Chapter 251 Side effects occur!


Chapter 251 Side effects occur!

"Holyshit! Qingshan Pharmaceutical is so awesome. The latest treatment plan can actually achieve at least 83% basic treatment effect!"

"Knowing what the minimum treatment effect of 83% means Does it mean that as long as there is no drug resistance, most acute leukemia patients can survive by long-term injection of drugs! Live! MyGod, my god! "

"Haha, I've said it long ago Qingshan Pharmaceutical is the absolute king of blood disease research and development! Qingshan Pharmaceutical YYDS! Eternal God! "

"Fuck! I knelt down for Qingshan Pharmaceutical. When I first saw 'Yibaizumab', only about 50% I didn't agree with the treatment effect. I didn't expect Qingshan Pharmaceutical to make a new breakthrough so fast! Strong, too strong! I've been chemotherapy for three years and it's not as good as Qingshan Pharmaceutical's 'Yibaichunbacter'! "


"Yes, I love Qingshan Pharmaceutical, I love China! Qingshan Pharmaceutical is the only beacon of mankind!"

"Yes, only Qingshan Pharmaceutical is the only hope!"


>Just when the patients in the Department of Hematology of Rongcheng Third People's Hospital were very dissatisfied,

Just when Pfizer was trying to cause some trouble for Qingshan Pharmaceutical, "Yibaizumab" was 83% basic treatment The news of the effect was not affected at all, and quickly caused heated discussions in foreign media.

Especially, overseas patients who have been paying attention to "Yibaizumab" were even more excited and praised Qingshan Pharmaceutical in the media with great praise.

The overseas flattery of Qingshan Pharmaceutical has also reached Zhang Yang's ears, but he has no intention of paying attention. At this time, he is closely monitoring the possibility of "Yibaizumab" + "alloyellow T cells" combined drug use with all researchers in the first project team. Unknown side effects.

However, after the hotly discussed news abroad was reprinted to China, especially domestic media also followed suit and reported that "Yibaizumab" is a magical drug for treating leukemia, Rongcheng Third People's Hospital The families of those patients who are participating in the second phase of clinical trials are becoming more and more impatient.

See it?

So many media at home and abroad have reported it, and they all say it is a magical medicine, so how about fake it?

Also, those subjects have been taking the medicine for half a month and have not seen any side effects!

Qingshan Pharmaceutical deliberately did not give us the best treatment plan.

A growing feeling of dissatisfaction overwhelms the hearts of patients' families, and more and more patients in clinical trials have also actively proposed to use more advanced treatment methods such as "alloy T cells" + "Ibaimab".

When everyone's dissatisfaction was rising, there was no way. In order to successfully complete the second phase of clinical trial, Director Hu still told Zhang Yang about this.

Zhang Yang really didn't expect that his kindness would be misinterpreted into this way.

He just hopes to first explore the side effects of the combination of "Ibaimab" drugs in patients with independent medication.

Then wait until the approximate side effects are understood, then slowly apply them to other patients to ensure the safety of each subject patient to the greatest extent.

"Mr. Zhang, in fact, the patient and their families have no other intentions. They just look at the good treatment effect of others and the poor results of themselves, and they are anxious."

Looking at Zhang Yang's face Although Director Hu was also heartbroken, he still spoke to persuade him.

Zhang Yang nodded slightly.

After a while, he said: "Actually, I don't want to apply the combination treatment plan to double-blind test patients in such a short time." "After allogeneic T cells" themselves There are strong side effects, and if it is used in leukemia patients, the probability of side effects is likely to increase exponentially! "

"But... since they don't believe it, they have to hurry up That's OK to perform combined treatment! "

"Let them sign a side effect informed consent form and disclaimer agreement like those critically ill patients. I'll trouble you about this, Director."


Having said that, Director Hu could only sigh and nod. "Okay, then I'll tell them what they choose."

The dissatisfaction of the clinical trial patients can only be considered a small episode for Zhang Yang. After talking to Director Hu, He left this matter behind his mind.

Director Hu quickly returned to the Department of Hematology. When the patient's family mentioned this matter again, he told the patient that he could apply for a combination of "Ibaimab" + "alloyellow T cells".

"Really? Director."

"Well, but a disclaimer agreement and a letter of information on side effects must be signed. That is to say, if serious side effects occur, everything has nothing to do with Qingshan Pharmaceutical."

"Don't worry, director, we are not afraid of any side effects. , Are they good to not use it? "

Director Hu looked at many ignorant patients who didn't know what to say. Soon, several subjects got a note and learned about the combination treatment medication plan. Book.

But just as many patients were waiting for the next treatment with anticipation, a few days later, many negative news about "Yibaizumab" suddenly broke out on the Internet abroad. "Shock! Qingshan Pharmaceutical's latest combined drug regimen is exposed and may cause organ failure or even bone marrow stem cell failure!"

"Many biological experts said that the combination treatment plan of 'allogeneic T cells' combined with 'ibaizumab' is not reliable and has extremely high risk!"

"Qingshan Pharmaceutical's latest magical drug for treating leukemia' Yibaizumab may be terminated..."

"This newspaper reported that today, our newspaper had contacted Qingshan Pharmaceutical as soon as possible, but according to the time of publication, Qingshan Pharmaceutical did not currently have any questions on the Internet. The news made any response. "

As soon as the news came out, domestic netizens were suddenly confused about the situation.

Didn’t I just reported on the Internet a few days ago that Qingshan Pharmaceutical’s “Yibaizumab” is invincible? Why are there any side effects now?

Is "Yibaimab" strong or has side effects?

Things come out, right?

However.

When the news was forwarded to the exchange groups of major leukemia patients in China, several patients and their families who had signed the "Yibaizumab" combination treatment plan were stunned. "Good guy, what Director Hu said is not true, right? It won't have any strong side effects, right?"

"Uh... the child's father, why don't we think about it anymore? Why don't we participate in this combination treatment plan for the time being?"

"Yes! Let's go find Director Hu again to see if it can be cancelled. …”

Half an hour later.

Many patients who had the most terrible troubles before knocked on Director Hu's office.

"Director, I'm sorry, we were wrong. We blame Qingshan Pharmaceutical for its kindness. We are wrong, we apologize!"

"You see if we can stop taking joint treatment for the time being."

Director Hu snorted coldly:

"Haha."

...
< br>The back and forth jump of subjects in Rongcheng Third People's Hospital was just a small episode for Zhang Yang.

At this time, he noticed many news about the side effects of "Ibaizumab" on the Internet at home and abroad.

In the office, Zhang Yang held a neutral pen with his fingers and gently tapped the tabletop.

"Wei Tian, ​​who did you think the news about the side effects of our 'Yibaizumab' has? The side effects in the report are still in the verification stage for us, and they can clearly mention it at a glance It's not easy to come out!" "Yes, boss, I guess a pharmaceutical company in the industry should have deliberately disclosed it to the media, and it is unlikely that even domestic pharmaceutical companies, it is very likely that it is a foreign drug "

"Foreign pharmaceutical companies? But what motive do they have to do this?!" "

Zhang Yang was a little puzzled.

Wei Tian also shook his head, with a hint of confusion on his face:

"I don't know, is it possible that we are too popular recently, so we want to suppress us?"

"Or they have drugs and we are competitors, and seeing 'Ibaimab' being touted as the number one magic medicine for leukemia on the Internet, so... create a little trouble for us?" "It's possible!" br>


Zhang Yang nodded, and a trace of solemnity suddenly appeared on his face.

"And, if the combination treatment plan of 'ibaizumab' and 'alloy T cells' is really as they said, it has a high probability of causing bone marrow failure, which is also a very troublesome for us. "

"This may mean that the combination treatment plan for 'Ibaimab' cannot be implemented, and the sales of our 'Ibaimab' after the launch of the market will definitely be affected in the future."
< br>"However, don't worry too much. I don't know whether the combination treatment plan for 'Ibaimab' has side effects, and it needs to be monitored!"

"Yes!"

Zhang Yang's ease did not last long.

In other words, as a top pharmaceutical company in the world's top 5, Pfizer does have something to do.

Just three weeks after Qingshan Pharmaceutical's "Yibaimab" used a combination treatment plan for independent drug patients, as Pfizer predicted, the "acute rejection reaction" due to long-term injection of "aliogenesis T cells" activated the "acute rejection reaction". "The side effects are emerging.

After receiving the call, Zhang Yang quickly came to the conference room of Qingshan Pharmaceutical R&D Center.

No mistakes, one poem, one post, one content, one in 6, one book, one bar, one read!

Wei Tian, ​​Dr. Zhou and several team leaders have been waiting for a long time.

Wei Tian hurriedly handed the latest clinical data from the Third People's Hospital to Zhang Yang with a solemn expression. "Boss, the results of the latest clinical examination report have come out." "Bed 79, a patient named Liu Xiaochuan has obvious abnormalities in the blood signs, and the number of platelets has been from three weeks ago The median normal value has dropped to now falling below the normal value. "

"In addition, the patient's red blood cells and white blood cells have also decreased significantly, which is a typical hematopoietic dysfunction."

"And his latest bone marrow apnea results also came out, and the bone marrow hematopoietic stem cells showed obvious failure."

Zhang Yang quickly received the patient examination report handed over by Wei Tian.

To be honest, he had already imagined such a situation in his mind countless times, but after the patient with such serious side effects actually appeared, he felt a little helpless. "How is the patient's condition now?" "The patient's condition is still fine now. I have instructed my colleagues who are responsible for clinical medication in the hospital to suspend Liu Xiaochuan's 'allotype T cells' first Injection, but 'Ibaimab' has been used first."

"I was deeply impressed by this patient. I still remember that he used 'Yibaizumab' to treat it alone, and it was effective at about 73%. Therefore, it is not a big problem to control leukemia in a short period of time."

"At the same time, I also discussed with Director Hu. Regarding his current low blood sign, Director Hu suggested that he could add the medicine to "Qingshan Avaqubopa Tablets" to him, and stabilize the blood sign indicators first." "However, until now he still doesn't know that his bone marrow hematopoietic stem cells have failed, and we are waiting for the right time to tell him about this."

At the end, Wei Tian's tone also became a little depressed.

Zhang Yang also sighed slightly. Sometimes modern medicine is like this. While treating a disease, it must bear the side effects brought by treatment.

Just like at this time, leukemia was controlled, but there was another problem with the bone marrow hematopoiesis ability. "Well, let me know the truth. Although the facts are a bit cruel, there is nothing I can do about it." "There is also a little more compensation to patients after the clinical trial is over." "Okay." Wei Tian nodded and agreed.

Seeing this, Zhang Yang let out a breath and looked at Dr. Zhou, who had not spoken aside.

He has now basically understood the current situation, and we will discuss the next issue next!

After a moment of contemplation, he said:

"Zhou Bo, now there are serious adverse reactions in the combination treatment plan. What are your plans next?"

"The most Importantly, should the combination treatment plan for the remaining thirty-one subjects be paused first? ”

Zhang Yang’s question can be said to be very sharp and realistic.

But as the leader of the "Ibaichunab" project, Dr. Zhou naturally has to deal with all problems.

Fortunately, Dr. Zhou had obviously thought about this problem a long time ago. He paused a little and said in a deep voice: "Mr. Zhang, although we have considered 'aliotropic T cells' for a long time before. Activating the 'acute rejection' may cause bone marrow stem cell damage to bone marrow transplant patients, but it has to be said that in the 32-person trial, such serious side effects occurred in just three weeks, but it was beyond my expectations! "

"So, if we look at it from a scientific perspective, the probability of this side effect is actually not low!"

"So, if we consider it from the perspective of patient safety, I tend to suspend the combination treatment plan of 'ibaizumab' + 'allogeneic T cells' to avoid such bone marrow failure in more subjects." "Just like this, at least 83% of the current combined treatment plan will definitely not be able to achieve the effect of at least 83%!" Zhang Yang sighed helplessly and said: > "This is also impossible. We can't cause bone marrow failure to treat leukemia, right?" "Okay, Zhou Bo, have you thought of any other ways to replace it now?"

"No." Dr. Zhou shook his head slightly.

"The reason we considered using 'allotype T cells' was to activate the body'acute rejection reaction' and thereby increase the metabolism rate of immune cells."

"Inject'allotype T cells" Cell' is already the most mainstream and safest way at the moment, otherwise we wouldn't think of it at the first time."

"I've read and understood all other ways, it's very difficult and the technology is not mature."

"So... there may not be a good breakthrough in a short period of time."

Zhang Yang was also silent. He also participated in the plan for the combination treatment of "Yibaizumab".

If there was really a better way, I would have thought of it at the first time, and how could I come up with it now.

The conference room suddenly became a little dull. The 83% efficient treatment rate achieved by combining "Yibaizumab" + "alloy T cells" now seems to be just a flash in the pan.

But just when the atmosphere was a little depressed, Wei Tian suddenly coughed lightly on the side.

"Mr. Zhang, I still have a situation to report."

"When I went to the hospital to get the clinical data results this morning, Director Hu and I had a brief conversation."


" > "He carefully looked at the patient's bone marrow apnea report and blood signs. He gave a suggestion. He said that in Liu Xiaochuan's condition, we can try our 'ITG human bone marrow amplification 'to see if this side effect can be cured!" >
ITG human myelogenesis? !

Cure side effects of bone marrow failure? !

(This chapter ends)

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