Chapter 245 Shocking subjects!
Hematology Department, in the ward.
Because the more than 30 subjects who participated in the "Yibaituzumab" medication alone were all critically ill patients and were in danger of life at any time, they were hospitalized after participating in the clinical trial.
On the one hand, it can maximize the life safety of these critically ill patients during clinical trials and avoid disputes.
On the other hand, it is more convenient for Qingshan Pharmaceutical to collect clinical data of subjects in detail and accurately.
At the same time, in order to facilitate management, Director Hu also specially designated ten wards to place subjects with independent medication.
In the ward.
The ward of the four-person room was originally filled with nearly thirty subjects.
Director Hu and Wei Tian were surrounded in the middle wearing masks.
"This is Mr. Wei, the person in charge of Qingshan Pharmaceutical, who is specifically responsible for the development of our 'Yibaimab' targeted drug, and everyone should know him."
"Well, Director Hu, we know this boss."
"Yes, I know it too. The last time I signed the letter of information was the video recorded by this boss!"
"Then let's go OK."
Director Hu briefly introduced Wei Tian. Obviously, everyone has a good impression of Wei Tian.
Immediately afterwards he paused:
"Since everyone knows it, I'll just talk about the topic."
"At present, you have all injected two injections of 'Ibaimab' targeted drug. This two-week treatment effect is also true. Everyone knows it."
"The good news is that the targeted drug of 'Ibaimab' is indeed effective. We have a total of 32 independent drug quotas and 32 leukemia cancer cells in the body of the subjects There have been significant reductions. "
"But the bad news is... Some patients have very good treatment effects, and the leukemia cells in their bodies have decreased by nearly 90% in just two weeks; >Some patients, after two weeks, there are still many leukemia cells in their bodies, with a low clearance rate, and the residual leukemia cells are close to 50%. "
"It is obvious that the treatment effect of 'Yibaimab' on different patients fluctuates greatly!"
After the words, everyone nodded.
In fact, everyone has already known this situation after the private exchanges in the past two weeks.
And those patients who had poor treatment effects in Director Hu couldn't help but feel unspeakable pain on their faces when they heard this. Everyone used the same medicine and the same treatment method. Others had good results, but they did not have any effect on their own. OK, is this fate?
The expressions of everyone fell into Director Hu's eyes. He coughed lightly and continued:
"So, given this, it can be confirmed that the treatment effect of 'Yibaimab' is not stable!"
"Qingshan Pharmaceutical, which is Mr. Wei next to me, hopes that I can turn 'Yibai next The therapeutic effect of monoclonal antibody is stable and can be increased to a stable therapeutic effect of 80-90%. Is it even possible to achieve cure in the end! "
Cure? !
This time, even those patients who had 70-80% treatment effect and had a calm expression just now could not help but be moved.
Although their treatment effect is very good at present, who doesn’t want to eliminate more leukemia cancer cells in the body?
Even, it's cured!
In just a few short words, the crowded ward suddenly became silent. Everyone looked at Director Hu, looking forward to his next topic!
"So, this requires everyone's help and cooperation!"
As he said, he looked at Wei Tian: "The next improvements of Qingshan Pharmaceutical The plan is: prepare to extract more and more comprehensive biological tissue and blood specimens from your bodies for more detailed analysis. ”
"The frequency of blood draw has changed from once every three days to once every six hours, and at least four blood draws a day are required to achieve more detailed monitoring every six hours."
"This process is currently tentatively set to seven days. "
Shut again:
"In addition, in the next week, two bone marrow aspirations will be required, and two bone marrow samples will be taken..." >
"At the same time, all stool and urine must be stored in accordance with regulations, and the whole process is a bit cumbersome."
The crowded ward was even quieter, and even the breathing sound seemed to be much smaller.
Especially when hearing about bone marrow puncture and the bone marrow sample was taken, everyone's expression changed slightly, and they remembered the pain of bone marrow puncture.
Wei Tian, who had not spoken, also felt the atmosphere in the ward becoming solemn. He coughed lightly and stood up and said: "Dear patients, I am Qingshan Pharmaceutical Industry One of the heads of the research and development of the 'Ibaimab' drug. "
"Our 'Ibaimab' currently achieves 90% of the leukemia cells in individual patients, which proves that we The drug ingredients are right, and our targets are approaching the right ones."
"But there are obvious differences between patients at present, so we need to find the reasons for the differences;
We want to analyze what is happening in the body of patients with 90% of the treatment effects, and 50% of the treatment effects effects What is the situation in the body, what is the difference between them after taking medication, and where is the problem! "
"Of course, this does not mean that we only need to analyze patients who have achieved 90% treatment effect and 50 % of patients with treatment effect, but we need to analyze the patient data of all treatment effect! "
"Because only with enough data specimens can we find the reasons for the difference!" "
"So, I hope that no matter how good or bad the treatment is, everyone will try to participate in this improvement plan!"
As he said that, Wei Tian couldn't help but take a deep breath and confessed: "Of course, this process must be a bit painful, and it may even have a certain impact on your body, but what I can guarantee is that we We will do our best to ensure everyone's health! "
"Of course, we also adopt the principle of voluntary improvement plan this time. Even if we have any concerns and are unwilling to participate, we will not force it."
After the words fell, more than thirty people in the ward fell silent.
To be honest, Wei Tian’s explanation is easy to understand, and even patients who have no experience in drug development can understand it at once.
Everyone knows in their hearts that Qingshan Pharmaceutical’s purpose is to find differences and develop drugs that are more effective in treating all patients with leukemia. But when you think of the pain of bone marrow puncture, you think of the harm caused to the human body by twice a week. , everyone hesitated.
The hesitation in everyone's eyes fell into Wei Tian's eyes. He could understand the worries and hesitation of all patients.
As the same thing, patients who can participate in the use of "Yibaituzumab" alone are all seriously ill patients, and they no longer have the capital to toss them!
A little sighed in my heart, and then said: "Dear patients, I have explained the specific situation and reasons to you."
"Let's do this, everyone can consider it. If you are willing to participate in the improvement plan, please contact Director Hu..."
"No need to think about it, I'm willing!"
Wei Tian's slightly disappointed voice was a little disappointed As soon as it fell, a firm and crisp sound suddenly rang!
Wei Tian suddenly shuddered all over, and his eyes looked at him with the sound. A young patient raised his right hand high, which was particularly dazzling in the crowded pile of patients!
He vaguely remembers the name of this patient - Liu Xiaochuan, 24 years old, just graduated from Sichuan University.
"Mr. Wei, I'm willing, I have nothing to consider!"
"Although the effect of my first injection reached about 73%, logically speaking, I don't need to be so anxious, but!" >
"If it weren't for Qingshan Pharmaceutical, if it weren't for this 'Yibaichunbacter', I would probably be almost seven years old now!"
"My life is Qingshan Pharmaceutical The karma was saved, so, please draw my blood. I am willing to give everything for this improvement plan! ”
With a rumbling sound, an indescribable shock suddenly exploded in Wei Tian’s heart.
At this moment, a young child's voice suddenly rang out. "Uncle, I'm willing to do it too. Suck my blood, I'm not afraid of pain!" Wei Tian looked along the voice, and he remembered the name of the child - Zhang Lele, eight years old. "Boss, I am willing to do it too! I will draw my bone marrow! I, a man, can't be worse than a child!" "Yes! I am willing to do it too! Isn't it just blood draw? Isn't it just bone piercing? I have all been through the gates of hell twice, and I will die if I die! ”
"Fuck! If you die, you will die, I am willing!"
The crowd was in agitation, and the sound of "I am willing" instantly broke the tranquility of the ward and resounded throughout the department.
Wei Tian's eyes became a little wet without realizing it, and the shock in his heart could no longer be described.
You can say that their ultimate goal is to hope that Qingshan Pharmaceutical can develop a drug to cure its own disease, but when it is truly aware that it is very painful and may even affect one's body or even life. It doesn’t take great courage to be willing to stand up calmly and take the initiative?
As the saying goes:
A true warrior is the daring to face the bleak life and the daring to face the blood!
They are all real warriors!
Wei Tian's wet eyes glanced at every patient who was "screaming", and finally his eyes fell on Xia Xue.
Xia Xue's hair, which had been shaved due to chemotherapy, had gradually grown out. At this moment, she no longer looked like a patient suffering from leukemia.
It is no different from a normal person.
And she was the one who responded the best to "Yibaizumab" among the 32 patients, and was also the only patient in Wei Tian who had received 90% of the treatment effect after two injections of the preparation.
In other words, Xia Xue's blood specimens and bone marrow tissue are actually the most analytical value!
Xia Xue also noticed that Wei Tian's eyes fell on her. Before Wei Tian could speak, she smiled slightly and said first: "Mr. Wei, don't ask me anymore, I do! ”
No mistakes, one song, one content, one in 6, one book, one bar, one reading!
"I am only 25 years old, so I don't want to take medicine for the rest of my life! I'm waiting for you to develop a drug that completely cures leukemia!" Wei Tian took a deep breath, and his face showed for the first time A happy but extremely heavy smile!
After a moment, he straightened his back, slowly glanced at all the patients present, and finally bowed deeply to everyone.
"Thank you for your support!"
"Don't worry, Qingshan Pharmaceutical will do its best to live up to your trust!"
This scene.
Huh!
Everyone exhaled heavily!
"Mr. Wei, Qingshan Pharmaceutical, please!"
...
Wei Tian and Director Hu never expected that this improvement plan would be so smooth, and would receive strong support from all 32 independent medication patients!
Even if you look at the clinical trials of any cancer-targeted drug around the world, it is difficult to obtain tissue and blood samples from so many patients in the same batch at the same time, almost exactly the same medication environment.
This is of great help in finding the differences between drugs to different individuals. It can be said that this is a convergent R&D environment that all pharmaceutical companies dream of!
However, everyone's passion was soon tortured by the almost harsh monitoring.
At 8 o'clock in the morning, just woke up from the hospital bed, the nurse had already walked to the bed with a treatment plate and started her first venous blood collection in the day.
After 5ML one tube, five tubes, the first blood draw in the morning ended.
But this is just the beginning. The electrocardiogram and color ultrasound will be tested at 9 o'clock in the morning. At the same time, all urine and stool must be saved separately and sent to the nurse station immediately, and then Professionals were sent to the laboratory for testing and testing.
At 2:00 pm, the second blood draw in the whole day began, the same 5ML tube and the same five tubes.
At 4:00 pm, the first bone puncture begins in seven days. At the same time as the bone puncture is penetrated, five milliliters of bone marrow fluid from the bone marrow will be extracted.
At this point, moving down the ground will be prohibited for the next ten hours.
At 8 o'clock in the evening, the electrocardiogram was performed before going to bed, and the third blood was drawn throughout the day. The same five tubes were used, and each tube was 5ML.
At two o'clock in the morning, when I was sleeping, the nurse performed the last blood draw for the whole day again, the same quantity, the same five milliliters per tube.
At this point, the subjects involved in the improvement plan had a vein in the right arm four times a day and would be replaced with the left arm to draw blood tomorrow.
Frequent blood draws four times a day are a great psychological pressure for any patient. What is even more painful is that 25 ml at a time, 4 times a day, 100 ML blood draws a day. The amount is already a considerable amount of blood loss for patients with leukemia who are almost all anemia.
For such monitoring, they need to perform 7 days, and they need to lose a total of 700ML of blood, which is undoubtedly a very dangerous amount of blood!
This is just an ordinary subject.
As Xia Xue, who has the best effect on medicine, she naturally became the key analytical target, and the pain she endured is even more heartbreaking. "Bed 45, Xia Xue, blood was drawn."
Lao Xia woke up from the nap in a daze when she heard the soft shouts of the nurse beside the bed.
Soon, he reacted.
Didn’t you just drew blood at 2:00 pm, just over an hour ago? Did I sniff for a while and it was eight o'clock in the evening?
But he took out his cell phone and took a look. It was just 4 pm.
He hurriedly put back his cell phone and looked at his daughter. The nurse had already placed the treatment plate on the bedside table and began to tighten the pulse belt for Xia Xue.
He said anxiously:
"Miss nurse, didn't you say that you would draw blood only once every six hours? Why did you need to draw blood again in just two hours?!"
Miss nurse stopped the movement in her hand and looked at Lao Xia. "We have just received a notice from the laboratory, asking us to collect blood immediately and then quickly deliver it to the laboratory."
When we heard that it was the notice from the laboratory, Lao Xia was silent.
After a moment, his voice became much lower:
"How much blood will be collected this time?"
"There are still twenty-five milliliters in total for five tubes!"
Old Xia sighed silently.
When he had a meeting two days ago, he thought Xia Xue was brave, but at this time he really saw tubes of blood being pulled out of his daughter's body, and was awakened by the nurse in his sleep again and again. Even the face was obviously bleak and anemia!
He really felt sorry!
I feel sorry for my daughter!
But... he also knows the importance of Qingshan Pharmaceutical's improvement plan this time!
"Xiaoxue..."
Old Xia looked at Xia Xue with pain, but instead, Xia Xue forced a smile on her slightly pale face:
"Dad , It's okay, I can still hold on, I'm fine!"
Old Xia's heart was cut like a knife, and finally sighed: "Xiaoxue, you are a good person." "Pump!" The crimson blood slowly came from the sky Xia Xue's veins flowed into the cold blood collection ducts. In the sun, Xia Xue's face seemed to be paler.
Old Xia in the distance looked at his daughter silently. He was in pain, but he never thought of quitting, never thought of giving up!
Because they all know that at this moment, only by firmly believing in Qingshan Pharmaceutical has the only hope.
Living, hope!
(This chapter ends)