Chapter 1032 Will it rust?
On the second day after the operation, Brian's drainage tube and urinary catheter were removed and he began to get out of bed with his waistline. He was very satisfied with the results of the operation.
Some researchers in the laboratory often come over to chat with Brian when they have time. Of course, the topic of these people's chats is still academic. Anyway, just a few casual conversations can get into academic topics. In particular, Lu Xiaolu was originally a rare genius, his understanding far exceeded that of ordinary people. After many communications with a master like Brian who stood at the forefront of academic circles, he benefited a lot and many problems were solved easily.
In terms of tumor research, Yang Ping's current idea is to use M13 phage as a carrier to carry K factor that can kill tumor cells into the human body, and then carry out selective affinity to tumor cells, thereby killing tumor cells. This kind of The idea is very good, but the actual implementation is very difficult.
Among them, embedding K factor into M13 phage is a difficult problem, and secondly, making this complex have selective affinity for tumor cells is another problem.
The system space can only provide time, space and materials, but cannot provide ideas for solving problems, so Yang Ping has to think about how to solve the problem himself. Yang Ping put forward the idea, and now many specific technologies are needed to realize this idea.
In terms of immunology, especially research on tumor immunology, Brian can be said to be the most advanced in the world, and some of his specific experimental methods can be used for reference.
Tolerance is a big thing, and this is the attitude of academics.
Brian's post-operative MRI photos were hung on the electronic reading screen. Although the metal implants interfered with the images to a certain extent, the details of the surgical area could still be seen clearly. The prolapsed nucleus pulposus of the huge intervertebral disc has been removed, and the compression of the nerves has naturally been relieved. The lumbar spondylolisthesis has been reduced, and the lumbar 4 and 5 vertebrae are firmly fixed by pedicle screws. In the future, the lumbar 4 and lumbar 5 vertebrae will fuse together, and the two fractures will become one bone, and this segment will gain lasting stability. Of course, you also lose your own mobility at this stage, but there are five lumbar vertebrae, and losing the mobility of one segment will not cause much loss to the mobility of the entire lumbar spine. It has almost no impact on the elderly, but it still has an impact on young people, who have higher requirements for waist activities.
"Professor, if there is no lumbar instability and it is just a simple lumbar intervertebral herniation, should we choose a combination of disc removal + intervertebral bone grafting and fusion + pedicle screw internal fixation?"
< br>
"Yes, many young and middle-aged people nowadays only have lumbar disc herniation. Can we just do disc removal?"
The students surrounding him raised their doubts.
"If the patient is a young or middle-aged patient and there is no lumbar segmental instability, then this combination of surgery should not be selected and only lumbar disc removal should be performed. Now a large number of samples show that the effect of only lumbar disc removal is very good." Yang Ping explained to everyone.
Brian was wearing a waistband and a walker next to him. In fact, he could walk by himself, but he just asked the escort to follow him with the walker. If he got tired, he could use the handrail of the walker to rest for a while.
Brian didn't know how to read MRI films, but Maninstein had shown him several times, and he understood a little bit, but he couldn't tell anything else. He could understand at least two things. First, the huge nucleus pulposus was a black thing on the MRI film, but now it has disappeared. Second, the front and rear edges of the two vertebrae were originally staggered, but now they are in line. It is obvious that the correct position has been restored.
Curiosity makes Brian have some random thoughts. In fact, the interlacing of lines is more prominent in English-speaking countries than in China. In the Chinese-speaking world, as long as you know the characters, you can understand a little bit of other professional books, at most some professional terms. I don’t understand the meaning, but I can still understand the basic content of the expression.
But in the English-speaking world, as long as you jump to a major that you have no contact with at all, even a professor as big as Brian can't understand anything. This kind of incomprehension means that you really can't understand, not at all, and all you see is letter.
This is like beef, dog meat, and pork. In Chinese, even if you know it, at least you know it is meat or animal meat. In the English-speaking world, your whole brain will be blank about what it is. Therefore, it is not surprising that many senior intellectuals in the English-speaking world do not know how to say cuboid and do not know what it is when they see the word cuboid. "If I bend down, will these metal screws break inside my body?" Brian was worried about this.
Yang Ping told him: "It is possible, but it may be slim."
"What if the fault is inside?" Academic people like to get to the bottom of things.
"The duty of these metal fixations is temporary fixation, that is, before the two vertebrae grow together, the stress is shared by the metal internal fixation. Once the vertebrae grow together, its duty has been completed. Therefore, this problem is divided into two In this case, if the screws break after the vertebrae are fused, the screws can be taken out. If the vertebrae have not been fused, the only option is to have another surgery to replace the broken internal fixation with a new one and re-fix it. "Yang Ping satisfied his curiosity.
"If the screw is broken inside the vertebrae, as if it is buried inside, how do you remove it?"
It seems that Brian took this issue as a serious academic issue.
It is also a good way to let everyone see how a Nobel Prize winner thinks about problems, and at the same time let everyone know that no professor is an authority. They are all human beings and must have their own cognitive limitations. There is no authority in the eyes of real scientific researchers. , must have the awareness and ability to question.
Yang Ping pointed at the internal fixation on the screen with the pencil's eraser end: "If it's broken inside the vertebrae, there's no need to remove it at all, just leave it in. But if you want to take it out, it's not impossible, it's just a little more troublesome. It's okay. This is necessary.”
"If metal stays in the body for a long time, will the released metal ions enter the blood? And then spread around the human body? Will it not affect physical health?"
The more Brian asked, the more curious he became, and he was already immersed in this kind of thinking.
Yang Ping told him slowly: "The question you asked is very meaningful. This is also the biggest potential risk of metal-on-metal artificial hip joints at present. A large amount of metal ions enter the human blood, which has unknown potential risks, such as causing cancer. But This exists in metal-on-metal artificial hip joints, because the friction between metal and metal will cause a large amount of metal debris to fall off, and a large amount of metal ions to enter the bloodstream. However, the situation you are worried about about the broken screws in the vertebrae just mentioned does not exist. The metal left in the vertebrae has no friction and is surrounded by bone. It can be considered as an inactive piece of metal. There is no large amount of metal ions entering the blood, so it can remain in the body for life. "
Brian was thoughtful, as if he didn't understand.
This was all common sense to a spine surgeon, but to Brian, he felt it was a momentous discovery.
This is not surprising, because this knowledge is in his blind spot. No matter how he thinks, he lacks corresponding thinking content. Without strong content to support, his thinking will appear pale and feeble.
"Will it rust? Or will it react chemically with ions in the surrounding bone tissue? If a chemical reaction occurs, can it be controlled?"
Brian touched his chin and raised the question seriously.