Chapter 160 The simulator finally "woke up"
"Is it similar to male sperm activity?"
"You mean the sAC male contraceptive pill?"
Ren Xiaomin I quickly realized that the only product that can be related to male sperm is the sAC male contraceptive pill! ‘’
But, this is a birth control pill!
Zhang Yang also saw Ren Xiaomin's confusion and explained:
"The full name of our 'sAC male contraceptive pill' is 'soluble adenylate cyclase sAC inhibitor', which is essentially an inhibitor. Inhibiting the 'cyclase sAC' that provides sperm activity in the epididymis to achieve contraceptive purposes."
"So I was thinking, if the 'cyclase sAC' is increased. Can the content of male epididymis increase sperm activity? ”
“Of course, the global medical community does not have much research information on the specific causes and specific treatment options for asthenozoospermia, and we do not. We can only explore step by step."
As he spoke, Zhang Yang handed another more detailed information to Ren Xiaomin and continued:
"In addition, I also want to conduct drug research on teratozoospermia."
"Currently, the medical community believes that there are many and complex reasons for the high rate of male sperm abnormalities, such as prostatitis and seminal vesiculitis. Varicocele, even smoking, drinking, and staying up late and sitting for long periods of time can lead to a high rate of deformity.”
“These reasons can be slightly improved by quitting smoking and drinking, and improving your work and rest, but after reading a lot of research information. , found that There is a common reason that has not been studied in depth in the medical community. "
"It is well known that the sperm production process is regulated by a variety of hormones, such as follicle-stimulating hormone (FSH) and luteinizing hormone (LH). and testosterone, etc. ”
“These hormones are regulated by the hypothalamic-pituitary-gonadal axis and control the rate and quality of sperm production. It can be said that they are the most important part of the sperm production process!
If there is a problem with any link in this regulatory system, it will inevitably affect sperm production and cause a high deformity rate.
I even think that part of the cause of azoospermia is problems with the endocrine system that produces sperm. "
"However, there is currently no in-depth and reliable research in the medical community at home and abroad. "
Hearing the end, Ren Xiaomin couldn't help but frowned. Zhang Yang mentioned too many knowledge points in one breath.
He slowly flipped through the information in his hand and gradually understood Following Zhang Yang’s idea.
There are probably two reasons for male sperm abnormalities and reduced activity: one is abnormalities during sperm production;
the other is that the produced sperm are originally fine, but when stored in the epididymis, Various reasons lead to reduced activity and sperm not moving.
Zhang Yang not only wants to increase sperm activity by increasing sAC cyclase in the male epididymis, but also wants to solve the problem of abnormal sperm production from the source.
But!
This is a huge project. Just thinking about it makes me think that the things involved are too complicated.
After thinking for a moment, he rubbed his temples and said:
"Zhang Yang, I am not opposed to establishing research on this kind of drug to improve male sperm. After all, there are indeed more and more infertile men around the world. There will be more in the future;”
“From a business perspective, this is called a promising future. Bright."
"But what should I say? From your simple introduction, I can feel the difficulty of research and development. I am afraid that the research and development results will not be achieved in a short time."
“Even, we have to be prepared to fail after investing a lot of resources.”
Zhang Yang suddenly fell silent.
Indeed.
Although infertility has only experienced explosive growth in the past decade, there are currently almost no drugs on the market to treat male sperm, and there are not even pharmaceutical companies that have set up projects to develop related drugs.
On the one hand, although there are many infertile couples, they still have IVF as a solution. Most couples can still get pregnant through IVF.
On the other hand, as Ren Xiaomin said, there are too many contents involved in male sperm production and storage, and it is too complicated.
To be honest, he didn't understand.
After a while, Zhang Yang took a deep breath and shook his head:
“Brother Ren, I can understand your worries, but it’s just like the medical V who spread rumors about us on Weibo said Likewise, infertility has been a big deal in our traditional concepts since ancient times.”
“We now have sAC inhibitors as a breakthrough, and the market prospects are also good. Even if there are difficulties in research and development, I think we can still try it.”
Hearing this, Ren Xiaomin knew that Zhang Yang was determined. He didn't try to persuade her any more, but finally expressed his opinion.
"Zhang Yang, I think it is too difficult to develop asthenozoospermia and teratozoospermia or azoospermia together."
"It is better to study them separately. Asthenozoospermia (activity) uses sAC cyclase as a breakthrough ; Teratozoospermia uses endocrine hormones as a breakthrough, so the two projects are developed separately as two drugs. I think the chance of success is much higher."
Zhang Yang nodded:
"I think so too."
The exchange between Zhang Yang and Ren Xiaomin ended quickly. "Soluble adenylyl cyclase sAC" was the research idea, and drugs for asthenozoospermia were identified.
The other one focuses on the study of male hormones such as follicle-stimulating hormone (FSH), luteinizing hormone (LH) and testosterone. Drugs for teratozoospermia and azoospermia have also been determined simultaneously.
The two drugs were quickly assigned to Qingshan Pharmaceutical Drug Research and Development Center.
The first drug "sAC cyclase active agent" was naturally assigned to the first project team with experience in sAC cyclase research and development.
However, the second drug involving hormones ran into a little trouble.
As we all know, the development of unknown drugs without clear targets is the most difficult.
Take hepatitis B virus, for example. Although hepatitis B virus is relatively stubborn, the R&D personnel also have a clear goal, clear ideas and direction.
Another example is kidney disease. Although it cannot be cured, scientific researchers all know that glomeruli are damaged. The solution is to find ways to prevent glomerular damage and protect glomeruli.
But male sperm is produced in the testicles and is affected by a variety of male hormones, chromosomal screening, and a three-month production cycle.
It can be said that if there is a problem in any of these links, it will It may cause sperm abnormalities or even azoospermia.
To find out the specific reasons and then pinpoint them to a specific target such as protein synthase, this requires a large number of repeated experiments and long-term continuous observation and research.
If you think about it for a moment, you will know that the amount of work is huge, and it will definitely not be completed in three to five years.
So after the project was announced, the leaders of several project teams were not very interested in it. In addition, they already had project research and development projects in their hands, and no one was willing to take over this hot potato.
Zhang Yang can understand.
At this moment, Wei Tian stepped forward and was willing to take over the research and development of this project.
Zhang Yang was quite pleased, but after thinking about it he finally refused. He decided to lead the research and development team himself. After all, Wei Tian, as the head of the drug research and development center, is very busy with his work. In addition, he has other drug research and development projects in hand, which makes it almost impossible to take care of it.
As for this hormone drug to treat teratozoospermia, there is no need to worry too much. The current research and development focus of high hopes is also set on "sAC cyclase activator".
In this case, it is better to take charge of the research and development of this drug by myself, and just take it slowly in three to five years.
Thinking of this, Zhang Yang couldn't help but sigh.
None of the various drugs previously launched by Qingshan Pharmaceutical, such as "ITG human myelopoietin" and "Kidney Toxic Clear Dialysis Injection", are as good as this endocrine drug for "sperm malformation" Simple.
I didn't feel much at first, but now that I think about it, I realize how difficult it is to develop these drugs.
“Simulator, when can you start it again.”
Just when Zhang Yang was sighing and sighing about the simulator, the article on Weibo criticizing Qingshan Pharmaceutical was really like The same thing as what Ren Xiaomin said began to slowly spread on the Internet.
Many netizens were convinced by the article’s views and agreed that Tsingshan Pharmaceuticals did not need to develop any male contraceptive pills. It would be better to invest more energy in developing infertility drugs.
It must be said that this situation would never happen to any domestic pharmaceutical company!
Just kidding, what drugs an independent biopharmaceutical company develops is its own business, what does it have to do with netizens?
But this is Qingshan Pharmaceutical!
The reputation and influence of Qingshan Pharmaceutical in China are too great.
"ITG human myelopoietin" that cured 4 million aplastic anemia;
"Icofenprofovir" that cured 120 million hepatitis B patients and troubled a generation;
As well as the chronic kidney disease drug "Kidney Clear Dialysis Replacement Injection" with an audience of 100 million people, and so on!
It can be said that
Every drug of Qingshan Pharmaceutical has brought rebirth and hope to countless patients!
But at the same time, patients suffering from other diseases have unparalleled expectations for Qingshan Pharmaceuticals.
Many patients have left messages hoping that Qingshan Pharmaceutical can develop drugs to cure liver cancer and lung cancer, but after all, they are only a handful.
But this time, under the Weibo article, there are more and more such voices.
Besides, the tree is big and attracts the wind.
The strong rise of Tsingshan Pharmaceutical in recent days has also made many pharmaceutical companies more and more difficult. Many people are eager for Tsingshan Pharmaceutical to fall into a crisis of public opinion.
After the two factors were superimposed, there was more and more public opinion on Tsingshan Pharmaceutical on the Internet, and the public opinion of Tsingshan Pharmaceutical seemed to be passive.
Zhang Yang saw this and frowned, but finally decided to ignore it.
Although the Qingshan Pharmaceutical R&D Center has already established a project to develop "sAC cyclase activator", the results cannot be obtained in a day or two, and there is no telling whether there will be any final results.
Besides.
If there is even a little bit of public opinion on the Internet, I will have to respond to the development of a new drug. When netizens make even more extreme demands, will I still have to agree to them all?
Impossible!
It is impossible for Qingshan Pharmaceutical to accept Internet coercion.
But what Zhang Yang didn't expect was that his silence did not cool down the public opinion on the Internet, but intensified it.
In a beautiful room in Shanghai, Weibo celebrity Liu Zhiyuan looked at the various comments with a smile on his face, hoping that Qingshan Pharmaceutical would develop infertility drugs.
Half a month ago, he received a new task from his MCN company. He was expected to criticize and smear Qingshan Pharmaceutical’s birth control pills from the perspective of a medical doctor, thereby affecting its sales.
At the same time, I also hope that he will try his best to influence Qingshan Pharmaceutical on public opinion.
After thinking about it, he finally came up with a perfect solution, which was to connect Tsingshan Pharmaceutical’s “sAC male contraceptive” with infertility drugs, thus causing Tsingshan Pharmaceutical to fall into a whirlpool of public opinion.
So far it looks pretty good.
Not only did he think it was good, but even the sponsor behind it was quite surprised by the good results. Just ten days later, Liu Zhiyuan received another notification from the sponsor’s father.
This time they did not continue to ask Liu Zhiyuan to attack Tsingshan Pharmaceutical's "sAC male contraceptive pill", but asked...
"Continue to incite netizens on the Internet to hope that Tsingshan Pharmaceutical will develop Infertility drugs have plunged him into a whirlpool of public opinion, making it difficult for him to get out of trouble."
As soon as the new task was issued, Liu Zhiyuan quickly understood the thoughts of the financial backers.
This is a determined attempt to lead Qingshan Pharmaceutical into a trap!
He even guessed that the money behind it was either a contraceptive pill manufacturer or a condom manufacturer. In short, it must be in direct conflict with Qingshan Pharmaceutical's "sAC male contraceptive pill".
Looking at the domestic market, the domestic contraceptive pill market is very small, and it is almost impossible to spend so much effort targeting Qingshan Pharmaceutical.
On the contrary, China is the world’s largest condom market!
So...
He almost guessed who the financial backer was.
However, he doesn't care, as long as he pays, he is willing to act as a pirate.
Soon,
driven by Liu Zhiyuan and more trolls, there were more and more public opinions about Tsingshan Pharmaceuticals on the Internet, and some reporters even called Qingshan Pharmaceuticals The headquarters asked if there were any plans to develop “infertility drugs”.
Zhang Yang has been investing in the research and development of drugs for "teratozoospermia" during this period. He originally didn't want to pay attention to it, but gradually, some staff began to reflect that it was almost impossible to promote "sAC male contraceptive pills" on the Internet. "Yes!"
Almost all the promotional screens have voices like "Stop using birth control pills and recommend developing infertility drugs!"
This kind of comment looks like trolls at first glance, but it does greatly reduce the promotional effect of Qingshan Pharmaceutical’s “sAC male contraceptive pill”.
"sAC male contraceptive pill" seems to be tied to infertility drugs.
Zhang Yang is not very concerned about the sales of "sAC male contraceptive pills". To be honest, the domestic market is just an initial market, far less than the sales in the European and American markets!
Just being coerced by the Internet like this made him very unhappy!
Moreover, when things have reached this stage, big Vs and Internet trolls have all appeared. This means that there is someone behind the bright brand!
This is someone who has made it clear that they are going to smear the "sAC male contraceptive pill"!
You must know that the "sAC male contraceptive pill" has just been launched, and Huang Gongzi and Duke's publicity is in the limelight. It is a good time to expand the market!
If you do this, all the rhythm will be interrupted!
If you want to develop the market again in the future, it will not be easy to gain greater popularity!
But what can he do?
It was announced that Tsingshan Pharmaceutical has started to develop infertility drugs, and then it was followed?
This is not what he wants!
The best way is to take out the results of infertility drugs now and slap them in the face directly with the results, stop being rude!
But!
The two drugs have just been approved as projects, and there is no hope of achieving results for another three to five years!
Zhang Yang shook his head,
But at this moment, a clear voice suddenly sounded in his mind:
"The update of version 2.0 of the medical simulator has been completed. Please enter as soon as possible, host. Check it out! ”
(End of this chapter)