Chapter 454 The experiment was successful
“Add alcohol to dissolve it.”
Psyche, who quickly invited help, gave an unexpected but reasonable solution.
Allicin is difficult to dissolve in water but easily soluble in alcohol. Just dissolve it in alcohol and then add physiological saline.
Frederick patted his head and said: "How could I forget? It's like having an old man in a family and a treasure."
There is alcohol in the blood after drinking too much, which is what defines drunk driving. Therefore, it is not a problem for alcohol to enter the blood vessels. Just control the concentration and drip rate.
It will be normal to be drunk by then, but it is still no problem compared to death from illness.
Psyche patted Frederick's head enthusiastically and said at the same time: "The only cosolvent that can be found now is alcohol. If you want to use Tween 80 or the like, you will have to wait a hundred or two hundred years. Use It’s okay to treat a dead horse as a living horse doctor.”
“Remember that the alcohol content is between 5% and 10%. When it exceeds 10%, the blood vessels will feel painful.”
Fu Li. Derich immediately went to prepare the medicine, and All Might had prepared the injection equipment.
Frederick thought for a long time and asked Psyche curiously: "What is Tween 80?"
Psyche replied in a low voice in Mandarin: "Its full name is sorbitan monooleic acid. Ester polyoxyethylene ether..."
"Stop!" Frederick interrupted in time, "This is an ester, an alkene, and an ether. It sounds like there is a satellite flying over my grave. It’s better not to listen to things that only exist.”
Let’s not talk about things that sound very complicated. Even the filter paper in the laboratory still took a lot of time to develop, and the equipment for producing pulp. All redesigned.
The next experiment will take time. Friedrich first determined under a microscope that the allicin agent added with an appropriate amount of alcohol was harmless to red blood cells, and then injected it into the piglets.
These piglets were divided into several groups, first according to different concentrations of allicin, only injected with normal saline, only injected with a mixture of normal saline and alcohol, and the control group. On this basis, they were then divided into groups according to the number of consecutive injection days, ranging from one to three days. Wait and observe the activities every day.
On the fourth day, all the piglets were slaughtered and dissected, and the conditions of blood, muscles, internal organs, and brains were examined.
The experiment showed that everything in the allicin-free group was normal.
The group of piglets with the highest allicin content showed uncomfortable symptoms on the first day, and the group with the second highest allicin content began to feel uncomfortable on the second day. The symptoms included swelling and coughing around the infusion point, and veins were found after autopsy. Blood vessels are damaged.
The group with the third highest allicin content had no damage to their veins at first, but the piglets in the third and fourth groups had obvious irritating cough symptoms, and the coughing stopped after the drug was stopped.
From the fifth group onwards everything was normal and no side effects were found in the daily behavior and anatomy of the piglets.
Fredelich determined the maximum daily dosage for each person based on the dosage of the fifth group through weight conversion, and then the patient tried it.
Bishop Clement brought his students from the church site to Friedrich's laboratory when they were dissecting piglets. Every time someone wanted to try a new drug, they had to be supervised by the church.
The Church of Light started by treating diseases and saving people, and has also made achievements in medicine. The priests can tell whether piglets have been harmed by drugs.
After confirming that the animal experiment was okay, Bishop Clement smiled and said to Frederick and Friedrich: "There are people on the street performing eating noodles with their noses, but it is unheard of to eat garlic directly with blood."< br>
Frederick said solemnly: "This is an impossible solution. Blessed by the God of Light, it succeeded this time."
"Other oral drugs may not be directly used in the blood, because the drugs are in Only the active ingredients are absorbed in the intestines, and the useless things are excreted as feces. If you try rashly, the part that becomes feces may enter the bloodstream.”
Frederick was excited about the results of the experiment, and it seemed like he was at this moment. A basin of cold water was poured on his head and he immediately calmed down. Bishop Clement felt that what Frederick said made sense, and said to Frederick: "Too much dust in the world has obscured the luminous gems, making the world think that the dust on the gems will also glow."
“Whether it is the glory of God or medicine, we need to work tirelessly to find the place where it truly shines.”
Frederick heard a different breath from it, but he didn't care so much about religious matters.
Bishop Clement reviewed Friedrich's human trial plan and said: "In the past, only twenty people were allowed to participate in the first phase of the experiment, but this time in order to save His Majesty Louis, I am not among the number. The Lord demands so much.”
As the saying goes, the nobles cannot be punished. Since it is to save the king, the bishop does not pay so much attention.
There are 100 patients in the first phase of the trial, all from Weissensee, half male and female, all adults over 18 years old, 20 people over 50 years old, including 20 healthy people and 15 sepsis patients. People, others are all patients with various inflammations.
Bishop Clement and the priests asked the patients and their families individually one by one to confirm whether they had been coerced or induced, whether they were aware of the risks, and whether they knew the compensation standards.
After the experiment started, Psyche was the busiest, leading a group of carefully selected nurse girls to teach them how to inject patients.
“The first step is to check the patient’s identity.” Psyche said to the nurses behind him, “There is only one kind of medicine now, and there may be more in the future. If the wrong medicine is given to the patient, the problem will be serious. "
"Then check the patient's injection card to see if the name is correct, and then check whether the medicine on the card matches the medicine issued by the pharmacy. "
Only then did Frederick know. She had been a nurse in another world and was still licensed.
Psyche continued: "Tie the tourniquet at this position. Ask the patient to make a fist and choose a thick, straight and elastic blood vessel. If there is none on the hand, you can choose the tail...not...choose the instep. For veins in other places, avoid venous valves.”
Frederick felt as if he had heard something extraordinary.
He once again lamented that having an elder in the family was a treasure. Although he had been given a lot of intravenous injections in his previous life, he really didn’t know the details.
On the first day, all patients were injected with only 2 grams of allicin. One person had a slight rash, and the others just felt a slight smell of garlic in their mouths.
The dose was increased the next day. The allergic reaction of the patient who had a rash yesterday became more severe. His trial was stopped. After he was sent for treatment, allicin was no longer injected. Later, only a mixture of normal saline and alcohol was injected. Finally, Diagnosed with alcohol allergy.
The time came to mid-April. Frederick and Psyche had been staying in Friedrich's laboratory to observe the experimental conditions. During this period, the two worked out the general principle of black and white photos and threw them to the people next to them. Weissenburg University for further research.
One hundred patients had preliminary results after 15 days of treatment.
Among the patients with sepsis, the four patients who received large doses of allicin basically recovered in 11 to 13 days. The patients who received medium and low doses also showed improvement. It seems that they can recover after continued treatment.
Allicin has also achieved good results in patients with other inflammations, and many patients have been cured or their conditions have improved.
However, allicin is powerless against an infection that causes green pus to flow from a wound. Large-dose treatment can only suppress it. It is estimated that for effective treatment, more than a safe dose of the drug must be used.
Experiments have proven that intravenous allicin is still useful. Although it is not as good as the antibiotics in Frederick's hometown, it is no different in this world than the god of light coming down to touch the patient's head.
After Bishop Clement signed and sealed the experimental report, he said to Frederick: "It is my honor to participate in the research and development of this medicine."
The next day, Frederick brought a large number of The drug and medical teams set off in an airship.
(End of this chapter)