Chapter 244 The painful improvement plan of Yibaizumab!
Zhang Yang felt the joy of the oil guy for the first time.
In just one week, Qingshan Pharmaceutical recruited nearly 40 first-line drug researchers from all over the world with rich experience in genetic drug research and development.
Thirty Chinese people, ten Americans and Europeans.
The R&D team of forty people was quickly established and immediately began to develop Qingshan Pharmaceutical's research and development work on "hemophilia gene drugs". The whole process was smoothly beyond Zhang Yang's imagination.
Of course, Qingshan Pharmaceutical's high salary poaching also shocked major genetic drug research and development companies in the United States.
You should know that although Qingshan Pharmaceutical has been recruiting globally before, the salary it gives follows industry rules, but is just slightly higher than the industry level.
What happened this time?
Soon, the news came to light. It turned out that Qingshan Pharmaceutical was preparing to develop a drug that can cure hemophilia!
At the same time, a more explosive news also spread that the reason why Qingshan Pharmaceutical began to develop hemophilia drugs was because the Saudi royal family took the initiative to contact Qingshan Pharmaceutical and paid 5 billion US dollars to request Qingshan Pharmaceutical. Develop hemophilia drugs!
The news completely shocked the entire genetic drug research and development industry!
Pfizer, United States.
Pfizer is the world's top well-known pharmaceutical company and is also in the industry's leading position in gene therapy drugs.
As early as 2014, Pfizer entered the gene therapy industry for layout and began to develop drugs for the treatment of genetic diseases such as hemophilia B, Duchenne muscular dystrophy, and amyotrophic lateral sclerosis.
In the office, President Daniel looked at the news about Qingshan Pharmaceutical in the communication group and couldn't help but snorted:
"Idiot, what a fool. Qingshan Pharmaceutical has any gene therapy drugs that can be used for? There is nothing!"
"Prince Salaman actually asked them to develop a genetic drug for 'hemophilia'. I gave me 5 billion US dollars, which is so stupid, so stupid! "
The president's assistant Ji Rui stood aside and lowered his head and did not dare to speak. After the president learned about 5 billion US dollars this morning, he learned about the news of 5 billion US dollars. , and the emotions change subtly.
"Qingshan Pharmaceutical is also a fool! Don't they know that they don't have the ability to develop hemophilia drugs at all?"
"This is a genetic genotype disease, so how can it be like this? Very curable? ! ”
"5 billion! I estimate that 10 billion US dollars may not be able to develop curative drugs. If you spend all your money, you haven't developed a genetic drug yet, so they won't cry to death? Humph!"
"Occursed me for not having any offenses? The Saudi royal family has their own good feelings, do you think so? Giri! "
Girie didn't want to speak at first, but when he heard the CEO Daniel call his name, he nodded obediently. "Mr. President, what you said is right!" "Prince Salaman will definitely regret it, and Qingshan Pharmaceutical will definitely suffer because of this cooperation!"
"Just you said, if a drug to cure hemophilia is so easy to develop, we would definitely agree when they came to us before."
President Daniel nodded.
But soon his face narrowed, and his expression, which was originally slightly calm, suddenly appeared a trace of white blue.
He looked at his assistant Giri with dissatisfaction. Prince Salaman did find Pfizer three years ago, but he didn't talk about the 5 billion US dollars at that time!
If the Saudi prince had offered US$5 billion at that time, no idiot would have agreed!
This is $5 billion!
Damn it!
Fcuk!
The Saudi prince is actually willing to bid $5 billion to Qingshan Pharmaceutical and is not willing to bid for Pfizer!
"Grie, if you can't speak, don't say it."
As he said that, he took a deep breath and took a sip of the coffee on the table.
After a moment, he suddenly frowned, and the dissatisfaction on his face became more obvious. "Grie Rui, how many times have you told me that you put more sugar in coffee and more sugar, why is it so bitter!"
Grie Rui was stunned. He would give it to me every morning every morning The President made a cup of coffee, and today he remembered clearly that he had put at least three packs of candy! "President, it shouldn't be hard, right? I specially put an extra bag of candy today..."
"Are you questioning me? Why don't you come and try it?!"
Looking at the anger on President Daniel's face, Giri understood instantly.
This is not the bitterness of coffee, it is the bitterness of heart!
…
Novartis.
Novartis is also an absolute leading company in the field of gene drug treatment. Its most important genetic drug achievement is the treatment of a genetic disease called "Spinal Muscular Atrophy (SMA)."
This disease is somewhat similar to ALS, but from the perspective of onset, spinal muscular atrophy is a hereditary disease and is a chromosomal abnormality;
ALS is a genetic factor Very small, mostly degenerative diseases of the autonomic neuronal system.
The reason why this drug is more famous is that it has an injection of up to 700,000 yuan and requires six injections a year, which is a sky-high drug and has been widely reported.
This time, the senior management of Novartis also quickly noticed that Qingshan Pharmaceutical and the Saudi royal family launched a $5 billion cooperation on hemophilia.
"Friedman, I didn't expect Qingshan Pharmaceutical to suddenly make a big news again!" "I remember that a few years ago, Prince Salaman from the Saudi royal family also came to us personally, and they seemed to have A little prince suffered from severe hemophilia...but they didn't mention 5 billion US dollars at the time!"
"5 billion US dollars, it's really enviable!"
President In the office, the person talking was Novartis president Green.
It's just that because I have been working well with Qingshan Pharmaceutical, after I heard the news, I must be envious, but Green did not have a strong sour smell like Pfizer.
Friedman, a Jew who had not seen for a long time, could not help but nod, and a light flashed in his eyes.
"President Green, you are right. This kind of cooperation with giving money is simply enviable!"
"But... I think the big reason for such cooperation is probably because Qingshan Pharmaceutical's recent development of 'Ibaimab' stimulated Saudi princes, making them truly believe that Qingshan Pharmaceutical has the ability to develop drugs to cure hemophilia! "
"Yes, it should be ! "
President Green nodded as well. After a moment, he couldn't help but sigh again:
"I have to say that Qingshan Pharmaceutical is becoming more and more famous around the world. If they can really develop drugs that can completely cure hemophilia this time, it will be a god!"
< br>"Think about it, how tempting will this matter have on the richest people around the world? Maybe in the future, there will be families who come to Qingshan Pharmaceutical to develop a drug that will last for a hundred years!"
"And even They are not able to develop drugs that completely cure hemophilia, and it is definitely not a loss. 5 billion US dollars is enough for Qingshan Pharmaceutical to lead the research on hemophilia! "
This time Friedman No more words.
As an executive of the world's top pharmaceutical companies, he is very clear about the approximate cost of developing a genetic drug.
Generally speaking, the cost of developing a genetic drug is between hundreds of millions of dollars and billions of dollars. This cost is not fixed and is determined based on the difficulty of genetic diseases.
But!
From big data, we can see that the median R&D cost of developing an innovative drug is $2.5 billion.
Even if the research and development of drugs that have completely cured hemophilia is very difficult, with Qingshan Pharmaceutical's capabilities, he believes that 5 billion US dollars should be the same!
At least it will not be too far from conquering!
The latest news says that Saudi princes don’t want all the achievements, and they all belong to Qingshan Pharmaceutical, which is definitely a sure profit and no loss!
As thinking about it, at this moment, President Green, who was envious on the side, took a deep breath: "Okay, let's not talk about this anymore. No matter how much we say, we can only envy you!"
"If you don't go again, I'm afraid that Qingshan Pharmaceutical will authorize North America to other companies!"
"You know, many companies are now looking forward to cooperating with Qingshan Pharmaceutical..."
When talking about this, Friedman, who had always looked calm, couldn't help but smile on his face.
He suddenly thought of the "gift" he carefully prepared for Zhang Yang.
"Sir, don't worry, the 'gift' is ready!"
"I'm going to go to China in person this week and give this gift to Zhang Yang personally. If he can like it... then we will cooperate more closely with them in the future! ”
"Yeah."
President Green also thought of the gift, nodded slightly, and a hint of expectation appeared in his eyes.
…
No mistakes, one song, one content, one in 6, one book, one bar, one reading!
Some news always grows wings, and inadvertently becomes a rumor.
Just when all genetic drug development companies around the world were envious and jealous, on the Chinese Internet, the news that the Saudi prince paid $5 billion to request Qingshan Pharmaceutical to develop hemophilia drugs went crazy.
As we all know, Chinese netizens have inexplicably good feelings for big dogs. As soon as the news came out, netizens laughed. "Haha, the big dog...dog head.jpg; 5 billion US dollars, it's really as straight as ever."
"What big dog is upstairs? Please put it Respect the key point, name it Mr. Sha or Daddy."
"Hahahaha, when I was talking to Qingshan Pharmaceutical, did I directly stretch out my five fingers and put them in front of Zhang Yang and said: I, Mr. Sha, have I invested in the project? ”
"Haha, Qingshan Pharmaceutical is so fat. I guess Mr. Zhang Yang's mouth is harder to suppress than AK now, right?! It's rare to encounter such a big grudge!" "Haha, laugh and make a fuss! No matter how bad it is, I have to say that the big dogs have a good vision, and it is absolutely reliable to find Qingshan Pharmaceutical to cooperate! "
"Well, this is definitely a real strong alliance? Why do I suddenly want to hit this Regarding 'Yaojin CP'? "
"You want to bet? I guess the one I want to bet the hemophilia patients in China the most, right? This time, Saudi father paid for the development of drugs to completely cure hemophilia , I still found Qingshan Pharmaceutical, can't I die in my dreams?! The hope of healing has increased greatly! "
The netizens are right, compared to other pharmaceutical companies and eating melons The people are the people who are really happy about the hemophilia in China.
They were originally a minority group, and now they finally saw a glimmer of hope.
…
The cooperation with the Saudi prince for 5 billion US dollars has caused considerable discussions from the outside world, but after handing over the recruitment task to Ren Xiaomin, Zhang Yang's energy fell back to clinical trials. on "Ibaimab".
The clinical trial results of "Yibaizumab" in the first week are quite good in the eyes of others. After all, 100% of the drug response was achieved in the double-blind test group, which proved that it is very universal.
In addition, patients who take independent medication also have 50 to 90% treatment effect, which is still barely qualified, but Zhang Yang is obviously not satisfied.
The minimum standard for "Yipaituzumab" is to achieve a leukemia cell killing rate of more than 79.6%. This data is not something you can think of casually.
A large number of experiments and data from various cancer targeted drugs show that only by controlling leukemia cells in the human body within a lower range can patients be guaranteed to have relatively healthy life safety.
In other words, a qualified killing (inhibition) rate must be achieved so that patients can survive by taking the medicine and coexist with cancer cells for a long time.
This is not only "Ibaimab", but all cancer targeted drugs on the market follow this rule.
So, improving the therapeutic stability of "Ibaimab" has become the most important task at present.
Wei Tian took action very early, and the first project team quickly set up a resolution team under the leadership of Dr. Zhou.
In a week, a feasible improvement plan is out.
As the situation after one week of the clinical trial of "Yibaimab" is: some patients have a treatment effect of 90%, but some patients have a treatment effect of only 50%. Therefore, Dr. Zhou and Wei Tian, the first project team, decided to start with the subject first and start to analyze the blood indicators and drug residues in the patient's body between different treatment effects in detail. More than ten more accurate human indicators, including immune cell residues, immune cells, microbiome, and bone marrow changes, are used to find out the reasons for the greater treatment differences among patients.
This method has high technical requirements and higher accuracy requirements for instruments and equipment. Qingshan Pharmaceutical can find ways to overcome these.
The most important thing is!
Because the indicators involved are very complicated, from blood to bone marrow, even stool and urine microorganisms need to be collected, and not once or twice, or even several times a day!
So the whole process is very troublesome and even painful,
So, the subjects need to cooperate very well and completely obey!
Rongcheng Third People's Hospital, Director Hu's Office.
Wei Tian personally came to the inpatient department and found Director Hu. After informing him of the next improvement plan, even Director Hu's face changed slightly. "You mean, in order to find the reasons for the differences in the treatment of 'ibaizumab' in various patients, a new round of improvement plans is needed?"
"Blood draw The frequency changed from once every three days to once every six hours? Is blood drawn four times a day? Monitoring for at least seven days! ? "
"Also, do bone perforation twice a week? Is it necessary to draw twice Bone marrow sample?! ”
Wei Tian nodded.
Director Hu was silent.
A full minute later, he spoke again:
"Mr. Wei, you know, they are all leukemia patients. They are already anemia and have poor hematopoietic function. And it is easy to get infected and bleeding! "
"The frequency of blood draws four times a day is too harmful to their bodies, right? And it is also a torture for their psychology!" "
"And... you have never experienced bone marrow puncture. It is very painful, especially when extracting bone marrow, which is heart-wrenching pain. Even if you get local numbness, it cannot be completely avoided. It feels very strong!"
" Moreover, after the operation, it takes most patients 2-3 days to completely relieve the pain! "
"It's too much bone piercing twice in seven days, too much!" "
This time it's the turn Wei Tian remained silent for a long time.
After a while.
"Director Hu, this may be the fastest and most likely to find a solution to the stability of the treatment of 'Ibaimab'!"
Silence in the office.
I don't know how long it took, a low voice echoed in the office.
"Forget it, I can come forward to explain to the patients in person and try to get their consent!"
(The end of this chapter)