Chapter 153 Shocking Big Melon
Looking at the experimental report on pseudouracil modification in his hand, Zhang Wei fell into deep thought.
There is no doubt that pseudouracil modification of nucleosides can allow mRNA to deceive cellular immune responses.
The future mRNA vaccine has actually been created and has even been used by billions of people.
If this scientific research result is false, there will be no subsequent mRNA vaccine.
You can repeat the same experiment and perform pseudouracil modification on nucleosides. Why did your experiment fail?
Since it is certain that this scientific research result is true, the problem must lie with you.
There are many variables in biological experiments, such as temperature, humidity, drug dosage, etc., which will all be different, and will also cause different experimental results.
“Mammals are warm-blooded animals. The body temperature of a healthy white mouse is similar to that of the human body, between 36.5 degrees and 37.5 degrees. There should be no problems with temperature and humidity.
Pseudouracilization In the modification experiment, I used the pharmaceutical glycine-arginine protein and the catalyst to stimulate the production of pseudouracil synthase, which is also no problem.
So the key point should be the dosage of the medicine. I either used too much medicine or too little. So should we increase the dosage of medicine, or should we reduce the dosage of medicine?
The function of the agent is to generate pseudouracil synthase. The amount of pseudouracil synthase generated is directly related to how much uracil is modified into pseudouracil.
If there is too much pseudouracil synthase, there will be too much pseudouracil, causing the cells to discover that there is something wrong with the mRNA, thus stimulating immunity. This makes perfect sense in theory.
If we extrapolate from this basis, if there is less pseudouracil synthase, there will be less pseudouracil. In this way, cells will not be able to detect problems with the mRNA and will not stimulate immunity! ”
After smoothing out this logic, Zhang Wei immediately realized that he had used too much medicine!
"Reduce the dose of the drug and do three more experiments, one-half, one-fourth and one-eighth of the original dose, and then observe the experimental results. If the immune system still works normally, then reduce it to One-sixteenth and one-thirty-two!”
Zhang Wei immediately formulated a new experimental plan.
……
Zhang Wei’s idea is correct. The higher the proportion of pseudouracil introduced into mRNA, the easier it is to trigger an immune response. When it reaches a certain critical value, immunity will definitely be activated. system.
On the contrary, the lower the proportion of pseudouracil introduced into the mRNA, the higher the proportion of normal uracil, which will not cause an immune response. As long as the proportion of pseudouracil is reduced to a certain critical value, the immune system can be evaded.
It's like there is one husky among a hundred wolves. It is difficult to find this husky even if you look carefully.
But if half of the hundred wolves are huskies, you can tell at a glance that there are huskies mixed in with the wolves.
With new experimental ideas, the three graduate students became busy again.
Zhang Wei stood behind, looking at the three people who were concentrating on each other. They were standing in front of the test bench. Their fingers were operating lightly and nimbly, constantly picking up and putting down various utensils, as if they were performers. Play a symphony.
“The experimental status of these people is very good. Apart from anything else, I can’t compare with their concentration. When I was tearing graphene apart before, I was not so focused. No wonder they can When I entered Tsinghua University and became a top student, I tried my best to pass the exam at the county testing station.”
Zhang Wei let out a long sigh and decided not to disturb the three graduate students. He quietly exited the laboratory.
Back in the dormitory, I saw Ye Haotian sitting at his desk with a sad face.
There are not many things that can make Ye Haotian, a sunny and cheerful boy, worry, so Zhang Wei asked curiously: "Brother Haotian, I rarely see you worried. What's wrong?"
"Have you ever felt that Chen Ming has been acting weird recently?" Ye Haotian asked.
“I’ve been busy working on new projects these days. I spent most of my time in the biology department laboratory, and I really didn’t pay attention to Chen Ming! The main reason is that Chen Ming has been missing out on the dragon lately, so he should Professor Fang probably gave me more experimental tasks!" Zhang Wei said.
"You are busy doing projects, I know that, but Chen Ming may not be busy doing experiments! Look, he has gained weight recently. If he was busy doing experiments, how could he gain weight!"
"Chen Ming Have you gained weight?" Zhang Wei thought for a while and it seemed that was really the case.
"Isn't it winter! Animals all have a saying of putting on autumn fat, and so do people. In winter, they will gain weight. Accumulating fat will help them resist freezing!" Zhang Wei said.
"Even if he has gained weight for the winter, his recent experimental tasks will definitely not be many. It is the end of the year, and the projects in the Department of Physics are almost completed, and next year's plan has also been submitted, so Professor Fang took annual leave and went to the North Sea Fleet to see his son.
It was said that Professor Fang’s son had found a partner, a new female military doctor assigned to their army, so Professor Fang went to see his future son. I’m a daughter-in-law. I’ll meet the girl’s parents by the way. If it’s suitable, the marriage will probably be settled.”
Ye Haotian is indeed a master of social science, well-informed, and even knows things about the physics department so clearly.
"If Professor Fang marries his daughter-in-law, even though the couple is stationed at the North Sea Fleet, he will probably come back to treat him to a banquet? Then I will have to follow the family! I usually give money to the family members in the capital. How much?" Zhang Wei said subconsciously.
"This is not the point! The point is that Professor Fang is not here, there are no big projects in the Department of Physics, and Chen Ming doesn't have that many experiments to do! But this guy still leaves early and comes back late. He doesn't see anyone every day. You don't Don’t you think it’s weird?”
“I almost forgot, we were talking about Chen Ming! No, it was you who started the topic of Professor Fang finding his daughter-in-law!”
Then Zhang Wei thought about it carefully, and if it was according to what Ye Haotian said, the autistic person's recent behavior was really weird.
This guy doesn't have many friends and has no need for social interaction. In addition to eating and sleeping, he usually goes to the physics department to do experiments, so he will only appear in three places, the dormitory, the cafeteria, and the physics department laboratory.
When there was no experiment, the autistic person did not go back to the dormitory to isolate himself. It was really abnormal.
Ye Haotian continued: "There is another thing, which is also very strange. When I came back, didn't I bring a box of beer to Chen Ming? But the next day I found that the box of beer was missing. Fully half!”
“Chen Ming drank half a box of beer in one day?”
“Do you think it’s possible with his drinking capacity?”
Zhang Wei shook his head: "I haven't heard of the theory of relativity recently!"
Having not heard of the theory of relativity means that the autistic person has not been drunk recently, and with his drinking capacity, how can he not be drunk with half a box of beer! "That's why I said that Chen Ming has been acting weird recently! I was wondering if he might have been abducted into some bad element group? For example, he was tricked into joining some cult organization!" Ye Haotian said.
"What are you speculating about! You have to believe in the security level of our country. And he is autistic and can't speak clearly. Why do you expect him to preach? A cult organization wants to What is he doing!"
"He is thinking about quantum physics, and he might be able to build a nuclear bomb!" Ye Haotian said.
"Well, you have a lot of imagination. You have watched too many science fiction movies."
"Anyway, I want to investigate!" Ye Haotian was possessed by Holmes.
"How to investigate?"
"Following!"
"I dare to be possessed by Kogoro Mori!" Zhang Wei sighed.
Ye Haotian continued: "I asked my senior brother from the Physics Department. Chen Ming was still in the Physics Department just now. I plan to go over now and wait for Chen Ming to come out at the door of the Physics Department, and then follow him to see what he is doing. ! "
"How about I go with you? Call Xiong Xinxin. She is better at fighting. If we encounter criminals, there will be someone to protect us!" Zhang Wei said.
"You have grown 1.8 meters tall, and you still need a woman to protect you?" Ye Haotian gave a look of disdain, and then said: "If you really encounter a criminal, you must call the police first! All your safety education was in vain!”
While chatting, the two walked out of the dormitory and walked to the door, just in time to see the pretender coming back from outside with a wad in his hand. A4 paper.
"Brother, I listened to you and posted the "Tomb Robber Diary" I wrote on the Qidian Chinese website. Guess what, they want to sign a contract with me! I will type out the contract. Okay, please help me take a look at it later!" The pretender raised the stack of A4 papers in his hand.
"I'll show it to you when I get back in the evening. I don't have time now, I'm busy!" Zhang Wei replied.
“What’s the good thing?” The pretender’s curiosity was instantly piqued.
"Brother Haotian wants to be Mouri Kogoro!" Zhang Wei said.
"Brother Haotian is Kogoro Mori, and with Viagra, you are Conan. Do you still need Officer Memu? I can do it! Brother Maori, Conan-san, let's go!"
" Conan is a generation younger than Officer Memu, are you trying to take advantage of me? Does this make you act ethically?”
"He is also taking advantage of me. He calls me brother Mouri Kogoro! I said Xiaolu, you really know how to choose roles, especially those with seniority!"
The three of them were playing around and arrived. Entrance to the Department of Physics.
Ye Haotian took out his mobile phone, sent a text message, and then said; "The senior brother from the physics department said that Chen Ming is coming downstairs. Let's hide quickly and don't let him see it."
Three The individual immediately hid in a corner.
Not long after, the autistic man indeed appeared in the sight of the three of them.
The autistic man took out his cell phone, glanced at the content on it, and then walked directly south.
"The dormitory is in the north. Chen Ming is walking south. It seems that he doesn't plan to return to the dormitory." Ye Haotian said.
The three people followed from a distance, and saw the autistic man walking towards the east again after reaching the intersection.
"Is the gymnasium to the east? Brother specimen is going to do some exercise?" Lu Yunxiang asked.
"You say he is a specimen, how can he still do sports! I still play ball occasionally. Have you seen him do sports?" Zhang Wei responded.
However, when he got to the basketball court, the autistic man turned south again.
"To the south is the main building, which is the office area! Chen Ming doesn't know the leaders in the school. What is he doing there?" Ye Haotian said.
"Don't forget, go further along the main building and you will leave the school. Maybe he will leave the school. If the criminal is outside the school, it will be really dangerous for us to follow him. Now his name is Xiong Xinxin It’s not too late to come over,” Zhang Wei said.
While the two were talking, they saw the autistic man turn around again and walk into the large green area behind the main building.
It is winter at this time, and the grass in the green area has turned yellow, with only a few pines still retaining some green.
"It's winter, and there's not much scenery to see inside. What's Chen Ming doing there?"
"Is Brother Specimen in need of urination and wants to go in for convenience?"
" What are you thinking about? There is no bathroom in the next building? Besides, Chen Ming is just autistic and not that shabby!"
While the three of them were talking, the dog came closer.
I only saw Chen Ming sitting under a tree from a distance, but he was not alone.
Next to Chen Ming, there was a girl wearing a light yellow down jacket and a red scarf sitting. The two were holding hands and leaning against each other!
At this moment, the three of them couldn't believe their eyes.
Shocking big melon!
Autistic people are actually in love!
(End of this chapter)