Chapter 249 The effects of combined medications are released! Qingshan Pharmaceutical is awesome! (Please give me a monthly ticket!)
"Bed 79, Liu Xiaochuan, after four weeks of clinical treatment, your acute leukemia can be said to have been well controlled."
"According to The latest peripheral blood smear test result yesterday, the proportion of leukemia cells in your peripheral blood is still controlled at about 27%, which means that compared to when you were initially admitted to the hospital, the leukemia cells were effectively killed. %."
"This treatment effect is at a moderate level among all subjects. Next, if the treatment is long-term injection of 'ibaizumab', it is possible to survive for a longer period of time, but …”
“After this period of time, Qingshan Pharmaceutical’s research and improvement on 'Ibaimab', they have re-customized a new combination treatment plan, and the treatment effect may be better, so I want to ask Ask if you would like to modify the previous treatment plan and change it to the latest combination treatment."
Combination therapy?
Although Liu Xiaochuan is only 24 years old, as an old patient, he certainly knows what combination treatment means.
But soon, his attention was removed from the combination treatment and suddenly said excitedly: ""
"Director Hu, is it the one we had fully supported Qingshan Pharmaceutical before. Is the improvement plan finally successful? "
"So, this combination treatment is actually the result of the improvement after the previous improvement plan?" "
Director Hu smiled.
He was deeply impressed by Liu Xiaochuan, the first patient in the ward to stand up and express his support for Qingshan Pharmaceutical's improvement plan.
Nodded, without hiding it:
"Yes, this combined treatment plan is the latest plan derived from the research of the improvement plan you supported before."
" > "What's there to hesitate about! I'm sure I'm willing to participate!"
Director Hu's smile even more, and he could clearly feel the trust and expectation of the patients in front of him.
After a moment, he shook his head and said, "I still have to explain it in detail to you."
"You also know that when we were conducting clinical trials before, All drugs were stopped and only injected with 'Ibaimab' once a week for treatment. "
"But in this combination treatment, in addition to using 'Ibaimab', we will also add A drug called 'allotype T cells'! ”
"This 'allogen T cell' is mainly used to activate the immune system in your body and thereby increase the metabolism speed of your immune cells;
I won't explain the specific treatment principles. In short, use this drug The ultimate goal is to enhance the therapeutic effect of Yibaimab! "
When I heard that it was to enhance the therapeutic effect of "Yibaimab", Liu Xiaochuan was even more stunned and suddenly excitedly wanted to speak .
Director Hu waved his hand again when he saw this, interrupted with a smile: "Don't worry about speaking first, listen to me first."
"Of course, there are 'allogeneic T cells' which are an immune drug, and there are many side effects that are likely to occur after injection."
"Common things include fever, immune dysfunction, endocrine disorders, etc., the most serious, even It is possible that organ failure in the body may occur due to a long-term acute rejection reaction, such as the normal bone marrow hematopoietic stem cell failure in your body! "
"This is a side effect that you must know!"
The last few Director Hu said the sentence with a serious expression, and Liu Xiaochuan was also slightly stunned.
But soon a smile appeared on his face and his white teeth were grinning:
"Director Hu, I know, but I'm not afraid; or I don't have any capital to be afraid of any side effects now! "I don't remember how many times I did chemotherapy before, as long as I can control my body I am willing to live for several years! "
Director Hu smiled hoarsely and nodded. "Okay, since you have no worries, then sign the informed consent form and will be transferred to joint treatment tomorrow at the latest . ”
“Okay! ”
…
Liu Xiaochuan was the first patient to be interviewed by Director Hu himself. Then, Zhang Lele, who was only eight years old, and his father also came to Director Hu's office.
"Dad Lele, Lele is in good condition at present... Recently, Qingshan Pharmaceutical has improved a new combination treatment plan..."
"Director Hu, we have already understood the side effects clearly Now, we are willing! ”
"Okay! ”
…
"Xia Xue..."
"Director Hu, let's not talk, I will sign it directly. As I said before, I accept all the plans of Qingshan Pharmaceutical. I'm still waiting for them to develop a drug that completely cures leukemia! "
...
The combination treatment plan using "alloy T cells" has been promoted very smoothly, especially when I learned about this combination plan It was the result of the previous improvement plan. Almost all of the thirty-two patients received a new combination treatment plan without hesitation.
Just kidding,
In the words of many patients, the pain suffered in the previous improvement plan is always "enjoy" now.
As for side effects, people don’t take it much.
Of course, Director Hu knew that this was a "terminal illness" and was on the verge of death. What are the side effects of him?
Secondly.
Director Hu also knows that this is everyone’s trust in Qingshan Pharmaceutical.
After two days, everything will be arranged.
Thirty-two patients who received independent medication began to switch to combined medication at week 5 after completing "Ibaimab" alone treatment for four weeks.
As a needle of a foreign injection of "allomal T cells" imported from abroad was injected into the bodies of 32 patients, Qingshan Pharmaceutical's first project team immediately started blood tests of 32 patients.
The first step is to test whether the patient has an "acute rejection reaction" in the body, which leads to an increase in the metabolism rate of immune cells.
The second step is to test whether the TEF glycoprotein concentration in the patient's body increases.
We must briefly talk about "aliosmotic T cell" injections.
"Allogenetic T cells" are a new immune preparation that has only appeared in recent years. They are mainly used in a new treatment method - a drug for CAR-T cell therapy!
The treatment principle is simply to activate the human immune system by implanting "alloy T cells" into the patient's body, and then killing tumor cells through autoimmune cells!
Yes, "alloyellow T cells" are actually an immune drug used to treat cancer, but the current technology is not very mature.
So, the "allotype T cells" that Qingshan Pharmaceutical directly used for thirty-two patients were all drugs that have completed clinical trials and approved for marketing, so they can be directly treated with medication.
Soon.
The "alloy T cell" injection drug was used for six hours, and Qingshan Pharmaceutical collected blood samples from thirty-two subjects for the first time.
"Mr. Zhang, after the injection of 'allogeneic T cells' into the human body, an immune response occurred according to the drug instructions. The immune cells in the patient's body, especially T cells, began to proliferate in large quantities and the metabolic speed began to increase!"
"Several patients had a low fever of 37.1, and it is very likely that they began to have acute rejection reactions!"
"And the concentration of TEF glycoprotein... has also increased slightly!"
Zhang Yang Exhale gently.
"Continue monitoring!"
"Okay."
Twelve hours later.
"Mr. Zhang, nineteen of the thirty-two patients all had low fever symptoms, and it has been confirmed that there was an acute rejection reaction in the body."
"All patients were immunized in the body. The cell metabolism rate has been increased to 0.3mmol/min, which is nearly twice that of normal people! "
"And TEF glycoprotein... The blood concentration of 32 patients has increased significantly, and some patients even have The concentration has nearly doubled before! ”
"Do you want to inject 'Ibaimab' into the patient now?" Zhang Yang thought for a moment and shook his head.
"Wait a little longer."
Twenty-four hours later.
"Mr. Zhang, 32 patients, 29 of whom had low fever symptoms, have been confirmed to have an acute rejection reaction in the body."
"At the same time, after a night, the metabolism rate of immune cells in all patients increased to three times the normal value!"
"As for TEF, even the patients with the lowest TEF glycoprotein in the body before, the concentration of TEF at this time is still It basically reached the level of Xia Xue before! "
Hearing this, Zhang Yang handed the experimental data in his hand to Dr. Zhou and Wei Tian who were beside him.
When the eyes of the two of them lit up, he nodded and said: "The time is almost the same, and the TEF concentration in all patients is enough!"
"Go and tell Director Hu that he can inject 'Ibaimab' into all patients and officially complete the combination medication!" "Okay."
Three days later.
Inpatient Department of Hematology Department of Rongcheng Third People's Hospital.
Ward No. 40.
"Lele, today is the fourth day of the combination of 'Yibaimab', and it is also the day when Qingshan Pharmaceutical is about to inform us of the treatment effect. Are you nervous?"
At only eight years old, alone Zhang Lele lying on the hospital bed playing with her cell phone, shook her head.
His father went to the hospital cafeteria to buy him food, and only Zhang Lele and Liu Xiaochuan were left in the entire ward.
"Brother Ogawa, I'm not nervous, I feel my health is getting better and better!"
"Dad said that in two months, we will be able to go home after completing the clinical trial. Now! ”
"What's wrong? Are you nervous?"
No mistakes, one song, one content, one in 6, one book, one bar, one bar, one bar!
"Yes!"
Liu Xiaochuan nodded heavily.
"Brother is very nervous now!"
"I don't believe it. Dad once said that brother, you are very brave. You are a man. Let me learn from you!"
"Haha!"
Liu Xiaochuan was slightly stunned, and then smiled bitterly. Shaking his head.
Yes, he had no worries when he participated in the "Yibaichunab" improvement plan before, but now...
After truly accepting Qingshan Pharmaceutical's latest combination medication, he endured it in his heart I kept getting nervous.
After a moment, he took a deep breath and continued: "By the way, Lele, are you getting better with a low fever? Do you still have a fever today?"
"No, take it this morning I didn't have a fever in my body temperature, but I heard from my father that low fever was a good thing, saying that some immune cells were mobilized...whether you? Brother Ogawa!" "I don't have a low fever either..." >
Liu Xiaochuan's tense mood slightly relieved, but at this moment, a nurse suddenly walked into the ward.
Liu Xiaochuan glanced out of the corner of his eyes, and his mood became nervous again in an instant.
"Liu Xiaochuan, your latest peripheral blood smear results..."
"There are Zhang Lele from bed 78, your father is not here, right? You can check your results , show it to your father later! ”
Liu Xiaochuan took the inspection report handed over by the nurse with a trembling trembling, and his eyes instantly fell on the most important indicator!
"Peripheral blood leukemia cell ratio: 13%."
13%!
He was shocked and then ecstatic!
Don't 13% ratio mean that 87% of leukemia cells in the body have been killed?
He remembered that the last test result was 73%!
Advanced by 14%!
Combination medication has really improved the effect!
"Brother Ogawa, is your treatment better? Please help me see?"
Lele, who was lying on the hospital bed, no longer played with his mobile phone, and looked expectant. Looking at Liu Xiaochuan.
Liu Xiaochuan hurriedly took Zhang Lele's inspection report and was even more shocked!
"Lele, I remember that your treatment effect seemed to be only...65% before, right?"
"Oh my God, your combined medication is better than mine, and the proportion of leukemia cells in your body is only 11%!"
"In other words, your treatment effect has reached 89%! It has been improved in full 24%! "
"Too strong!" "Brother Ogawa, can I go back to school? "
"Well, sure ! If you can achieve this effect for a long time, you can go back to study! ”
"Oh yeah, I can study! I can study!"
...
As the nurse distributed thirty-two test results to the patient, the entire department of hematology was in the blood disease department. Suddenly, bursts of cheers broke out.
Qingshan Pharmaceutical, Zhangyang Office. "Mr. Zhang, good news! The medication results of the thirty-two independent subjects have all come out!"
"The treatment effects of thirty-two patients have been improved in all respects, especially in terms of stability. The worst treatment effect before was only 51%, but now!"
"After the combination of medication, even if it is The patients with the worst treatment effect all achieved a killing rate of 82%, and 80% of the patients directly achieved a treatment effect of more than 86%! "
"It can be said that 'Yibaimab' The effect of treating acute myeloid leukemia has completely met our expectations! ”
Hearing Wei Tian’s excited report!
Even though Zhang Yang had expected it, he couldn't help but breathe out loud at this moment!
The plan to improve the stability of "Yibaizumab" treatment has finally been successful!
But soon, he thought of Xia Xue and was looking forward to it. "By the way, what about Xia Xue's data?" "Xia Xue's treatment data before reached 91%. What is the effect after combining 'opposite T cells' this time? "
Wei Tian was obviously very concerned about Xia Xue, and he replied quickly without hesitation:
"Xia Xue's treatment effect has also been improved, but the increase is not large!"
"It has increased from the previous 91% to 94%!"
Zhang Yang was stunned, and then a trace of it was squeezed out from the corner of his mouth. wry smile.
Wei Tian continued to speak: "Boss, I also carefully analyzed the reason. Although the TEF protein concentration in Xia Xue's body increased again, there should still be a small number of leukemia cells in her body. Even TEF proteins cannot be well recognized.”
"So..."
Please sighed and said:
"However, I think her condition is already very good. If drug resistance does not occur, such a low amount of virus Life that lasts for twenty or thirty years is no problem! "
"I'm afraid leukemia will be conquered in twenty or thirty years!" Zhang Yang nodded and took back his mind.
Indeed, this result is very satisfactory!
"Wei Tian, you are right, we really don't need to pick on it!"
"Yes!"
Wei Tian smiled on his face and pondered for a moment. "Boss, now our latest clinical trial results are out. Am I going to announce them to the public?"
Zhang Yang did not hesitate!
"Announce it, and let the whole world see the latest progress of our 'Ibaimab'!"
"Okay, 83% of the basic treatment effect! Can this data be sent out? I know how much shock it will cause! "
Wei Tian is right. After Qingshan Pharmaceutical's latest combination drug effect was released on the official website of the review center,
The entire leukemia patient The group exploded directly.
But the first one to explode was unexpectedly a double-blind patient who is undergoing clinical trials!
(This chapter ends)