Chapter 161 Simulator 2.0 comprehensive update!
"Welcome host to Medical Life Simulator 2.0."
After telling the office assistant that he wanted to take a rest, Zhang Yang locked the office door and immediately entered the simulator.
As soon as he entered the simulator, Zhang Yang was slightly startled by the brand new scene.
Previously, the simulator was a light blue translucent light screen, and the light screen displayed the nodes that can currently simulate the plot.
But after this update, the entire simulator scene has been fully upgraded, and even the environment you are in has undergone huge changes!
The previous light blue translucent task panel is still there, but the entire simulator background has turned into a huge...
Biological laboratory? !
That’s right!
Zhang Yang glanced around and saw that the neat laboratory under the bright lights was shining with the light of various precision instruments.
There are cryo-electron microscopes worth tens of millions each;
There are third-generation gene sequencers equipped only in top laboratories;
There are also Beckman ultrasonic machines that can isolate viral nucleic acids. High-speed centrifuge...
His.
Even though Tsingshan Pharmaceutical's R&D center is already one of the best in the country, Zhang Yang was still surprised to see so many of the world's top precision equipment in one laboratory.
At this moment, the system's crisp prompt sounded.
"Dear host, the Medicine Life Simulator version 2.0 upgrade has been completed."
"The 'plot simulator' in version 1.0 is still retained. You can choose simulation from the light blue light screen The plot enters the simulation, and you can get the corresponding energy points and medicine rewards as before."
Zhang Yang's eyes then fell on the light blue translucent light screen.
Several previously completed "simulation plot copies" are displayed on the light screen and have been lit.
"The Death of Blood" - "The Destiny of a Generation" - "The Silent Killer".
He tried it, and if it was lit, he could still view the ending and even re-simulate it.
However.
After the last simulated plot "Silent Killer", the next node still displays a small lock (not unlocked).
Zhang Yang did not expect that there would be no new node after so long.
I couldn’t help but ask:
“Why hasn’t it been unlocked yet?”
The system voice sounded:
“The initial three plots are novice plots, and the subsequent simulated plots are continuous plots! "
"The drug research and development capabilities of Qingshan Pharmaceutical created by the host are currently weak, and the conditions for starting a coherent plot have not been met. The system will automatically unlock it when it is reached."
The drug research and development ability is weak,
it has not met the conditions to start the subsequent plot...
Zhang Yang was a little surprised, but he quickly shook his head.
Compared with the simulator, Qingshan Pharmaceutical’s R&D capabilities are indeed very weak.
“The 1.0 version of the simulator has not updated new simulation nodes, so what features has been added to version 2.0?”
"Hello, dear host, the added function of version 2.0 is the biological research and development laboratory in front of you."
Zhang Yang was stunned and looked around at the huge drug research and development laboratory in front of him.
“You mean I can do new drug simulations here?”
“That’s right!”
The sound of the system is very stable.
"This simulator aims to promote the development of human medicine. At present, Qingshan Pharmaceutical, created by the host, already has certain drug research and development capabilities."
"But in the long history of medical research and development, the emergence of a new drug It often takes several years or even more than ten years of research and development, and even after spending more than ten years, it is discovered that the research and development direction is on the wrong path, and ultimately ends in vain, wasting a lot of time."
"2 The .0 version of the drug development simulation laboratory can speed up the research and development process. The real time and laboratory simulation time are 1:10. "
"In layman's terms, it takes 10 months of data to be observed in the real world for simulation. It only takes 1 month to obtain 10 months of data in the laboratory, thus greatly reducing the development time.”
Zhang Yang was immediately surprised and immediately realized the power of the simulation laboratory.
You know, why does the research and development process of a new drug often take several years or more than ten years?
Determining the target and finding effective compounds is one of the factors. More importantly,
After finding many effective compounds, the verification and screening stages are also extremely time-consuming.
For example, for the sAC cyclase activator that is being developed, even if an effective compound is discovered, it must be tested for at least three months to half a year, right?
After three months to half a year, the effect is not good, and the ingredients of the drug have to be modified, and then another three months to half a year of trial phase is required.
In addition, the same is true for clinical trials. Continuous modifications and verifications all take time.
However, after being surprised, Zhang Yang suddenly had a whim and asked:
"The 10 times acceleration of time in the simulation laboratory, can it be made faster? For example, 1:20?"< br>
The system was silent for two seconds and replied:
"The simulation laboratory time ratio has been fixed and cannot be modified. However, if the host wants to increase the research and development speed, it can pay the energy value."
"Energy value?"
Zhang Yang felt a little familiar.
“You mean the energy value obtained when completing the ‘simulation plot’ before?”
“Yes, the host currently has accumulated 1,000 energy points; the energy value can be used to accelerate drug development. ”
“This function is relatively complex, and it is recommended that the host try it directly with a new drug that has not yet been developed.”
"Oh?"
Zhang Yang's eyes lit up and his interest greatly increased. Then he thought that the first project team of the drug research and development center is currently developing "sAC cyclase activator" to improve sperm activity?
Just in time to try it out.
"How can I try it?"
After the words fell, the light blue light curtain in front of Zhang Yang disappeared, and the whole person appeared in the simulation laboratory.
After a while, several data options appeared on the center console of the simulation laboratory.
Types of diseases,
Research directions,
Drug targets,
Molecular formulas of compounds, animal experimental data...
"The host only needs to enter the data of new drugs that have not yet been successfully developed into the system, and the simulation laboratory will automatically calculate the current development progress of the drug and create a simulation process."
As a drug developer, Zhang Yang I took a look at the data options on the center console and understood it instantly.
He immediately exited the simulator and quickly came to the drug research and development center to get the latest research and development information on "sAC cyclase active agent" from the first project team.
The "sAC cyclase active agent" project has only been established for more than a month, and the results have been limited. The first project team is still looking for targets to generate "sAC cyclase".
But this is just right.
Zhang Yang returned to the office again and entered the simulation laboratory.
Type of disease: Asthenozoospermia.
Research direction: increasing "soluble adenylyl cyclase sAC" in men.
Discovered targets: None.
Molecular formula of the compound: None.
Zhang Yang quickly filled in the data, and about a minute later, a piece of text was displayed on the center console of the simulation laboratory.
New drug research and development project: "sAC cyclase activity generating agent".
Current drug progress: 5%, the research and development direction has been discovered - sAC cyclase.
Next stage: target exploration (10%).
"Soluble adenylyl cyclase sAC" is an important substance for male sperm to maintain activity and helps improve male sperm activity.
At this stage, it is necessary to find the target of "sAC cyclase" produced in the male body, so as to use drugs to make the male epididymis produce more "sAC cyclase" and improve sperm activity.
The host can independently explore the target in the simulation laboratory. This method does not require paying any energy value.
At the same time, you can also pay energy values to start automatic exploration.
“To carry out target exploration, you need to pay 50 energy points. After completion, the research and development progress will be increased to 10%, and the corresponding data simulation laboratory will be automatically filled.”
“Can the host proceed? The next phase of 'target exploration'? ”
50 energy points.
Zhang Yang glanced at the energy value of 1,000 points in the upper right corner and confirmed without hesitation:
"Carry out 'target exploration'."
"Payment successful, in progress Conducting 'target exploration'... The exploration failed and no valid target was found."
Oh shit!
Exploration failed?
Can it still fail?
Zhang Yang was stunned, it was incredible.
At this moment, the system sound sounded.
“The simulated drug laboratory uses in-depth scanning and data mining of biomolecules to target targets based on the pathogenesis of the disease.”
"The more complex the disease, the more unknown the pathogenesis of the disease, such as ALS and Parkinson's disease, the greater the data required for target locking, and the more difficult it is to discover."
This explanation of the system is not too public. Understand, it would be too easy if 50 energy points could 100% find the target of a disease.
However, he was still a little unhappy. 50 energy points were gone?
“It is recommended that the host can continue to try.”
Zhang Yang shook his head helplessly, and then said:
"Continue to conduct 'target exploration'."
"Conduct 'target exploration'..."
"Congratulations to the host for successfully discovering the target of 'sAC cyclase', and the current drug The research and development progress is 10%. "
"Next stage: lead compound screening (30%)"
This time Zhang Yang did not rush to continue the research and development progress, but took a look at the console. data.
Sure enough, the drug target item changed from "none" to "HCO in the epididymis".
He then clicked on the more detailed information interface, and all the information about the target appeared in front of him. "HCO is the most important physiological activator of sAC. In the cell, HCO binds to the specific regulatory site β-C of sAC, triggering a conformational change in the sAC protein, thereby activating its catalytic activity and prompting it to convert ATP into cAMP..."
After reading it quickly, Zhang Yang became more and more shocked. He could almost immediately judge that this target should be true!
After all, although these materials look very professional, in the eyes of a professional like Zhang Yang, this is a complete instruction manual!
And the most shocking thing is!
According to his past experience, if a drug research and development team wants to figure out the target information of sAC, it can take half a year if they are lucky, or a year if they are not lucky!
Now!
The simulation laboratory was completed in just a few minutes...
Thinking of this, his eyes fell on the "next stage: lead compound screening (30%)".
The system sounded a voice at the right time:
“After determining the target, the simulation laboratory will conduct a 'target-compound' combination simulation in a huge compound database, and initially screen out a series of possible combinations with the target. Compounds that interact with each other are called 'lead compounds'."
"At the same time, preliminary laboratory testing will be conducted using simple cell models. Their effect on the target;
In this process, most compounds will be eliminated due to insufficient activity or poor selectivity, and only a few compounds that show certain potential can enter the next round of optimization. ”
“The process data is huge, and each attempt requires 100 energy points. After completion, the research and development progress will increase to 30%.”
"Similarly, all the screened 'lead compound' information will be automatically completed."
"Of course, the host can try to find compounds by yourself in the simulation laboratory, and independent research and development does not require any energy value."
Independent research and development?
Zhang Yang couldn't help but smile bitterly. Who could switch back to manual transmission after trying an automatic transmission?
The next second, his eyes fell directly on the required energy value.
100 points.
With the experience of exploring the target in the previous stage, he knew that there was a high probability of failure in this link.
And the chance should be quite high.
But looking at the 900 energy value left in front of him, after a little thought, Zhang Yang decided to give it a try.
“Pay 100 energy points to conduct ‘lead compound screening’.”
"'Lead Compound Screening' in progress..."
"Screening failed."
"Continue screening."
"Screening failed."
Two consecutive failures made Zhang Yang a little nervous.
However, he has also determined the operating mechanism of the simulated biological laboratory.
The simulation laboratory should, like the normal R&D team, determine the effect of the compound by observing the target compound.
If you are lucky, you can successfully discover an effective compound once. If you are not lucky, you may fail dozens or hundreds of times.
“Try again!”
Fortunately, I finally succeeded the third time.
"Congratulations to the host for successfully discovering multiple effective 'lead compounds'. The current drug development progress is 30%."
"The next stage: compound optimization and candidate drug identification (50%)."
Zhang Yang smiled bitterly again, this was really a link that made people want to stop.
The system prompt sounded again:
"After discovering a variety of effective 'lead compounds', the core components of the new drug have basically been determined. Next, we need to structure the screened 'lead compounds' Optimize.”
"This stage requires the use of chemical synthesis technology to change the molecular structure, crystal form and other small but key changes of the compound, thereby enhancing its binding and affinity to the target, improving pharmacokinetic properties and reducing potential toxicity."
“After multiple rounds of optimization and repeated testing, one or several most promising follow-up drugs will be identified from many optimized compounds. ”
“The amount of data in this link is not large, but it is the most technically difficult. Each attempt requires 200 energy points. After completion, the research and development progress will be increased to 50%.”
“ At the same time, it also means that the drug has basically completed the main research and development stage.”
“Will the host conduct research and development?”
Zhang Yang did not make a choice immediately.
He just checked that the "sAC cyclase activity generator" has completed 30% of the research and development progress, and the simulation laboratory has screened out nearly 25 effective "lead compounds".
He can download all the detailed information.
He now has several options:
1. Provide the downloaded data to Qingshan Pharmaceutical New Drug Research and Development Center. There are 25 "lead compounds" and it will be completed within a few years. Drug development.
2. If you conduct simulation in the simulation laboratory yourself, the speed should be slightly faster than that of the R&D team, but you will need to conduct simulation tests for a long time.
3. That is to continue to use 200 energy values to let the simulation laboratory complete the test.
The three options can be said to be from slow to fast.
“That’s all, I still have 600 energy points, let’s try it.”
“Once the ‘compound optimization and candidate drug identification’ stage is completed, you should be able to develop it yourself later.”< br>
"Conducting 'compound optimization'."
"Conducting 'compound optimization'... The optimization attempt failed."
Zhang Yang's heart thumped, and he still had 400 energy points.
Try again.
“Continue with ‘Compound Optimization’.”
"Congratulations to the host for successfully completing 'Compound Optimization and Candidate Drug Identification'. The current drug development progress is 50%."
"Next stage: preclinical research (70%)."
"Optimization After selecting the drug candidate, this means that the main research and development aspects of this drug have been completed.”
“But in clinical practice. "Pharmacokinetics, pharmacodynamics, and toxicology studies need to be carried out comprehensively on large animals before marketing, and parameters such as the duration and intensity of the drug effect after combining the drug with the target must be recorded."
“The most important thing is to strictly record possible toxic reactions to prepare for submission of clinical trial applications.”
"You need to pay 100 energy points to carry out this link. After completion, the research and development progress will be increased to 70%, and all animal experiment data will be automatically completed."
After the words fell, Zhang Yang decisively refused.
He has completely understood that his energy value is the currency in the simulation laboratory!
Having energy value means that the simulation laboratory can be completed quickly from the beginning of "target exploration" to the final "animal experiment".
Thinking of this,
Zhang Yang looked at the "sAC cyclase activity generating agent" which was already 50% finished.
Half an hour ago, the "sAC cyclase activity generating agent" had not even determined its drug target;
Half an hour later, the "sAC cyclase activity generating agent" had been completed. "Candidate Drug Identification", a large amount of information is available for download in the simulation laboratory.
This is too fast!
Of course, you must have enough energy in advance!
Thinking of the energy value, Zhang Yang looked at the only 200 energy points left in his system.
By the way...
It's so cool, how do you get energy points?
The system replied:
“There are three ways to obtain energy value:
1. Complete the 'simulation plot' and obtain the corresponding energy value after reaching the effective ending;
2. Complete the research and development tasks provided by the 'simulation laboratory', such as 'lead compound screening' of a certain drug, After completing tasks such as clinical trials, the corresponding energy value can be obtained;
3. Provide complete drug data patented by the host to the 'simulation laboratory'. (Full drug required.)
Note: The better the drug is and the more difficult it is to target the disease, the higher points can be earned. ”
Seeing the end, Zhang Yang focused directly on the second and third items.
At present, the "simulation plot" in the simulator 1.0 has not had a new node for a long time, and it is difficult to obtain energy values from here regularly.
The second "Simulation Laboratory" research and development task... you can take a look at what it is in a moment.
The third one was that Zhang Yang never expected that such a powerful "simulation laboratory" would actually "collect" his own patented drug information?
You know, the simulator has provided itself with drugs such as "ITG Human Myelopoietin", "Kidney Toxin Clearing Dialysis Injection", etc., which are among the top drugs in the history of human medicine!
And now!
Do you actually value your own self-developed drugs?
But gradually, he realized:
The "simulated drug laboratory" in front of him seemed to be like a huge drug database, an extremely powerful computer?
You can let the "Simulation Laboratory" help you complete drug simulations at an unimaginable speed by paying energy values.
But if you want to obtain energy values, you need to complete the task. , as well as providing patent drug data.
Do both sides help each other?
“It’s interesting!”
Zhang Yang also thinks this method is pretty good. Just when he is about to complete 50%,
the progress has reached “Animal Experiment” When all the information on "sAC Cyclase Activity Generating Agent" was downloaded into my mind, the system voice sounded again.
“Dear host, I would like to introduce to you the ‘Medical Simulator 2.0’ version, the last function of the simulation laboratory.”
"Looking at the long history of human medicine, there are countless drug formulas that cannot be marketed due to side effects and other reasons, and are eventually discarded in the garbage dump."
"The 'Simulation Laboratory' provides drug formula optimization functions, which also require energy values."
“Remarks, not all drug formulas can be optimized, only some drug formulas with optimization potential.”
After hearing the last word, Zhang Yang fell silent, completely feeling the "simulation experiment" "Room" is powerful.
The first thing that popped into his mind was the many drugs around the world that have been unable to be put on the market due to side effects in recent years.
"It seems that we have to pay more attention to the discarded prescriptions of other pharmaceutical companies in the future..."
After sighing, Zhang Yang quit the Medical Life Simulator 2.0.
This update has been a huge gain.
Thinking of the "sAC cyclase activity generator" that had already been tested on animals in his mind, Zhang Yang quickly came to Qingshan Pharmaceutical Drug Research and Development Center.
Of course, he would not be so stupid as to take out 50% of all the information at once.
After a while, Wei Tian appeared in the laboratory.
Zhang Yang said:
"Wei Tian, on a whim, I seem to have found a target for 'sAC cyclase'. Give me a shot and I'll try it."
Wei Tian was a little surprised, but he had experienced Zhang Yang's talent many times.
“Good boss.”
Two days later, there was a sound of surprise from the Qingshan Pharmaceutical Drug Research and Development Center!
“Boss, you are so awesome, it’s hard to imagine that you really found the target of ‘sAC cyclase’ so quickly!”
“Well, good luck, let’s start with the next step Let’s screen the ‘lead compound’, I happen to have a little idea about the ‘lead compound’!”
6K, I also know that there are fewer, more, and more recently!
(End of this chapter)