Chapter 120 Do you know the value of antibiotics? (Big Chapter)
"Garlic?"
By the kitchen.
Hearing Xu Yun's words, Fatty Meng couldn't help but be slightly startled.
Immediately he thought of something, pointed to the basket on the side and said:
"Brother, are you talking about the gourd? Is that the thing over there?"
Xu Yun turned around and looked in the direction he was pointing, and found heads of garlic placed in the basket at the corner of the kitchen.
These garlics are consistent with similar ones from later generations, but they are generally very large in size. They are obviously carefully selected high-quality garlics.
He quickly walked to the basket, picked up a head of six cloves of garlic, looked at it, nodded repeatedly and said:
"Yes, that's it!"
Hearing this, Fatty Meng couldn't help but smile proudly:
"This little brother, garlic is the name of Dengzhou. We in Kyoto call this thing gourd or garlic.
If my husband's family hadn't been from Dengzhou, I might not have understood what you were saying! ”
Xu Yun smiled politely at Fatty Meng:
"Thank you, Brother Meng, for your advice,"
As a non-botanical practitioner, he only knew that garlic was introduced to China during the Han Dynasty. As for garlic's other names, he really didn't know much about it.
Actually.
In ancient China, garlic had many names.
Larger garlic is generally called gourd, and smaller garlic is called mountain garlic. The collective names would not be officially unified until the middle of the Ming Dynasty.
Xu Yun then turned around and said to Mr. Xie:
"Old Du Guan, could you please prepare a stone mortar and boil it with hot water first? Ahem, then boil it with hot soup.
In addition, prepare a bag of salt for me. The finer the better, and by the way, I also need a gut-shaped bottle of salt. ”
Mr. Xie nodded:
"No problem."
A little less than half an hour later.
The old governor came over with a few belongings and handed them to Xu Yun:
"The mortar, salt, and polyester bottles are all here."
Xu Yun thanked him and then chose a relatively clean room.
He asked Mr. Xie to stay outside the door and wait while he entered the house with a few prepared things.
After entering the house.
Xu Yun put the stone mortar, chopped garlic, salt, the small bottle he brought with him, the bile-shaped poli bottle, and something similar to a casserole that he got from Fatty Meng on the table.
Among them, the bold-shaped Poli bottle refers to glass.
That's right.
In this day and age, glass craftsmanship has emerged.
One of the more famous evidences is the line in the work "Children Make Ice" written by the Song Dynasty poet Yang Wanli, "A jade chime was beaten into a ring through the forest, and suddenly there was a sound of breaking glass."
Other than that.
Emperor Zhenzong of the Song Dynasty also ordered tin workers to coat glass bottles with mercury, then drink from them and lick them before going to bed every day.
Yes, you read that right - drinking with mercury, so there is a reason why the old Zhao family has a high rate of premature death.
all in all.
The current glass technology is still far behind future generations, but it is very close in terms of practicality or functionality.
After preparing all this.
Xu Yun first put the peeled garlic into a stone mortar and began to mash it vigorously.
Dong Dong Dong——
Five or six minutes passed.
A big mouthful of crushed garlic came out of the oven.
Xu Yun poured them into the glass bottle one by one and closed the lid.
Fill the casserole with salt, put the glass bottle into the salt, and lift the casserole in a manner similar to hanging.
Then light the fire, adjust the quantity and height of the firewood, control the temperature at about 40 degrees, and then start heating.
Another half hour passed.
Seeing that the fire was almost done, Xu Yun pulled out the cap of the small bottle with a pop.
In an instant.
An extremely strong smell of alcohol filled the room.
That's right.
Alcohol.
Seeing this, the smart classmates must have understood Xu Yun's thinking.
Yes, what Xu Yun is preparing is allicin.
Although garlic seems to be available everywhere, it sounds like it is of low quality, far inferior to penicillium or willow branches.
Actually.
This is a time-travel black technology that can be called an artifact!
Quite literally.
Cement, papermaking, taro, all are younger brothers in front of allicin.
If you have to compare them, black powder and potatoes can barely be considered as divine items of the same level.
Because it is a class of antibiotics and is particularly easy to make.
Speaking of antibiotics, penicillin, erythromycin, and tetracycline may come to mind.
But in fact, allicin is also a particularly powerful antibiotic.
Its antibacterial ability is no worse than penicillin, and it has a wider range of antibacterial types - penicillin is only effective against bacteria but not fungi, while allicin is one of the rare antibiotics that can deal with both bacteria and fungi.
The main reason why allicin is difficult to popularize in later generations is that it is difficult to preserve and can only exist for one to two hours at room temperature. In addition, common antibiotic resistance is also a big problem.
But after traveling through time, its advantages were fully revealed:
Compared with the preparation of penicillin, the production of allicin is really simple.
It can be said that as long as the time you travel to is after the Han Dynasty, you can produce allicin with your hands.
Because to prepare allicin, you only need garlic and high-concentration alcohol.
First, mash the garlic and let it sit for an hour.
Then use high concentration alcohol to soak and extract, and then
Take your hands off the console and you're done!
That's right.
It's that simple, you can prepare a low-concentration alcohol solution of allicin in a fool-proof way.
What?
You ask how high-concentration alcohol was produced in ancient times?
Those with a basic knowledge of chemistry can use distillation to prepare it, while students who have failed in chemistry can directly use lime to remove the water in spirits.
If you can't find any lime, you can find a corner and kill him.
In addition, if you want higher concentration of allicin, you can use a simple salt bath to promote enzymatic hydrolysis like Xu Yun. For more advanced methods, you can add condensation reflux.
Just ask someone to make a copper pipe for the condenser pipe and soak it in water. (There is no problem with this theory, because before writing this chapter, I personally verified it once and successfully produced garlic essential oil, and then added some soy sauce and vinegar to dip the dumplings during the Chinese New Year)
So Xu Yun never understood.
Why do some protagonists in those novels that travel through ancient times have to go through logical loopholes to purify penicillin, instead of tinkering with fool-like artifacts like allicin?
His gaze returned to its original position.
Xu Yun then opened the garlic residue that had been enzymatically hydrolyzed in the salt bath, added the absolute ethanol he brought into it, and let it sit for a while.
This bottle of anhydrous ethanol was originally prepared by Xu Yun for emergency use. Now that Wang Yue was in critical condition, he had no choice but to consume this good thing first.
Another hour passed.
Counting the time spent preparing things before and after, it is already very close to the hour agreed with Lao Su.
Xu Yun glanced at the glass and found that a little oily liquid had appeared in the gaps between some of the garlic.
This is standard garlic essential oil.
It is not a decomposition product of allicin, but an important raw material for allicin extraction.
In the local industrial field, factories use this stuff to extract allicin.
Therefore, with its appearance, it basically indicates a result:
Allicin was successfully produced!
Think of this.
Xu Yun quickly took off the glass, walked out of the room with it, and said to Mr. Xie outside the door:
"Thank you for your help. The medicine is ready. Let's go back to the east wing as soon as possible!"
Looking at Xu Yun, who had a slightly raised brow, Mr. Xie couldn't help but feel doubts in his heart while keeping up the pace:
Could it be that this guy has been getting through for a long time, and he really has some confidence?
Then the two of them hurried back to the east wing.
After another simple verification, he was placed in the courtyard.
Then Governor Xie led Xu Yun to the door and said respectfully:
"Master, let's go back"
Before Mr. Xie finished speaking, he heard a creak and the door was opened from the inside.
The person who opened the door was clearly Wang Zhen, and he said to Xu Yun hastily:
"How is it? Have you brought the medicine?"
Xu Yun nodded and raised the glass bottle in his hand:
"The medicine is here."
Wang Zhen quickly moved aside and urged:
"Come in quickly, you are already lost in thought!"
The ancient proverb about losing consciousness is not A Heiyan in the H-manga, but the literal meaning of losing consciousness, which is also known as coma or shock as the saying goes.
This is also a very, very dangerous signal.
Therefore, Xu Yun did not dare to neglect, and quickly walked into the room and came to the bedside.
Just as Wang Zhen said.
At this time, Wang Yue had completely lost consciousness and could not even hear the roaring sound in his throat.
However, Xu Yun noticed that there were several silver needles inserted into the Zhonghou's Baihui point, left temple and ankle.
If nothing else, it should be what Lao Su calls a life-saving means.
Acupuncture has always been a magical program.
Especially for people like Xu Yun (who was a coder in his previous life), his fingers, neck and shoulders would have problems basically every month.
Xu Yun has tried ibuprofen, flurbiprofen and Voltaren, but in many cases it is not as effective as going to the hospital for acupuncture.
At least in Xu Yun's mind, acupuncture is indeed a subject worthy of further study.
After seeing him enter the house, Lao Su glanced at the glass bottle in his hand, and the silver needle in his hand was still shaking:
"Wang Lin, is this the folk remedy you call?"
Xu Yun nodded, protected the bottle with both hands, and raised it in front of him:
"In the bottle is a medicine called allicin."
"Garlic?"
Hearing this name, Lao Su couldn't help but frown.
garlic?
Can this thing save people?
However, considering that Wang Yue's life is now in critical condition, it is no longer easy for him to question:
"Since your condition is beyond repair, I can give it a try, hey"
Seeing the obvious pessimism on Lao Su's face, Xu Yun didn't explain much.
After all, for people of this era, fecal water infection is basically like late-stage liver cancer in later generations, and it is an absolute terminal disease.
What Xu Yun is doing now is as outrageous as in the 21st century, when a beggar went to the hepatobiliary ward of the hospital and told a chief physician that he could solve liver cancer.
However, the chief physician (Lao Su) allowed Xu Yun to administer the medicine because of the emotions of the patient's family (Wang Zhen) and because he really didn't have much means.
So you can't say that Lao Su is pedantic or looking down on others. In the final analysis, it's still a problem of cognitive ceiling.
After all, in this era, both the East and the West are far from the concept of modern medicine.
Then Lao Su stepped aside and motioned for Xu Yun to step forward.
Xu Yun quickly came to Wang Yue and gently tore open his strip of cloth.
I don’t know if it’s an illusion.
Xu Yun felt that after not seeing him for more than two hours, the wounds on this man's body had worsened a lot.
The main suppuration site on Wang Yue's body was in the lower part of his chest. This location is between the lungs and the stomach and is a very sensitive area.
The fecal water contains a large amount of conditioned harmful bacteria such as Escherichia coli and Staphylococcus aureus, so Wang Yue's injury is actually more serious than it seems.
But again.
It is precisely because the source of infection is feces that allicin has the highest antibacterial effect.
Among them, Escherichia coli, Gram-positive cocci and Gram-negative bacilli are all the target bacteria of allicin.
Even if Wang Yue does develop severe sepsis, allicin can effectively achieve the killing effect, but the method is more complicated. (See writer’s words)
Of course.
It would be better if it was just bacteremia.
After all, today's medical conditions are too limited, and many treatment plans for future generations cannot be replicated.
Xu Yun then opened the glass bottle containing allicin, dug into it with a sterilized spoon, and took a sip of the alcohol solution containing allicin.
Then he gently applied it to Wang Yue's wound.
Anyone who has used alcohol to apply wounds should know this.
Alcohol is different from iodine. When applied to a wound, it will produce a strong irritation. The sourness is simply not something that ordinary people can bear.
Even a break the size of a fingernail can make a grown man scream in pain.
However, when Xu Yun applied the allicin solution to Wang Yue's wound, the big man barely made any reaction, except for a few slight muscle twitches.
This is not good news and suggests that the coupling signal in some areas has been completely blocked.
The coupling signal can be blocked, not to mention the function of the body, and the proteins in some areas may even be inactivated.
Seeing this situation, Lao Su on the side couldn't help but frowned.
Although he doesn’t know the concepts of allicin and antibiotics, his sense of smell is fine:
He could smell alcohol in the bottle and was sure it was hard liquor.
Naturally, this Northern Song Dynasty medical scientist knew what would happen if strong alcohol was spilled on the wound.
However, Xu Yun's hand only paused slightly, and then continued to apply the solution.
A moment later.
The wound on Wang Yue's chest was covered with garlic solution, and the whole room was filled with the smell of garlic.
Banglang——
Xu Yun put the spoon back into the glass, stood up and said to Lao Su:
"Master, the medicine is ready."
Wang Zhen on the side could not wait any longer and asked quickly:
"How long will it take to correct you? If you can be saved, how long will it take to see the results?"
Xu Yun thought for a while and found that the local allicin usually takes two hours to take effect when applied externally. The resistance of ancient people was much lower than that of later generations, so the effect must be much faster.
Come and see with full calculation
One and a half hours is enough, right?
However, out of caution, he still reported a safer time:
"If nothing else happens, it will be effective within an hour."
Wang Zhen murmured a few times, but in the end he remained silent.
During the previous process of Xu Yun's pharmaceutical preparation, he had already learned about Xu Yun's origin from Lao Su.
A male actor escaped from the boat. Apart from his strange clothes, he didn't have any special appearance.
Therefore, although from an emotional perspective, Wang Zhen hopes that his brother can survive.
But his reason kept telling him that Wang Yue's life might have come to a close.
that's all.
In the room, Wang Zhen and Lao Su were sitting, and Xu Yun was standing at the bedside.
The three of them were silent, waiting for the final result together.
A quarter of an hour
Two quarters of an hour.
Three quarters of an hour.
Time passed slowly, and Wang Yue still showed no sign of waking up.
But gradually, Lao Su’s eyes quietly shone with light:
Previously, in order to save Wang Yue's life, he used silver needles to stimulate several of Wang Yue's acupuncture points, basically stimulating his life potential without reservation.
Therefore, theoretically speaking, Wang Yue's vitality can only last about two quarters of an hour.
At present, including Xu Yun's application process, a full four-quarters of an hour has passed.
That is exactly half an hour.
Although Wang Yue's pulse condition is still critical, his life has not come to an end.
That is to say
Xu Yun’s folk remedy seems to be effective?
Of course.
Lao Su did not say these words.
After all, no one can say for sure whether Wang Yue's vitality is tenacious and he has always refused the call of black and white.
Even if Hua Tuo and Bian Que were alive, it would be impossible to accurately measure a person's life to a certain quarter of an hour.
Therefore, he could only choose to continue waiting, but the sitting position was changed from the chair in the middle of the room to the bedside where Wang Yue was.
And every once in a while, a pulse will be diagnosed.
Another quarter of an hour passed.
Lao Su once again checked Wang Yue's pulse as a routine.
But not long after he put his hand on her, his breath hitched.
His eyes were filled with complex emotions of shock, surprise, joy and a little guilt.
He opened his mouth slightly and his eyes quickly jumped between Xu Yun and Wang Zhen several times:
"Zheng Ru's pulse condition seems to be improving!"
Hula——
Upon hearing this, Wang Zhen immediately stood up from the chair and ran to the bed with a long stride. He didn't even know that the chair had been brought down:
"Su Bo, are you telling the truth?"
Lao Su closed his eyes and checked his pulse again. When he opened his eyes this time, his eyes were much calmer.
He was silent for a moment, nodded slowly and said:
"Zheng Ru's pulse condition has tended to be stable, although the internal evil still persists and the underlying fire is hot and dry.
But compared with before, it’s much better.”
As soon as Lao Su finished speaking, a dry voice came from the bed:
"Shui Shui."
Some readers say that allicin cannot treat toxemia. In fact, this is wrong. There are many types of pathogenic bacteria that are responsible for toxemia, which are related to PAI-1 gene polymorphisms. For the paper, please refer to 10.27812/d.cnki .glnyx.2021.000116 and 10.19460/j.cnki.0253-3685.2021.10.009
At present, the main reason why allicin cannot treat sepsis is drug resistance, but the target body is actually suitable and can destroy enzymes containing thiol groups. This is why it is said that allicin has the prospect of treating insulin and tonsillitis. For example, West China Hospital has a case of allicin injection curing burns and pus, 10.13313/j.issn.1673-4890.20200217005
(End of chapter)