Chapter 246 The truth - TEF glycoprotein! (Happy New Year!)
"How is the situation?"
"Boss, I'm a little surprised."
"We have drawn thirty-two in the past two or three days. After a few days of analysis, we have found that Xia Xue has dozens of microbial indicators and blood indicators significantly higher than other patients. "
" At the same time, " More than ten residual substance factors that have never been found in Xia Xue's blood residues, but we are not clear about which indicators or substances affect the effect of drug treatment, and we need to be more detailed. Analysis and verification of items! ”
"Well, thank you for your hard work, Wei Tian."
Qingshan Pharmaceutical Drug R&D Center, in the biological laboratory where the first project team is located.
Zhang Yang listened carefully to Wei Tian’s latest report and nodded gently to express his approval.
"By the way, you can arrange an analysis project for me, and I want to participate."
"You want to participate too?"
Wei Tian was a little surprised.
"Yeah."
Zhang Yang nodded again:
"I heard about all the patients who supported you when you went to the hospital two days ago, and I am quite good. Shocked! "
"So, I also want to do my part, we can't let their expectations down, right?!" "
Wei Tian was stunned, then took a deep breath, nodded and said, "Okay boss, then I will arrange a task for you!" "It just so happens that we really need manpower in urgent need, The amount of data in this experiment is too large! "
"Yes."
...
...
Zhang Yang's active joining is also a microcosm of the entire Qingshan Pharmaceutical's emphasis on the improvement plan of "Yibaizumab".
In the next few days, more blood specimens and biological tissues were sent to Qingshan Pharmaceutical Drug R&D Center.
Seven days after implementing the Yibaimab improvement plan,
A total of thirty-two subjects were collected every six hours for up to seven days, and all blood samples were collected every six hours without missing out Appeared at Qingshan Pharmaceutical's drug research and development center!
The thirty-two patients who participated in the improvement plan finally breathed a sigh of relief, twenty-five milliliters at a time and one hundred milliliters a day!
The blood loss of 700 milliliters in the entire seven days had approached the limit of their human body.
While they were breathing a sigh of relief, Qingshan Pharmaceutical quietly took over the baton.
Three days later.
Eleven at night.
The biological experiment on the first floor of Qingshan Pharmaceutical Drug R&D Center was brightly lit, and more than 40 drug R&D personnel from the first project team were still fighting at night.
"Boss, it's eleven o'clock. It's the latest overtime time specified by the company. Do you think you'll be here today?!" Zhang Yang looked up at the clock hanging high in the middle of the laboratory. , exhaled slightly, and nodded. "Well, let's stop here today, please come back from get off work; after all, the body is the capital of revolution!" "By the way, have the results of the analysis and experiment in your hands come out? How is it? Is it positively related to the treatment effect? "
Wai Tian shook his head when he heard this:
"The experimental results have come out, but no obvious correlation between the experimental plan and the treatment effect was found. We have to continue to screen."
"What about you? Boss."
"I No connection was found. "
"Okay, boss, then I'll go and greet everyone from get off work first." "
"Okay."
After a simple conversation, Wei Tian slowly walked to various experimental tables and greeted everyone after get off work.
Yang's eyes gradually left Wei Tian, and his thoughts returned to the analysis experiment in front of him.
Although there are only dozens of obvious "abnormal indicators" found in Xia Xue's body this time, and only more than ten unknown residual substances were found, however!
It is very troublesome to verify the correlation between each indicator and the treatment effect. Apart from trying one by one, there is no better way!
More than ten unknown residual substances are even more troublesome. Before verifying the correlation of treatment, you must also understand the components and sources of the unknown substances, which also requires a lot of experiments.
"Huh... I can't be anxious, I can only take it step by step."
"At this time, I really felt how awesome the medicine given by the simulator was!"
" >Zhang Yang couldn't help but sigh in his heart, and a bitter smile appeared on his face.
After obtaining the drug ingredients from the simulator, I tried every means to set obstacles for the R&D team. Now it is my turn to develop independently, and I hope that the less trouble the better!
After feeling moved, Zhang Yang slowly stood up. Seeing that everyone started to clean up the laboratory bench and start sorting out the experimental data, he stepped forward and walked to the middle of the laboratory and said:
"Everyone has worked hard, just clean up and leave."
"The half-hour postponed to work tomorrow morning, so everyone rested for a while."
"Is the car ready? Wei God? "
"Well, you're ready." Wei Tian looked at Zhang Yang, then nodded and confirmed:
"The company's commuter cars are ready, and the three masters are waiting in the car. It's still the same as before, with three cars in three different directions. Everyone takes the car heading home by themselves."
< br>"Okay, Director Wei, we know."
There were many responses from colleagues in the laboratory, and Zhang Yang also had a satisfied smile on his face.
When several colleagues who were moving quickly had packed up the laboratory bench and prepared to leave, Zhang Yang suddenly noticed that there was another colleague in a corner not far away, still lowering his head, as if he was still conducting experimental monitoring.
He was slightly surprised and walked slowly over, getting closer. He barely remembered the name of the drug developer - Qin Xiaohua through his back.
Qin Xiaohua has not been in the company for a long time, and he was even not a drug researcher in the first project team at the beginning.
If he remembered correctly, Qin Xiaohua should have been the sixth project team? It was also a researcher in the eighth project team. It was only after Wei Tian convened most researchers in the R&D center to sprint for the "Yibaizumab" progress that Qin Xiaohua took the initiative to stay in the first project team and officially returned to the previous drug development track. Turned to the development of leukemia drugs.
Thinking of this, Zhang Yang couldn't help but get a little faster. It's a good thing to focus on experiments, but it's really a bit late today.
But just as soon as he walked behind him, Qin Xiaohua suddenly shook all over and then shouted excitedly: "I discovered it, I discovered it!"
"Team leader, I discovered it, I discovered it!" Zhang Yang was suddenly startled, but after hearing what Qin Xiaohua shouted loudly, he was also shocked. The relaxed expression suddenly became nervous, excited and even said with a little expectation: "Qin Xiaohua, what's wrong?! What did you find?!"
Qin Xiaohua focused on the experiment. He didn't notice that Mr. Zhang had quietly appeared behind him at some point!
After a sudden stunned moment, he looked around, and then he realized that not only Mr. Zhang was standing behind him, but his colleagues were already cleaning up the laboratory bench and preparing to get off work!
Oh my God, it's eleven o'clock in the evening? ?
Hiss!
I was so focused on the experiment that I didn't even notice everyone's situation!
"Qin Xiaohua, what are you stunned? Tell me quickly, what did you find!?"
Qin Xiaohua's loud shout naturally attracted the attention of all his colleagues, and everyone stopped. Steps await him to speak out new discoveries.
But after Mr. Zhang's question, he not only did not answer in time, but was stunned, which made the team leader beside him remind him quickly.
Fortunately, Qin Xiaohua finally reacted. He looked at Zhang Yang in front of him, and remembered the experimental results he had just obtained again in his mind. He became excited in an instant:
"Mr. Zhang, I found out. An unknown substance factor that is positively related to the therapeutic effect! ”
! ! !
Zhang Yang's expression suddenly shook, and his heartbeat couldn't help but accelerate!
I really discovered it!
After a moment, he held his excitement and said in a deep voice:
"Don't worry, you can say it slowly!"
Not only Zhang Yang, but all the things in the biology laboratory are there. Everyone moved over in an instant, and even a few colleagues who had already reached the door and were about to leave turned around and leaned over!
Just kidding, who doesn’t want to know Qin Xiaohua’s discovery? !
Qin Xiaohua recovered: "Just Zhang is like this!" "Didn't we find some unknown substance factors in Xia Xue's blood sample a few days ago? Of course, it's accurate The statement should be that there are no material factors that have been studied in a large amount of research materials. "
No mistakes, one poem, one content, one in 6, one book, one bar, one reading! "The experimental task I assigned is to analyze one of the unknown substance factors and figure out the components, sources and functions!"
"After several experiments, I confirmed that this unknown substance factor is a glycoprotein secreted by a special subtype of CD8+ T cells, a subset of immune cells."
"For the sake of convenience of recording, I Previously, this glycoprotein secreted by a special subtype of CD8+ T cells was named Target-enhancingFactor, referred to as TEF for short. "
"And, I want to correct an error here." "
" We previously thought that this unknown substance factor, that is, TEF glycoprotein, only appeared in Xia Xue's blood samples, but after I analyzed the blood samples of other patients in detail again, I found that TEF glycoprotein not only appeared in Xia Xue's blood. There are also present in the blood samples of other patients! ”
“Just! ”
"Xia Xue's blood concentration of TEF glycoprotein is much higher than that of other patients, and the cellular signal is very active, while other patients' blood concentrations of TEF are low and very stable, so it is difficult to detect without using special methods!"
Zhang Yang's expression was slightly stunned.
The subset of immune cells - CD8+ T cells, which are normal immune cells in the human body.
In fact,
The immune cells in the human body are actually similar to normal cells in operation. They will also go through the process of generation and failure, so when they are running normally, they will also secrete various sugars. Protein and cellular metabolites.
It is just that the glycoproteins secreted by various immune cells are different, and the secreted content is extremely low and the structure is stable, so the pharmacological community generally regards it as a substance produced by normal metabolism of immune cells, so there is no further research.
Is it!
The reason why "Yibaizumab" is so effective in Xia Xue's body is because it is related to this TEF glycoprotein? !
Qin Xiaohua also saw Zhang Yang's doubts and urgency, and hurriedly said: "Mr. Zhang, you know!"
"Our 'Yibaituzumab' was not an inhibitory target drug, but a killer that directly targets the antigens on the surface of leukemia cells!"
"Its core drug design principle It is to use drug components to combine the surface antigen of leukemia cells to determine which cells are leukemia cells and which are normal cells, so as to identify and kill them! "
" But everyone has seen the effects in clinical trials. The volatility of the treatment effect is very large, so I guess the biggest possibility is the violent fluctuation caused by the unstable binding efficiency of 'ibaizumab' on the surface of leukemia cells. "
" And just so happened to be, Xia Xue High concentration of TEF glycoprotein in the body seems to allow 'ibaizumab' to better bind the surface antigens of leukemia cells! "
"This is also the result I obtained in my experimental analysis just now!" "
Zhang Yang was shocked all over and his face was shocked!
Does of top drug personnel who had already formed a circle next to them were also surprised. A TEF glycoprotein secreted by immune cells actually allowed ibaizumab to better bind to the surface antigens of leukemia cells. ? !
This... this is a discovery that has never been made before!
"Qin Xiaohua, what is the principle? Do you know how to implement it?!"
Qin Xiaohua's face suddenly smiled bitterly, shook his head, and said:
"Mr. Zhang, I have just verified the positive correlation between the therapeutic effect of TEF glycoprotein and 'ibaizumab'. I don't know why and what principle can better bind surface antigens of leukemia cells. "
Zhang Yang took a deep breath, then took the experimental results handed over by Qin Xiaohua and quickly scanned. Half a minute later, he handed it to Dr. Zhou, the leader of the project team, on the side.
A minute later, Dr. Zhou nodded heavily.
"This TEF glycoprotein does have a significant positive correlation with 'Ibaimab'!"
"Mr. Zhang, why don't we work overtime and figure out the specific details tonight Reason? ! ”
After the words finished, before Zhang Yang could speak, the onlookers were ready to rub their hands, and the tiredness in the middle of the night was wiped out.
What can be more exciting than discovering the "New World"? "Okay!" Zhang Yang nodded, but soon his words changed and his eyes fell on the other R&D personnel present! "But everyone, don't stay up late. Go back and rest first, and continue fighting tomorrow!"
"Tonight, I, Zhou Bo, Wei Tian and Qin Xiaohua, let's work overtime to figure out the situation of TEF glycoprotein?"
"How is it, Xiaohua?"
< br>"Okay!"
Qin Xiaohua naturally agreed, but was very excited.
…
With specific research and development directions, Zhang Yang, Zhou Bo and Wei Tian are all truly top drug developers.
A night passed, more secrets about TEF glycoprotein were revealed. How it is connected with "Ibaimab", what paths and principles are used to better combine the surface of leukemia cells. The antigen was also parsed.
At 8:30 am the next morning, the R&D team of the first project team who rushed to work came to an accurate and clear conclusion.
TEF glycoprotein is indeed secreted by a special subtype of CD8+ T cells, a subset of immune cells.
When the concentration of TEF glycoprotein in the blood becomes high, the TEF glycoprotein will fully bind specifically to the FC-segment drug components of "Ibaituzumab" and specific receptors on the surface of leukemia cells at the same time. .
Simply put, after TEF glycoprotein first binds to the Fc segment of "Ibaituzumab", it will change the steric conformation of the antibody, so that the antigen binding part of the original drug can be more accurately and efficiently with The binding of antigens on the surface of leukemia cells, like a "recognition enhancer", greatly enhances the recognition of highly occult leukemia cells!
At the same time, TEF will also bind to the surface receptor of leukemia cells, induce the aggregation and conformational changes of the surface antigen of leukemia cells, further improving the affinity of the "Ibaituzumab" antigen, making Ibaituzumab Anti-anti- tion can be anchored more firmly on the surface of leukemia cells, not easily fall off, and enhance drug killing!
It can be said that
TEF glycoprotein is like a targeting factor synergist. After binding to the FC segment of Yibaimab, it greatly enhances the "Yibaimab" "The ability to identify occult and genetic mutations in leukemia cells!
But then, a huge confusion appeared in the minds of all R&D personnel.
So!
Why are they all severe leukemia? Only Xia Xue’s blood concentration of TEF glycoprotein is so high?
TEF glycoprotein is secreted by CD8+ T cells, a subset of immune cells. Is it related to immune cells?
(This chapter ends)