Chapter 170 New drug - nano-nodule developer!
"Sorry, Evans, I hurt you just now."
"Fcuk, Zhang! When you grabbed my collar just now, I really thought you were crazy! Don't make such a joke with me next time, or I will fall out with you!"
"Okay, Evans"
Zhang Yang returned to normal with an apology. He said, and then sat down in front of a computer next to Evans.
After a while, with in-depth communication with Evans, he obtained more detailed and effective information.
This is exactly what Evans said, it is the "Adlev" biological laboratory located in Norway, Europe.
The head of the laboratory, Dr. Eric, is a top molecular biology expert in Europe. His main research direction is to evaluate the activation effect of respiratory microbiota on lung cancer carcinogens and determine the risk factors for lung cancer susceptibility.
The identity of his host and the Evans in front of him are also experts in the field of lung cancer!
It can be said that this is a top-notch biological laboratory with rich experience in lung cancer research.
After understanding the scene information, Zhang Yang immediately focused on how to complete the simulation plot.
Based on past experience, if you want to complete the simulation plot next, you will most likely start with Evans in front of you and promote the development of the plot from him.
But when Zhang Yang tried various methods to find clues from Evans, Evans was always surprised and confused. In the end, he did not forget to remind Zhang Yang to quickly complete "Dr. Eric" assigned statistical tasks.
What surprised Zhang Yang even more was that in the past simulation plots, as long as no clues were found after a certain period of time, the simulator would automatically end and return to the void.
But this time a full fifteen minutes were wasted, and the simulation plot had no intention of ending.
"Isn't it possible that the plot this time is not an 'exploration mission', but that we only need to complete some statistical mission that Evans said?"
"It won't be that simple, right?"
Zhang Yang is a little bit It was unbelievable, but the next second he focused on the statistical task.
As a top drug developer, Zhang Yang still knows something about biological laboratories.
First of all, it should be noted that biological laboratories and drug research and development centers are two different things.
In terms of nature, biological laboratories are more inclined to scientific research work, while drug research and development centers of pharmaceutical companies are more commercial operations.
For example, Adelev Biological Laboratory’s main job is not to develop drugs to treat lung cancer; they focus on the research of lung cancer, so the focus of their work is on the microscopic level, on the pathological mechanisms. above.
To be more detailed, their daily work involves culturing various lung cancer cells, and then using cell models to study the physiological functions and pathological changes of these cancer cells.
For example, a virus suspected of causing lung cancer is infected with normal lung epithelial cells, and the metabolic changes, gene expression changes, and cell apoptosis or proliferation of the cells are observed.
Another example: We will study very microscopic research on how lung cancer cells conduct signal transduction with surrounding immune cells and fibroblasts.
The purpose is, of course, to fully understand the operating mechanism of a lung cancer cell.
Once these research results make progress, they will be published in the world's top medical journals. Not only will they gain a lot of fame in the industry, but some pharmaceutical companies will also come to seek business cooperation and technical support.
It can be said that
from a certain perspective, the top biological laboratories around the world are the "upstream" of pharmaceutical companies.
They have provided a lot of basic research on various diseases, viruses, and bacteria, and provided a theoretical cornerstone for drug research and development by pharmaceutical companies.
The statistics Evans mentioned are also an important part of studying a disease in biological laboratories and are important basic data.
"Evans, what did you just say I should count?!"
"Mygod! Zhang, what happened to you today?"
"You need to be responsible for statistics The data is about the incidence rate and various characteristics of lung adenocarcinoma in the Nordic race in the past ten years and the past five years; and I am in charge of the Asian race!"
"Okay, thank you. Vince, I got it.”
For the first time, Zhang Yang began to take the statistics that Evans said seriously.
To be honest, this job is actually not difficult. It is nothing more than filtering out the collected patient data and incorporating it into the patient database.
The only difficulty is that there are too many projects involved in the data.
In addition to basic information such as name, age, and family history, it even includes the patient’s DNA, gene analysis, and protein expression.
Zhang Yang was a little surprised how he obtained such detailed patient data!
You must know that these are the most sensitive personal and genetic information of patients. If it is accidentally exposed, it is very likely to have serious consequences for the patient.
And!
The most terrifying thing is that
these detailed data are not just one or two. At first glance, there are tens of thousands of data that need to be counted on his computer!
"Huh... Are the data collected by these top foreign biological laboratories so complete? DNA, gene sequencing and protein expression... too detailed!"
"But, how long does it take to enter these tens of thousands of data?!"
Zhang Yang sighed, but he had no choice but to start entering patient data into the computer.
One hour, two hours, three hours.
Zhang Yang’s eyes were dazzled, but he finally confirmed that this simulation plot was really not an “exploration mission” like before, but an ongoing mission.
Another two hours later, Evans and several other staff on the side got off work one after another. Seeing that there were still 14,000 patient data that had not been collected, Zhang Yang couldn't help but feel his scalp numb.
"There is so much data left, it is definitely unrealistic to finish it all at once!"
"This simulation cannot be 'archived'. Can we continue the simulation tomorrow?!"
>Thinking of this, Zhang Yang decided to try to leave the biology laboratory like Evans.
Out of the laboratory door, sure enough!
The screen suddenly went black, and Zhang Yang directly exited the simulation plot and returned to the void.
"Good guy, it's true!"
Zhang Yang's guess was correct. When he entered the simulation again the next day, he found that the time of the simulation plot changed from yesterday's August 9, 2018 to August 10. .
The last patient data entered yesterday also stayed at the moment he left the laboratory.
"Okay, it seems that this plot simulation task is to enter all the more than 10,000 pieces of data into the database!"
Zhang Yang determined the direction of completing the simulation plot task, and the next step For a few days, he devoted himself almost entirely to data entry.
Three days later, a total of 18,000 records of "lung adenocarcinoma" among Nordic people were entered into the laboratory database!
Zhang Yang breathed a heavy sigh of relief, now he can finally complete the task, right?
But after waiting and waiting, the simulation plot still had no intention of ending. When his eyes fell on Evans beside him, he suddenly had an idea.
"Don't you need Evans to finish the statistics together?" "It's possible!"
Thinking of this, Zhang Yang immediately turned to Evans aside.
"Evans, I have completed the statistics of all patients, what about you?"
Evans shook his head with a wry smile:
"Zhang, you have to Wait for me for a moment. Your data for Nordic people only has 18,000 records. Mine is The data on Asians is much more than yours!”
“You have to know that China has the highest incidence rate of lung cancer, as high as 37.5%...so your data is too much, but it’s okay. I have been typing it in a few days in advance..."
Zhang Yang had been immersed in thoughts of completing the task for the past few days, and only then did he pay special attention to the Asian race that Evans mentioned.
However, he could not help at this time and could only wait patiently for Evans to enter the final data into the database.
"Okay, hurry up!"
After waiting for nearly four hours, Evans finally completed his work.
"It's finally done, Zhang! How's it going? What's the result of your Nordic race data?"
Zhang Yang was already impatient with waiting. He immediately handed the statistical data he compiled to Evans, and then said:
"This time, a total of 18,000 Nordic people's lungs were counted. Patients with lung adenocarcinoma;
Compared with the data ten years ago, the proportion of lung adenocarcinoma has slightly increased from 39% ten years ago to 40%. This data can It shows that the incidence rate of 'pulmonary adenocarcinoma' has not increased in the past decade. ”
“At least among northern Europeans, the incidence rate of ‘lung adenocarcinoma’ has not increased.”
“ In terms of gender distribution, the data is almost the same as that of ten years ago, with 64% of men and 36% of women... It can be said that lung adenocarcinoma is still mainly male."
"In addition, the age of onset is still 70% after 50 years old, 20% between 35 and 50 years old, and 10% under 35 years old."
"It can be said that from the age of onset, Gender, and incidence rates Judging from the perspective, "Lung adenocarcinoma" has not changed significantly in the Nordic race in the past ten years."
"What about you, Evans?"
Evans also handed the compiled data to Zhang Yang for review.
“In the past ten years, that is, between 2008 and 2018, the incidence rates of Asians and Northern Europeans are almost the same in terms of gender and age.”
"'Lung adenocarcinoma' accounts for 41% of lung cancers in Asians, and 65% are male. At the same time, 72% of patients are over 50 years old!"
"Based on the above basic data, we can already get A basic conclusion is drawn. In the past ten years, 'lung adenocarcinoma' has increased in Asians. There is no obvious difference in the incidence characteristics between European and European races.”
“It can be said that the cause of ‘lung adenocarcinoma’ has almost no obvious relationship with race!”
Zhang Yang nodded! :
“It can be understood this way.”
After the words fell, Evans smiled and handed the two compiled data results back to Zhang Yang.
"Zhang, thank you for your hard work. The task assigned by Dr. Eric was finally completed on time. Let's have a meal together after get off work!"
"I know there is a good Italian restaurant... ..."
As Evans said, Zhang Yang was thinking about why he hadn't completed the simulation task yet.
Just when Zhang Yang was a little flustered, Evans in front of him finally gradually became blurry, and then, a long list of rewards suddenly appeared in front of him.
["Biological Laboratory"-the first stage of plot simulation is over! ]
[Completion: 100%]
[This simulation score: B]
[Achieve the ending: complete statistics]
[ Evaluation: To understand a disease, we not only need to understand its internal pathogenesis and viral pathology, but also need to collect statistics on patients of different races to conduct a more in-depth study of the differences between different races and find out the disease. effective target. 】
[Although statistics is very basic, it plays a key role in the analysis and research of various diseases. 】
[The host successfully completed large-scale data statistics, well done! 】
【This simulation is effectively completed and the ending can be viewed. 】
[Reward: 300 energy points]
[Reward: "Nano Nodule Developer" crystal form patent, synthesis route, and synthesis process. 】
[Reward: Data analysis data on pharmacokinetics, toxicokinetics, ethics, acute toxicity, and chronic toxicity of "Nano Nodule Developer". 】
【Reward: Complete clinical phase I and II data of "Nano Nodule Imaging Agent". 】
[Reward: ‘CT machine’ special radiation spectrum imaging technology. 】
Energy value 300 points!
Zhang Yang was very happy, the simulation plot was so good!
In just a few days...
No!
His eyes quickly fell on the most critical drug reward, and his heart suddenly trembled.
Nano nodule developer?
From the name... this is not a drug for pulmonary nodules, right?
Suppressing his excitement, Zhang Yang quickly clicked on the explanatory information on the light blue light screen and took a look. After just a few seconds, his eyes widened with disbelief on his face!
Holy shit!
What a drug for pulmonary nodules!
Moreover,
It is not a therapeutic drug, but a pulmonary nodule identification drug that I have been thinking about recently!
Identify whether it is a benign or malignant nodule!
Nano nodule imaging agent:
After the human body injects the imaging agent through the veins, its active ingredients will quickly reach the lung tissue and quickly interact with the "solid nodes" on the lung tissue. Nodules" and "ground glass nodules" specific molecular markers were combined.
If it is a benign nodule, there will be no change in the combination of cell surface markers and drug ingredients!
Once the drug component is combined with a specific molecular marker of a malignant nodule, the bound nodule will emit a specific fluorescent signal.
This fluorescent signal can be displayed as red in CT images through the improved "special radiation spectrum CT machine", thus reminding medical staff that the nodule is a malignant nodule!
Zhang Yang was completely shocked when he saw the end!
Recently, he has been thinking about how to use drugs to judge benign and malignant nodules. He did not expect that the contrast agent provided by the system turned out to be such a solution!
First use drugs to combine with markers of malignant nodules to form a fluorescent reaction!
Then by changing the spectrum of the CT machine, the image results are fed back!
I have to say, this idea is indeed a bit awesome!
Zhang Yang sighed with emotion, but soon he became excited.
The emergence of this pulmonary nodule imaging agent will bring hope to how many patients suffering from pulmonary nodules? !
All patients with pulmonary nodules no longer need to worry about gains and losses, or worry about being misdiagnosed!
The tragedy of Director Feng Gang and Feng will no longer happen!
(End of this chapter)