Chapter 163 Durex, it’s time to fight back! (Please subscribe)
Doctor Feng Yan paused for a moment and said:
“The first-generation test tube costs about 30,000 yuan, and the second-generation test tube baby you want to do is about 30,000 yuan. About 50,000 yuan.”
“However, there is one thing I must explain to you in advance. The baby does not succeed in one go. On the contrary, according to our past clinical experience, the success rate in the first time is very low.”
“The vast majority of couples succeed in 3-4 times, and even 7 times. -I only got pregnant after the 8th time. For people like you who are more serious, you should be mentally prepared.”
After saying that, watching Xu Min and Liu Qiang's expressions change from anxious to shocked, Feng Yan added and explained:
"This is what happens in medicine. IVF can only be said to be forced through artificial intervention." Sperm and eggs are synthesized into fertilized eggs, and then the fertilized embryos are transplanted into the uterus.”
“But the human body has a strict and sophisticated screening mechanism. We believe that. After a good embryo is transplanted into the uterus, there will often be developmental abnormalities and failure to implant, which will eventually cause the embryo to stop developing and lead to miscarriage.”
“So, once this happens, we must. Repeat the test tube transplant... until the embryo develops smoothly in the uterus."
Dr. Feng Yan's explanation is easy to understand, but...
Xu Min bit her lip and looked at her husband Liu Qiang.
If Dr. Feng Yan said that IVF would fail 3-4 times or more, wouldn't it cost at least 200,000 yuan?
At least 200,000!
This is already a huge sum of money for an ordinary family like them!
"What about reimbursement for doctors? How much can medical insurance reimburse?"
Xu Min asked with her last hope.
Feng Yan shook her head:
"Medical insurance reimbursement... At present, most reproductive technology outpatient clinics have local reimbursement policies. The policies in each region are different. We in Chengdu can reimburse some but not much! ”
“Like you being the second generation The one-time cost of test tube is 50,000 yuan, and about 10,000 yuan can be reimbursed; and even 10,000 yuan is a policy that was just introduced this year, and it was almost not reimbursed before."
After finishing speaking, Liu Qiang and Xu Min. The two were silent, which meant that each test tube cost at least 40,000 yuan.
One test tube is nearly half a year's salary.
A long while.
A trace of determination flashed in Xu Min's eyes, and she looked at doctor Feng Yan:
"Doctor, we will listen to you and start in vitro fertilization!"
" OK! ”
Feng Yan nodded, and then looked at the two of them:
“Now that we have decided, let’s sign the informed letter.”
“Bring your marriage certificate and ID card tomorrow. , we need to give you a comprehensive physical examination first, Then we have to take medicine, take progesterone and other preliminary preparations.”
“With any luck, I can start trying IVF after my period ends next month.”
“Then I’ll bother the doctor. ”
After two years of trying to conceive naturally, to no avail, and even after taking medication and increasing exercise, their sperm quality was still seriously abnormal.
Liu Qiang and Xu Min finally decided to start IVF immediately.
Of course,
Before carrying out in vitro fertilization, it is not as simple as it sounds. Both men and women need to undergo comprehensive examinations, especially women who need to inject a large number of injections to artificially adjust the hormone levels in the body. ...
Xu Min began to cooperate with the doctor in preparing for IVF.
other side.
The sAC cyclase project of Qingshan Pharmaceutical R&D Center is also proceeding in an orderly manner.
With Zhang Yang’s help, the “sAC Cyclase Project” completed the screening of “lead compounds” in just 2 months, with terrifyingly high efficiency!
The next step is to optimize the internal molecular structure of the compound and start animal experiments.
Once animal testing is completed, clinical trials can begin!
In addition to the smooth progress of the "sAC cyclase" project to improve sperm activity, Zhang Yang's "severe teratozoospermia" project that was hanging up in the simulation laboratory to explore targets also continued to run every day.
Soon,
ten days, half a month, a month.
Just as Zhang Yang watched the energy value decrease every day, on the 45th day, a full 450 hours, equivalent to 4500 hours later,
The simulation laboratory finally passed a large amount of test data An important target was discovered!
Sperm Morphology Regulator Protein (SMRP);
Abbreviation: SMRP.
As we all know, the male sperm production process is mainly completed in the testicles, and the production process also involves the influence of male hormones such as luteinizing hormone (LH) and testosterone.
Zhang Yang initially thought that hormones maximized the morphology of sperm during male sperm production, but after a large number of experiments and data screening, he found that many men/male animals with severe teratozoospermia had related Hormone levels turned out to be normal.
In other words, male hormone levels are not necessarily positively correlated with sperm abnormalities.
He immediately changed the direction of his research.
As we all know, sperm is a complex cellular structure composed of a variety of substances.
The most important substances are proteins and nucleic acids.
Nucleic acid can be understood as the genetic material carrying paternal DNA, which includes various important genetic information.
This genetic information is combined with the genetic information of the egg after fertilization to determine the genetic characteristics of the offspring, such as appearance, physical characteristics, susceptibility to certain diseases, etc.
Protein is an important substance that maintains the structure of sperm and also plays an important role in protecting DNA!
It was while analyzing a substance called "structural protein" in proteins that Zhang Yang finally discovered the target named "sperm morphology regulatory protein" (SMRP).
SMRP is also a protein that participates in the formation and development of sperm throughout the sperm production process.
It can bind to specific gene promoter regions and regulate the expression of a series of genes related to sperm morphology.
In human terms, although it is just protein, it is the brain generated by each sperm and controls the shape of each sperm!
The test results also confirmed Zhang Yang’s judgment.
Once the expression of SMRP protein is reduced, it will lead to insufficient synthesis of some key structural proteins, resulting in abnormal sperm head shapes, such as too large, too small, irregular shapes, etc.
On the other hand, if the activity of SMRP is interfered with, it may affect the assembly of the sperm tail and the function of dynein, resulting in sperm tail deformities, such as bending, short tail, multiple tails, etc. In addition, environmental factors, genetic mutations or certain disease states may affect the stability and function of SMRP, causing it to lose its normal regulatory role, thereby causing teratozoospermia.
In other words, the target that causes teratozoospermia and even azoospermia has been found!
The next step is to find the right and effective compound!
Zhang Yang did not hesitate and continued to search for "lead compounds" in the "simulation laboratory".
At the same time,
he immediately extracted the target data obtained in the "simulation laboratory" which lasted 450 hours, and then quickly established the ninth project team under his direct responsibility and began preparations Realistic reproduction of the "SMRP" target!
But just when Zhang Yang was excitedly transferring the "SMRP" target results to the real world, Ren Xiaomin suddenly came to the office again.
This time, Ren Xiaomin's mood was obviously much better than the last time he reported to Weibo big V Liu Zhiyuan.
As soon as he entered the door, he said cheerfully:
"Zhang Yang, I heard that the 'sAC cyclase' developed by our R&D center to treat sperm activity is making rapid progress. The final adjustment of the molecular structure has begun, and the next step is animal experiments!
Isn’t this progress too fast?”
Zhang Yang put down the document in his hand and laughed.
What Brother Ren didn't know was that there was an even more amazing drug on the way, a drug to treat teratozoospermia and even azoospermia.
“It’s not too fast. After all, we have a foundation in sAC cyclase before. After discovering the target, we quickly found the corresponding compound.”
“It’s faster. I understand.”
“Also...”
Ren Xiaomin did not continue to say more on this matter, and this was not the main purpose of his visit today.
After a while, he talked about something else.
“Zhang Yang, do you still remember Liu Zhiyuan, the great medical V who posted articles on Weibo to slander and criticize us?”
“The two articles he posted before did indeed give us It caused a lot of pressure from public opinion, especially the article 'Qingshan Pharmaceutical should not develop contraceptive pills, but should develop infertility' ''s article made it impossible for us to promote the 'sAC male contraceptive pill', which made us very passive."
"However, yesterday, the 'sAC male contraceptive pill' was sold in China for the past two months. The sales volume has come out, and the sales volume is very good, far better than we expected.”
Oh?
Hearing this, Zhang Yang was a little surprised, and immediately laughed:
“It seems that there are still a majority of normal people, and they are not led by the big Vs and trolls on the Internet.”
“Originally Also, is it because we are Qingshan Pharmaceuticals that we should develop infertility drugs? So it is wrong for us to develop male contraceptives? "
Ren Xiaomin smiled bitterly and then drank water. Half a glass of water was poured on the plane.
Moisten your throat and say:
"In addition, I have also discovered an important clue these days. Medical tycoon Liu Zhiyuan was indeed instigated by someone else."
"His should be an overseas condom company."
“Condom company?!”
Zhang Yang was startled, and his expression instantly became serious.
"Which company do you know specifically? Durex? Okamoto? Or others?"
Ren Xiaomin's expression also became serious.
“I guess it is Durex, but there is no absolute evidence yet.”
Durex.
Zhang Yang stood up from the chair and fell into thinking. At this moment, Ren Xiaomin continued:
“According to our sales statistics of male contraceptive pills at the retail end, our main customers In addition to middle-aged men aged 35-45, the largest customer group is unmarried young people under the age of 25. ”
"These young people used to use condoms for contraception, but now some of them choose us... and it just so happens that these unmarried young people under the age of 25 are also the core user group of Durex."
"In other words , the emergence of our male contraceptive pills stole their core customers."
"No wonder..."
Zhang Yang reacted immediately.
If it were Durex, then everything would make sense.
The sAC male contraceptive pill is a direct competitor of Durex, so it has a complete motive to try every means and even hire trolls to criticize Tsingshan Pharmaceutical's male contraceptive pill.
At this moment:
"Zhang Yang, they asked big V to criticize us before for developing infertility drugs. Look, now our 'sAC cyclase' for treating asthenozoospermia has Animal experiments are about to begin, how about we Are you going to make this news public?”
“Didn’t they say, ‘We should develop infertility drugs’?”
One second later, Zhang Yang nodded:
"That's right, the heat on this matter has dropped now. Let's heat it up!"
"Send a press release to share the latest progress of 'sAC cyclase', which will be used for treatment Possible reports of weak sperm in men ”
“Tell me! They, we Qingshan Pharmaceutical can not only develop male contraceptives, we can also develop infertility drugs."
"I want to see what other reasons they have to criticize us!"
< br>Ren Xiaomin's eyes flashed, it's time to fight back!
Two hours later, Qingshan Pharmaceutical had made a breakthrough in the treatment of "male asthenozoospermia", and news of upcoming animal experiments spread throughout the Internet.
Originally about Qingshan Pharmaceutical’s male contraceptive pill;
The topic that had been silent for a few days suddenly became popular again!
There was a heated discussion on the Internet.
(End of this chapter)