Chapter 15: Easy to catch
It is difficult for Lin Jia to imagine Chen Yuanguang’s brain circuit and his mental state when he made this decision.
Chen Yuanguang said lightly: "Yes, the Science Fiction World official account I followed at the time pushed me the news about this Science Fiction Rising Star Competition. I clicked in and took a look. It said that the final jury invited the Nobel Prize in Chemistry Award winner Levitt Michael came to participate.
I thought that no matter what happened, I could win a bronze medal. As long as I had the chance to meet Levitt Michael, I would have the confidence to ask him to write me a recommendation. Letter."
Lin Jia said helplessly: "Yuan Guang, your mind is really big. Normal people can't imagine that they don't have this ability.
Not only could you imagine it, but you could actually turn it into reality. Not only did you win an award, but you also received a gold medal.
I am about to completely upgrade the image of you in my mind. From now on, your prefix will be omnipotent hahaha. "Lin Jia is very happy, because Chen Yuanguang's progress is so smooth, which means that the probability of applying to Americen University has greatly increased.
She knows very well that with the endorsement of the Nobel Prize winner, her application at Americen University How powerful is it?
To put it bluntly, it is equivalent to a Nobel Prize winner using his reputation to guarantee that you can do a good job
Witte will join Fudan in September this year, founding the Institute of Multiscale Research on Complex Systems and serving as the honorary dean. He helped write very few letters of recommendation while teaching at Fudan
Because the news of winning the award spread quickly, especially within Jiangda, Lin Jia, former roommates, counselors, etc. almost took turns calling him to congratulate him.
Chen Yuanguang was thinking that it would be great if AI could simulate his voice to help him answer such calls. This feature of future mobile phones is already very mature, but it is not very useful.
Because there will be no harassing phone calls in the future, the relationship between people will be atomized to the extreme. This type of AI anti-phone harassment function is a product of the times. It is available but of little use.
"Hello Mr. Levitt, I am the gold medal winner of this science fiction rising star competition and also a fan of yours."
The Goose Factory arranged for him to stay in Levitt's hotel conference room When they met, in addition to the two of them, they were also accompanied by Guo Wei. Levitt smiled and shook hands with Chen Yuanguang and said: "Hello, I also like your work very much. It is very interesting.
There are many interesting predictions about the future. "
Chen Yuanguang said: "This is probably because I am more concerned about science and cutting-edge technology, so I can make some interesting achievements.
Sir, I am meeting you this time mainly because I have a paper that I want you to correct. I have constructed a computer simulation method to simulate the directed evolution of proteins.
This method only needs to use the physical and chemical characteristics and sequence information of the protein to achieve the simulation of protein directed evolution.
The research object I chose is the protein DHR8. Through computer simulation, it has evolved to have the ability to bind DNA or RNA.
Before simulating evolution, I first constructed an evaluation library containing 30 pentapeptide repeat proteins based on sequence diversity and nucleic acid binding.
The pentapeptide repeat protein is a proven RNA-binding protein. Its binding site is clear and has been systematically characterized.
In this way, every PPR in my evaluation library will have two clear binding sites. We center each binding site and use a short sequence of 13 amino acids in length as an evaluation window. , in this case it will have a total of 60 evaluation windows.
For each short sequence in the evaluation window, we use 544 indicators describing the physical and chemical properties of amino acids in the existing database to represent amino acids. Therefore, the amino acid at each position will be a 544×1 matrix, thirteen such matrices are combined to represent a peptide sequence of length 13. For a 544×13 matrix of an evaluation window, I optimized the K-means++ algorithm, and then used the optimized algorithm for clustering to cluster the 544 row vectors into 50 categories. In terms of visualization, each category represents A waveform, for each class, we can use the arithmetic mean of each column of the subset of matrices contained in that class to generate the signature waveform of that class. ”
After Chen Yuanguang handed the printed paper to Levitt, he briefly introduced his ideas.
An important direction of Levitt's work includes protein simulation, predicting protein structure through computational analysis of protein sequences, focusing on homology modeling.
The paper written by Chen Yuanguang is highly consistent with his direction, and the ideas and algorithm optimization embodied are of very high value.
Levitt was a little disapproving at first, because he knew that the other party was still a senior, and he felt that the paper the other party presented was just a paper written to find a topic, and at best it was a good summary review.
As a result, I didn’t expect that it would be a big move as soon as it started. Whether it was the calculation rules of the design or the optimization of the classic clustering algorithm K-means++, it was full of thinking.
"Great work." Levit commented, and then discussed with Chen Yuanguang some details in the paper.
And Guo Wei fell into a state of doubting life, who am I and where am I?
Guo Wei joined Goose Factory in 2013 and became the senior manager of Goose Factory Video in 5 years. He also graduated from a prestigious school. Because he often needs to go abroad to do copyright operations, his English has not fallen behind. It’s not like that The theoretical ones who passed CET-4 and CET-6 may not speak well, but they can still have direct conversations in English.
He only saw that the nice meeting between Chen Yuanguang and Levitt was over. Chen Yuanguang handed Levitt a stack of paper, and then he could not understand the conversation at all. There were a lot of professional vocabulary, and he was confused. I can't even guess what it means.
Guo Wei thought to himself, are all young people today so fierce?
"Yes, that's right. There is a reserved region to prevent the internal helical hydrogen bond interaction points of DHR8 from being destroyed and to avoid damaging the repeated protein structural motifs. This design is correct. Such simulations can both The real situation can also limit the mutation to a certain range. ”
“A great idea. Constantly simulate randomly, then select the one with the smallest difference as the best match, and then compare it with the waveform to calculate the fit. "Excellence."
Levitt greatly praised Chen Yuanguang's paper. Originally, Levitt had reserved fifteen minutes for this conversation, but now that we have talked for more than two hours, he is still a little reluctant to leave.
"Yuan Guang, there is only one thing missing from your paper, and that is experiments to verify your theory, and use your simulation method to transform DRH8 into a short peptide that can bind nucleic acids.
Yes. This paper can be published in Nature, or it can be published without it, but it may only be published in sub-journals,” Levitt said.
Chen Yuanguang replied: "I have an idea. I will apply to the school later and improve it."
Because there was no laboratory for him to use before, Chen Yuanguang's paper was completely computational simulation and lacked experimentation. inspection part.
Levitt asked: "Did you complete this paper alone or jointly with others?"
Levitt knew the main contribution of this paper just from the communication between the two parties. The author must be Chen Yuanguang, because he explained the ideas and design very clearly.
Chen Yuanguang said: "I am alone."
Levitt said: "Then when the time comes to publish it in Nature, if you don't mind, you can give me a second author, so that it will definitely be published in Nature."
(End of Chapter)