Chapter 234 New Drugs -Ibaopuzumab!
"Name?"
"Xia Xue."
"Body temperature?"
"39.8 degrees... Well, the patient's family just said that the patient had a fever last night. He took ibuprofen capsules three hours ago to reduce the fever, but the effect was not good, and now the temperature has gone up again."
"Um."
Chengdu Third People's Hospital, in the emergency room of the Department of Hematology.
A middle-aged man looked at Xia Xue lying on the emergency table and asked a doctor next to him.
"Blood pressure, the result of ECG?"
"Blood pressure 110/70, normal; there is no abnormal situation of the electrocardiogram."
The middle-aged man quickly recorded on the paper record sheet again.
"Also, Mr. Wei, this patient received the first bone marrow stem cell transplant five years ago, and the second bone marrow transplant about three months ago due to the recurrence of leukemia."
"The surgery is very successful, but the second month after the operation, that is, there was an acute rejection response in the last month!"
"After the patient came to the hospital for a simple treatment at that time, the patient and his family chose to give up treatment."
"When they were discharged from the hospital, I prescribed Tsingshan Pharmaceutical's Tsingshan Avatrombopag Tablets and anti-rejection cyclosporine to them. The patients should have been taking their medicines normally in the past month."
"But now it seems that the drug can no longer suppress the rejection reaction, causing the transplanted 'bone marrow stem cells' to completely lose their function, and the patient's leukemia relapses...the leukemia cancer cells are proliferating and spreading in large numbers again."
The middle-aged man who asked was Wei Tian, and the doctor standing beside him was Director Hu.
After obtaining Qingshan Pharmaceuticals developed a drug that can treat "acute myeloid leukemia", and immediately after clinical trials, Director Hu thought of Xia Xue for the first time.
It was learned that Xia Xue was still alive, but the situation was very critical. He hurriedly contacted Zhang Yang through his personal relationship. He hoped that Zhang Yang could open a mouth and help Xia Xue immediately with medicine.
As we all know, clinical trials of innovative drugs are conducted in batches and in groups, which also involve probabilistic issues such as "double-blind testing" and may not actually use the experimental drugs.
After Zhang Yang learned about the situation, he paid great attention to it, and immediately asked Wei Tian to come to understand the specific situation in person, and to take care of the patient's medication alone.
Wei Tian is the person in charge of this "BXB01" drug project. The first human clinical trial of "BXB01" was applied to leukemia patients with such a serious condition. Naturally, he did not dare to worry about it and was very energetic!
"What about the blood picture? Director Hu, what is the blood picture now?"
"Just after the blood test came out, the white blood cell count has reached 231×10/L. Generally, the normal adult is 4.0~10.0×10/L. It is now 23 times higher than normal!"
"At the same time, the patient's hemoglobin and platelet counts also dropped below 40% of normal values, and this was while continuing to take Qingshan Ava!"
"In summary, the blood image also fully meets the high -risk situation of advanced leukemia."
Wei Tian breathed out gently and nodded.
However, he did not end this inquiry. He glanced at the record sheet in his hand and continued:
"The last item, what about the color Doppler ultrasound and PET-CT results?"
Director Hu was not impatient at all. He quickly looked through the inspection report in his hand and said quickly:
"The result of color ultrasound is that the patient has obvious hepatomegaly and splenomegaly, which are also typical symptoms of late-stage leukemia."
"I just had a PET-CT (which examines the distribution of cancer cells in the body). I have already urged the radiology department to hurry up and get the results, but I don't think the results will be very good."
As he said that, he paused and looked at Wei Tian:
"I guess that the cells of leukemia cancer should have spread to the whole body, but fortunately, leukemia will not cause traditional metastasis like a traditional physical tumor."
"The cells of leukemia cancer do attack the organ, such as the liver, lymph, and the spleen, but now the medicine should be too late now!"
"Yeah!"
Wei Tian nodded heavily, and then put away the record table in his hand.
He glanced at Xia Xue, who was lying weakly on the rescue table, and stopped talking:
"Director, I have understood and recorded!"
"This patient's condition fully meets the conditions for clinical trial patients of our new drug, so we won't waste time, right? Let's take the medicine immediately after her family members sign the clinical trial information form!"
"Okay."
Director Hu's face was happy, and finally relieved heavily:
"Mr. Wei, I'm going to notify the patient's family now to sign... By the way, shall I take you to the conference room first?"
"No need, director, I'll go to the conference room and wait for you!"
"Alright!"
...
When the words fell, Director Hu Yima first walked towards the ward placed when Xia Xue was admitted to the hospital, and Wei Tian quickly came to a small conference room next to the department's corridor.
This time he was accompanied by Dr. Zhou from the first project team and another staff member. The two had been waiting in the conference room for a while.
Two minutes later, Director Hu personally walked into the conference room with Lao Xia himself.
Looking at the three people sitting in front of the conference table, Lao Xia looked dull and confused.
In fact, since I received a call from Director Hu to the hospital, he was embarrassed.
His daughter was promoted to the rescue room. He didn't know what he should do and what he could do next. He could only wait for Director Hu's arrangements quietly.
"Lao Xia, don't be stunned. These are all CEOs of Qingshan Pharmaceutical. They are here specifically to deal with your daughter!"
"Now that your daughter's situation can be used, you can use the medicine. Next, you only need to sign it. After recording a image, you can use the medicine of Qingshan Pharmaceutical!"
Seeing Lao Xia's confused face, Director Hu hurriedly reminded him.
After a while, the helpless Lao Xia finally came to his senses. His eyes instantly fell on Wei Tian, who was sitting in the middle, and he said hurriedly:
"Hello, you, you, please! Please save my daughter!"
Wei Tian stood up in a hurry, soothing:
"Brother, don't worry, you are a family member of the patient Xia Xue, right?"
"Yeah!"
Lao Xia's mood calmed down slightly.
Seeing this, Wei Tian continued:
"That's good. Now there are a few main issues that I must clarify with you in advance!"
"Because your daughter's situation is special, it is very dangerous now, so we can't let her participate according to the normal clinical trial process, and can only use the use of emergency medication to conduct medication experiments alone!"
"So, before taking the medicine, we need to record and sign the whole process to ensure that you know this risk!"
Only then did Lao Xia notice that a small DV player had been set up on the conference table nearby, with the camera facing him.
But soon he reacted and nodded again and again:
"Boss, I can accept it, I am willing!"
"OK! You sit first, let's start now."
"Okay!"
When the words fell, everything was ready, and Wei Tian nodded at the staff next to him.
Two seconds, the staff's gesture of OK signaled that the camera mode had been opened.
Wei Tian's expression became serious in an instant, and his tone became dignified.
He looked at Lao Xia, low sinking:
"Are you a direct family member of the subject Xia Xue?" "Yes!"
"Excuse me, what is your relationship?"
"The father of my subject Xia Xue, now Xia Xue's life cannot be signed, so I will sign it on behalf of it!"
"Okay!"
Wei Tian breathed a sigh of relief, but soon his expression became more serious.
"Okay, the father of the subject Xia Xue, I will now inform you verbally and later in writing about the relevant situation of this clinical trial drug and the possible risks!"
< br>
"The subject Xia Xue will be clinically taking the latest drug developed by our company Qingshan Pharmaceutical for the treatment of 'acute myeloid leukemia'. The full name of the drug is - ibatozumab, referred to as 'ibactuzumab' .”
"This drug is an antigen-targeted drug that our company has developed over more than seven years and invested massive scientific research funds. It can effectively kill acute myeloid leukemia cancer cells."
"In our more than 1,000 complete animal tests, the drug finally achieved an effective killing rate of 79 to 82% in the animal body."
"But!"
There is no mistake in every song, one post, one content, one 6 one, one book, one book, take a look!
"In animal experiments, many adverse reactions also occurred. For example, some normal white blood cells and red blood cells were misidentified and killed by drug ingredients, resulting in a decrease in the number of white blood cells in the animal's body and causing bleeding."
"For example, if drug ingredients remain in the body for a long time, normal hematopoietic stem cells will eventually be affected and lose their hematopoietic function or become incomplete!"
"Even the most extreme case may cause white blood cells and red blood cells at the same time, causing animal receptors to die directly!"
"At the same time, this is just known in the animal test, and there are more unknown risks unknown!"
"Excuse me, have you already know the risks and are willing to bear all the consequences after taking the medicine?"
Effective killing rate of 79%~82%!
Lao Xia looked stunned, and all he could think about was the effective killing rate of 79% to 82%!
At this moment, his daughter is already on the verge of death, so how can she care about the risks of drugs!
"I am willing, I am willing! I will sign it here!"
"If there is any problem, I will never find you!"
Lao Xia signed his name on the information form without hesitation, and this moment was also recorded on DV.
A few seconds later, the staff on the side stopped filming. After checking that there was no problem, Wei Tian breathed a sigh of relief.
Soon, his eyes fell on Lao Xia's face again.
He could understand Lao Xia's mood at this time, but even so, he must thank Lao Xia for his contribution to the clinical trials of new drugs.
solemnly said:
"Brother Xia, thank you for your support of our Qingshan Pharmaceutical's new drugs! We will give your daughter the medicine right away!"
"Of course, you don't have to worry too much. Although our new drugs have certain drug risks, I think there is still a high probability that they can produce certain therapeutic effects!"
Lao Xia's expression also softened, and his eyes even regained a trace of vitality.
He kept focusing on the focus, at this time, Wei Tian then said:
"By the way, there is one more thing I want to tell you!"
"Since you are willing to participate in the clinical trial of our new drugs' Ibaopo Ming Ming", all your daughter's treatment costs in the hospital will be borne by us! "
"This! Do you take it?!"
Lao Xia was unbelievable!
You know, even though he brought his daughter to the hospital, the cost of treatment was always weighing on his mind and he couldn't even breathe!
"Hmm!"
"At the same time, after completing the six-month clinical trial, we will also give you a compensation of approximately 35,000 yuan!"
"Still, thank you for your contribution to our new drug 'ibumab'."
Affordable for treatment costs.
Give another 35,000 yuan!
Lao Xia was silent.
After a moment, he suddenly knelt down, his dry eyes already filled with tears.
"Boss, you not only treat us for free, but you also give us money!"
"How can I be at ease?"
"You are all good people, and you are truly the best and best company in the world!"
The sudden situation made Wei Tian caught off guard. Fortunately, Director Hu had seen much.
Take the lead in responding, take a step forward to persuade Lao Xia:
"Lao Xia, get up, Qingshan Pharmaceutical has always been a pharmaceutical company for the people, and has always thought about our ordinary patients."
Wei Tian also hurried forward to help Lao Xia:
"Brother Xia, you don't have to do this."
"Just like what our President Zhang said, developing drugs to treat various diseases is our job and what we should do!"
The small conference room was a little noisy for a while. Dr. Zhou on the side quietly looked at Lao Xia who was kneeling on the ground with tears streaming down his face. Hearing the heartfelt thanks, he suddenly felt that everything was worth it!
Is there anything else in the world more meaningful than saving people's lives?
...
After signing the clinical trial informed consent form, Dr. Zhou handed over to Director Hu the "ibituzumab" that he had personally brought but had not yet been provided to the clinical trial center.
"Ibatuzumab" can also be regarded as a targeted drug. It is an injectable drug and only needs one injection a week.
At the same time, "ibituzumab" is currently unable to cure "acute leukemia". Even the results of animal experiments can only eliminate about 80% of leukemia cancer cells in the body.
This time, Director Hu was going to stop all the other drugs of Xia Xue, and then began to use the "Ibaobuzumab" for clinical trials.
As the world's first "Ibukuzumab" was injected into Xia Xue's body, Xia Xue began to accept more accurate and precise data records.
4 hours after injection, Xia Xue's situation began to improve.
The 40 -degree high temperature began to decline for the first time under the intervention of non -fever drugs, 39.5 degrees.
The temperature decreased, and Xia Xue's spiritual situation began to improve.
8 hours after injection, Xia Xue's body temperature dropped to 39.1 degrees.
The first blood was checked for the first time.
Previously, the white blood cell count of 231 × 10/L dropped to 170 × 10/L.
24 hours later, Xia Xue's body temperature dropped to 38.5 degrees, and her mental state completely improved.
The white blood cell count also dropped to 120×10/L, which was only 12 times higher than the normal value!
At the same time, important leukemia indicators such as red blood cells and hemoglobin data began to rise steadily!
A large amount of monitoring data was passed to Director Hu, and then shared it with Dr. Wei Tian and Dr. Zhou. In just one day, everyone realized-
The latest research and development of Tsingshan Pharmaceutical, "ibintuzumab" for the treatment of acute leukemia, is really effective on the human body!
At this moment, Tsingshan Pharmaceutical finally officially announced that "ibituzumab" has passed the ethical review and will soon enter the hospital for clinical trials!
As soon as the news came out, the Internet was suddenly exploded!
(End of chapter)