Chapter 137 This medicine has some effect (please subscribe!)
Dr. William was one of the doctors who participated in the "Kidney Disease Summit" and was quite familiar with Qingshan Pharmaceutical's "Kidney Toxin Clear Dialysis Replacement Injection".
So, when Novartis contacted the Mayo Clinic to prepare for a clinical trial, he noticed the "dialysis needle" immediately and proactively started recommending it to patients.
Seeing Professor Stephen's slightly surprised expression, he nodded and explained:
"The efficiency of Qingshan Pharmaceutical is indeed surprising, but I think this is mainly due to this 'dialysis' Acupuncture is not only undergoing clinical trials in our country, but also in India. ”
"The number of samples and clinical data they will get will be very large, which will undoubtedly provide them with a lot of data for reference."
Professor Stephen recovered and breathed a sigh of relief:
"I am doing it too. Although I am not in the field of biopharmaceutical research, a large amount of data will indeed have a positive impact on the research and development process..."
"I can understand!"
"That's good."< br>
Dr. William smiled slightly:
"Then do you want to try this 'kidney toxin clearing dialysis needle'?"
"Now that the effective toxin removal rate reaches 70%, because it is 'instant Due to the elimination mechanism, the toxins remaining in the body after 12 hours are even less than dialysis; comprehensive calculation , the toxin residue in the patient's body within 48 hours is only a little more than dialysis..."
"It can be said that the risk is much smaller than before."
"You don't want to experience urination again. Don’t you want to go to watch football games and travel again? ”
"Try the 'Kidney Toxin Clearing Dialysis Needle', it will definitely meet your needs."
Stephen's heart was moved,
for the first time, his eyes fell on Qingshan Pharmaceutical's "Kidney Injection" "Duqing Dialysis Needle" brochure.
As a university professor, Dr. William needless to say, he quickly realized the advantages of the "Kidney Tox Clear Dialysis Needle" compared to dialysis.
Although the effective clearance rate of 70% is lower than that of dialysis, it is better than "instant clearance" and can replace dialysis with just one injection!
After just a minute, he showed a bitter look on his face:
"Dr. William, I believe you, so I will try it reluctantly. You must know that this is the first time I have used drugs from China. It is also the first time to conduct a clinical trial.”
“I hope my choice is not wrong. , it can bring me a better life.”
“Haha, don’t worry, there is a lot of clinical data that has proven that it can work!”
from the University of Minnesota’s semiconductor major. Professor Stephen became one of the Phase II clinical subjects of the "Shenduqing Replacement Injection".
In fact, people like Professor Stephen are not alone.
In the United States, influenced by liberalism and multiculturalism, Americans advocate freedom more and prefer to travel and take risks. However, dialysis has completely turned them into "puppet people" and left them completely tied up. Set on the dialysis machine.
So,
Even though Novartis stated at the beginning that the "Kidney Toxic Clear Dialysis Injection" was a drug from China Qingshan Pharmaceuticals, there are still countless American dialysis patients who "reluctantly ” accepted.
Novartis clinical phase II recruitment is progressing smoothly,
On the other side of the ocean, the Phase I and II clinical trials led by GlaxoSmithKline in India also passed quickly, and recruitment for Phase III clinical trials has now begun.
At eight o'clock in the morning, Lucas arrived at the clinical trial base in Delhi, India. At this time, there were dozens of patients waiting in line outside the base.
There have been rumors circulating on the Chinese Internet that India has achieved nationwide free medical care.
Indeed, taking dialysis as an example, Indian officials implemented a plan called the "National Dialysis Plan" in the early years. According to this plan, patients at the poverty line and below can apply for dialysis for free.
The specific requirements are that the annual income is less than 100,000 rupees (about 8,500 yuan), and the annual pension is less than 300,000 rupees. As long as you meet the conditions, you can apply for free dialysis at an officially designated specialist hospital.
However, there are still many problems.
For example, there is a plan, but there are not many specialized hospitals, and the dialysis equipment and dialysis conditions in the hospitals are relatively low, which will greatly affect the quality of dialysis.
In addition, it is more expensive for patients who do not meet the requirements for free dialysis to undergo dialysis.
When GlaxoSmithKline launched a clinical trial of the "Kidney Clear Dialysis Injection" in India, there was an endless stream of dialysis patients willing to participate because the drug and weekly dialysis were provided free of charge.
Looking at the long queue of Indians waiting to register for Phase III clinical trials outside the window, the assistant smiled slightly:
"President Lucas, it seems that it won't be long before we can recruit enough subjects. I have to say that India is the fastest recruiting place for patients."
"If it were placed in our country, 450 It takes at least one year to recruit people for the third phase of clinical trials.”
Lucas also smiled. What the assistant did not say was:
In India, not only are there a large number of patients, but the recruitment speed is also fast. Recruitment fees are also pleasantly low.
450 subjects only need 15,000 rupees each to grab their heads, which works out to less than $180 per person.
Compared with the thousands of dollars per person in the mainland, this is simply a cabbage price.
"David, I see that many of the people below are very skinny. You will make arrangements later so that everyone can receive a bottle of milk and a piece of bread each time they are tested to avoid any accidents due to low blood sugar."
“President Lucas, you are such a kind person "
......
Clinical trials of the "Kidney Toxin Clearing Dialysis Injection" in the United States and India are proceeding in an orderly manner, especially after Qingshan Pharmaceutical continues to improve the toxin removal rate to 70%. , attracting the attention of more dialysis patients and even the medical community.
Gradually, more and more reports about "Kidney Toxin Clearing Dialysis Needle" appeared in relevant journals, magazines and self-media.
The news finally spread back to China.
When Qingshan Pharmaceutical first went overseas for clinical trials of the "Kidney Toxin Clearing Dialysis Needle", it briefly disclosed the therapeutic effects and functions on its official website, and domestic patients were quite looking forward to it.
Unexpectedly, there was no clinical trial news from Qingshan Pharmaceutical in one month, two months, and three months.
I originally thought that this "Kidney Toxin Clearing Dialysis Needle" encountered some problems and was delayed in starting clinical trials in China. It was only when the news came back to China that I suddenly realized it.
Good guy, it’s not that Tsingshan Pharmaceutical’s “Kidney Toxin Clearing Replacement Injection” has not undergone clinical trials, but it has gone overseas and been tested overseas first!
Excessive!
"Is it too unkind to say that Qingshan Pharmaceutical is testing such a good drug overseas first? It is not tested in China? It's too much!"
"That's right, it's just that. Bolt from the blue! I can still tolerate it in the United States. The most annoying thing is that there are clinical trials in India but not in our country? Not even as good as Third Brother? ”
“...I have been waiting for this medicine for a long time! I saw that many people on the Internet said that the "Kidney Toxin Clearing Dialysis Injection" is very effective. I can resume urinating immediately after the injection. I am so envious! Mr. Zhang, please start clinical trials in China as soon as possible!”
"Hey, this reminds me that Huawei's Meta series was always the first to be sold overseas. From a business perspective, the overseas prices of Tsingshan Pharmaceutical's drugs are indeed much higher than those in China, and the profits are also greater. It is understandable that they attach importance to overseas markets. ……
Looks like It should be ready to be launched overseas first, and then slowly launched in China..."
"I feel so sad, I want to cry! Qingshan Pharmaceutical has gradually changed, eh"
When the news spread back to China, it immediately aroused discussion among a small number of dialysis patients.
However, due to the good reputation of Tsingshan Pharmaceutical and the clobazam incident some time ago, everyone is completely convinced of Tsingshan Pharmaceutical. The vast majority of patients still believe that Tsingshan Pharmaceutical will not treat patients for purely commercial interests. Domestic patients are treated differently.
"I think Tsingshan Pharmaceutical should have its own considerations. Don't be too anxious. I suggest you wait and see!"
"Yes, so many drugs developed by Tsingshan Pharmaceutical have always been the first in the market. This is the first time a clinical trial has been carried out in China. Although I don’t know the specific reason, I still believe in Tsingshan Pharmaceutical and their decision-making. ! ”
“I also believe in Qingshan Pharmaceutical and Mr. Zhang. If it doesn’t work, we can ask on Qingshan Pharmaceutical’s Weibo. I heard that Qingshan Pharmaceutical’s official Weibo will answer all questions.”
“Okay, this is a good idea!”
Like many companies, Qingshan Pharmaceutical’s external publicity windows are Weibo and Douyin in addition to its own official website. The person in charge of Qingshan Pharmaceutical's Weibo is a post-2000 girl from the Information Department. After noticing that many patients left messages on Weibo, she immediately came to the office and reported the problem to Zhang Yang.
“Why not conduct clinical trials in China?”
Looking at the questions raised by patients on Weibo, Zhang Yang really couldn’t laugh or cry.
When I worked so hard to allow the "Kidney Toxin Clearing Dialysis Injection" to be the first to be clinically tested overseas, wasn't it because I was worried that domestic patients would suffer organ damage due to side effects?
How do you answer now?
It cannot be said that 60% of the previous "kidney poison clearing dialysis needles" may cause irreversible damage to the human body, so we should be the first to conduct trials overseas and let the United States and Indians test the poison first, right?
But looking at the dozens of comments, he also knew that it would be impossible not to reply.
After thinking for a moment, he slowly said:
"Well, to reply to our patient friends, Qingshan Pharmaceutical has not forgotten domestic patients. The main reason for not conducting clinical trials in China at this stage is' Shenduqing replacement injection is still in the research and development stage, and there is still room for improvement in its toxin removal effect!"
"After the drug matures in the next few months, clinical trials will be arranged in China as soon as possible. Please Please be patient. ”
Qingshan Pharmaceutical's timely reply barely calmed the patients' doubts, and Zhang Yang couldn't help but think about whether to start a domestic clinical trial of the "Kidney Toxin Clearing Dialysis Injection" now.
After thinking about it, I decided to wait for the approval of the second clinical phase in the United States. After Shenduqing is upgraded to 80% complete product, the third phase clinical trial will be started directly in China. The time will not be much different.
Just as Zhang Yang was preparing to upgrade "Shenduqing" to a complete product, the "catalyst" drug that had attracted Wei Tian's attention to BI Company had also officially started its first clinical phase.
BI Company is Germany's top renal drug research and development company. The "catalyst" that impressed Zhang Yang at the "Kidney Summit" was mainly used to improve the toxin filtration rate of dialysis machines.
The reason for Zhang Yang's concern was that he suddenly thought about whether this drug could be used in conjunction with Qingshan Pharmaceutical's "Kidney Toxin Clearing Dialysis Injection" to increase the toxin removal rate.
Now this "catalyst" is officially named "BI-Toxin Filtration Catalyst" after the first clinical phase.
Zhang Yang immediately told Wei Tian to pay close attention to its Phase I clinical data. If it can increase the toxin clearance rate by more than 7% as Hans of BI Company said, he would like to discuss cooperation with BI Company.
Of course, there is no rush to do this. We have to wait until the first round of clinical phase 1 data from BI Company is released before we can get a rough idea.
While Zhang Yang was dealing with these trivial matters, on the other side of the ocean, the second clinical phase of the "Kidney Clear Dialysis Replacement Injection" recruited by Novartis was completed.
March 16,
Professor Stephen received accurate notification that he had successfully enrolled in the group and would officially start injecting the first injection of "Kidney Clear Dialysis Injection" two days later.
March 18, 9:30 am.
Professor Stephen arrived at the Mayo Clinic Medical Clinical Trial Center on time, and his attending physician William was already waiting for him here.
"Professor Stephen, don't be stressed, believe me this is definitely a good experiment."
"I hope so, I have read a lot of reports about Huaxia Qingshan Pharmaceutical in the past few days. , I really hope they can be as good as they are in the field of blood diseases.”
"No problem. Don't worry, Professor. It's your turn. Go to the second window. I wish you good luck."
"I'll lend you some good words."
Professor Stephen, hurry up Walking to the second window that William said, there was a black female nurse.
"Mr. Stephen Howard?"
"Yes, here are my medical records and clinical trial registration card."
"Okay, wait a minute."
The black female nurse quickly confirmed Stephen's identity and then returned all the information to the professor.
"Okay, Mr. Stephen, your identity has been confirmed."
As she spoke, the female nurse's tone became formal and serious:
"Then I will give you the answer again now. Please confirm once that you are currently participating in the Phase II clinical trial of the 'Shenduqing Dialysis Replacement Injection' developed by Huaxia Qingshan Pharmaceutical Company and conducted on behalf of Novartis. Are you sure to participate? ”
< br>
Stephen paused for two seconds and nodded:
"I'm sure."
"Okay, then I will tell you the entire clinical trial process in detail."
"I will then give you the first injection of 'Nephrotoxic Clear Dialysis Replacement Injection' via intravenous injection, which will last about two days. You will have a urination reaction after an hour. "
"At that time, you will feel a slight pain in your urinary system, that is, below your lower abdomen, but don't be afraid, this is the drug ingredient restarting your kidneys. , and tells the urinary system that it is about to start working again.”
"You cannot leave the hospital within these two hours. You need to put all your first urine into this bottle and bring it back to me."
"I will also give you post-medication at that time. It’s my first time to draw blood, do you understand?”
Stephen looked at the disposable urinal in front of him and pouted, obviously not expecting it to be so troublesome.
“Okay, I got it, I’ll get it back on time.”
“Okay, great!”
The black female nurse smiled, showing her white teeth.
But as soon as she finished speaking, she immediately took out two larger disposable urine containers under Professor Stephen's surprised eyes.
“Of these two containers, the larger one is used to hold all the urine from today; while the other smaller one is used to hold all the urine from tomorrow. Remember, it’s all.”
Professor Stephen suddenly shook his head and complained:
“Why is it so troublesome...”
"How can you call it a clinical trial if it's not troublesome?"
The black female nurse shrugged.
“By the way, you must remember to pack all urine separately. This is very important clinical data and will be very helpful for subsequent improvement of drug ingredients!”
“Waiting for you. After collecting the urine and bringing it over on the third morning, I will inject you with the second injection of medicine, do you understand?"
Stephen nodded unhappily.
Seeing Stephen's expression like this, the black female nurse could understand and said with a smile:
"Don't worry, the requirements will be more in the first two weeks, and then in the third, fourth and even the following weeks. You only need to collect clinical data once a week in the second and third months!”
“Okay, now I will give you the first injection, Mr. Stephen.”
Professor Stephen suddenly became energetic and stretched out his right arm.
One minute later,
About 20ML of transparent and colorless medicine was slowly injected into the body through the veins on the arm, and Stephen did not feel any discomfort.
Ten minutes later,
He began to feel a slight chill in his body.
About an hour and forty minutes later, he suddenly felt a slight swelling and pain in his lower abdomen, and then, the urge to urinate that had not been felt for half a year suddenly came to his brain.
Although he had been prepared in his heart, when the moment actually came, he couldn't help but get goosebumps all over his body.
After more than half a year, the dormant kidneys actually started to urinate again!
Hiss!
This medicine has some effect!
(End of this chapter)