Chapter 243 Micro Environment
Jiang Miao looked at today's airship test.
Before leaving, he ordered Wan Gaofeng, the head of the airship company,: "Gaofeng, although the safety design can prevent the explosion of hydrogen airbags, necessary safety tests must be carried out."
Listen After understanding the boss's instructions, Wan Gaofeng nodded: "I understand, but the Lufeng airship test base is not suitable for testing. I suggest that when the construction of the Minqin base is completed in September, a safety testing center will be set up in the desert around Minqin."
"Yes, you can do it!"
In order to ensure safety, it is estimated that more than a dozen full-size airships will have to be bombed to figure out the true safety of the airship when an emergency occurs.
These test costs about several hundred million.
But these investments are necessary costs.
When Jiang Miao came back, it was already setting. On the road, the evening breeze gently blew, bringing a hint of coolness to the hot July.
On the road back to the city from Lufeng, he could see from time to time that there were many vehicles transporting litchi wood and longan wood on the roadside.
Since May, due to the great success of Hailufeng Company's new technology durian, many local farmers have begun to seek cooperation.
These longan wood and lychee wood are farmers who switched to durian. They cut off the lychee longan from the old orchard and sold the wood to wood buyers. Generally, these lychee wood longan wood are resold to some charcoal The factory makes charcoal, or sells it directly to catering workshops such as roast goose and pork.
Of course, Hailufeng generally does not cooperate with small farmers to grow durian, which is mainly difficult to manage.
Usually, the company will cooperate with local cooperatives, agricultural companies, and large-scale owners.
In fact, there are no people in rural areas now, and many families have moved to urban areas to live, which is more beneficial to the merger management work.
Many farmers find relatives and friends who move to the city to rent orchards and slopes. By getting together, they can meet the minimum standard for signing cooperation, that is, 10 acres.
After all, the planting model in the past was too difficult to manage. The plot was very small and very scattered. The agricultural technicians that Hailufeng Company had to send guidance to waste a lot of manpower and material resources.
The company's agricultural cooperation department has made a very detailed division of the two durian planting areas of Shanmei and Qiongzhou.
For example, the local area of Shanmei is divided according to quarter and region, and is divided into:
Xia District (May-September): Urban District, Gongping Town, Luhe County.
Autumn and Winter Area (August-December): Haifeng Area.
Winter and spring area (January-May): Lufeng area.
These planting areas can be adjusted through special agents to allow durians to bloom and bear fruit regularly, ensuring that durians are produced throughout the year.
In fact, it is better to cut off these local lychee longans. Jiang Miao's family used to plant lychee longans. Lychee longans are of different sizes and years, and picking them is very time-consuming and labor-intensive, so they can only be picked by manpower.
Moreover, the local lychee longan varieties in Shanmei are not competitive.
For example, in the good times, the purchase price of some varieties of lychees is only a few cents; in the Little Year, although the purchase price of lychees is a few dollars, the output is not much, and it may even be unrecovered.
In addition, the younger labor force in rural areas is getting smaller and smaller, and the older generation can no longer work. Young people feel that there is no profit to grow lychee longan. Many local lychee longan orchards are actually in a semi-wild state.
It just so happened that the economic situation outside the country was not good in recent years, and many young people were forced to come back. Now local agriculture has switched to durian cultivation, absorbing a large number of young people returning home.
Jiang Miao couldn't help but think of something when he saw these lychee woods.
That is the scientific research department of Hailufeng Company, which established the lychee genetically modified rootstock project and the longan genetically modified rootstock project in April this year.
GMO rootstock technology can be manually set up to allow GMO rootstock to have extremely strong drought-tolerant and low-temperature resistance, and also has special nutrient storage root blocks, which can support fruit trees and economic trees to blossom and bear fruit all year round.
Especially in areas like Lingnan where there is basically no zero degrees throughout the year, you can basically achieve rewards for twelve months a year.
This technique is very useful.
Take lychees as an example. If the time of flowering and fruiting is not artificially adjusted through genetically modified rootstocks, domestic lychees will be launched in summer every year.
This seasonal fruit will bring two major problems.
The first problem is that concentrated listing brings the risk of stampedeship, especially in the bumper years, fruit farmers face price cuts from buyers and have no room for resistance.
The second problem is that the risks are concentrated. The main lychee production areas in China are in Lingnan, Guizhou, Fuzhou, Qiongzhou, that is, the F4 area in South China. This area is a high-incidence area of typhoons. When lychees are on the market in summer, they are on the market. , it is easy to encounter typhoons, causing heavy losses to fruit farmers.
These two problems can be solved through genetically modified rootstock technology. As long as the season of flowering and fruiting is dispersed, the risks will also be dispersed.
At the same time, the market price of lychees will also be flattened and there will be no too serious fluctuations.
This is beneficial to both growers and consumers.
Jiang Miao did not participate in the development of lychee genetically modified rootstocks and longan genetically modified rootstocks, and mainly did technical guidance. After all, genetically modified rootstock technology has formed a relatively mature set of products within the scientific research department of Hailufeng Company. Technology, as long as you use the Nuwa system and Jiang Miao’s guidance, you can usually obtain relatively mature genetically modified rootstocks in two or three years.
At present, Jiang Miao's energy is mainly focused on cultivating new varieties, as well as pistachio genetically modified rootstocks and cherry genetically modified rootstocks.
In addition to the rubber grass and soybeans he has been cultivating, there are also sugarcane and cassava that he has studied before.
In addition, he also assigned several tasks to the GM Rootstock Laboratory, including using mature Isokapop GM Rootstock as the basis to study grafting kapok; studying oil tea genetically modified rootstock; and studying citrus genetically modified rootstock.
Some of these breeding research projects are still staggering, while others are already fruitful.
For example, sugar cane breeding projects.
Because it was a project led by Jiang Miao himself, the progress of this project was very fast. Starting from the first generation of sugarcane varieties last year, the fourth generation of sugarcane varieties has been cultivated through genetically targeted screening.
Three of these sugar cane varieties have been experimentally planted.
These three varieties are named: Mucane No. 1, Mucane No. 2, and Mucane No. 3 respectively.
There is naturally a reason for the name Mucane.
Theoretically, the sugar content limit of sugar cane is about 30%. Among the common sugar cane varieties on the market, such as Yunzhe 081609, the maximum sugar content can reach 19.2%.
Then why sugarcane cannot break through the limit of 30% sugar content? The reason is that the sugar content is too high, which will lead to cell dehydration. The biological instinct to resist the evolution of sugar content exceeding 30% sugar, because this is not in line with Evolutionary trends in biological survival.
Jiang Miao naturally knew this.
Therefore, his solution has three directions: high yield, results and specialization.
As a result, during a series of cultivation processes, Jiang Miao found that there is an upper limit for sugarcane yield per mu. Even the water, fertilizer, light and heat are very sufficient, and the sugarcane yield per mu is about 18 tons, which is difficult to break through this upper limit.
Results There is no way to cultivate the group. Even though he used many primitive species of wild sugar cane, he still could not cultivate varieties with high sugar content and high fruit yield per mu.
On the contrary, the special group, during a series of mutations, a special bud change appears, and this special bud change is the origin of the mother origin of the wood cane series.
The wood cane series has changed the true nature of sugarcane's grass family. The lignin content of its stems soared, and its lignin is almost the same as another giant of the grass family, bamboo.
This evolutionary method makes the stem of the wood cane similar to that of bamboo, forming a hollow structure inside the stem.
But the difference from bamboo is that the inside of the cane joints of the wooden cane is not really hollow, but has become a structure that stores sugar and moisture.
In addition, the stem diameter of the specialized wooden cane will continue to grow. In the 1,500 acres of experimental fields currently planted in experiments, the stem diameter has generally grown to about 7 cm, and it is still continuing. In growth.
In addition, the root system of wood cane is like bamboo, and the root system becomes extremely developed and almost firmly rooted in the soil; the leaves become smaller and denser.
How to harvest the wooden cane?
The answer is that no harvest is needed.
Instead, it is similar to the northern collection of maple saccharin water. It only requires drilling holes in the cane sections under the wood cane, installing a stainless steel sealing interface, and then using a water pumping device to continuously extract sugar-containing solutions from the wood cane body.
On average, you can draw once a month, for about 3 days each time. Currently, you can draw about 600 kilograms of sugar solution per mu of wood cane each time, and these sugar content is about 24%.
At present, 7,200 kilograms of sugar liquid can be pumped per mu of wood cane every year, and about 1,728 kilograms of sugar can be extracted. According to the monthly output measurement by the technicians at the experimental planting base, the yield of sugar liquid per mu of wood cane shows an increasing trend.
Jiang Miao observed through the identification panel that the stem diameter of the wooden cane can generally grow to about 15 cm, and the annual yield of sugar liquid per mu may reach about 20,000 kilograms.
Using sugar liquid to extract sucrose is easier than using sugar cane to press. It does not require decolorization or filter impurities. It is directly sent to the production line for concentration, and then it can produce sugar.
As long as the stainless steel interface is arranged in the early stage, the sugar solution can be drawn regularly every month, saving a large part of the labor cost of cutting sugar cane.
From the data obtained from the identification panel, the high yield of wood cane can last for about 15 to 20 years. When entering the later stage, when new seeds are replaced, wood can also be sold. After all, the structure of wood cane is almost the same as that of bamboo. , and the stem is very thick and can be used as bamboo.
There are three other benefits to planting wood cane.
One of the things is that wood cane is more suitable for slopes and mountains, because wood cane does not need to be harvested. It only requires plastic hoses to connect stainless steel joints. Using the height difference between slopes and mountains, it can also save sugar extraction liquid. electricity.
Secondly, it is conducive to the production of sugar factories. After all, wooden cane can be produced almost all year round in South China, and sugar factories do not need to worry about the problem of the sugar-squeezing season.
Third, it is conducive to transportation. During the transportation of solid sugar cane, manpower or mechanical lifting is required. The liquid sugar liquid is directly pumped with a pump, and then transported to the sugar factory by a tanker.
In addition, the yield of white sugar per mu of wood cane is much higher than that of sugar cane.
No mistakes, one poem, one post, one content, one in 6, one book, one bar, one read!
For example, Guizhou, the main sugar-sugar-producing area in China, planted about 11.3 million mu of sugar-sugar-sugar-producing a year, with an annual output of between 6 million tons and 7 million tons of sugar.
If wood cane is planted instead, 11.3 million mu of cane can theoretically produce about 19 million tons of sucrose. When it reaches the high yield period, it can theoretically produce about 54.24 million tons of sucrose.
You should know that the annual output of domestic sucrose in recent years has only been more than 8 million tons.
The advantage of changing the planting of wood cane is too great.
It is estimated that traditional sugar cane can only be used as fruit in the future, and its status in sugar crops is likely to plummet.
The benefits of wood cane are too many, but considering the risk issue, one or two planting areas must be arranged in F4, South China to avoid being taken to one pot by typhoons or extreme weather.
But Guizhou Province is definitely the main planting area.
Although it is still in the experimental planting stage, Hailufeng Company has established a subsidiary responsible for sugar production, namely Nanguo Sugar Industry.
Nanguo Sugar Liquid has been deployed in Leizhou Peninsula and Guizhou Province. It is expected that hundreds of thousands of acres will be planted as an experiment by the end of this year, and the sugar production factory is also under construction.
As the fleeting scenery of the roadside flashed by.
Jiang Miao's convoy returned to Magong Town.
Just after coming back, Shuya was holding her daughter and chatting with her senior brother Luo Yulin in the living room.
While he changed into slippers, he asked, "Yulin, how are you doing recently?"
Luo Yulin then stood up: "Boss, I'm here today, mainly to report something. "
"Sit down, don't be polite." Jiang Miao sat down, picked up the Phoenix Dancong Tea poured by Li Wenna and took a sip.
Luo Yulin, who was seated, did not delay and handed over a document to directly explain the purpose of the article: "The new antibiotic that started researching last year has completed the cultivation of high-yield bacterial strains and the production process of antibiotic extraction and production of antibiotics. , the clinical trial laboratory has also completed animal experiments and is currently applying for human trials. ”
Putting down the teacup, Jiang Miao picked up the documents and looked through them for a while.
When he saw the report of the clinical trial, he suddenly raised his eyebrows, then raised his head and asked, "Yulin, have you understood this animal experiment in Group 3047?"
" Boss, this is also one of the reasons why I came to report. "Luo Yulin pointed to that page of report: "During the experiment, the clinical trial laboratory found that drugs can destroy the tumor microenvironment and allow the immune system in the mice to re-identify the tumor. cells, thus killing tumor cells. "
"This should not be the credit of the new antibiotics, right?" Jiang Miao said and looked.
Luo Yulin nodded and replied: "The old man's concept is as good as a god. We have conducted many experiments in conjunction with the clinical trial laboratory, and finally found that it is a by-product of the bacteria, which has produced some tumor microenvironment. Destruction. ”
At this time, Jiang Miao had already turned to the part of what Luo Yulin said.
This compound is a by-product of the bacterial production at high temperatures and is a mutated protein.
The mechanism of action is to combine with some cells, turning these cells into "foreign bodies", which in turn causes the biological immune system to attack these "alienated cells", and finally eliminate these through the body's own immunity. alienated cells.”
This special protein does not have infection characteristics for all cells.
From the report, Luo Yulin's team studied the situation of this mutant protein in detail. They found that the production mechanism of this mutant protein is very special and has a lot to do with the raw materials of bacterial culture medium.
They tried several different biological culture media and found that as long as raw materials similar to Hela cells were used as culture media, mutant proteins that specifically infect cancer cells could be produced.
This customized version is a mutant protein. After intravenous injection, it will soon infect cancer cells in the organism, but it will not infect normal cells. The infected cancer cells will be quickly "alienated" after being infected. ”, and then recognized by the immune system.
And after the mutant protein infects cancer cells, it will interfere with the self-replication of cancer cells, thus preventing cancer cells from proliferating rapidly.
The report also mentioned that Luo Yulin's team tried to use normal mouse cells as culture medium. The special-variable protein cultivated in this way will infect normal cells after injecting it back into the mice through intravenous injection. , but because this protein does not have the ability to replicate itself, it will only cause severe allergic reactions in the body.
In addition, many experiments have been done in the clinical trial laboratory.
For example, using surgical assistance to inject this protein directly into the tumor area can effectively utilize the properties of this protein.
For some visceral tumors, surgically assisted injection can effectively and quickly infect tumor cells.
Especially tumors in the brain, such as diffuse glioma, because the brain has a blood-brain barrier, under normal circumstances, intravenous mutant proteins cannot enter the brain, which will lead to mutant proteins. If the brain tumor cannot be effectively infected, surgical intervention must be used.
Jiang Miao looked carefully at the report and showed the infection and treatment effects of various tumors.
Even if it is a terminally ill pancreatic cancer and diffuse glioma, when faced with the interventional injection of mutant proteins, these cancer cells will be killed by the body's immune system within two or three weeks after being infected.
The survival rate of cancer in the mice used in the experiment was as high as 93%.
If surgical resection is assisted, the survival rate can be greatly increased.
Especially for larger tumors, they must be removed through surgical resection for better treatment.
The existence of mutant proteins does not require worrying about the spread of cancer cells throughout the body. Cancer cells leaving the core of the tumor are more likely to be infected by mutant proteins.
If those super-large tumors are not removed by surgical surgery, although the mutant protein will quickly infect the inside of the tumor, the immune system can easily lead to local severe inflammatory reactions and even pus in the process of mad attack on the tumor. The situation where blood explodes in the body.
The mice that died in the experiment were leaked due to the blood in the tumor, which led to severe shock and infection.
Jiang Miao put down the document and ordered: "This discovery is very valuable, Yulin."
"Boss, please give me instructions."
"You and the clinical trial laboratory Intensify research and do a good job in applying for human experiments as soon as possible. I will come forward to promote the approval of human experiments."
"Okay." Luo Yulin looked happy: "Boss, please name this mutant protein. Right! ”
"Since it was discovered by your team, you can decide for yourself!" Jiang Miao didn't care about such things.
But Luo Yulin was still very persistent: "Boss, our team hopes that the boss can name this mutant protein."
"Is this how?" Jiang Miao thought for a while: "Just just say it." Call it Yulin Egg! "
"Isn't this good?" Luo Yulin waved his hand quickly.
Jiang Miao said directly: "Let's settle it like this! Many times abroad use the inventor's discovery name as the name, so don't be polite."
"Thank you for your cultivation." Luo Yulin was very excited and was very grateful to Jiang Miao.
(This chapter ends)