Chapter 247 The real truth - acute rejection!
Twelve o'clock noon.
Qingshan Pharmaceutical's Zhangyang office.
Zhang Yang slowly opened his eyes. After a moment, he took out his phone and looked at the time on the screen, then turned over and got out of bed.
Last night, Qin Xiaohua discovered TEF glycoprotein, he took the initiative to work overtime all night with Dr. Zhou and Wei Tian and conducted an experimental analysis for 9 hours.
Until 8 a.m., he couldn't stand it anymore and simply returned to the office to rest for a while.
Seeing that he had been sleeping for 4 hours, Zhang Yang was no longer sleepy, so he cleaned up and prepared to go to the drug research and development center again.
The noise of Zhang Yang getting up in the office fell into the ears of office assistant Xiao Chen. When Zhang Yang pushed open the door and walked out of the office door, assistant Xiao Chen appeared at the door.
"Mr. Zhang, you have only been resting for 4 hours. Do you want to take a while?"
"No, 4 hours are enough!"
Zhang Yang shook his head and then said after a moment: "Is there any new news from the drug R&D center?" "No." "Okay."
Zhang Yang was not surprised. While speaking, he walked quickly towards the elevator.
Just entered the elevator: "Xiao Chen, I'm going to the drug research and development center now, so you don't have to follow me." "This way, you go to the cafeteria to help me get some food, so I'll do it too I'm really a little hungry! "
"Okay Mr. Zhang."
After arranging the office assistant Xiao Chen, Zhang Yang quickly came to the first floor of the first project team of Qingshan Pharmaceutical R&D Center. Office area.
At this time, the office area was crowded with people, and dozens of R&D personnel of the "Yibaichunbacter" project were busy. He immediately looked at the innermost place in the office area, which was a small person where Dr. Zhou was located. Closet.
After a moment, he looked a little surprised. He not only saw Dr. Zhou, but also Wei Tian's figure.
Hurried over.
"Zhou Bo and Wei Tian, haven't you rested after I left? This has been working continuously for more than 24 hours!"
The appearance of Zhang Yang was slightly stunned by the two of them. Zhou Bo immediately smiled and replied:
"Mr. Zhang is fine. I'm not very sleepy yet. If I don't understand the situation of TEF glycoprotein, I really can't sleep." Wei Tian, who was standing beside him, even more concerned about Zhang Yang:
" Boss, you only had a rest for a while, right? Do you want to go to bed for a while? "
"Don't worry, there are Dr. Zhou and me here, we can do it."
Zhang Yang suddenly He took a deep breath and shook his head and said:
"I'm not sleeping anymore, I've been worrying about this and can't sleep."
As he said, his eyes fell on Dr. Zhou again and said seriously:
"Zhou Bo, I'm Understand your mood, but we can't work so hard, the body is the capital of the revolution! "
"You go and rest now, and you, Wei Tian, you go back and rest together, leave the matter here to me "
Watching Zhang Yang's face gradually becoming serious, neither Wei Tian nor Dr. Zhou could help but feel a little fear.
After a moment, Dr. Zhou lost the relaxed smile on his face and said: "Okay, Mr. Zhang, I'll listen to you." "However, you asked me to give the last experiment After you know, you will leave for up to five minutes."
The serious expression of the stern expression then relaxed, and nodded and said:
"Okay, after seeing the result, you must go home. I've had a rest, I'll ask my assistant to give you it."
As he said that, Zhang Yang sat down and turned to the topic: "Before eight o'clock this morning, we have confirmed the principle and operating mechanism of 'TEF glycoprotein'!"
"How is the situation now?"
"Did you find out the reason why Xia Xue's TEF glycoprotein concentration is high in these four hours?"
"Is it as we expected That is because the concentration of CD8+ T cells in Xia Xue's subset of immune cells - the concentration of CD8+ T cells is higher than that of other patients? So the concentration of TEF glycoprotein is higher? ”
"No."
After the words, Wei Tian glanced at Postdoctor Zhou and shook his head slowly.
After a moment, he picked up a stack of reports from his desk and handed them to Zhang Yang. "Boss, this is a newly released experimental data analysis report!" "You went to rest and had a colleague come to work. Zhou Bo and I immediately arranged for each R&D team to start following the We have experimentally verified the ideas we expected."
"But after analyzing the blood samples of ten patients, it was found that even if the treatment effect was only 51%, the concentration of CD8+ T cells in the blood and the blood content of Xia Xue was not significantly different!"
" There is no obvious difference? ! ”
"Are you sure? ! ”
"Well, I'm sure!" Zhang Yang was stunned. The result was completely beyond his expectations!
A moment later, he took the experimental report handed over by Wei Tian in surprise. After quickly scanning the pages, he couldn't help but put on a mask of pain on his face.
According to normal logic, since TEF glycoprotein is secreted by immune cell CD8+ T cells, the higher the number of CD8+ T cells in the blood, the more it is produced The more TEF glycoprotein, the higher the concentration.
Yes, that's the logic!
But now!
Although Xia Xue's TEF glycoprotein in her body is obviously higher than that in other patients, the immune cell data is basically the same as that in other patients!
This!
What's going on?
Zhang Yang suddenly fell into a dead end.
At this moment, Dr. Zhou, who was standing beside him, coughing lightly. It was obvious that he had experienced such a confused period as Zhang Yang, and seemed to have found a reasonable explanation.
"Mr. Zhang, when we first got the experimental results, we doubted life as much as you."
"However, after checking some leukemia-related information, I found that patients with leukemia, especially those with severe leukemia, have been diagnosed with long-term internal organs. Being eroded by leukemia and the influence of chemotherapy and radiotherapy, the immune cells in the body will be lowered below the normal value of ordinary people in the later stage. This is also the reason why all leukemia patients are prone to infection because their immune system has been destroyed. "
"So, it would be abnormal if Xia Xue's immune cells are far more than others. Just imagine, if Xia Xue's immune cells are extremely large and the concentration is very high, then she With his powerful immune cells, he can kill leukemia cells and will not become a serious disease! ”
Dr. Zhou’s explanation is easy to understand.
Indeed, the typical symptom of patients with leukemia is low immunity and immune cells are in a state of shutdown.
But this made Zhang Yang even more confused!
Low and low-density immune cells actually produce high-density and high-density TEF glycoprotein secretions, which is so strange!
Isn't TEF glycoprotein related to the number of immune cells?
What is that? !
Zhang Yang has no answer.
His eyes fell on Wei Tian and Dr. Zhou inadvertently, and he knew that Zhou Bo and Wei Tian must have no answer!
Thinking of this, he took a deep breath. It seemed that the truth of TEF had to continue to search for the experiment one by one.
At this moment, Xiao Chen, the office assistant who had previously ordered, hurriedly walked in with a box of lunch. He quickly walked to Zhang Yang and said, "Mr. Zhang, I have made some food for you in the cafeteria. Do you think it's up to your taste?"
Zhang Yang could not eat at this time, and he waved his hand without even looking at it, "Let's put it aside!" As he said that, he looked at Wei Tian on the side, "Wei Tian, show me the information about all the patients participating in the improvement plan this time. I want to re-examine my idea!" "After finding it, go home quickly Now! And Zhou Bo, the experimental data you are waiting for is also out? If you don’t find any major discoveries, hurry up and go home! ”
"Xiao Chen, arrange two drivers to send Director Wei and Zhou Bo home!"
"Okay, Mr. Zhang."
As Xiao Chen's answer, Dr. Zhou couldn't help but face with his face. A wry smile appeared, and after a moment, he had to nod and said, "Okay, Mr. Zhang, then I will pack up my things and go back to rest."
"Yes!" >
Dr. Zhou began to pack up his things simply, and Wei Tian also found a piece of information and data from a pile of materials and handed it to Zhang Yang.
No mistakes, one poem, one post, one content, one in 6, one book, one bar, one read!
Zhang Yang lowered his head and began to check it out.
The improvement plan included thirty-two subjects, the first patient was Xia Xue.
【Xia Xue, female, 25 years old, after one week of injecting 'ibaimab', the leukemia cells in the body decreased by about 85% (estimated by CT-PET data). After two weeks, the number of leukemia cells decreased by 91% . (Bone Marrow Apnea Smear), maintained at 91% after three weeks. 】
[Cheng Wei, male, 26 years old, after one week of injection, the leukemia cells in the body decreased by about 79% (CT-PET). After two weeks, the number of leukemia cells decreased to 85%, and after three weeks, 84.6%. 】
【Xu Guanghua, female, 18 years old, after one week of injection, the leukemia cells in the body decreased by about 76%. After two weeks, the number of leukemia cells decreased to 82%, and after three weeks, 82.6%. 】
【…】
Zhang Yang checked one by one.
Xia Xue's treatment effect is the best among the 32 people in this batch, followed by a 26-year-old man named Cheng Wei, and then an 18-year-old girl.
After watching the thirty-two patients, Zhang Yang did not find any rules or abnormalities. If he had to say that there was, then the top ten were all 18-30 patients, all of whom were very young.
But this obviously cannot become any rule.
Soon, a thin stack of patient information was flipped to the last two pages.
【Patient medical record. 】
【Xia Xue: Five years ago, the patient underwent the first bone marrow transplant surgery and transplanted the donor's father; five years later, in June this year, he found a recurrence. After three months of chemotherapy, A secondary transplant was performed. 】
[The operation is in good condition, but two months after the operation, the sudden "acute rejection" suddenly appeared and it could not be controlled. After one month of acute rejection, it was treated with the clinical trial of "Ibaimab". 】
[Cheng Wei: The first bone marrow transplant operation was performed four years ago, and the mother of the donor patient was transplanted; the 'chronic rejection symptoms' appeared one year after the operation, and the transplanted bone marrow three years after the drug control Stem cells were inactivated, leukemia completely relapsed, and then received a clinical trial of 'ibaizumab'. 】
【Xu Guanghua: A bone marrow transplant surgery three years ago, and an infection occurred one month after the operation, and chronic rejection immediately occurred. Two years later, the transplant failed and leukemia relapsed, and then he received 'Yibaishan Anti-epidemic 'Clinical trial treatment. 】
Zhang Yang still read the detailed medical records of each patient very seriously, but after seeing them from beginning to end, he still found no abnormalities.
Because all patients who participated in the independent drug "Yibaimab" were severely ill patients, all subjects had received at least one bone marrow transplant, and eventually they either had rejection, which led to the failure of the transplant. or the patient who relapses directly after leukemia.
After all, if there is no recurrence or rejection, even if it is cured and becomes a normal person, how can you participate in any clinical trial?
So, everyone's medical records are actually similar.
When thinking of this, Zhang Yang was really puzzled.
"Rejection and recurrence are common conditions for all subjects, and Xia Xue's medical records are no exception. But what exactly causes Xia Xue's blood to have higher TEF glycoprotein than others?"
As he said that, he frowned and slowly turned to the next page.
But as soon as he finished speaking, his expression suddenly faded, and the page he had turned over suddenly turned back again.
The starry eyes fell directly on the first line Xia Xue's past medical records.
[Xia Xue: Five years ago, the patient underwent the first bone marrow transplant surgery and transplanted the donor's father; five years later, in June this year, he found a recurrence, and after three months of chemotherapy, he performed A secondary transplant. 】
[The operation is completed well, but two months after the operation, the sudden "acute rejection" suddenly appeared and the acute rejection was uncontrollable. After one month of the acute rejection, he received the clinical trial of "Ibaimab". 】
Acute rejection!
This time, Zhang Yang's attention was directly focused on the four words "acute rejection"!
The next second, his eyes quickly moved down, and he became more and more shocked as he looked!
[Cheng Wei: Chronic rejection. 】
【Xu Guanghua: Chronic rejection. 】
【Zhang Lele: Chronic rejection. 】
[Liu Xiaochuan: Chronic rejection! 】
! ! !
The thirty-two subjects who participated in the independent drug use of clinical trials, except Xia Xue, all of them had chronic rejection!
Yes!
Chronic rejection!
The sudden discovery was like a ray of light in the dark night that illuminated his chaotic mind instantly, and the keenness of the top drug developer made him react in an instant!
This kind of keenness made him not even need to think about it, a complete set of logical closed loops instantly emerged in his mind!
Qin Xiaohua's conclusion is actually wrong, or incomplete.
"TEF glycoprotein" is indeed secreted by immune cell D8+ T cells, but!
The number of immune cells will not increase the concentration of TEF glycoprotein. What can really affect TEF glycoprotein should be an acute rejection reaction!
right!
Acute rejection reaction!
Zhang Yang's mind exploded instantly, and all his thoughts became extremely clear!
What is an acute rejection reaction? !
Simply put, the human immune cells discover foreign substances and start to kill invading objects crazily!
At this time, the immune cells will run at full speed, commanding the brain center to collect a large amount of energy substances in the body to provide them to immune cells!
Why!
Because immune cells have to work, they consume a lot of glycogen and energy!
Once immune cells begin to activate and experience rejection reactions, the rate of proliferation and the rate of immune cells metabolism will be far several times or even dozens of times higher than normal conditions!
Yes!
Especially the speed of metabolism!
When immune cells need to kill target cells, they need to release cytotoxic substances such as perforin and granzyme through exocytosis. This process requires ATP to provide energy.
In other words!
The faster the metabolism of immune cells, the more perforin, granzyme and other substances are secreted, and the stronger the immune cells are!
And just so happens that TEF glycoprotein is the metabolite of immune cells!
"It makes sense, it makes sense!"
"Xia Xue's body's 'TEF glycoprotein' concentration is so high because acute rejection still occurred in her body three weeks before participating in the clinical trial. Reaction', so a large number of metabolites for acute rejection reactions appear in the body - TEF glycoprotein! "
As for why the TEF glycoprotein in patients with chronic rejection reactions is not so high, it is because of chronic rejection. Although the heterogeneity is also rejection, the degree is mild, and the metabolism of immune cells in the body is not acute and intense, so TEF glycoprotein is controlled in a relatively stable metabolic state!
As for why, except Xia Xue, there was no acute rejection patient among the thirty-two subjects.
This idea just appeared in Zhang Yang's mind and he got the answer in an instant.
If Xia Xue had not met Director Hu by chance, she would have received "Yibaizumab treatment" as soon as possible, she would have died at this moment.
That's right.
Compared with chronic rejection, patients with acute rejection have a very high mortality rate...
Those patients with acute rejection died without waiting for Yibaizumab.
Xia Xue is just one of the lucky ones!
(This chapter ends)