Chapter 669 Cross-blood type heart transplant
Yang Ping sent his wife to the gate of Sanbo Hospital, and then drove to Nandu Affiliated One.
He was already very familiar with Annex 1. When he arrived at Annex 1, he parked his car and called Professor Yao. Professor Yao immediately went downstairs to greet Yang Ping.
The Organ Transplantation Center at the First Affiliated Hospital of Nandu enjoys a high reputation in China because of Professor Yao's ischemia-free transplantation technology.
Professor Yao took Yang Ping to the doctor's office. The doctors here were not very familiar with Yang Ping. Unlike the orthopedics department, almost everyone knew Professor Yang.
"This is Professor Yang from Sanbo Hospital!" Professor Yao introduced Yang Ping to several chief physicians in the department.
The chief doctors just nodded symbolically. They had never seen such a young professor before, so he must not be a big figure.
Professor Yao asked the doctor in charge to bring the medical records. Yang Ping read the medical records in detail, not missing a word.
Xu Jiujiang, male, 45 years old, diagnosed: dilated cardiomyopathy.
Starting from 3 years ago, Mr. Xu would experience palpitations, shortness of breath, and hypoxia as long as he did a little exercise. He was diagnosed with dilated cardiomyopathy by a local university-affiliated hospital. He underwent standardized anti-heart failure treatment at the hospital. After 3 years of treatment, his condition has not improved. 4 months ago, Mr. Xu's condition began to worsen, with frequent episodes of chest tightness, palpitations, shortness of breath, and dizziness. He was unable to lie down or eat.
This made Mr. Xu feel deeply desperate. He knew that his time was short, but his child was still in high school, so Mr. Xu was unwilling to give in.
In order to seek a chance of survival, Mr. Xu made inquiries and came to Nandu Affiliated One to find Professor Yao. Professor Yao conducted a series of examinations on him.
Among them, cardiac color ultrasound showed that the diameter of the left ventricle has expanded to 76 mm, while the left ventricle of a normal person is about 45 mm, and the volume of the heart is more than 2 times larger than that of a normal person. The heart function is very poor, and the left ventricular ejection fraction has dropped to 28 %, while for normal people it is at least 50%. This kind of heart is already in danger.
After being hospitalized in the First Affiliated Hospital of Nandu, Professor Yao actively treated him with anti-heart failure. However, Mr. Xu had fluctuations in the systemic circulation and internal environment disorders, and required the use of dopamine and norepinephrine to maintain blood pressure.
In order to alleviate the condition and give Mr. Xu a chance to wait for a heartbeat, Professor Yao installed an intra-aortic balloon counterpulsation device to assist the left ventricle.
Yang Ping already understood the basic condition of Mr. Xu, and now he is more familiar with it again.
"There is only one chance for a heart transplant, so please come over and discuss it together. I once performed a heart transplant with different blood types. It was a donor with type O blood transplanted to a patient with type A blood, because type O blood is "compatible" with type A. Blood, coupled with the use of new drugs, the risk of rejection is relatively controllable, so we dared to try it at that time. Now this patient has type B blood, and the possible donor is type A blood, which is a completely incompatible blood type. In heart transplantation We dare not try it.”
"If you are a young child, the body's immune system is not yet complete, you can try a cross-blood type transplant, which may "cheat" the immune system, but for adults, whose immune system is intact, there is no way to try."
Professor Yao was very polite and shared his difficulties and worries.
At present, if the cross-blood type transplantation method of kidney transplantation is applied to heart transplantation, it still seems a bit crude and inappropriate.
Yang Ping admired Professor Yao quite a lot. His ischemia-free transplantation technology was world-class, but it took some time to perfect. He just pushed it and accelerated it. Unexpectedly, Professor Yao was not only not angry, but also respected him so much. Put yourself in a position to learn.
Professor Yao really has a great demeanor, and Yang Ping decided to transfer some of his experience to Professor Yao without reservation.
ABO blood type is the basic principle for organ transplant matching. If the blood types are incompatible, the transplant recipient will have a strong immune rejection reaction after surgery.
If a cross-blood type transplant is to be performed, either the antibodies must be thoroughly washed away or the immune system must be strongly suppressed. This can ensure that strong immune rejection does not occur and allows the transplanted organ to get along well with the human body and integrate into the human family. Several chief doctors around him didn't understand why Professor Yao respected this young man so much.
Yang Ping thought for a moment and said:
"Professor Yao, in fact, this case still requires the use of blood washing methods, but a more advanced blood washing method is needed. There is currently a new method. The research team at the University of Toronto in Canada uses two enzymes, FpGalNAcdeacetylase and FpGalactosaminidase, and supporting technologies to clean blood types. Antibodies can completely cleanse the AB blood type antibodies and transform the organ into a universal donor. It is recommended to use this technology. ”
Ordinary blood-washing technology can no longer complete such a difficult blood-washing process, so new technologies can only be used.
"I have also read this paper, but it is still an experimental technology. I don't know whether the technology is mature, and it is impossible to obtain this set of enzymes and related technologies." Professor Yao was quite embarrassed.
It is not practical to use this cutting-edge technology. If nothing else, getting this set of enzymes is a problem.
"Now there are only two ways for this patient to be saved. One way is to get a heart donor with matching blood type, and the other way is to get a method like the University of Toronto. Which one do you think is more likely? The former depends entirely on luck. You have to have The luck of winning the five million lottery, and the latter can be achieved through hard work. If Professor Yao is willing to give it a try, I can help contact the team at the University of Toronto and invite you to Professor Li Zehui of the Cleveland Medical Center, and his senior brother Dodge, both of the North American Heart Institute The giant in surgery can help contact the University of Toronto." Yang Ping suggested that Professor Yao give it a try.
Yang Ping had calculated that if this patient did not undergo a heart transplant, he would have no chance.
Of course, there is another way to perform artificial heart transplantation, gain buffer time, and then wait for a heart transplant. However, the cost of an artificial heart suitable for this patient is not affordable by ordinary people. Likewise, even if you wait, you still have no chance of getting a heart of the same blood type.
Professor Yao pondered for a moment and decided to listen to Yang Ping's words and give it a try.
"Then you have to trouble Professor Yang to help me contact the team at the University of Toronto?"
Since he lent a machine to perform surgery on Yang Ping and got to know Yang Ping, Professor Yao found that he seemed to be leaning against a big tree.
"Okay, I'll send you an email later and take the time to fly over and learn their technology. In fact, I'm also familiar with their technology, but you need to get two of their blood-washing enzymes. If It takes a long time to prepare these types of blood-washing enzymes. ”
Yang Ping's words reassured Professor Yao that he was not recommending new technologies to him based on a paper.
Yang Ping is indeed very familiar with this new technology.
Because in the system space, when Yang Ping reads papers, whenever he sees new results that he is interested in, he will find a way to do experiments in the system laboratory.
The several chief doctors standing nearby and listening to Yang Ping and Professor Yao discuss the condition were like listening to a book from heaven.
As for the University of Toronto team, just contact him if you ask him to. Also, Li Zehui from Cleveland and the Dodgers seem to be his close brothers. It seems that if he sends an email, others will definitely help him.
And when he said this, he seemed very domineering.
Professor Yao was very excited to be able to learn the latest AB antibody washing technology from the University of Toronto and get two of the most advanced enzymes.
Based on this alone, I can take several steps forward in the field of organ transplantation.
(End of chapter)