Chapter 252 Use your own medicine to treat the side effects caused by your own medicine! (5K)
"Hey, Xiao Liu, have you heard that all the combined medication treatment plans in the quarantine critical care trial area have been stopped! It is said that in the future, only 'ibaizumab' will be treated alone, and no longer What kind of 'alien T cells' was injected! "
"Ah?! Sister Li, I don't know what happened? They didn't use it well, and they all said that the treatment effect is good!" "Hey, what else can I do? It is said that there are serious side effects. A patient has bone marrow stem cell failure!"
"Bone marrow stem cell failure?! Do they have side effects?!"< br>
"Hey, yes, it seems that Director Hu and Qingshan Pharmaceutical did not deceive us before. The combination treatment plan has really had strong side effects!
But... I feel even more uncomfortable now, but I hope Qingshan is on the contrary. The pharmaceutical industry really doesn’t give us medicine to make more money, so it’s better than now that the combination treatment plan is stopped due to side effects!
What if the combination treatment plan is gone, what should we leukemia patients do! ”
"Ah..."
After brief discussions with Wei Tian and Dr. Zhou, Zhang Yang immediately stopped the clinical trial of the combination treatment plan of "Ibaizumab" + "alloyellow T cells".
On the one hand, Zhang Yang has realized the severity of this side effect.
On the other hand, this is also a regulation of clinical trials.
Once clinical trials cause irreversible damage to important human organs, clinical trial companies must stop clinical trials as soon as possible.
It is not until a solution to the side effects is found, or after a comprehensive evaluation, it is believed that the side effects are only a very small probability that the clinical trial will be restarted!
This action of course attracted the attention of all subjects, and the news of serious side effects of the combination of "Ibaimab" treatment spread wildly.
However, compared with the private discussions and concerns of ordinary subjects, Director Hu and Wei Tian were somewhat difficult to face Liu Xiaochuan, who had side effects at this time. "Liu Xiaochuan, this is probably the case." "Unfortunately, during the latest bone marrow apnea, we found that your bone marrow stem cells had failed and have been diagnosed with Functional failure of bone marrow stem cells."
"According to our judgment, this should be the side effect of 'allogeneic T cells' long-term activation of the body's acute immune response, I'm sorry..."
Dear Director Hu Both Wei Tian and Wei Tian looked solemn. When they came to their ward in person, Liu Xiaochuan noticed a trace of abnormality.
But after hearing Director Hu say that he had the side effects of bone marrow failure, his mood still couldn't help but fall to the bottom.
Why is it me again? "So, Director Hu, the reason why everyone stopped the combined treatment plan this time is because I had side effects?"
"Yes!"
Director Hu was very serious The place nodded, without hiding it.
"Okay!"
After the shock, perhaps because he had experienced too much, Liu Xiaochuan breathed heavily, and his face became calm.
Even, he showed a faint smile: "Director Hu, and Mr. Wei, don't blame yourself."
"After all, clinical trials were conducted before You will inform you of the possible risks of side effects. I am also a reasonable person. I will not blame you or cause trouble for you."
Director Hu nodded slightly and exhaled gently.
For decades of medical practice, he has seen too many unreasonable patients and many reasonable patients.
After a moment, he continued: "Thank you for your understanding."
"However, today Mr. Wei and I will come together to tell you about the side effects, in addition to telling you about the side effects. , there is another thing."
"Although you do have 'bone marrow stem cell failure' in your body, we have also thought of another way."
"We want to inject you with 'ITG human bone marrow cell failure', see Can it reverse the bone marrow stem cell failure in your body? "
"Because although Qingshan Pharmaceutical's 'ITG human bone marrow stem cell failure" is used to treat aplastic anemia, the essence of 'abora' is actually bone marrow stem cell failure , abnormal, this can be considered as symptomatic treatment! "
Liu Xiaochuan was stunned and immediately said excitedly: "Yes, yes, yes! 'ITG human bone marrow' I know, it is to treat bone marrow function Abnormal! Sure enough! ”
"Director Hu, I'm willing, I'm willing!"
...
After obtaining Liu Xiaochuan's consent, Qingshan Pharmaceutical immediately began to exert the side effects of "bone marrow stem cell functional failure" on Liu Xiaochuan. Conduct treatment.
To be honest, Zhang Yang, Director Hu, and anyone else don’t know if it will work, so they can only give it a try.
It is precisely because of this uncertainty that Qingshan Pharmaceutical has not disclosed the treatment plan for "ITG myelogenin" this time, and even reminded Liu Xiaochuan not to leak it.
Of course, Liu Xiaochuan agreed.
Soon, a ten milliliter injection of Qingshan Pharmaceutical, the "ITG human bone marrow entropin" that Qingshan Pharmaceutical has been on the market for more than seven years, entered Liu Xiaochuan's body.
A week later, Liu Xiaochuan's first blood test result came out.
The blood image results are not very good, and red blood cells, white blood cells, and red blood cells are still below the normal range.
Director Hu was not too anxious.
Years of experience in using "ITG human myelogenin" tells him that the effect will be seen after at least four injections of ITG.
However, Director Hu was not in a hurry, and the remaining 31 critically ill patients were anxious after being discontinued for one week of combined treatment. "Director Hu, can you stop our combined treatment plan?! I just stopped taking the medicine for a week, and my leukemia cell proportion has increased again! I am really anxious!"
"Yes, Director! The previous half month of combined treatment was the best treatment effect after I was diagnosed with leukemia! The cancer cells in my body cannot even be detected! The complications also disappeared. I stopped for a week, what symptoms were there? All are back! "
"Hey! Director, we are really going to die. Can you tell Qingshan Pharmaceutical? I understand that you are worried about our side effects, but have we signed an informed agreement? Even if the side effects occur I admit it too! Isn’t it just bone marrow failure? It’s better than being tortured to death by leukemia, right?”
"Yes, bone marrow failure is always better than leukemia metastasis, right? Besides! Even if there are side effects, not everyone will have side effects!"
"Director Hu, is there any other way now? ? We really want to use the combined treatment plan again! "
Enjoying the patients' complaints and inquiries, Director Hu was also quite helpless, and he could only make excuses that Qingshan Pharmaceutical was already taking action.
Not only domestic patients pay close attention to the side effects of the combined treatment of "Ibaimab", but foreign leukemia patients also pay close attention!
You must know,
Qingshan Pharmaceutical's "Yibaimab" combination treatment plan has just come out, but it is named "Acute Leukemia Magic Drug" with an 83% basic treatment efficiency. It has spread wildly on social media such as Titok and Facebook overseas, and has been to countless people. Overseas leukemia patients and families bring hope!
In order to understand the latest situation, many overseas patients even opened translation software to download Chinese APPs such as Weibo and Xiaohongshu, and then sent the learned situation back to China.
It can be said that for a time, the combination treatment plan of "Ibaimab" + "alloyellow T cells" was suspended, which touched the hearts of countless leukemia patients.
Director Hu knew about this situation, and Zhang Yang also knew about it, but everything had to wait for the treatment results of "ITG human bone marrow entropin".
However...
After just two weeks of injecting "ITG human myelogenin" treatment, an exciting good news suddenly appeared on Director Hu's desk! "Damn, Liu Xiaochuan's blood signs have not improved last week, and they have recovered in just one week?!" "Also, bone marrow smear is normal. ! ”
"So fast! ITG is simply a magic medicine! ”
Director Hu swears a little. According to his years of clinical experience, "ITG myelogenin" should have obvious results only in the fourth week, but I didn't expect it to be so fast!
But he was too lazy to think about the specific reason, so he quickly called Zhang Yang to inform Zhang Yang of the news.
"Mr. Zhang, it's done, it's done!"
"The result just came out, in just two weeks, Liu Xiaochuan's bone marrow hematopoietic stem cells actually returned to normal!"
< br>"ITG myelogenin can really treat the side effects of bone marrow failure caused by 'allogeneic T cells'!"
"Ah!" Zhang Yang was also extremely surprised on the other end of the phone.
He thought that "ITG myelogenin" might be able to treat bone marrow stem cell failure, but he didn't expect it to be so quickly.
"It's still awesome for the simulator!"
"ITG myelogenin, seven years after it was launched, has been developed for a new purpose and has become a part of the treatment of leukemia!" It's so outrageous! ”
As he said that, he breathed a sigh of relief! "Director Hu, don't be excited. I'll come to the hospital right away. I want to see the treatment effect with my own eyes!" "Okay, I'll wait for you!"
... …
Solving the side effects caused by "aliosomal T cells" means that all obstacles that block the combination treatment plan of "Ibaimab" have been eliminated, and it also means that the minimum basic treatment rate is 83% Top leukemia treatment options will launch clinical trials again.
In Qingshan Pharmaceutical Drug R&D Center, the haze that had been lingering in everyone's hearts for half a month was finally wiped out.
Wei Tian sat at the conference table, excited. "Mr. Zhang, I didn't expect that in the end I had to rely on the drug we developed seven years ago. "ITG myelogenin" is really 'heavier to be strong'."
"Haha!"
People in the conference room laughed.
No mistakes, one poem, one post, one content, one in 6, one book, one bar, one read!
In fact, after so many years of clinical use of drugs like "ITG", the basic scope of use of clinical diseases has been explored. I really didn't expect that new uses can be expanded here. "Boss, then our plan to treat leukemia can basically be determined."
"Patients can use the combination treatment of 'Ibaimab' + 'allogeneic T cells'. It is best not to have side effects. If side effects occur, inject our 'ITG myelogenesis' treatment' Yibaimab' Anti-' side effects! "
"Yes! That's the logic."
Zhang Yang nodded, but soon, not only him, but everyone present at the meeting discovered a very subtle The problem.
The person who spoke was Ren Xiaomin who came to listen to the interview after learning that there were significant progress in "Yibaizhongb".
He couldn't help but frown slightly:
"Zhang Yang, from a medical perspective, I really agree with the logic you just mentioned."
"But..."
"Emotionally, I always feel a little strange. Yes, use our medication to treat side effects caused by our medication? ? ! ”
”If I say this, how can I feel that I will be led by someone? ! ”
” Is it a disease that sells two medicines? ”
Zhang Yang also realized this problem at this time.
If "ITG human bone marrow entropin" is a drug from other pharmaceutical companies, it is easy to say, but it is exclusively produced and sold by Qingshan Pharmaceutical, it is difficult not to make people think of it!
Finally.
Thinking for a long time, Zhang Yang smiled bitterly, and he had no good way to solve this problem!
"Forget it, we have a clear conscience!"
"People think whatever they like, and say whatever they like!"
"Okay!"
Everyone stopped saying anything more when they see this:
"Boss, then I will report the treatment results to the ethics committee and apply to restart the combination treatment plan of 'Yibaizumab'!"
"According to Director Hu, many severe patients in the hospital can't wait. , their physical condition has indeed rebounded! ”
"Okay!"
Wei Tian quickly started to act, but Pfizer was still immersed in the excitement of the suspension of the clinical trial of "Ibaimab".
In the president's office, Daniel looked at Mike, the director of the technology research and development department in front of him with a smile.
"Mike, you are right. Qingshan Pharmaceutical's 'Ibaimab' and 'also T cells' have a problem!"
"And I just I got a new news from them. They were helpless about the side effects that appeared and were frustrated! ”
"Haha, this feeling is so good!" Mike looked at the excited Mr. President and smiled slightly: "Mr. President, I have said before, 'Allogenetic T cells' Mainly used in CAR-T cell therapy, we have in-depth research on 'allogeneic T cells', which includes side effects! "
"In Trump's words, no one understands better than me' Allogeneic T cells'! "
"Haha! Mike, I haven't seen you feel so humorous before, come on, cheers! Cheers for the little trouble we have caused to Qingshan Pharmaceutical!" "
"cheers."
Although the two did not have red wine glasses, there were two freshly brewed coffee on the coffee table.
A light touch, Daniel took a sip of coffee with a smile on his face and said: "Before, Qingshan Pharmaceutical's 'Ibaimab' was touted worldwide as a treatment for acute leukemia 'The magical medicine, now that they have improved, they can even stop clinical trials! '
"Mike, how is our project to treat leukemia drugs going? Can catch up with Qingshan Pharmaceutical through this time Progress? ”
Hearing Daniel talking about the drug he is developing, which is also a treatment for acute leukemia, Mike gently put down his coffee cup and said confidently: "Of course, president, don't worry, our latest leukemia drugs are also available. New progress... I have to say that Qingshan Pharmaceutical's 'Yibaimab' also provides us with a lot of ideas, and we will be able to conduct clinical trials soon!"
"Oh? OK ! ”
Daniel's originally very good mood suddenly became colder after no reason.
Perhaps the sentence "Qingshan Pharmaceutical's 'Yibaichunbacter' also provided us with a lot of ideas" stimulated him. He did not continue to speak, but paused for a few seconds before slowly saying:
"Mike, let's talk about Qingshan Pharmaceutical again!"
"Now Qingshan Pharmaceutical does not seem to be able to solve the side effects brought by 'alien T cells'. Do you think they can solve this side effect? ? ! ”
“We must admit that putting aside the side effects, Qingshan Pharmaceutical’s 'Yibaizumab' combination treatment plan is indeed very strong! ”
“If they are asked to solve it With the side effects problem, 'Yibaizumab' will 100% kill madly in the field of acute leukemia. All our leukemia drugs will be crushed and completely withdraw from the market! This is something we cannot tolerate! ”
Mike shook his head without hesitation:
"Mr. President, don't worry, I have carefully studied the core treatment plan of Qingshan Pharmaceutical's 'Ibaimab'. The core is to stimulate acute rejection of the human body to enhance a glycogen..."
"At present, 'allotype T cells' are the most mainstream solution. As long as their core treatment plan does not change, they can't avoid the side effects of 'allotype T cells'!"
"So, don't worry, they can't do it at all. Avoid the side effects of bone marrow functional failure! "
"Okay!"
Daniel's face once again showed a bright smile and raised his glass again:
"Mike, it is a blessing for us Pfizer to have top R&D talents like you..."
As he said, Daniel suddenly glanced at the corner of his eyes and the screen of the Iphone17 placed on the coffee table suddenly lit up.
Before he could react, a push message appeared on the screen.
This is an industry APP that specializes in reporting on pharmaceutical research and development.
[Latest news: Qingshan Pharmaceutical has restarted the combination treatment plan of ‘Yibaimab’, and the miracle leukemia drug has started clinical trials again! 】
"Impossible!"
Daniel suddenly put down the coffee cup and quickly clicked on the APP message.
After a full minute, he looked at Mike with shock on his face and looked angrily at him!
"Fuck!"
"Mike, you are right. Qingshan Pharmaceutical really has no way to avoid the side effects caused by 'alien T cells', and has never thought about bypassing the side effects. ! ”
"They actually used 'ITG human bone marrow-genetin' to treat side effects directly!"
"It's cured!"
"Fuck! How could they think of such a solution!"
Mike was confused and quickly took the phone handed over by Daniel. When he saw that his blood and blood was pouring out: "ITG human myelogenin?!"
"They actually used their own medicine to treat the side effects caused by their own medicine?!"
"Shameless!"
(The end of this chapter)