Chapter 236 Lao Xia, President Zhang is here!
"I agree."
After the words fell, Dr. Zhou in the conference room was the first to raise his hands in agreement.
After a moment, he glanced at everyone and continued:
"When we first started to develop 'Iblakuzumab", the initial starting point was to completely treat the "acute marrow leukemia". Switching preparations "
"But now according to the actual treatment we have, the best data of the" Yibai Mipide 'in animal experiments, that is, can identify and kill about 80%of leukemia vicious cancer cells in the main body of the host, the remaining 20%of the remaining 20% The response of leukemia cancer cells may not be completely eliminated due to poor response and other reasons. "
"In other words, the current probability of‘ Yibai Mipida ’will become a long -term injection of drugs, which will be accompanied by‘ acute myeline leukemia ’for life.”
"So just like what Director Wei said just now, if lifelong injections are necessary, it is best to develop tablets, which are more convenient for patients to take and will have stronger compliance!"
"Of course!"
"The current‘ Yibai Mipida ’is mainly through intravenous injection. The drug component directly enters the blood to identify and attack the white hemiocyte cells in the blood;
If you replace it with oral tablets, you need to absorb the gastrointestinal tract before entering the blood. The entire cycle is relatively complicated, and a special oral preparation team must be set up ... "
Having said this, Dr. Zhou's eyes fell on Zhang Yang, who was sitting in the middle.
Zhang Yang smiled.
As a top drug developer, he certainly knows the difference between the two.
Moreover, he also knew very well that after what Wei Tian and Dr. Zhou said, they ultimately hoped that he would agree to start the research and development of oral tablets.
After all, developing tablets requires a lot of additional research and development expenses.
However, he also feels that it is really necessary to develop oral tablets of "ibakumab". Patients can take one tablet every day, which has high compliance and has minimal impact on the patient's life.
"Zhou Bo, you can do it next to the development of oral tablets."
"At that time, the injectable 'ibumab' can be used in hospitals and when the patient's condition is critical. After stabilization, when the condition is under control and the patient is discharged, it can be switched to oral preparations!"
Wei Tian and Dr. Zhou looked happy.
Dr. Zhou said urgent:
"Okay, Mr. Zhang, since you agree, I will go down and arrange for the team to start developing oral tablets."
"With the experience of‘ Yibaiab ’targeted medicine, research and development of oral tablets should not be a problem.”
"Yeah."
Zhang Yang nodded, and the atmosphere in the conference room suddenly became relaxed.
Wei Tian on the side also smiled and said:
"Boss, since the development of oral tablets has been settled, then we will perform the second topic of this meeting!"
“Previously, because we had to concentrate our efforts on conquering the ‘ibakumab’ project, we urgently mobilized almost all the R&D backbones of the R&D center. Now, the ‘ibakumab’ project has successfully entered the clinical trial stage..."
"Although there is some gap with the completely healing leukemia, do you see if you want to relieve the mobilization and let the backbone of the R & D bones return to their respective research and development teams?
Or is it ... wait for the ‘Yibaiab’ to complete the clinical phase of the third phase of the clinic. Intersection "
After the words fell, the doctors from several major project teams present at the meeting sat up straight.
This meeting was attended not only by Zhang Yang and Dr. Zhou, but also by doctors from major project teams in the R&D center!
Clearly, this is a matter of great concern to them!
After a while, before Zhang Yang could speak, Dr. Liu from the second project team couldn’t wait to speak:
"President Zhang, it must be disbanded now and returned people to us! Now the" Yibai Double Anti "of the first project team is all clinical trials, and the next clinical work is enough for their original research and development team!"
"The projects in each group have been stopped for a long time, and we can't afford it!"
When the words fell, with the speech of Dr. Liu, the second project team, the doctoral doctors of the rest of the project team also said:
"Yes, Mr. Zhang! The 'fatty liver reversal' project of our third project team is also at a critical moment, and we are also in urgent need of people!"
"That is, don't hide it, President Zhang, several researchers in our group told me that they didn't want to stay in the first project team, and they wanted to come back."
Upon hearing this, Dr. Zhou, who was originally waiting for Zhang Yang's decision, suddenly became unhappy and hurriedly retorted:
"I said Lao Liu, what you said is just nonsense!"
"I haven't said it to President Zhang yet. Several researchers in your group found me privately, saying that I want to stay in our first project team, and I want to develop drug -related drugs!"
"Hum! You put your shit, who tell me who wants to stay in your first project team?!"
Listening to Dr. Zhou and Dr. Liu suddenly quarreling, Zhang Yang couldn't help but smile bitterly.
Of course he can understand the importance that doctors in major project teams place on talents. After all, only with a large number of professional R&D personnel can it be possible to successfully advance the process of new drugs.
Moreover, this was the first time for him to see the powerful drug research and development capabilities that Qingshan Pharmaceutical R&D Center has unleashed after mobilizing nearly a hundred top R&D personnel!
Drug research and development, in the final analysis, is about the accumulation of talents!
Thinking of this, Zhang Yang smiled and interrupted the quarrel between the two:
"Okay, don't make noisy Zhou Bo and Liu Bo."
"Well, currently 'ibumab' is indeed one of the most important R&D projects of our Qingshan Pharmaceutical,"
"If any R&D personnel are willing to stay in the first project team, then transfer the work department to the first project team!"
After finishing speaking, seeing that the doctors from all the major project teams wanted to speak, Zhang Yang hurriedly continued:
"Of course, it won't happen next time."
"At the same time, I am also going to make a larger -scale recruitment next to double the scale of our current professional R & D personnel!"
Double the size!
After hearing this, the major doctors who were still a little restless calmed down a little.
Zhang Yang looked at Wei Tian and continued:
"Wei Tian, I will give it to you."
"Of course, not only should you recruit research and developers with work experience, but also recruit more fresh graduates to gradually start cultivating our future backbone."
"Okay!"
Wei Tian quickly recorded, at this time, Zhang Yang exhaled gently, glanced at the crowd, and then said:
"Okay, the two issues of today's meeting have been discussed, right?"
"Now, let me announce one thing."
Everyone's face was a little confused, and she smiled openly:
"Although 'ibumab' has not yet passed clinical trials and is officially on the market, reaching the stage of clinical trials is already a huge breakthrough and an important step!"
"Wei Tian, Zhou Bo, please go and sort out all the R&D personnel participating in the 'ibumab' project in a moment. Each person will be rewarded with one million yuan!"
"Three million yuan with special contributions and excellent performance, and ..."
With that said, Zhang Yang glanced around the doctors present again:
"This time, the doctors have lowered their own projects at the most critical time, and they participated in the final sprint of this 'Ibabagaba'. Everyone has worked hard."
"Similarly, everyone is also a R & D reward of three million yuan per person. Then I will notify the old money of finance, with the salary of wages next month!"
Three hundred ... 10,000!
The doctors present were stunned, and all their dissatisfaction disappeared instantly!
Just kidding, 3 million rewards per person!
You know, although they are doctors, the project leader, the annual salary of more than one million, but!
Who would dislike more money? Intersection
"Mr. Zhang, you are so polite. We just did our little bit... Don't worry, next time there are projects that need to be tackled intensively, we will go all out!"
"Yes, yes, Mr. Zhang, we must cooperate with all my best. You are really the boss I have seen the greatest!"
Zhang Yang smiled and waved his hands and said: "Since everyone has no objections, that's the end of today's meeting. Let's break up the meeting!"
"Okay, thank you President Zhang!"
No one expected that today's conference ended in this way. Dr. Dr. stood up and thanked Zhang Yang with a smile on his face, and then exited.
After a while, the doctors of each project team were happy to return to the R & D Center, and only Wei Tian and Zhang Yang left in the conference room.
Wei Tian was about to speak, but Zhang Yang took the lead and said:
"Wei Tian, do you have anything else to do now?"
Wei Tian was stunned for a moment and shook his head:
"No, what's the boss?"
"Nothing."
Slightly thought about it:
"I think you accompanied me to the Third People's Hospital to see. Didn't you have a patient who used our 'Yibai Mipide' in advance?"
"Today is exactly the seventh day after the injection. Let's go and see the effect."
Wei Tian instantly recalled Xia Xue, who was lying dying in the rescue room, and Lao Xia, but just as he was about to nod, he suddenly paused and took out his phone to take a look.
There is no mistake in every song, one post, one content, one 6 one, one book, one book, take a look!
Then there was some hesitation:
"Boss, now at 11:10 in the morning, we should drive to the three people at 11:40."
"You came to the company at 7 o'clock this morning. If you are busy now, don't you go to the hospital with you after lunch?"
Zhang Yang suddenly felt a little hungry, but after thinking about it he shook his head:
"It's okay, let's go to the hospital first. When we will be too hungry, just eat something near the hospital."
"Okay!"
Seeing Zhang Yang's insistence, Wei Tian did not persuade him anymore. The two then went downstairs to the parking lot.
Thirty minutes later, Wei Tian stopped the car and Zhang Yang together in the Hematology Hospital Department of Rongcheng Third People's Hospital.
This is not the first time that Zhang Yang has come to the inpatient department of the Department of Hematology. As early as when he was using "Qingshan Ava" and "ITG Human Myelopoietin", he often came to the inpatient department of the Department of Hematology to learn about the conditions of patients with aplastic anemia.
But Rao was so scared by the corridor passage filled with the patient in front of him.
When he arrived at Director Hu's office, he calmed down slightly.
"Director Hu, why are there suddenly so many people in the hematology department!"
It is not surprising that Director Hu's sudden visit.
In his impression, Zhang Yang would personally go to the hospital to understand the situation and problems encountered in the clinical trials of any important new drug clinical trials of Qingshan Pharmaceutical.
He took off his black-rimmed glasses, rubbed his temples, his eyes showed deep fatigue, and replied:
"Mr. Zhang, today is already considered a small number."
"The two days ago, the second day when you 'Yibaipuzumab" just released, our inpatient department, outpatient department, and clinical trial center were all leukemia patients from all over the country. >
"All patients can't wait to take the clinical test of our new drugs, and the registration cannot be registered!"
Speaking, Director Hu re -put back the black -frame glasses, and then took out a piece of information from the desk drawer:
"This time,‘ Yibai Mipida ’is the first phase of the second phase of the combined clinical trial, with a total of 104 places.”
"This is the registration data as of this morning. There are 240 patients registered. This afternoon I will cooperate with your staff to screen out eligible leukemia patients to conduct clinical double -blind trials."
"But..."
He glanced at Zhang Yang and said:
"However, more than 30 of these patients are particularly serious and dangerous in life. Now they have already completed the procedures for admission. They hope that we can use the medicine directly and not participate in any double -blind test!"
"Do you think we can add about 30 more places for direct medication..."
Zhang Yang took the information from Director Hu and glanced quickly.
As we all know, when all new drugs are conducted in clinical trials, they must conduct double -blind tests, that is, there is a control (placebo) group, a test group;
At the same time, not even pharmaceutical companies, patients, and doctors know which patients took the experimental drugs, thus ensuring the authenticity of drug clinical trials.
but.
When encountering some particularly high-risk diseases, or diseases with very few patients, such as advanced cancer, leukemia, and some rare diseases, regulations can allow separate medication and record it separately.
It is just that this method is complicated than the standard dual -blind test process, the approval is very troublesome, and the credibility is low. It is a burden on pharmaceutical companies.
Therefore, general pharmaceutical companies will not open this mouth for patients.
Soon Zhang Yang handed the information in his hand back to Director Hu, nodded and said:
"Okay, since Director Hu also feels that it is necessary to take the medicine directly, let these patients directly apply for medicine directly!"
"Everyone who can be saved counts!"
Director Hu's expression relaxed, and the tiredness on his face seemed to disappear instantly.
A smile appeared on his face and he said:
"Mr. Zhang, are you here to see the first patient who used the medicine before?"
"She has been transferred to the general ward now. Please wait a moment. I will get some information and take you there right away!"
"Okay!"
Zhang Yang nodded. About two minutes later, Director Hu took Zhang Yang through the corridor with a tablet in his hand and walked towards Xia Xue's ward.
As he walked, he looked at the tablet in his hand and introduced:
"Mr. Zhang, let me give you a brief introduction to the patient's condition."
"The patient's name is Xia Xue, 26 years old, and injected our first needle 'Yibai Mipide' 7 days ago. The PET-CT manifestations performed when admitted to the hospital were widely metabolized in the body. Obvious high metabolism performance in the long bone marrow. "
"These are all manifestations of late-stage leukemia."
"The same goes for the blood picture. The white blood cell count was as high as 231×10/L when admitted to hospital, but now after one injection of treatment, in just seven days..."
"I conducted another PET-CT examination yesterday. The high metabolic response of the bone marrow of the whole body was significantly reduced. There was only a certain high metabolic reaction in the whole body, and there were no obvious abnormalities in other places!"
"At the same time, important blood indicators such as white blood cells, red blood cells, and lymphocytes are approaching normal!"
“It can be said that the current patient’s leukemia symptoms have been effectively controlled with just one injection!”
Zhang Yang nodded.
At this time, the two of them just walked into the ward.
This is a ward between two people. Xia Xue was lying on the bed and resting, and Lao Xia looked at the phone bored.
Director Hu hurriedly stepped forward:
"Old Xia!"
"This is Mr. Zhang from Qingshan Pharmaceutical, who came here specifically to see Xia Xue's situation!"
Lao Xia was shocked and hurriedly stood up.
After just taking a look at Zhang Yang, his expression instantly became tense and respectful.
(End of this chapter)