Chapter 245 Clinical Test (Super Large Cup)
Jiang Miao and his group took the high-speed rail to Chang'an, the core city in the northwest.
He did not go to Minqin County immediately, but stopped in Chang'an.
Because the third phase clinical test he coordinated in July, it was passed at the end of August. At the same time, Hailufeng Hospital also found three public hospitals to cooperate with pilot hospitals for clinical testing.
One of the public hospitals is located in Chang'an City.
Today, Jiang Miao happened to pass by Chang'an, so he stopped and took a look at the clinical tests of this hospital.
"Hello, Professor He."
The chief physician of neurosurgery at the hospital also smiled and stretched out his hand: "Hello, Professor Jiang."
After shaking hands, Jiang Miao stood at the door of the ward and looked at several patients inside through the crack of the door: "Professor He, what is the patient's condition?"
"The situation is OK. One of the patients has passed 20 days. Treatment, the current CT and laboratory conditions are in line with expectations. "Professor He took the medical record from his doctoral student:
"This patient has a relatively serious diffuse glioma, and the location is very troublesome. Surgery can easily cause serious damage to brain function. If the surgery is not done, the tumor is growing rapidly and will soon compress the brain stem."
Several people have already walked into the ward. Jiang Miao took a look at the medical record and looked at the patient's condition: "Professor He uses cranial drainage surgery to cooperate with the treatment!"
Professor He nodded slightly: "Yes, Professor Jiang's eyes are full of raging eyes. This is how I think about it. After Yulin protein infects tumor cells, the patient's body's immune system will launch a fierce attack, which will lead to large-scale death of tumor cells, and the location where the tumor has formed is relatively concentrated. It was also an inconvenient brain resection, so I implanted the drainage tube into the tumor. "
"I just observed it. Professor He was worried that the patient's body would not be able to bear the side effects, so he adopted a phased treatment plan. ? "
Professor He nodded again, and at the same time he was very surprised by Jiang Miao's medical level, and secretly exclaimed: No one is worthy of his reputation.
"Professor Jiang hit the nail on the head. I am worried about the side effects of treatment. Through these twenty days of exploration and attempt, we have figured out some of the situation. Now, we inject a certain amount of Yulin protein into the patient's skull tumor every five days. Infect a small number of tumor cells, allowing the patient's immune system to kill these tumor cells, and then suck the dead tumor cells out of the body through the diversion tube. "
"What is the case with an allergic reaction?"
<< "A patient had a serious allergic reaction, and had a rash on his body, and needed to use drugs to deal with the allergic reaction. The other four patients had a relatively mild allergic reaction."
Jiang Miao was very good at allergic reactions. It is clear that the allergic reaction of Yulin protein is basically impossible to remove.
Because the treatment mechanism of Yulin protein is to infect tumor cells and induce the human immune system to attack tumor cells.
If Yulin protein does not have the characteristics of being allergic to the body, its ability to induce tumor cells attacked by the human immune system will be weakened, thus not having a therapeutic effect.
In other words, Yulin Protein is a double-edged sword.
To achieve treatment results, the patient must endure allergic reactions.
If there is no allergic reaction, it means that the body cannot recognize the "harmful" of Yulin protein, which will cause the immune system to "silence" the Yulin protein and the tumor cells infected by it.
Professor He also knows the reason: "The treatment mechanism of Yulin protein is destined to trigger an allergic reaction, but as long as the allergic reaction does not endanger life, the benefits will be greater than the damage."
Jiang Miao took the medical record, and after reading it for a while, he asked in a low voice: "Professor He, do you know the cause of this patient's disease?"
"I don't know much about this. What did Professor Jiang find out? ? "Professor He dared not ignore Jiang Miao's opinions.
"Where is his family?"
Hearing Jiang Miao's words, the intern doctoral student on the side quickly called the family of the patient standing on the other side of the hospital bed: "Mr. Li, this is a new medicine Professor Jiang, the CEO of the development company, wants to know your situation, you must answer truthfully."
The middle-aged man with a gully face came over and said nervously: "Hello Professor Jiang, I am The patient's father, ask any questions if you have! I will answer truthfully."
Jiang Miao glanced at the middle-aged man and frowned.
Seeing this scene, the middle-aged man became more and more nervous.
"Have your family renovated a house in the past few years? Or moved into a new house?"
"Ah? Uh..." The middle-aged man was stunned for a moment, and then answered truthfully: "Yes," , My family just renovated the house two years ago. "
"Do you use a lot of cheap synthetic wood in your house?"
"This..." the middle-aged man recalled, his face suddenly turned pale: "It's quite a lot..."
Jiang Miao shook his head: "After going back, he threw away all the synthetic wooden furniture at home. Either use plastic or iron products. I guess the formaldehyde and other harmful gases in your home are seriously exceeding the standard. Don’t be reluctant to leave. Some cheap synthetic wood will release formaldehyde and harmful gases for more than ten years. "
" OK, OK, Professor Jiang. "The middle-aged man's head was like pounding garlic, his face was pale, and he was obviously scared.
Jiang Miao knew very well that many people had no experience in decorating, or were greedy for small gains and bought cheap materials.
Although many synthetic woods on the market are marked as formaldehyde emission meet the standards, the manufacturer will never tell you that a single product does meet the standards, but once you use a lot of cheap synthetic wood products at home, a big deal If the stack of synthetic wood that meets the standards, the formaldehyde and harmful gases released indoors will be superimposed, resulting in serious problems such as formaldehyde and harmful gases exceeding the standard.
The even more fatal problem is that commercial housing is now very sealed, especially in winter, the interior is basically airtight. Under the heating of floor heating, many synthetic furniture and building materials will increase formaldehyde and harmful gases. Release amount.
To solve the problem of excessive indoor formaldehyde and harmful gases, either maintain good ventilation or discard synthetic wood furniture and building materials, and use materials such as plastics, solid wood, ceramic tiles, iron products, and aluminum alloys.
As for the higher-priced synthetic wood, the improvement effect is actually limited.
Because of the fact that many synthetic wood furniture are single, most of them meet the standards.
But once there are too many synthetic wood furniture and building materials used in the same indoor space, the result of superposition will definitely exceed the standard.
If the unit price of so-called solid wood furniture is too low, don’t expect to buy real solid wood. After all, the domestic natural wood production capacity is limited. After importing natural wood from abroad, after a few hands, the price of solid wood products is destined to be expensive.
Especially for families with limited financial resources, they are likely to be able to buy synthetic wood that pretends to be solid wood. Instead of trying your luck, it is better to recognize the reality and buy iron and plastic furniture, which is more safe. And it's good price/performance.
…
Jiang Miao, accompanied by Professor He, visited other patients participating in the test.
These patients all had diffuse glioma.
Patients participating in clinical trials not only have medical expenses contracted by Hailufeng Company, but also receive an additional special subsidy of 10,000 yuan each month.
In fact, for these patients, they and their families were desperate, so they were killed.
After all, diffuse gliomas are too easy to recur, and they are often entangled with the brain, and it is difficult to remove them through surgical procedures. They often recur again after a few years.
If you are lucky, you can last for about ten years after one operation, and some patients can even survive for more than twenty years.
But if you are not lucky, you may even relapse in two or three years.
Every operation is a huge adventure for patients with diffuse glioma, because diffuse glioma and the brain are entangled, and accidentally cuts into the nerve structure and brain tissue of the brain, it is possible that Causes various dysfunctions in patients.
For example, after the operation, you can't hear, smell, see, or your limbs are paralyzed, your movements are incoordinated, and you even become a vegetative person.
The treatment plan for Yulin protein is relatively safe. It does not require direct cutting of tumors inside the cranial cavity. Instead, it kills tumor cells through the body's immune system, retaining normal cells.
The only troublesome thing is that the treatment process of Yulin protein needs to be carried out in the hospital throughout the process.
After all, Yulin protein can cause allergic reactions to patients. If you don’t pay attention to them all the time in the hospital, a serious allergic reaction may send the patient away.
In addition, tumor cells are killed in the body. If too many tumor cells are eliminated in a short period of time, pus and blood stasis will form, which will trigger a serious inflammatory reaction.
This must be treated with auxiliary treatment similar to drainage surgery, resection surgery, etc.
For example, Professor He's treatment plan is surgically implanted in the drainage tube and combined with Yulin protein for treatment.
After Jiang Miao visited five tumor patients who participated in clinical testing, he held a small academic symposium at the hospital at the invitation of the director of the hospital.
Considering that everyone has no time, Jiang Miao did not ask them to arrange their time specifically. Just during lunch, everyone would have dinner together and participate in the symposium together.
"Professor Jiang, the food is simple, so be sure." Dean Zhu Guozhi said with a smile.
Jiang Miao shook his head: "I also have an ordinary meal at home."
After eating half full, Jiang Miao went straight to the point: "Everyone doesn't have to be too serious, we just treat it as friends and each other. Communication, then I will first throw a brick and attract jade..."
"You may already know that I am engaged in breeding, so I also know a little about genetic technology. At present, the treatment of tumors in cutting-edge fields and tumor microscopy There are many environmental concepts. This time the discovery of Yulin protein was actually an unexpected result..."
Jiang Miao explained the source of Yulin protein slightly, and at the same time introduced to everyone that Hailufeng Company is currently undergoing clinical trials. Antibiotics: Anchor hydrochloride.
There are several reasons why it is called this name.
Hydrochloric acid represents the process. After this antibiotic is produced from bacterial extracts, it must be treated with hydrochloric acid to make the drug more stable and reduce some side effects.
The meaning of ankelin is that the antibiotic has the side effects of causing patients to drowsiness, and it can also target many more stubborn drug-resistant bacteria.
"Professor Jiang, hello, I am..." After introducing himself, a chief physician asked Jiang Miao: "I checked Professor Lin's paper some time ago. In the papers of her and her student He Youwei, When I arrived at a medical technology for the treatment of lupus erythematosus, I want to know what the current development prospects of this technology are? "
Jiang Miao directly replied: "My wife and students' research has actually completed the technical verification. Because that student himself is a patient with lupus erythematosus.”
"Has it been put into use?"
"Yes, Hailufeng Hospital is currently conducting clinical tests. A total of 50 patients have participated in the treatment, and the effect is still very good. These patients can live normally at present. , as long as you take special medicines daily and pay attention to your diet, you will generally not have recurrence." Hearing Jiang Miao's answer, the chief physicians in several related fields began to discuss in a low voice.
It was the chief physician I asked just now. She asked curiously: "Professor Jiang, I have read this medical technology and related papers. I am afraid it is necessary to prepare special medicines for patients. A big cost, right? "
"The cost in this aspect is the core of labor costs. Special drugs are common drugs, nutrients, and natural plant extracts. Our hospital has a special special drug configuration. In the laboratory, the ingredients of special medicines are generally determined, and the later stage is just configured according to this proportion. ”
Jiang Miao paused for a moment and continued: "In terms of charges, it takes about 20,000 to 30,000 yuan in the early stage of genetic testing and drug distribution, and the later stage of drugs costs about 300 to 400 yuan per month."
" After medical insurance? "
"We are a private hospital, and there is definitely no way to use medical insurance for this fee." Jiang Miao shook his head. "The cost of three or four hundred yuan per month is really not high when using this specially configured special medicine." A pharmacist said in a low voice.
After all, a pharmacist who specializes in drug configuration, plus various equipment, is a considerable expense.
Hailufeng Hospital gives such a low charging standard to benefit patients as much as possible.
After all, the core formula ingredients of these special medicines are common chemical drugs, nutrients, and plant extracts. These ingredients are relatively fixed types, but the proportion of the ingredients of special medicines is somewhat different.
No mistakes, one poem, one post, one content, one in 6, one book, one bar, one read!
In fact, the cost of the drug is only a few dollars. The core cost is labor cost. Each time the drug is dispensed, it requires at least two specialized pharmacists. With the ingredient testing, the cost of this part is about one hundred. RMB.
In addition to equipment depreciation, loss of drug reserves, site expenses and other expenses, a special medicine for treating lupus erythematosus has a gross profit of only about 30% to 40%.
This makes it relatively less profitable for the pharmaceutical industry.
After all, this kind of special medicine that cannot be produced on a large scale. It is necessary to use specialized drugs. The cost can be compressed to such a low level. Hailufeng Company has adopted various methods. If the model of other pharmaceutical companies is followed by other pharmaceutical companies, it is already a matter of use. , It is estimated that the monthly medical expenses will cost at least tens of thousands of yuan.
Only for drug ingredients testing alone, it costs several thousand yuan to start with a one-time fee in ordinary institutions.
According to the current experience of Hailufeng Hospital, a group of pharmacists can only provide medication to 384 patients every month, and on average, one patient's medication is given every half hour.
According to the per capita charging standard of about 350 yuan, monthly revenue is 134,400 yuan.
Two of the pharmacists' salaries plus other welfare expenses cost about 30,000 yuan per month, and the other costs are about 60,000 yuan.
After expanding the scope of treatment in the future, professional pharmacists may need hundreds of people.
After all, the number of potential patients with lupus erythematosus in China has reached millions. Even if one-tenth of the patients come to seek customization of special drugs, it is still at the level of 100,000.
If each patient receives three months of medicine every time, at least 30,000 patients will come to buy special medicines every month, which requires at least 172 medicines in the pharmaceutical dispensing laboratory. division.
Of course, in the later stage, Hailufeng Hospital will definitely introduce fully automatic dispensing and pharmaceutical equipment to reduce manpower expenditure in this regard.
The doctors present felt it was very troublesome to have this model in Hailufeng Hospital. After all, the one-person model is doomed to be difficult to suppress labor costs.
Jiang Miao briefly introduced how to determine the genetic targets of patients with lupus erythematosus. Especially when hearing that some confidentiality technologies are needed, many doctors know that this technology is probably difficult to promote on a large scale.
In fact, the previous one-person model, coupled with the need for a special pharmacist to dispense medicine, makes it difficult for many public hospitals to imitate.
Because in this case, the more patients the hospital needs to configure, the more pharmacists and professional testing equipment, as well as a large reserve of pharmaceutical raw materials.
In addition, it also requires professional genetic target analysts and drug treatment plans to adjust two or three months, which is too complicated.
If there are no large-scale patients, the costs of equipment, personnel, and raw materials cannot be covered.
However, if there are large-scale patients, various applications from public hospitals are more troublesome, especially those who need to increase their staffing, which generally will not come down so quickly.
So even if we want to promote the popularization of this treatment technology, it is probably not simply and roughly promoted to all hospitals.
Many doctors present thought of a cooperation model, that is, the Hailufeng Hospital provides technical services and pharmaceutical services, and the local hospital provides auxiliary work in the early stage.
For example, blood collection, testing, monitoring medication conditions, etc., these can be handed over to local hospitals. Hailufeng Hospital only needs to determine the patient's genetic target and special drug formula. Once the special drug formula is determined, then only You need to send medication to patients regularly.
On the Hailufeng Specialty Store APP, it has planned to add a drug exclusive mini program to customize drugs for patients.
As for the sale of this drug, it is definitely not that simple. Before obtaining a special license, it is estimated that patients can only come to Shanmei Hailufeng Hospital to buy it themselves, and there is no way to buy it online or mail it.
After all, these special drugs are difficult to apply for patents and drug marketing authorization one by one, and can only be supplied to patients in the form of special prescription drugs in the hospital.
Selling special medicines through APP must go through various strict approval procedures.
The management of drugs is very strict.
Patients who are far away can only wait until Hailufeng Hospital expands to the surrounding areas before they can obtain special medicines more conveniently.
At present, there are only two Hailufeng Hospitals, one is Shanmei Hailufeng Hospital and the other is Zhelimu Hailufeng Hospital. Other areas may need to wait for two or three years.
In fact, Hailufeng Company is also promoting the development of medical tourism, and has built several professional sanatoriums in various parts of Shantou and America, specializing in serving cancer patients and lupus erythematosus patients.
Although Yulin protein will definitely be launched on a large scale in the future, Jiang Miao is very clear that if Yulin protein wants to achieve the greatest therapeutic effect, it is best to use autologous tumor cells as bacterial culture medium to allow Yulin protein Specialized features specifically infecting the tumor cells.
The universal Yulin protein is only effective for most common tumor cells. Some tumor cells may be immune to the universal Yulin protein. At this time, a customized version of Yulin protein must be used.
To customize special Yulin protein, patients can only come to Hailufeng Hospital in person to receive live tumor cell extraction, and then allow the laboratory to undergo special cultivation.
This is a relatively suitable treatment plan for those relatively rare tumor types.
After all, there are some rare types of tumors, and there may be dozens of patients across the country. Pharmaceutical companies cannot open a production line for dozens of patients, and hospitals cannot purchase this kind of drug for reserve. They can only wait. After the patient came to treat, he found that the general Yulin protein was ineffective, so he recommended them to come to Hailufeng Hospital for customized drugs.
In fact, even if it is a general-purpose Yulin protein, ordinary hospitals will not make reserves.
As a special protein, this thing must be stored at low temperatures, and the storage time is only about three or four months.
The future treatment plan of each hospital is probably to first perform genetic testing of tumor cells on the patients, and then after confirming that the tumor cells have corresponding genetic targets, then purchase general-purpose Yulin protein from Xinkangle Pharmaceutical.
If the test results do not have a receptor target for the universal Yulin protein, then the patient can only be recommended to come to Hailufeng Hospital.
This is a more reasonable solution.
After all, small batches of customized Yulin proteins are used in laboratory production, and the cost of the medicines required by each person is about a few thousand yuan.
Add to other expenses, the total treatment cost of a single person can be reduced to less than 100,000 yuan, and the treatment time lasts one to two months.
Of course, this is just an early-stage cancer patient. If it is a late-stage cancer patient, the cost will definitely not be low.
Because patients with advanced cancer are not only a problem of eliminating cancer cells, but also associated with insufficiency of the organ.
For example, even if the cancer cells are eliminated, the lung tissue in the patient's body cannot recover. It may even cause complications such as pulmonary edema and pneumonia during the treatment process, which is likely to be inserted. Ventilator, even artificial lung lobes.
After the advanced stage, the patient's organ function is often irreversible, and it is really difficult to treat it at this time.
If possible, consider resection of the cancer-affected organ, then transplant the organ, and then perform cancer-killing treatment simultaneously.
However, the current rejection of allogeneic organ transplantation is very troublesome, and there are few donor organs suitable for transplantation. Unless the organ cloning technology is successful and the cloned organs are relatively cheap, the overall treatment cost for patients with advanced cancer will definitely be high.
Jiang Miao communicated with the doctors in the hospital for more than an hour and then took the initiative to say goodbye.
In the afternoon of that day, the group took the high-speed train to Gansu Province again.
At the same time.
In Minqin High-tech Industrial Park.
Many related companies are also studying the silicon bean silk that was produced on a small scale yesterday.
Some companies directly use silicone bean silk to weave, and then use silicone bean silk thread to weave it again to form various parts, and then use glue injection process to form special parts.
For example, Panshi Auto's Minqin Parts R&D Center will use silicone bean silk thread to weave the frame and shell, and then use special fireproof epoxy resin to inject glue, so the frame can be formed as one.
In order to reduce weight, the entire frame uses a very dense hollow and hollow design.
The freshly baked composite frame immediately carried out various impact, crushing, dropping and incineration tests.
Although the chassis material is mainly silicon bean silk, in order to enhance the overall fire resistance, researchers from the R&D center used silicon carbide tube doped with fireproof epoxy resin as the bottom layer material.
In the test site, even if the sponge shell is completely destroyed and these batteries are ignited, the flames still cannot burn the bottom plate of the chassis.
Silicon carbide tubes with a special braided structure have very good thermal conductivity, so a special fast heat dissipation box is set up in the upper part behind the chassis of the silicon carbide tube.
The fast radiator has components similar to air conditioning refrigerant, which can ensure that after combustion under the chassis, the temperature in the car can be maintained within a relatively stable limit.
In the test, all batteries burn to the maximum extent, and can also last for about fifteen minutes to keep the temperature in the car below 40 degrees Celsius, so as not to turn passengers into iron barbecue.
(This chapter ends)