Chapter 254 Beauty Scheme?
Because Zhang Yang is a technical R&D person, there is no pressure to discuss with Wei Tian, Dr. Zhou and many group leaders, nor does he have the rules and regulations of ordinary senior executives during meetings, and he is extremely efficient.
One hour later,
After intense discussion, the subsequent improvement plan for the combination of "Ibaimab" + "alloyellow T cells" was determined.
First of all, let me briefly talk about the causes of the side effects of bone marrow failure due to the combination of "Ibaimab" + "alloyellow T cells".
In fact, "Ibaimab" itself is a targeted drug for surface antigens.
Compared with common inhibitor/blocking targeting drugs such as "gleevec" and "tenofovir", surface antigen targeting drugs directly recognize cancer cells for killing. It has certain toxicity of the drug itself, so it is impossible to avoid some side effects.
Of course,
Through six or seven years of repeated experiments and thousands of animal experiments, Wei Tian, Dr. Zhou and others have controlled these side effects to a very small probability. Intra;
It can be said that even if long-term use causes severe side effects, such as bone marrow failure, the probability of severe side effects is extremely low.
And what about "aliosmotic T cell" injections?
"Allogenetic T cell" injection is actually a relatively safe and mainstream immune preparation. If it is very dangerous, it cannot be successfully marketed through supervision.
It is currently mainly used in CAT-T cell therapy in clinical practice. To put it bluntly, it mainly treats some cancer patients.
The principle is probably to inject "alloy T cells" into the body of cancer patients, or directly inject them into tumor tissues. Through the emergence of "alloy T cells", the immune system in the patient can be activated to produce emergency responses, forcing the patient to have The immune cells in the patient's body begin to work, thus achieving the effect of eliminating some cancer cells.
This method can also have certain effects on cancer patients, and the side effects are not very obvious.
But the bad thing is that although most cancer patients have cancer, they have not undergone organ transplantation, and there is no long-term acute rejection in the body!
The vast majority of patients with leukemia have undergone bone marrow transplant surgery, and there are allogeneic bone marrow stem cells in the body, and they are even in chronic rejection.
The emergence of "alloy T cells" will undoubtedly accelerate the rejection rate of leukemia patients, triggering the immune system to attack bone marrow stem cells with normal hematopoietic functions, and eventually causing failure.
In addition, the "Ibaimab" I just mentioned is also toxic. Under multiple BUFF, the side effects of the combination treatment plan are obviously several times beyond the normal range!
Dr. Zhou and others finally finalized the plan:
Since the purpose of injecting "alogeneic T cell" injections is to allow patients to experience acute rejection, thereby increasing the metabolism rate of immune cells in the body.
So, can we directly skip the step of acute rejection and directly control the immune cell pathway through drugs to convey the instructions to speed up metabolism?
In this way, the immune system in the body will not be activated, and there will be no acute rejection reaction, and T cells will not attack the transplanted bone marrow stem cells.
And immune cells should also be able to generate a large amount of TEF glycoprotein after accelerating their metabolism, thereby enhancing the therapeutic effect of "Ibaizumab"!
It can be said that this method bypasses the acute rejection reaction and reaches its goal, and the side effects are nothing more than that the patient feels hungry faster.
But this is obviously not a side effect.
Zhang Yang was also quite looking forward to this preliminary plan. After putting forward some suggestions, one of the focus of the next work of the first project team was determined:
Find immune cells to improve metabolism velocity target pathway, thus developing a drug to replace the current "allogeneic T cell" injection.
After doing this, Zhang Yang finally returned to the office with satisfaction.
At this time, Ren Xiaomin in the office had left, and was empty. He looked through the window at the city with tall buildings not far away, and Zhang Yang couldn't help but breathe a sigh of relief.
The biggest side effect of the combination treatment of "Ibaimab" is solved by ITG myelopoietin, and the future improvement plan has also been determined. Next, with the current basic treatment effect of "Ibaimab" of up to 83%, as long as there is no particularly significant Side effects, it is not difficult to pass the clinical trial smoothly.
It can be said that the matter about "Yibaizumab" has basically come to an end in a short period of time.
Of course, "Ibaimab" failed to completely cure acute myeloid leukemia in the end, but its appearance can at least give more leukemia patients new choices.
Especially those patients who relapse after bone marrow transplantation like Xia Xue, and those who have become resistant to chemotherapy drugs and can only wait to die!
For them, Yibaizumab is their only hope!
Although "Yibaizumab" cannot completely cure the leukemia cancer cells in their bodies, it can at least maintain a longer life cycle normally.
Ten years, or even twenty years are possible!
As for the resistance of "Ibaimab"...
This is the top advantage of cellular antigen-type targeted drugs. Since it adopts a violent method of direct antigen killing, It is not easy to have any immune escape or genetic mutations!
Once the patient persists for ten years...
After ten years, can Qingshan Pharmaceutical still develop drugs that can completely cure acute leukemia? !
Zhang Yang couldn't help but smile. With more and more patient data, as "Yibaizumab" is more used in clinical practice in the future, he is confident that he can completely overcome it in the next ten years. Acute leukemia. "Come on, Zhang Yang!" Thinking of this, Zhang Yang's heart also ignited a strong sense of accomplishment and mission.
But at this moment, a low knock on the door suddenly rang out from the closed office door. Zhang Yang said with a big smile: "Please come in."
Assistant Xiao Chen walked in , holding a bouquet of flowers in his hand.
"Mr. Zhang, a running errand just now gave me a bouquet of flowers and said it was for you."
"Take it for me?"
< br>
Zhang Yang was in a good mood, and he hadn't received any flowers for a long time. He walked over quickly after curiously.
But just picked up the message card on the flowers and looked at it, and his face suddenly became a little strange. "It turned out to be her?" Xiao Chen naturally didn't know who gave it to him. After delivering the flowers to Zhang Yang, he left the office very tactfully.
As soon as the office door was closed, a crisp ringtone of the cell phone suddenly rang.
Zhang Yang took out his cell phone and couldn't help but smile at the call number in front of him.
It came quite fast! "Hey, hello."
A sweet but elegant voice came from the other end of the phone.
"Hello, Mr. Zhang, I am Minako. Do you still remember me?"
"Of course I remember, Miss Minako, what's wrong?"
"Thank you for remembering me. I finally felt relieved when I heard your relaxed tone... Mr. Zhang, I ordered a bouquet of flowers for you. Have you received it? "
Zhang Yang lowered his head and sniffed the flowers in his hand, and said with a smile: "Thank you, I received it."
"But I'm not very I like white roses, I prefer sunflowers and orchids…”
"Ah! Is this true? Mr. Zhang, then I'll order you a bunch again."
"No need."
When Minak heard the other end of the phone, she was panicked and wanted to give it to her. Order a bouquet of flowers by himself, and Zhang Yang hurriedly stopped him: "I just said casually, thank you for your flowers, I am still very satisfied." "That's good." Minako felt relieved. The earth breathed a sigh of relief, and after a moment, her sweet and elegant voice came from the phone again.
"Minako is really happy to get your likes."
"Yesterday I saw a lot of bad news about Qingshan Pharmaceutical on the Internet, and I was worried that you would be in a mood. No, so I specially sent you a bouquet of flowers, hoping that you can smile happily after receiving it. "
"I didn't expect that Minako still underestimated your freedom and freedom. In your eyes, such a thing may be It's really not worth mentioning!"
I have to say that Zhang Yang is surrounded by straight men like Wei Tian, Dr. Zhou, and Ren Xiaomin. Even Wei Tian just flatters occasionally. Minako speaks respectfully, and her words are full of concern and praise.
Zhang Yang knew that Minako was pleasing herself and flattering her, but this did not affect the sound of these words.
"Haha, it's not as free and easy as you said."
"I have read some comments on the Internet, and I'll be angry with the comments of many netizens!"
"Is this true?"
Minako's tone was a little surprised, and she immediately received:
"Since that's the case, Minako wants to invite you to have dinner together, okay?"
No mistakes, one song, one content, one book, one bar, one bar, one bar, one bar!
"Dinner? Tonight?"
"Well, I'm going to tell you, after seeing the comments on the Internet that criticized Qingshan Pharmaceutical and you, I took a special leave today to fly from the Magic City. Come here, now you are almost downstairs of your company! "
Zhang Yang was slightly stunned. He didn't expect that Minako not only gave her flowers, but also took the initiative to fly from the Magic City to Rongcheng.
But soon he realized that Minako chose this time node well.
Many netizens on the Internet are slandering Qingshan Pharmaceutical. Normally, they will definitely not be in a good mood. Minako appears to comfort herself at this time, and her favorability will definitely increase greatly.
Humans are often strange animals. Even though Zhang Yang knew that Minako had a purpose to please him like this, he couldn't help but feel a little strange at this time. "Mr. Zhang, do you think it's OK?"
When he said this, Zhang Yang had no choice but to refuse.
"Okay, it's all right tonight, so let's have a meal together."
"That's great. I'll be at your company in five minutes... Can I come to your office? "
"Yes." Minako was very punctual. Five minutes later, she was tall and beautiful like a star and walked into the office.
"Mr. Zhang, I'm very happy to see you again."
"Sit down, Miss Minako, you are more beautiful than last time."
This is the second time Zhang Yang saw Minako, and his eyes couldn't help but look at it again.
Compared to wearing traditional workplace clothes for the first time, Minako's clothes were obviously more fashionable this time. She was wearing a slim-fitting dress that outlined her graceful figure, and the irregular tailoring design at the hem of the skirt , adding a bit of elegance and sexy.
Paired with a pair of black thin-belt high heels, revealing a small piece of white calves, which looks seductive and elegant, with a bit of a devilish and angel-like feeling.
"Thank you for your compliment. It seems that you like Minako to wear a little more elegantly...Minako remembers it!"
"..."
Zhang Yang couldn't help but sigh in his heart. He had to say that it felt so good to be held by someone.
Ten minutes later, he finished processing some emergency documents. Seeing that it was six o'clock in the afternoon, he immediately called Minako to leave. "Let's go, I'm done with it. Do you have anything to eat?" "Mr. Zhang, I promised that I'll invite you. I've looked at a traditional Chinese restaurant. Their dishes are pretty good. Do you think it's appropriate? ”
"Yes." Zhang Yang was not confused, and soon the two drove to the traditional Chinese restaurant in the city center.
It was meal time, and the hall was filled with people and full of seats. It was obvious that the business was very booming.
The two of them came to the private room that had been booked in advance. After sitting down, Zhang Yang suddenly felt that the atmosphere in the private room was suddenly a bit charming.
In particular, Minako's body emitted a faint fragrance, and the chest of her dress was faintly visible, which made him feel a little distracted.
Coughed lightly, and quickly changed his attention: "Minako, did you say you are a mixed Chinese and Japanese race? Is your father Chinese or his mother Chinese?" Zhang Yang poured a cup of tea, smiled slightly, and replied: "Mr. Zhang, my father is Chinese, my mother is Japanese, I was born in Japan, so I am Japanese nationality."
< br>"But when I was ten years old, I was brought to China by my father and lived in China for nearly ten years, so... I have a little understanding of both Japanese culture and Chinese culture."
"Oh."
Zhang Yang nodded slightly:
"Then how did you join Novartis?"
When talking about Novartis, a faint pride appeared on Minako's face. .
"I went to the United States to study after I was eighteen years old. Later, I received my master's degree in molecular biology from the University of Pennsylvania, and later I received Novartis' office."
Zhang Yang was stunned. Unexpectedly, Minako in front of him was actually a master's degree in biology at one of the Ivy League universities in the United States.
"You are so awesome. It is not easy to get a master's degree in biology from the University of Pennsylvania."
Hearing Zhang Yang's praise, Minako smiled brightly:
"With you It's far worse than me! You are my idol!" As he said that, Minako picked up the teacup and walked to Zhang Yang. The distance between the two was only less than ten centimeters.
Zhang Yang could even clearly see the tender pores on Minako's fair neck and his bulging breasts were about to touch him.
"Mr. Zhang, I'll give you a cup."
Zhang Yang smiled slightly and did not refuse.
After a moment, he smiled and said, "Call the waiter to serve the food and chat while eating."
(This chapter ends)