Chapter 1001 The blind man touches the elephant
Yang Ping has a rough understanding of the whole process, but from a rational and objective point of view, this is far from making a definite judgment on Guan Ruyan. Next, he has to wait for the defense meeting arranged by Principal Rao, so that Guan Ruyan can judge him alone. When you have a face-to-face defense on several key topics and papers, it will be clear at a glance what your level is, because in a real defense meeting, no one can cheat, unless the experts participating in the defense are cheating or the experts themselves are very good.
Lu Xiaolu was indeed a rare talent. It was a pity to let him go in vain. Yang Ping decided to find a way to keep him. In fact, he was also a victim.
The defense meeting proposed by President Rao will start soon. Outstanding young candidates from the entire Nandu Medical University system must participate in the defense meeting, and all questions in the defense meeting must be answered by the project leader himself. Assistants cannot be used to replace him, even if reminded. Principal Rao said that the purpose of this is to allow the defense experts to truly understand the content of the topic. Assistants often do not have as deep a understanding as the leader, so this lazy behavior of letting assistants answer for them should be avoided.
This notice made Guan Ruyan anxious. Lu Xiaolu had not yet recovered. He had already explained to Guan Ruyan that he had suffered from diarrhea and dehydration for several days and that his body really couldn't handle it and needed to take a good rest.
Guan Ruyan is the ant in the hot pot now. If this defense meeting is carried out according to Principal Rao's requirements, the assistant will not be able to help at all. Even if Lu Xiaolu is brought to the defense meeting, Lu Xiaolu cannot answer on his behalf. At most, Lu Xiaolu Help pass the note or something, but in this situation, there is no way to accept the note while standing on the stage.
It would be a good idea to put on headphones so that Lu Xiaolu can help remind him, but then Lu Xiaolu will probably only be in the audience with people everywhere around him. There is also no way to transmit the answer to his ears, so now Guan Ruyan There was no way at all. He didn't know what Principal Rao meant by doing this.
All Outstanding Youth candidates must participate and defend their past major scientific research achievements. It seems that it is not targeted at Guan Ruyan alone. I heard that this was proposed by Academician Xiang. He has mentioned it several times, but Principal Rao has never agreed. But this time Principal Rao agreed.
After Yang Ping talked to Lu Xiaolu, he decided to talk to Guan Ruyan again, so Principal Rao arranged for Yang Ping to visit Guan Ruyan's laboratory, and Principal Rao personally ordered Guan Ruyan to receive him personally.
Guan Ruyan's head was getting big now. He called Lu Xiaolu and asked Lu Xiaolu to come quickly to deal with Professor Yang's visit. However, Lu Xiaolu said that he couldn't stand upright now, so how could he go to deal with the visit? There was really no way. Weakhearted.
After Yang Ping visited Guan Ruyan's laboratory and came back, he was almost 100% sure that Guan Ruyan's famous scientific research results could not have been made by himself. In fact, to be at the top of the scientific research pyramid, the research scope is very narrow and very deep. You can't get it by reading a few books or studying a few papers. You must have a very deep understanding of this major.
So taking the opportunity of the visit, Yang Ping communicated with Guan Ruyan about his research field. Guan Ruyan was indeed good, but he was only slightly better than an ordinary professor, and it was far from matching his current scientific research results.
Lu Xiaolu is just the opposite. He has a very deep understanding of this major. Lu Xiaolu is the real young talent.
Now Yang Ping is in a very difficult situation. If he attacks Guan Ruyan now, it will hurt Lu Xiaolu's heart. Yang Ping still wants to keep Lu Xiaolu. Besides, without Lu Xiaolu's help, it is really difficult to determine the situation about Guan Ruyan.
At the home of Academician Xiang Lao, President Rao, Yang Ping and Academician Xiang met again to exchange information about this matter to discuss what to do next. In any case, this matter must not be determined until it is truly determined. Publicity can only be limited to a small area of three people.
Yang Ping expressed his intention to keep Lu Xiaolu to Principal Rao. Principal Rao told Yang Ping not to waste time on this matter. Leave it to him to handle. He knows how to handle it. At the same time, he will keep Lu Xiaolu.
Since Principal Rao agreed, it meant that he must have a way. Yang Ping didn't want to waste time on this. His project was at a critical period, and there was no room for distraction, and there was no need to be distracted.
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Fu Xiaotao's Castleman disease is being treated. The reexamination results after his treatment with cetuximab have come out. Yang Ping has been paying attention to this case. Judging from the reexamination indicators, the drug has no effect at all. After glucocorticoid treatment, It had already entered the remission period after treatment, but now various indicators have begun to deteriorate again. It seems that a large amount of hormones are still needed to control symptoms. "Cetuximab is useless?" Song Zimo was very confused.
''This time the oncology department used hormones again to no avail, and the disease was stabilized only by chemotherapy. "Yang Ping said, staring at the medical records on the computer.
"From the perspective of the pathogenesis, isn't interleukin 6 the culprit? If so, theoretically speaking, cetuximab should be able to control the disease, but why has it no effect at all?" Song Zimo was also puzzled and immediately became interested in this case. interested.
Yang Ping leaned back in his chair and thought for a moment and said: "Either there is a problem with the medicine, or there is a problem with the disease model. There is always a problem with one of them, because the theory is useless in the face of real cases, then there must be something wrong with the theory."
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Questioning is the basis of progress. Nothing cannot be questioned, so even things that have been recognized need to be questioned. The naked fact is here, drugs are useless.
"But cetuximab is very effective in other diseases based on interleukin 6, and a large number of reliable documents can prove it." Song Zimo continued to ask.
Yang Ping just reviewed a lot of literature: "So I am thinking that the pathogenesis of Castleman's disease must be wrong. The root cause is not interleukin-6. I have read all the papers on Castleman's disease, and they almost all Like a blind man touching an elephant, everyone only sees one side of the disease, no one sees the whole picture, and they each think they are right.”
''Find a student to go to the oncology department and bring over all of Fu Xiaotao's examination materials, including those from other hospitals. "Yang Ping feels that he must spend some energy on this disease because he has seen doubts. If he does not figure it out, it will obviously not be in line with his personality.
Song Zimo sent his students to the Department of Oncology to get all of Fu Xiaotao's examination data. Fortunately, all of Fu Xiaotao's examination data were well preserved. He copied all the medical records every time he was hospitalized.
Yang Ping looked at the information one by one, and then connected all the information as a whole, abandoning the inherent thinking in his mind. In fact, from the onset of the disease, almost every doctor was very serious and tried their best to do their best from their own point of view. In an attempt to uncover the true nature of the disease, he has thoroughly perfected his examinations. He has done several puncture examinations of lymph nodes and various blood tests.
In order to better access the medical records, Yang Ping took everyone to the conference room and placed these examinations one by one on the conference table. Because the conference table was relatively large, only it could place so many examination sheets.
"But the changes in various indicators I just saw are indeed consistent with the disease model of interleukin 6?" Song Zimo thinks there is no problem with the disease model.
Yang Ping lowered his head and constantly adjusted the examination list: "That's because you only see the examination results of each disease. You touch the part of the elephant. If you pull the field of view higher, from the first Don’t miss every item on the checklist until you see it, and you will find something different. You see, half a year before the symptoms appear for the second time, the T cells in the body have begun to activate abnormally, and after the second recurrence. In the past three months, the level of vascular endothelial growth factor in his body has increased, which is a signal that the immune system is speeding up. Does this mean that the entire chain of disease is completely different from the recognized interleukin-6?"