficult for even the most developed small towns to have top scientific experimental equipment.
Therefore, Morton, who is unable to conduct high-tech scientific experiments, in addition to taking care of his body every day, will occasionally take on the task of reviewing journal articles.
Not long ago, he received a call from an old friend.
After the long-lost pleasantries, the other party expressed the hope that he could serve as an external review editor for one of his students' papers.
Morton actually refused at first. After all, no matter what he was doing as a Ph.D. student, he couldn’t compete with a manuscript-contracting journal like NAR.
But after some haggling, the Lasker Award winner was finally bought for five pounds of two vitex sticks and bacon - he likes to eat Sichuan food, and he is the kind of person who loves spicy food but can't eat much spicy food. Among the types, fried bacon with two vitex sticks is my favorite.
However, bribery is bribery, and he still told his old friend one thing very seriously:
If the quality of the paper is not up to standard, he will not allow it to be reviewed!
The old friend readily agreed to this, and there seemed to be an inexplicable meaning between the lines, as if
show off?
And just a few days after they reached the agreement, an email arrived in Morton's mailbox as promised.
"Common Pheromone Binding Proteins"
Morton read the title of the paper gently and had a rough judgment on the content of the paper:
"The synthesis idea of the fourth generation imidacloprid? This is interesting."
Morton once did a project in 2014, which was about the synthesis of white moth pheromones, and the results were published in Medicine.
Later, he won the title of lifelong director of the Eagle Sauce Agricultural Association and a five-year licensing fee of US$3 million based on this patent.
In addition, many of his students and acquaintances work for top biopharmaceutical companies, so Morton's understanding of imidacloprid is actually quite deep.
"Cockroaches belong to the order Blattidae and Blattidae, and are a worldwide urban pest."
".When most cockroaches are looking for a mate, mature female adults will release two types of sex pheromones: the volatile sex pheromone cockroach quinone (3,6-dioxane-1,4-diene-1 -methyl)methyl ester), as well as two contact sex pheromones, 3,11-dimethyln-heptacosane-2-one and 3,11-dimethyln-heptacosane-2-one". ”
"Based on the transcriptome data of tissues such as the antennae of Periplaneta americana, this article used the tissue expression profiles of 109 OBPs to screen out two highly expressed candidate PBP genes in male antennae, BgerOBP26 and BgerOBP40"
"Subsequently using in vitro protein expression and purification, high-purity recombinant proteins of two OBPs were obtained"
"". Through small molecule fluorescence competitive binding experiments, the binding abilities of two OBPs with three sex pheromones and analogs were studied"
After reading the abstract of Xu Yun's thesis, Morton had some doubts about his initial judgment:
The content of this paper seems to be more than just the fourth generation imidacloprid
After all, if you just synthesize it with pheromones, there is no need to discuss the issues related to 3,11-dimethyl-n-heptacosane-2-one, right?
With this mentality, he continued to read the text.
After just a few glances, Morton's eyes lit up:
"Cyclization? Or using transition metals? Good idea!"
Then he read it line by line, only pausing for a few seconds at the 5-epoxy-1-hexadecene link:
Xu Yun did not describe in detail the changes of 5-epoxy-1-hexadecyne at constant temperature, and the attached diagram was also slightly concise. It was like we were still scratching our heads at the beginning, and we have fast forwarded to it in the blink of an eye. Deeply ingrained in general.
But Morton didn't pay too much attention to it. After all, it was just an intermediate link in the transition, and the follow-up was the key.
"LTHF"
"Hehezi Primer"
Morton just looked at it line by line, becoming more and more fascinated.
Speaking of scientific research papers, many people may have doubts:
Since advanced technologies are kept confidential, why are there so many so-called scientific research papers published?
The reason is simple.
First, most publishers apply for patents before the paper is published.
That is to say, apply for a patent first and then publish a paper, so that your own interests can be protected legally.
Secondly, the content of the paper does not blindly disclose all information.
Papers are usually about theoretical things, such as the principles of chemical reactions, the main components of materials (extremely low content but very important components are usually kept secret), the metallographic structure of alloys, etc.
These can be made public - or whether they are made public or not, competitors can obtain relevant information by analyzing the products.
There are some key pieces of information left that are usually not touched on in papers:
For example, key process parameters, temperature, pressure, ingredient ratio, catalyst composition and status, etc. are kept confidential.
In addition, papers are usually in laboratory status, not mass production status. Laboratory small batch status and industrial production status are two completely different things.
Therefore, papers often explain the same idea, and few people reveal all the core technologies. Only the third brother once foolishly revealed it.
Of course.
Except for mathematics papers.
Four hours later.
Morton exhaled with emotion, and a look of excitement suddenly appeared on his face:
"Bayer's D.E laboratory. Morishita Pharmaceutical's Kameno project team and Roche's AIRC laboratory.
If I remember correctly, these laboratories are currently developing the fourth generation of imidacloprid or dinotefuran, and the funds invested are not small
Tsk tsk, now there is something good to watch. ”
Then he turned his attention to the author column and looked at the name for the first time:
"First author."
"Xu Yun."(End of this chapter)