Chapter 185: The Tone Buster and the Thousand Years of Bonds, Right? (6.6K)
Qiu Sheng.
He is 186cm tall, weighs 70kg, has thick hair and is handsome.
A Ph.D. in Biology from HKUST and a school scholarship winner is the ultimate template that almost every boy dreams of.
But such a seemingly perfect person has an unspeakable secret that is unknown to everyone:
He has a tone.
According to statistics from Uptodate.
The local incidence of bad breath is about 30%, that is, almost 1 in 3 people suffers from bad breath.
It's just that in most cases, we have smelled it for a long time and have become accustomed to the smell of bad breath, so we don't feel anything at all.
The cause of bad breath is actually very simple. To put it bluntly, there are two common triggers:
20% is due to Helicobacter pylori and 80% is due to microbial metabolism in the oral cavity.
The latter includes a large number of bacteria such as Neisseria and anaerobic Streptococcus mentioned before.
Actually.
There are many types of bacteria in the human oral cavity, with about 5,600 common species.
There are pathogenic bacteria, non-pathogenic bacteria, opportunistic pathogenic bacteria and so on.
In general.
In every gram of tartar in a normal healthy person, 10 billion bacteria can be found.
With the secretion of saliva, these bacteria will decompose the food residues remaining in the teeth into organic amines, ammonia, sulfides, etc.
It smells like that after long-term accumulation
Of course.
There is another rare situation:
It means that there is something wrong with a person's rectum, causing the smell of some excrement to flow directly back into the mouth.
This situation does exist, but it must be attributed to the complications of intestinal diseases and does not belong to the concept of bad breath that is usually mentioned.
"Old Xu, the incidence rate of bad breath is 30%!"
In the laboratory.
Qiu Sheng put his hands on the stage and leaned forward, his expression even a little ferocious in excitement:
"Think about how many people there are in the country, not just around the world? If you can apply this new species of microorganisms to clinical practice, your company will be able to walk on two feet!"
As a breath patient, Qiu Sheng has tried almost all kinds of treatments on the market.
But whether it's teeth cleaning, mouthwash, or toothpaste that costs tens or even hundreds of dollars a piece, the effect is not ideal.
That’s not to say that all of these are useless, the key is that their duration is too short.
Take Listerine mouthwash, for example.
This should be one of the more representative brands in oral disinfection at present. Objectively speaking, it does feel okay after rinsing the mouth.
But over time, that taste will reappear in your mouth.
Therefore, the moment he saw the experimental report, Qiu Sheng realized the value of this strain:
Like imidacloprid, the discovery of this strain may not win a high-level award.
But it has unimaginable commercial value!
Compared with Qiu Sheng's excitement, Xu Yun's mood is much calmer. After all, the experience of his previous life is here:
"Calm down first, Lao Qiu, we haven't even finished the horoscope yet."
"You are also engaged in scientific research, and you should know how difficult it is to move from the laboratory to popular products."
"Among other things, the cultivation of plants is a big problem, and the other is the direction of the finished product. Should it be made into toothpaste, medicine or potion?"
"With different directions, the positioning will be different, and the difficulty will also change."
"So in the final analysis, we still have to take a long-term view. As the saying goes, you can't eat enough in one breath."
After hearing what Xu Yun said, Qiu Sheng gradually calmed down.
Actually.
He is not usually an irritable character. After all, he has a very stable temperament when it comes to scientific research.
However, he was an audience member of a new type of microorganism, and he had been troubled by his tone for too long, so he suddenly lost his temper.
Then he was silent for a moment and asked Xu Yun:
"Old Xu, what are you going to do?"
Xu Yun raised his eyelids and glanced at him, took a picture of his card on the table, pointed at the USTC above and said:
"Of course it's shaking people!"
Half an hour later.
Life Sciences Building.
Dean's Office.
"What? A new type of microorganism?"
Looking at Xu Yun and Qiu Sheng, who looked serious, Tian Liangwei adjusted his black-framed glasses in confusion:
"For the new eukaryotic species, why don't you just invest in "Fungal Diversity"? Why do you come to me?"
Friends who were microorganisms in their previous lives should know this.
In the biological world, there are actually certain standards for the submission of papers on new species of microorganisms.
For example, bacteria is submitted to "IJSEM", whose full name is "International Journal of Systematic and Evolutionary Microbiology", and cannot be submitted to other magazines.
The new species of eukaryotes is "FungalDiversity", an international journal sponsored by the Institute of Plant Research, Chinese Academy of Sciences.
It ranks second among global journals in the field of mycology and ranks third among all 188 SCI journals sponsored by relevant local academic institutions.
Of course.
If you encounter a very valuable new microorganism, it may appear on "pnas" as an exception, but it is basically a rare occurrence in several years.
The University of Science and Technology and the Institute of Kunming and Zoology are both affiliated units of the Chinese Academy of Sciences, so if Xu Yun wants to submit relevant results, he only needs to contact the other party directly.
At least judging from the situation, there was no need to go to the dean's office to inform Tian Liangwei with such a big fanfare.
Looking at Tian Liangwei who looked confused, Xu Yun couldn't help but turn his head and look at Qiu Sheng.
Then he took out a report from his body and handed it to Tian Liangwei:
"Teacher, take a look at this first."
Tian Liangwei said nothing, but took the report and read it:
"New species of Arthlosporium. Width 1.5μm elliptical."
The content at the front of the report is mainly graphical data of the new species, which seems to be purely a new type of fungus.
But as the eyes move downward.
His eyes suddenly became sharp.
After a few minutes.
Tian Liangwei raised his head solemnly and said to Xu Yunde:
"Xiao Xu, is this data accurate?"
Xu Yun nodded heavily and affirmed:
"It's accurate. Before coming here, we collected multiple saliva samples and conducted multiple sets of control experiments."
"In the end, it was found that the disinfecting effect of the new microorganisms was extremely amazing and stable, especially in the saliva sample of a friend of mine, the efficiency was even faster than other ordinary samples."
Qiu Sheng:
"."
Tian Liangwei looked at the report again, was silent for a moment, and said:
"If the new species is really what the report says, then its commercial value will be astonishingly high. Xiao Xu, do you have any ideas?"
Xu Yun picked up the teacup and moistened his throat, then pointed at Qiu Sheng:
"Lao Qiu and I had a brief discussion on the way here, and finally we came up with a direction."
Tian Liangwei straightened his body and became interested:
"Oh? Which direction? Mouthwash or spray?"
"No, it's toothpaste."
"Toothpaste?"
Tian Liangwei was stunned when he heard this, but he quickly responded:
"A product similar to lysozyme toothpaste?"
Xu Yun nodded and said:
"Yes, it is somewhat similar to lysozyme toothpaste, but it is just an idea at the moment, and further experiments are needed to determine how to operate it."
toothpaste.
This is the prototype of a product discussed by Xu Yun and Qiu Sheng.
The concept of biological toothpaste can be traced back to 20 years ago, but the current development of this field is not rapid.
As of 2022, there is only one most common biological toothpaste on the market:
Plant lysozyme toothpaste.
Plant lysozyme can hydrolyze bacterial cell walls and dissolve a variety of oral bacteria. Plant lysozyme currently on the market is mainly extracted from figs.
But it’s the same as the mouthwash mentioned above.
Although lysozyme toothpaste has a very good disinfecting effect in the laboratory, the duration of the practical session is also limited.
If I have to say it, I can only say that it is a little better than the IQ tax of enzyme toothpaste, but I am also sorry for its price.
So it can be said.
In the field of toothpaste, there is currently no truly effective biological toothpaste.
This is a huge and empty market.
At the same time, compared with the previous imidacloprid, the biological toothpaste has only one barrier in the preparation process:
inactivated.
The so-called inactivation refers to a kind of beneficial bacteria that retains its original structure and characteristics through special inactivation technology, but no longer has the ability to grow and reproduce.
For example, all the probiotic yogurt that everyone drinks uses inactivated bacteria technology.
You can imagine:
If there is a toothpaste on the market that can be used for three months, it can still implant beneficial bacteria in the mouth while cleaning the mouth. This beneficial bacteria will not only disinfect various pathogenic bacteria, but also decompose the bacteria in the gaps between the teeth. Food debris, producing calorie-free metabolites,
Moreover, the taste of this metabolite is very good. You can choose mint flavor, lemon flavor, etc. according to your preference.
In this way, the prospects of this product can be described in three words:
Who else?
Of course.
This is just a prospect idea.
If you want to make new species into finished products, in addition to the barriers in the preparation of finished products, there are also many technical difficulties:
For example, the unit density mentioned before.
Let alone one million units like penicillin, it must be at least 500,000 units.
At the same time, how to ensure the timeliness of the flora is also a topic that requires careful research:
If you ask someone with bad breath to brush their teeth twice a day, it will definitely be fine. If you ask them to brush their teeth three times, they can barely do it.
But what if you have to swipe five, six, seven or eight times or even more?
Then this kind of toothpaste will lose its practical value.
Think of this.
Tian Liangwei couldn't help but look at Xu Yun and asked:
"Tell me, Xiao Xu, how can the courtyard or college cooperate with you?"
Xu Yun's palms placed under the table were slightly clenched, but on the surface he was still very calm:
"The first is the collection of samples. We found that this microorganism will excite green fluorescence when exposed to the wavelength of 365nm, so we hope to collect all-round bacterial strains from the underground pipes in the school."
Tian Liangwei nodded when he heard this:
"That's no problem. I can apply directly to the school board. It's just a matter of adding a laser test to the hardware test. It's not difficult."
Actually.
It is not difficult to see from the rewards given by the halo that this new species most likely only exists in the sewer pipe under the basketball court.
However, Tian Liangwei and the others did not know this news. From the perspective of an outsider, it was normal to launch a blanket search.
That's why Xu Yun came up with this idea, trying to make his discovery appear more accidental.
Then Tian Liangwei paused and continued:
"In addition to comprehensive inspection, what else?"
“There is also support in terms of equipment and funding.”
Xu Yun leaned forward slightly and naturally asked for the money:
"Theoretically, the new microorganisms have high commercial value, which is exactly in line with the business scope of our Huadun Biotech, so the school should do it"
Tian Liangwei glanced at Xu Yun and said:
"Isn't that right? Isn't there still a lot of money in the company account?"
In the previous financing process, HKUST New Venture Fund, as the leading party, invested a total of 8 million Huaxia coins in cash flow.
The School of Physics and the School of Life Sciences of HKUST each invested two million, for a total of four million.
Xu Yun injected 100 cash by signing up for HKUST's entrepreneurial support.
After deducting the rent of 1,314,222 yuan for the factory building, the company still has over 10 million yuan on its books.
Facing his teacher's question, Xu Yun scratched his head and said calmly:
"I don't want to save some money. Our company will have a lot of expenses in the future, and all that money is reserved."
"Not to mention anything else, logistics, product costs, and production equipment are all not a small number."
"When the company gets on the right track, we will definitely set up laboratories or even R&D centers and gradually establish our own R&D system."
"But now I haven't sold any cockroach poison. I'm as poor as an Internet writer. You see."
"Go, go, you poor man."
Tian Liangwei waved to him, then pondered for a moment and said:
"Well, the hospital just received a few Micro-Matrix 36-well micro bioreactors not long ago. The boxes have not been unpacked, and there is also a 350RPM orbital shaker. I will find someone to send them to your laboratory in a while. ”
"Good guy, Micro-Matrix?"
Xu Yun raised his eyelids and looked at his teacher in surprise:
"And a 350RPM orbital shaker? Teacher, since when have you been so generous? Don't you have some conspiracy?"
Facing Xu Yun's suspicious gaze, Tian Liangwei's eyes dodge slightly, and he took a tactical drink of water:
"Don't think too much. There is no conspiracy. I just want you to try a new microfluidic interface nanoliter injection technology and high polymer feeding method."
"This is a new project that Professor Huang Qian's research group in the hospital just completed a week ago. We are just short of Xiaobai. Ahem, practical report from the laboratory, didn't I just think of you?"
"To paraphrase an old friend of mine who is engaged in blasting and a top blasting expert at the Academy of Engineering, Ren Danza, it is, it doesn't cost any money, just give it a try."
Xu Yunjian said that the corner of his mouth twitched slightly for a few times, and finally sighed quietly:
"Okay, just do as you say."
It is not an easy task to conduct practical projects for others. Which links are successful and which links fail, as well as the failure situations and data must be collected and summarized.
The two technologies mentioned by Tian Liangwei, if practiced alone, including equipment losses, would basically not cost 150,000 to 200,000 yuan.
Seeing that Xu Yun agreed to his request, Tian Liangwei nodded with satisfaction.
Then I thought of something and took out a fax from the drawer:
"By the way, there was a reply to Dean Hou's patent recommendation yesterday. The patent has been officially approved and the patent number is 20221"
"However, considering that the paper has not yet been released, the patent number has not been announced yet."
"I have inquired about the paper for you. It will be published in about one to two weeks. After all, it is a form of manuscript invitation. In short, just wait patiently for a few days."
"By the way, Dean Hou asked me to tell you that this young man has a bright future, so work hard. If you encounter any problems, you can come to him."
"Dean Hou"
Xu Yun took the fax and read several points, silently remembering Hou Xingyuan's favor in his heart.
I may not have enough ability to help Hou Xingyuan at the moment. After all, he is a single-digit boss standing at the top of the Republic's scientific research pyramid.
Their figures went straight into the clouds, and Xu Yun could only look up for the time being.
But with the completion of the Halo mission, he believed that one day he would be able to return this favor to Hou Xingyuan.
Even go one step further and help the country.
This is not conjecture.
Mentioned previously.
Before the dungeon mission appeared, Xu Yun's education was about to graduate with a Ph.D., and his ability was probably at the deputy senior level.
At that time, his goal was to follow in the footsteps of academician Cao Xuetao, president of Nankai University, and be selected for the senior professional title, that is, full professor, at the age of 28.
But with the use of the Mavericks experience card, Xu Yun's knowledge of biology has broken through to a whole new level.
The ability is already infinitely close to the high level of popular majors, and all that is missing is a professional title selection link.
If there are more rewards similar to thinking cards in the future, Xu Yun firmly believes that it will not take long for him to reach the top of the pyramid.
Then he chatted with Tian Liangwei on some other topics and learned about the recent trends and arrangements in the school.
An hour later.
Tian Liangwei received a fax from the school board:
Agree to conduct a scan of groundwater pipes on campus to try to find new species of microbial plants.
The basketball court area was given to Xu Yun, and he was assisted by a force directly affiliated with the University of Science and Technology - the school security team who had accompanied him into Building 14 to collect the cockroach corpses.
Ten minutes later.
Xu Yun and Qiu Sheng said goodbye to Tian Liangwei and left the office.
Just when the two of them had just walked out of the medical building, Qiu Sheng suddenly let out a light sigh, pointed in a certain direction and said:
"Old Xu, look there."
Xu Yun took advantage of the situation and looked around.
I only see this moment.
There was a group of people gathered under a tree not far away, as if they were watching something, and some were taking pictures with their mobile phones.
Eating melon is an instinct that everyone has, even a doctor. Xu Yun suddenly patted Qiu Sheng on the shoulder:
"Let's go and have a look!"
In less than two minutes, the two of them reached the edge of the crowd.
As soon as they got close to the crowd, they heard a bunch of chattering discussions:
"It's so strange, why are there still wild animals running in these days?"
"It's not wild, is it? Our school is in the city center."
"What's going on in the city center? Have you forgotten the wild boar from the year before last?"
"The wild boar thing is not an easy concept to eliminate. They came down the mountain and sneaked in during the nationwide lockdown."
"This one probably escaped from some restaurant."
Wild animals?
When Xu Yun heard this, a trace of curiosity flashed in his eyes.
Is it a snake or a sheep?
After all, if I remember correctly, there was a snake meat stove near the West District.
At this moment, a boy in front of Xu Yun gave up his seat, and he jumped into the front row.
I only see this moment.
Several security personnel were standing in the center of the crowd, working together to suppress
A donkey.
Looking at this black donkey, for some reason, Xu Yun suddenly had a strange idea in his mind:
I feel like this donkey looks familiar
Just when he was wondering.
The donkey that was pressed down on the ground suddenly caught a glimpse of Xu Yun's face, and suddenly became excited, and its four hooves struck quickly:
"Oh-oh-oh-" (End of this chapter)