Chapter 1003 The life-saving medicine is at hand
Although Fu Xiaotao's mother always had an unfriendly expression on her face, Yang Ping didn't care about this at all and did not spend any extra energy to pay attention to this issue. If it were another doctor, he would definitely pay attention to the attitude of the family members. If the family members objected Opinion or distrust, treatment will be withheld unless it is life-saving emergency treatment.
Not long after Yang Ping left the medical oncology department, a doctor sent Fu Xiaotao an informed consent document about scientific research treatment for him to sign. Of course, when signing, Fu Xiaotao had to argue with his mother, because her mother believed that experimental treatment meant using her son as a guinea pig. If signing is equivalent to selling his son's health to the hospital and Professor Yang, this is absolutely unacceptable.
His father's opinion was exactly the opposite. He believed that since traditional treatment methods have been confirmed to be ineffective, why not try new methods? This way, there is at least a glimmer of hope. Fu Xiaotao's illness went to so many hospitals without a correct diagnosis. He quickly recovered here. As far as obtaining a diagnosis through pathological examination, there is every reason to believe in the doctor's ability.
The two-to-one duel advantage allowed Fu Xiaotao to successfully complete the signature. In fact, it was not that Fu Xiaotao disrespected his mother's opinions, but that her opinions were often based on biased subjective judgments and had no reference at all. She even asked to take Fu Xiaotao to see her. A master, Fu Xiaotao, did not go, so my mother went alone and spent 60,000 yuan to buy back a pillow to cure illnesses.
The money was spent and the pillow was bought, but it did not have the desired effect. In the end, he was sent to the hospital for life-saving treatment.
At this critical moment of life and death, Fu Xiaotao still had his own opinions. He signed the informed consent form for participating in the experiment and was successfully transferred to the Institute of Surgery. At the Institute of Surgery, Fu Xiaotao drew a lot of blood and performed some things that he had never done before. Examinations. Many examinations are not routine hospital examinations at all, but biochemical examinations that study various pathways of the human immune system.
These examinations simply cannot be completed in other hospitals, and these hospitals would never even think of doing these examinations, because Sanbo Hospital has several powerful basic medical laboratories, so it has the ability to conduct such examinations.
A few days later, all of Fu Xiaotao's test results came out. Yang Ping went to the laboratory to see the results in person, and Tang Shun pulled up the research results from the computer: "From these biochemical analyses, the key to the disease should be the mTOR signaling pathway. ”
Tang Shun is not a clinician. He is good at basic medical research. For a doctor who is proficient in basic medicine, it is obviously very easy to use these tests to find what signaling pathways are, because these tasks are routine for them, and for them For clinicians, research on signaling pathways is a highly sophisticated technology that is rarely involved. Even some clinical medicine experts who are good at scientific research seriously lack complete biochemical knowledge. This is the gap between professions.
Yang Ping carefully analyzed each test result, and everything was so obvious. Indeed, the key to the problem has been found, which is the mTOR signaling pathway. If the mTOR signaling pathway can be blocked, can the disease be cured? In theory, this must be the case.
This bold idea made Yang Ping very excited. He had found a new idea for Castleman's disease. Whether it would work or not still needs to be tested in practice.
Tang Shun is now in a dilemma: "But what drug should be used to block the mTOR signaling pathway?"
"Sirolimus for anti-rejection after kidney transplantation!" Song Zimo blurted out, because this is a very familiar drug to clinicians.
If sirolimus is used to block the mTOR signaling pathway to treat Castleman's disease, there is no need for any approval operation at all, because sirolimus is not a new drug and it should have been used in clinical practice for a long time. It has been used in the treatment of kidney transplantation. Rejection treatment uses it to block the mTOR signaling pathway.
"Should we stop the chemotherapy and give him sirolimus?" Song Zimo also became excited. No doctor would not be excited at this time.
Yang Ping said decisively: "Stop all chemotherapy, stop hormone treatment, only use sirolimus treatment, start immediately."
Without the combination of rich basic medical knowledge and clinical medical knowledge, it is impossible to overturn the recognized pathogenesis model of interleukin 6. This shows the importance of comprehensively mastering relevant knowledge in the medical field, because without comprehensive knowledge, doctors will always be trapped in themselves. of expertise in a cocoon. The gap between basic medicine and clinical medicine is very huge. When clinicians encounter problems in clinical practice, the basic medical research methods they can use are very limited, let alone those high-precision methods, and basic medicine does not know the specifics of clinical medicine at all. No matter what problem they face, a very small number of doctors who can straddle two fields can easily make amazing academic achievements. For example, a professor in the Department of Anesthesiology in West China used his pharmacological knowledge and clinical knowledge to develop a new of local anesthetics.
Back in the ward, Yang Ping talked to Fu Xiaotao again. The conversation was held in the interview room instead of the ward, so as to avoid unnecessary interference.
"We found new pathogenesis of Castleman's disease and new therapeutic drugs. Fortunately, the new drugs are actually mature drugs that have been used for many years, but they have never been used to treat Castleman's disease. Judging from its performance in the anti-rejection reaction after kidney transplantation, it should be effective for your disease because it targets the same mechanism." Yang Ping introduced his findings to Fu Xiaotao. listen.
Song Zimo also made some additions: "We plan to start new treatment for you as soon as possible, and all previous chemotherapy, hormones, etc. will be stopped."
Although Fu Xiaotao has read a lot of information about Castleman's disease, he is still a layman compared to doctors, so he said without hesitation: "Everything is in line with your treatment plan, and if you want to sign, I can sign it at any time. ”
"Sirolimus!" Fu Xiaotao suddenly remembered something.
"Yes! Sirolimus!" Yang Ping was very sure.
Fu Xiaotao remembered: "I was once hospitalized and the patient in the next bed was a patient after kidney transplantation. He had been taking simolox. I thought he was so familiar." It turned out that the life-saving medicine was right next to him. He was once so close.
Since Fu Xiaotao was so cooperative, the next treatment was very easy to handle. Everything was progressed according to the new plan. On that day, Fu Xiaotao stopped using chemotherapy drugs and started taking sirolimus. Time waits for no one. Fu Xiaotao's condition does not have much time to wait. .
News came out from Nandu Medical University that Principal Ding was admitted to the ICU of Nandu Affiliated One due to illness. This is sometimes the case with some brain cancers. When there are no symptoms, they are like normal people, but once symptoms appear, they will die immediately or be in critical condition. .
What happened to Principal Ding was a bit sudden. Lu Xiaolu really regarded Principal Ding as a father. When he heard that Principal Ding suddenly fell ill and was admitted to the ICU, he kept waiting outside the ICU, and then kept contacting Yang Ping and asked Yang Ping to help. Let’s see if Principal Ding can be saved.
Another brainstem tumor!
Yang Ping didn't know that this was the first brainstem tumor he had encountered. Perhaps it was because this kind of surgery was too difficult and risky. There were not many doctors for patients to find and not many hospitals to go to, so this was the reason. a convergence effect.
There is absolutely nothing that can be done about this kind of brainstem tumor in the First Affiliated Hospital of Nandu. Apart from Sanbo Hospital, only Tiantan Hospital has the capability to operate on it.
Not long after Lu Xiaolu sent Principal Ding's CT scan, Yang Ping received a call from his father-in-law, Professor Su, inviting him for an emergency consultation. The person being consulted was none other than Principal Ding. Just after hanging up the phone, I received another call from Principal Rao, talking about Principal Ding's condition.
Principal Ding has actually made a lot of contributions to the school, and his academic achievements are also very fruitful. Unfortunately, he loves his daughter so much that he is overly helpful to his son-in-law. After he learned about his illness, he was still accelerating. Paving the way for the future of his daughter and son-in-law.
PS: This case comes from a true story: In the United States, a medical student suffered from Castleman's disease. It was incurable at the time and was thought to live for less than two years. However, the medical student refused to accept his fate and decided to save himself. While suffering from the disease and dying several times, he devoted a lot of energy to researching the disease. Through extensive research, he overturned the pathogenesis of interleukin 6 and believed that the real mechanism was the mTOR signaling pathway. He firmly believed in his judgment and stopped After chemotherapy, he started taking sirolimus. Half a year, one year, and two years later, his Castleman disease was cured and has never relapsed since. He went from a dying, haggard patient to a vigorous, healthy patient. Healthy Castleman disease experts - the world's top experts. This is an inspirational self-help story of perseverance and defiance of authority.